{"id":17329,"date":"2020-05-09T09:19:15","date_gmt":"2020-05-09T06:19:15","guid":{"rendered":"https:\/\/xenobg.com\/?p=17329"},"modified":"2020-05-09T09:43:04","modified_gmt":"2020-05-09T06:43:04","slug":"povishavane-na-nad-terapevtichno-za-covid-19","status":"publish","type":"post","link":"https:\/\/xenobg.com\/el\/povishavane-na-nad-terapevtichno-za-covid-19\/","title":{"rendered":"\u041f\u043e\u0432\u0438\u0448\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u043d\u0438\u0432\u0430\u0442\u0430 NAD \u0431\u0438 \u043c\u043e\u0433\u043b\u043e \u0434\u0430 \u0431\u044a\u0434\u0435 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u043d\u043e \u0437\u0430 COVID-19"},"content":{"rendered":"

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https:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.17.047480v2.full<\/a><\/p>\n\n\n\n

https:\/\/www.nutritionaloutlook.com\/science\/preclinical-research-shows-covid-19-infection-may-dysregulate-nad-synthesis<\/a><\/p>\n\n\n\n

\u201c\u2026A new preclinical study<\/a> found that SARS-CoV-2<\/strong> (the virus that causes COVID-19) infection of cell lines, infected ferrets, and a deceased patient\u2019s lung dysregulates nicotinamide adenine dinucleotide (NAD+) synthesis and utilization<\/strong>. Explaining the findings that led to this current preclinical study, Charles Brenner, PhD, chief scientific advisor to ChromaDex (Los Angeles, CA), and co-author of the study states: \u201cWe started by looking at the effect of a related coronavirus that infects mice. It disturbs the gene set that controls cellular NAD<\/strong>. Moreover, we showed that within 12 hours of initial infection, the virus greatly depresses levels of NAD, the central catalyst of metabolism<\/strong>.<\/span>\u201d In the current preclinical study, Brenner explains, researchers found that the COVID-19- causing virus turns off two gene pathways for NAD production and increases gene activity in two other pathways when it infects a cell<\/strong>. \u201cThe nicotinamide riboside pathway is frequently up-regulated in conditions of metabolic stress. Viral infection is such a condition,\u201d says Benner. The study provides important evidence about the nature of immune defense to the virus, but further research is necessary to determine potential treatments. \u201cOur data says that the innate immune defense against viral infection depends on NAD and that it may be more effective at higher NAD<\/strong>,<\/span>\u201d says Brenner. \u201cWe\u2019re looking at whether nicotinamide\u2026<\/strong> a vitamin<\/strong>\u2026will protect against viral infection in cells and animals<\/strong>. We need a bit more proof of concept, and then we\u2019ll be able to do human clinical studies.\u201d<\/p>\n\n\n\n

\u03a0\u03b7\u03b3\u03ae: http:\/\/haidut.me\/?p=1055<\/a><\/p>\n\n\n

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\u0414\u043e\u0441\u0442\u0430 \u043d\u0430\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435, \u043a\u043e\u0435\u0442\u043e \u043e\u0449\u0435 \u0432\u0435\u0434\u043d\u044a\u0436 \u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u0430 \u0440\u0435\u0448\u0430\u0432\u0430\u0449\u0430\u0442\u0430 \u0440\u043e\u043b\u044f \u043d\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f\u0442\u0430 \u0434\u043e\u0440\u0438 \u043f\u0440\u0438 „\u043d\u0435-\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0438“ \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f, \u043a\u0430\u0442\u043e \u0432\u0438\u0440\u0443\u0441\u043d\u0438\u0442\u0435 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438. \u0412 \u0442\u043e\u0437\u0438 \u043c\u043e\u043c\u0435\u043d\u0442 \u0434\u043e\u0440\u0438 \u043a\u043e\u043d\u0432\u0435\u043d\u0446\u0438\u043e\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430 \u043f\u0440\u0438\u0437\u043d\u0430\u0432\u0430, \u0447\u0435 \u0432\u0441\u044f\u043a\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f \u043d\u0430 \u0442\u044f\u043b\u043e\u0442\u043e \u0441\u0435 \u043d\u0443\u0436\u0434\u0430\u0435 \u043e\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u044f, \u0437\u0430\u0442\u043e\u0432\u0430 \u0435 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u0434\u0430 \u0441\u0435 \u043e\u0447\u0430\u043a\u0432\u0430, \u0447\u0435 \u0442\u044f\u043b\u043e \u0441 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438 \u0440\u0435\u0437\u0435\u0440\u0432\u0438 \u0449\u0435 \u0431\u044a\u0434\u0435 \u043f\u043e-\u0434\u043e\u0431\u0440\u0435 \u0437\u0430\u0449\u0438\u0442\u0435\u043d\u043e \u043e\u0442 \u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438, \u043a\u0430\u0442\u043e COVID-19. 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