{"id":22653,"date":"2024-02-29T21:54:22","date_gmt":"2024-02-29T19:54:22","guid":{"rendered":"https:\/\/xenobg.com\/?p=22653"},"modified":"2024-02-29T21:55:37","modified_gmt":"2024-02-29T19:55:37","slug":"vitamin-d-e-polezen-pri-rak-na-gastrointestinalnia-trakt","status":"publish","type":"post","link":"https:\/\/xenobg.com\/el\/vitamin-d-e-polezen-pri-rak-na-gastrointestinalnia-trakt\/","title":{"rendered":"\u0412\u0438\u0442\u0430\u043c\u0438\u043d D \u0435 \u043f\u043e\u043b\u0435\u0437\u0435\u043d \u043f\u0440\u0438 \u0440\u0430\u043a \u043d\u0430 \u0433\u0430\u0441\u0442\u0440\u043e\u0438\u043d\u0442\u0435\u0441\u0442\u0438\u043d\u0430\u043b\u043d\u0438\u044f \u0442\u0440\u0430\u043a\u0442."},"content":{"rendered":"<p>\u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435 \u043f\u043e\u043a\u0430\u0437\u0432\u0430, \u0447\u0435 \u0434\u043d\u0435\u0432\u043d\u0430 \u0434\u043e\u0437\u0430 \u043e\u0442 4,000 IU \u2013 8,000 IU \u0432\u0438\u0442\u0430\u043c\u0438\u043d D \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0440\u0430\u043a \u0441 \u0434\u043e 36%. \u041f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u043e \u0432 \u0434\u0432\u0435 \u0444\u0430\u0437\u0438 \u2013 \u043f\u0440\u0438 \u043f\u044a\u0440\u0432\u0430\u0442\u0430 \u0441\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430 4,000 IU \u0432\u0438\u0442\u0430\u043c\u0438\u043d D \u0434\u043d\u0435\u0432\u043d\u043e, \u0430 \u043f\u0440\u0438 \u0432\u0442\u043e\u0440\u0430\u0442\u0430 &nbsp;&#8211; 8,000 IU \u0434\u043d\u0435\u0432\u043d\u043e. \u0418 \u0434\u0432\u0435\u0442\u0435 \u0444\u0430\u0437\u0438 \u043e\u0442\u0447\u0438\u0442\u0430\u0442 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u043d\u0438 \u043f\u043e\u043b\u0437\u0438 \u043e\u0442 \u043f\u0440\u0438\u0435\u043c\u044a\u0442 \u043d\u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d D. \u0417\u0430\u0431\u0435\u043b\u044f\u0437\u0432\u0430 \u0441\u0435 \u0441\u044a\u0449\u043e \u0435\u0434\u0438\u043d \u0434\u0435\u0442\u0430\u0439\u043b, \u0437\u0430 \u043a\u043e\u0439\u0442\u043e \u041f\u0438\u0439\u0442 \u0433\u043e\u0432\u043e\u0440\u0438 \u0432 \u0438\u043c\u0435\u0439\u043b \u043a\u043e\u0440\u0435\u0441\u043f\u043e\u043d\u0434\u0435\u043d\u0446\u0438\u044f\u0442\u0430 \u0441\u0438\u2013 \u0445\u043e\u0440\u0430\u0442\u0430 \u0441 \u043d\u0430\u0434\u043d\u043e\u0440\u043c\u0435\u043d\u043e \u0442\u0435\u0433\u043b\u043e \u0441\u0440\u0435\u0449\u0430\u0442 \u0442\u0440\u0443\u0434\u043d\u043e\u0441\u0442\u0438 \u0432 \u043f\u043e\u0432\u0438\u0448\u0430\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u043d\u0438\u0432\u0430\u0442\u0430 \u043d\u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d D, \u0434\u043e\u0440\u0438 \u043f\u0440\u0438 \u043f\u0440\u0438\u0435\u043c \u043d\u0430 \u0433\u043e\u043b\u0435\u043c\u0438 \u0434\u043e\u0437\u0438. \u0412 \u0442\u043e\u0437\u0438 \u0440\u0435\u0434 \u043d\u0430 \u043c\u0438\u0441\u043b\u0438, \u0437\u0430 \u0442\u0435\u0437\u0438 \u0445\u043e\u0440\u0430 \u043c\u043e\u0436\u0435 \u0434\u0430 \u0435 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0430 \u0434\u043d\u0435\u0432\u043d\u0430 \u0434\u043e\u0437\u0430 \u043e\u0442 8,000 IU \u2013 10,000 IU. \u0414\u0440\u0443\u0433\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435, \u043f\u0440\u0438\u043a\u0430\u0447\u0435\u043d\u043e \u043f\u043e-\u0434\u043e\u043b\u0443, \u0440\u0430\u0437\u0433\u043b\u0435\u0436\u0434\u0430 \u0435\u0444\u0435\u043a\u0442\u0438\u0442\u0435 \u043d\u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d D \u0432\u044a\u0440\u0445\u0443 \u0432\u0441\u0438\u0447\u043a\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a \u043d\u0430 \u0433\u0430\u0441\u0442\u0440\u043e\u0438\u043d\u0442\u0435\u0441\u0442\u0438\u043d\u0430\u043b\u043d\u0438\u044f \u0442\u0440\u0430\u043a\u0442. \u041e\u0442\u043a\u0440\u0438\u0432\u0430\u0442 \u0441\u0435 \u043f\u043e\u043b\u0437\u0438 \u043f\u0440\u0438 \u0434\u043e\u0437\u0438 \u043e\u0442 \u0441\u0430\u043c\u043e 2,000 IU \u0434\u043d\u0435\u0432\u043d\u043e, \u043f\u043e\u0442\u0432\u044a\u0440\u0436\u0434\u0430\u0432\u0430\u0439\u043a\u0438, \u0447\u0435 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438\u0442\u0435 \u0434\u043e\u0437\u0438 \u0441\u0430 \u043e\u0449\u0435 \u043f\u043e-\u0431\u043b\u0430\u0433\u043e\u043f\u0440\u0438\u044f\u0442\u043d\u0438.<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.medpagetoday.com\/hematologyoncology\/coloncancer\/79139\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2017.35.15_suppl.3506\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-harvard-gazette wp-block-embed-harvard-gazette\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"vpJ2xypHM7\"><a href=\"https:\/\/news.harvard.edu\/gazette\/story\/2019\/04\/high-dose-vitamin-d-shows-benefit-in-patients-with-advanced-colorectal-cancer\/\">Vitamin D may slow progression of metastatic colorectal cancer<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Vitamin D may slow progression of metastatic colorectal cancer&#8221; &#8212; Harvard Gazette\" src=\"https:\/\/news.harvard.edu\/gazette\/story\/2019\/04\/high-dose-vitamin-d-shows-benefit-in-patients-with-advanced-colorectal-cancer\/embed\/#?secret=mUYhDyvSQO#?secret=vpJ2xypHM7\" data-secret=\"vpJ2xypHM7\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>\u201c\u2026<strong>Results of a small clinical trial suggest that supplementing chemotherapy with high doses of vitamin D may benefit patients with metastatic colorectal cancer by delaying progression of the disease<\/strong>, say scientists from Harvard-affiliated&nbsp;<a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__icm-2Dtracking.meltwater.com_link.php-3FDynEngagement-3Dtrue-26H-3D5eXH0qSKdBRphS6WO4YlQwwSTi8wtQOqejFjZKiddbCzZ5Bbl4XDYSvGv2qAF4Yd3dTvcu1rvse7GHt1Ohw5fir0pahsnMLdRLQWEtrQUqO6dedCW09zDjf-252FaVrFPz1S-26G-3D0-26R-3Dhttps-253A-252F-252Fwww.dana-2Dfarber.org-252F-26I-3D20190408152903.0000004fa53e-2540mail6-2D43-2Dusnbn1-26X-3DMHwxMDQ2NzU4OjVjYWI2N2I5MmQ3OGYyZmM0ZWFmODc5Njs-253D-26S-3DIflv8btPHHCBZLeIxE5f0BdUhkxc4NYzHsApfeKcfj8&amp;d=DwMFaQ&amp;c=WO-RGvefibhHBZq3fL85hQ&amp;r=DnS34uF8FMox2vVhGrzlX28MWrSDyn-iGaJF58zdbu4&amp;m=6ZLN6KsHq14bg-8hMvLrXDy4pfhzLBhK0fgWPZzmaGc&amp;s=ooLnNc6x7FVU0LBtfLhjDpphj9M_x98OE5n-VP4mtCk&amp;e=\">Dana-Farber Cancer Institute<\/a>. Prompted by the&nbsp;<strong>\u201cvery encouraging\u201d results of the&nbsp;<\/strong><a href=\"https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2017.35.15_suppl.3506\"><strong>Sunshine clinical trial<\/strong><\/a>, the potential benefits of vitamin D supplementation in metastatic colorectal cancer will be evaluated in a larger clinical trial planned to open at several hundred sites across the U.S. later this year, said&nbsp;<a href=\"https:\/\/www.dana-farber.org\/find-a-doctor\/kimmie-ng\/\">Kimmie Ng<\/a>,&nbsp;director of clinical research in&nbsp;<a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=http-3A__icm-2Dtracking.meltwater.com_link.php-3FDynEngagement-3Dtrue-26H-3D5eXH0qSKdBRphS6WO4YlQwwSTi8wtQOqejFjZKiddbCzZ5Bbl4XDYSvGv2qAF4Yd3dTvcu1rvse7GHt1Ohw5fir0pahsnMLdRLQWEtrQUqO6dedCW09zDjf-252FaVrFPz1S-26G-3D0-26R-3Dhttps-253A-252F-252Fwww.dana-2Dfarber.org-252Fgastrointestinal-2Dcancer-2Dtreatment-2Dcenter-252F-26I-3D20190408152903.0000004fa53e-2540mail6-2D43-2Dusnbn1-26X-3DMHwxMDQ2NzU4OjVjYWI2N2I5MmQ3OGYyZmM0ZWFmODc5Njs-253D-26S-3DjF8LXbcZHRycIxOFlS3bS0tbZoTjml6CPZoRJs30V2w&amp;d=DwMFaQ&amp;c=WO-RGvefibhHBZq3fL85hQ&amp;r=DnS34uF8FMox2vVhGrzlX28MWrSDyn-iGaJF58zdbu4&amp;m=6ZLN6KsHq14bg-8hMvLrXDy4pfhzLBhK0fgWPZzmaGc&amp;s=HEQojx5HDmb9QklRXPtFqB9wIT8H-WO-hUA-Z3z1c4o&amp;e=\">Dana-Farber\u2019s Gastrointestinal Cancer Center<\/a>, and corresponding author of the Sunshine study. \u201cTo our knowledge, this study is the first completed randomized clinical trial of vitamin D supplementation for treatment of advanced or metastatic colorectal cancer,\u201d Ng said.&nbsp;<strong>In the high-dose group, patients had a median delay of 13 months before their disease worsened; in the low-dose group, the median delay was 11 months. In addition, patients in the high-dose vitamin D group were 36 percent less likely to have disease progression or death during the follow-up period of 22.9 months<\/strong>. The trial included too few patients to determine whether those who took high-dose vitamin D survived longer overall. \u201cThe results of our trial suggest an improved outcome for patients who received vitamin D supplementation, and we look forward to launching a larger trial to confirm these exciting and provocative findings,\u201d said Charles Fuchs, formerly of Dana-Farber and now director of Yale Cancer Center, the senior author of the study.\u201d<\/p>\n\n\n\n<p>\u201c\u2026 The Sunshine trial randomized 139 patients with previously untreated metastatic colorectal cancer.&nbsp;<strong>One group took pills containing 4,000 international units (IU) of vitamin D per day along with standard chemotherapy, while the other group took 400 units<\/strong>&nbsp;(about the dose found in a multivitamin) along with chemotherapy. \u201c<\/p>\n\n\n\n<p>\u201c\u2026 Against this backdrop, the randomized, prospective phase 2 Sunshine trial recruited patients at 11 academic and community centers across the U.S. to test whether vitamin D supplementation can improve outcomes in patients with metastatic colorectal cancer.&nbsp;<strong>All patients received standard chemotherapy. Patients in the high-dose vitamin D group initially took 8,000 IU a day for 14 days, then 4,000 IU a day thereafter. The low or standard-dose vitamin D group took 400 IU daily<\/strong>&nbsp;during all cycles. All patients were asked not to take any other vitamin D or calcium supplements during the trial period. \u201c<\/p>\n\n\n\n<p>\u201c\u2026<strong>Analysis of the results showed less benefit from high-dose vitamin D in patients who were obese<\/strong>, and those whose tumors contained a mutated&nbsp;<em>KRAS&nbsp;<\/em>gene, suggesting \u201cthat certain subsets of patients may need even higher doses of vitamin D for anti-tumor activity,\u201d the researchers said. They cautioned, however, that high doses of vitamin D shouldn\u2019t be taken except within the context of a clinical trial.\u201d<\/p>\n\n\n\n<p>\u03a0\u03b7\u03b3\u03ae:<\/p>\n\n\n\n<p><a href=\"http:\/\/haidut.me\/?p=19\">http:\/\/haidut.me\/<\/a><a href=\"http:\/\/haidut.me\/?p=19\" target=\"_blank\" rel=\"noreferrer noopener\">?p=19<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435 \u043f\u043e\u043a\u0430\u0437\u0432\u0430, \u0447\u0435 \u0434\u043d\u0435\u0432\u043d\u0430 \u0434\u043e\u0437\u0430 \u043e\u0442 4,000 IU \u2013 8,000 IU \u0432\u0438\u0442\u0430\u043c\u0438\u043d D \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0440\u0430\u043a \u0441 \u0434\u043e 36%. \u041f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u043e \u0432 \u0434\u0432\u0435 \u0444\u0430\u0437\u0438 \u2013 \u043f\u0440\u0438 \u043f\u044a\u0440\u0432\u0430\u0442\u0430 \u0441\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430 4,000 IU \u0432\u0438\u0442\u0430\u043c\u0438\u043d D \u0434\u043d\u0435\u0432\u043d\u043e, \u0430 \u043f\u0440\u0438 \u0432\u0442\u043e\u0440\u0430\u0442\u0430 &nbsp;&#8211; 8,000 IU \u0434\u043d\u0435\u0432\u043d\u043e. \u0418 \u0434\u0432\u0435\u0442\u0435 \u0444\u0430\u0437\u0438 \u043e\u0442\u0447\u0438\u0442\u0430\u0442 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u043d\u0438 \u043f\u043e\u043b\u0437\u0438 \u043e\u0442 \u043f\u0440\u0438\u0435\u043c\u044a\u0442 \u043d\u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d D. \u0417\u0430\u0431\u0435\u043b\u044f\u0437\u0432\u0430 \u0441\u0435 \u0441\u044a\u0449\u043e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[850],"tags":[1023,972,329,803,1024,1069,201,802,885],"class_list":["post-22653","post","type-post","status-publish","format-standard","hentry","category-haidut","tag-cholecalciferol","tag-georgi-dinkov","tag-haidut","tag-ray-peat","tag-vitamin-d3","tag-1069","tag-201","tag-802","tag-885"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u0412\u0438\u0442\u0430\u043c\u0438\u043d D \u0435 \u043f\u043e\u043b\u0435\u0437\u0435\u043d \u043f\u0440\u0438 \u0440\u0430\u043a \u043d\u0430 \u0433\u0430\u0441\u0442\u0440\u043e\u0438\u043d\u0442\u0435\u0441\u0442\u0438\u043d\u0430\u043b\u043d\u0438\u044f \u0442\u0440\u0430\u043a\u0442. - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xenobg.com\/el\/vitamin-d-e-polezen-pri-rak-na-gastrointestinalnia-trakt\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0412\u0438\u0442\u0430\u043c\u0438\u043d D \u0435 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