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https:\/\/www.theatlantic.com\/health\/archive\/2019\/05\/food-cancer\/589714<\/a><\/p>\n\n\n\n \u201c\u2026Cancer cells grow in distinctive patterns that defy normal limitations. That growth activity requires energy, and so cancer cells metabolize nutrients in different ways from the healthy cells around them. In an attempt to kill the tumor without killing the normally functioning cells, chemotherapy drugs target these pathways inside of cancer cells. This is notoriously difficult, expensive, and prone to toxic side effects that account for much of the suffering associated with the disease<\/strong>.\u201d<\/p>\n\n\n\n \u201c\u2026Now doctors are starting to think more about specific nutrients that feed tumor cells<\/strong>. That is, how what we eat affects how cancers grow\u2014and whether there are ways to potentially \u201cstarve\u201d cancer cells without leaving a person undernourished, or even hungry<\/strong>. \u201cFor a long time, the prevailing thought was that altered metabolism in cancer cells was the result of genes and mutations that determined metabolism<\/strong>,\u201d says Jason Locasale<\/a>, a cancer biologist at Duke University. \u201cNow, as we know, it\u2019s a complex interaction of environment and genes, and one of the major factors at play is nutrition<\/strong>.\u201d The importance of nutrition has long been accepted for conditions such as diabetes and hypertension, diagnoses that come with well-known dietary prescriptions. Even the most commonly used drug in type 2 diabetes, metformin, has been found in clinical trials to be inferior to diet and exercise. Cell biologists like Locasale see extending that line of thinking to cancer as a logical step, because at the cellular level, cancer is also a disease of metabolic pathways<\/strong>.\u201d<\/p>\n\n\n\n \u201c\u2026While the sugar-and-insulin angle has shown promise, more of the research has focused on dietary protein\u2014or, specifically, individual amino acids that make up that protein. Studies have shown that the restriction of the amino acids serine and glycine can modulate cancer outcomes<\/strong>. According to a 2018 study in Nature<\/em><\/a>, the chemotherapy drug methotrexate is affected by the amino acid histidine<\/strong>. Another, asparagine, is involved in the progression of breast cancer<\/a> metastasis.\u201d<\/p>\n\n\n\n \u201c\u2026The most interest has gone to methionine, which is found in high levels in <\/strong>eggs<\/strong><\/a>\u03ba\u03b1\u03b9 <\/strong>red meat<\/strong><\/a>. In 2018, a <\/strong>review<\/strong><\/a> of existing evidence from the Rutgers Cancer Institute of New Jersey deemed restricting methionine \u201ca promising anti-tumor strategy.\u201d That promise has also shown itself in brain tumors and melanomas<\/strong>, as the UC San Diego surgeon Robert Hoffman detailed<\/a> in February. Methionine is made in normal cells\u2014out of homocysteine, folate, and vitamin B12. However, many types of cancer cells lack the enzyme that makes cellular manufacturing of methionine possible. So they require extra methionine from outside the body\u2014via food we eat\u2014for survival. Cut off that supply, and it should help to slow the tumor without starving the person. This month, Locasale and his colleagues at Duke released <\/strong>findings<\/strong><\/a> showing that restricting methionine decreased tumor growth in mice and human subjects<\/strong>. Locasale\u2019s particular area of research, known as metabolomics, uses enormous data sets to quantify metabolic activity. This allows the <\/strong>controversial<\/strong><\/a>field of nutrition research to operate with new levels of precision, where specific metabolic pathways can be monitored.<\/strong> Most nutrition research relies on self-reported data, in which people who say they eat almonds are found to have lower rates of some sort of cancer, and the best we can do is assume these two things are related. Locasale\u2019s paper, by contrast, is full of complex statistical calculus involving \u201cEuclidian distances\u201d and \u201cmultidimensional scaling.\u201d<\/p>\n\n\n\n \u201c\u2026In 2017, I reported on a provocative study of <\/strong>vitamin B12 supplements<\/strong><\/a>, which can prevent anemia in people who don\u2019t get enough through food. In excessive amounts, though, using these supplements was associated with higher rates of lung cancer<\/strong>. Again, this seemed to be by way of a metabolic pathway<\/strong> that fuels the tumor cells<\/strong>. Nutrients or vitamins are not simply good or bad, cancer-causing or cancer-fighting. If a book or blog recommends a single \u201ccancer diet\u201d\u2014or even a supplement that promises to fight cancer\u2014beware. It could end up making things worse. Especially if there is a person on the cover in a white coat with arms folded, and with teeth that look like they have never been used.<\/p>\n\n\n\n \u201c\u2026For now, unless an oncologist has advised a specific diet tailored to your specific tumor, the most common recommendation is to eat a generally healthy diet. None of this challenges the principle that staying well nourished is part of a healthy approach to any disease; and there is no evidence that overall starvation is good or even safe. But focusing on specific patterns of eating will likely be part of many cancer-treatment guidelines<\/strong> in coming years. Food is medicine\u2014or metabolic therapy<\/strong>. And no metabolic therapy is good or bad for everyone in every condition.\u201d<\/p>\n\n\n\n \u03a0\u03b7\u03b3\u03ae:<\/p>\n\n\n\n http:\/\/haidut.me\/?p=154<\/a><\/p>\n\n\n \u0422\u043e\u0432\u0430 \u043c\u043e\u0436\u0435 \u0431\u0438 \u0435 \u043d\u0430\u0439-\u0443\u0434\u0438\u0432\u0438\u0442\u0435\u043b\u043d\u0430\u0442\u0430 \u0441\u0442\u0430\u0442\u0438\u044f, \u043a\u043e\u044f\u0442\u043e \u0441\u044a\u043c \u0432\u0438\u0436\u0434\u0430\u043b \u0432 \u043e\u0441\u043d\u043e\u0432\u043d\u0438\u0442\u0435 \u043c\u0435\u0434\u0438\u0438. \u041f\u043e\u0432\u0435\u0447\u0435 \u043e\u0442 100 \u0433\u043e\u0434\u0438\u043d\u0438 \u0441\u0435 \u0442\u0432\u044a\u0440\u0434\u0438, \u0447\u0435 \u0440\u0430\u043a\u044a\u0442 \u0435 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435, \u043f\u043e\u0440\u043e\u0434\u0435\u043d\u043e \u043e\u0442 \u043c\u0443\u0442\u0430\u0446\u0438\u0438, \u043a\u043e\u0438\u0442\u043e \u043f\u0440\u0435\u0432\u0440\u044a\u0449\u0430\u0442 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u0432 \u0443\u0431\u0438\u0439\u0446\u0438. \u0421\u0435\u0433\u0430 \u0435\u0434\u043d\u0430 \u043e\u0442 \u043a\u0440\u0435\u043f\u043e\u0441\u0442\u0438\u0442\u0435 \u043d\u0430 \u043c\u0435\u0439\u043d\u0441\u0442\u0440\u0438\u0439\u043c \u043c\u0435\u0434\u0438\u0438\u0442\u0435 – \u043c\u043e\u0449\u043d\u0438\u044f\u0442 „Atlantic“, \u043f\u0443\u0431\u043b\u0438\u043a\u0443\u0432\u0430 \u0441\u0442\u0430\u0442\u0438\u044f, \u043a\u043e\u044f\u0442\u043e \u0437\u0432\u0443\u0447\u0438 \u043a\u0430\u0442\u043e \u0434\u0430 \u0435 \u043a\u043e\u043f\u0438\u0440\u0430\u043d\u0430 \u0434\u0438\u0440\u0435\u043a\u0442\u043d\u043e \u043e\u0442 \u0441\u0442\u0430\u0442\u0438\u0438 \u043d\u0430 \u0420\u0435\u0439 \u041f\u0438\u0439\u0442 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[850,949],"tags":[329,803,229,201,802,885],"class_list":["post-23458","post","type-post","status-publish","format-standard","hentry","category-haidut","category-949","tag-haidut","tag-ray-peat","tag-229","tag-201","tag-802","tag-885"],"yoast_head":"\n