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T\u043e\u0432\u0430 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u0435 \u0435\u0434\u0438\u043d\u0441\u0442\u0432\u0435\u043d\u0430\u0442\u0430 \u043f\u043e\u043b\u0437\u0430 \u043e\u0442 \u043a\u0435\u0442\u043e\u0433\u0435\u043d\u043d\u0430\u0442\u0430 \u0434\u0438\u0435\u0442\u0430 \u0438 \u0434\u0438\u0435\u0442\u0430 \u0441 \u043d\u0443\u043b\u0435\u0432\u043e \u0441\u044a\u0434\u044a\u0440\u0436\u0430\u043d\u0438\u0435 \u043d\u0430 \u043c\u0430\u0437\u043d\u0438\u043d\u0438 \u0438 \u0432\u0438\u0441\u043e\u043a\u043e \u0441\u044a\u0434\u044a\u0440\u0436\u0430\u043d\u0438\u0435 \u043d\u0430 \u0432\u044a\u0433\u043b\u0435\u0445\u0438\u0434\u0440\u0430\u0442\u0438 \u0441 \u043f\u043e-\u043b\u0438\u043f\u043e\u0444\u0438\u043b\u0435\u043d \u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043d\u043e\u0432 \u0430\u043d\u0442\u0430\u0433\u043e\u043d\u0438\u0441\u0442 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u0449\u0435\u0448\u0435 \u0434\u0430 \u0440\u0430\u0431\u043e\u0442\u0438 \u043c\u043d\u043e\u0433\u043e \u043f\u043e-\u0434\u043e\u0431\u0440\u0435.<\/p>\n\n\n\n<p>\u041d\u043e, \u0445\u0435\u0439, \u0442\u043e\u0432\u0430 \u0435 \u0434\u043e\u0431\u0440\u043e \u043d\u0430\u0447\u0430\u043b\u043e \u0438 \u0430\u0437 \u0441\u044a\u043c \u0440\u0430\u0437\u0432\u044a\u043b\u043d\u0443\u0432\u0430\u043d, \u0447\u0435 \u043d\u0430\u0439-\u043d\u0430\u043a\u0440\u0430\u044f \u0432\u0438\u0436\u0434\u0430\u043c \u0441\u0435\u0440\u0438\u043e\u0437\u0435\u043d \u0442\u043b\u0430\u0441\u044a\u043a \u0437\u0430 \u043f\u0440\u043e\u043c\u044f\u043d\u0430 \u0432 \u043d\u0430\u0447\u0438\u043d\u0430, \u043f\u043e \u043a\u043e\u0439\u0442\u043e \u0441\u0435 \u043b\u0435\u043a\u0443\u0432\u0430 \u0440\u0430\u043a\u044a\u0442. \u0412 \u0441\u0430\u043c\u043e\u0442\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435 \u0441\u0435 \u043f\u043e\u0441\u043e\u0447\u0432\u0430, \u0447\u0435 \u0442\u043e\u0437\u0438 \u0434\u0438\u0435\u0442\u0438\u0447\u0435\u043d \u043f\u043e\u0434\u0445\u043e\u0434 \u0431\u0438 \u0442\u0440\u044f\u0431\u0432\u0430\u043b\u043e \u0434\u0430 \u0440\u0430\u0431\u043e\u0442\u0438 \u043f\u0440\u0438 \u0432\u0441\u0435\u043a\u0438 \u0432\u0438\u0434 \u0440\u0430\u043a, \u0442\u044a\u0439 \u043a\u0430\u0442\u043e \u0432\u0441\u0438\u0447\u043a\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438 \u0434\u043e\u0441\u0435\u0433\u0430 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a \u0440\u0430\u0437\u0447\u0438\u0442\u0430\u0442 \u043d\u0430 \u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043d \u0438 \u043c\u043b\u0435\u0447\u043d\u0430 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0430 \u0437\u0430 \u0440\u0430\u0441\u0442\u0435\u0436\u0430 \u0438 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u0438\u0440\u0430\u043d\u0435\u0442\u043e. \u041d\u0435\u0449\u0430\u0442\u0430 \u043d\u0435 \u0438\u0437\u0433\u043b\u0435\u0436\u0434\u0430\u0442 \u0434\u043e\u0431\u0440\u0435 \u0437\u0430 \u0433\u0435\u043d\u043e\u043c\u043d\u0430\u0442\u0430 \u0444\u0430\u0440\u043c\u0430\u0446\u0435\u0432\u0442\u0438\u0447\u043d\u0430 \u0438\u043d\u0434\u0443\u0441\u0442\u0440\u0438\u044f, \u043a\u043e\u044f\u0442\u043e \u0435 \u0437\u0432\u044f\u0440, \u043f\u043e\u0433\u043b\u044a\u0449\u0430\u0449 \u0434\u0435\u0441\u0435\u0442\u043a\u0438 \u043c\u0438\u043b\u0438\u0430\u0440\u0434\u0438 \u0434\u043e\u043b\u0430\u0440\u0438 (\u043d\u0430\u0439-\u0432\u0435\u0447\u0435 \u043d\u0430 \u0434\u0430\u043d\u044a\u043a\u043e\u043f\u043b\u0430\u0442\u0446\u0438\u0442\u0435) \u0432\u0441\u044f\u043a\u0430 \u0433\u043e\u0434\u0438\u043d\u0430.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s42003-019-0455-x\">https:\/\/www.nature.com\/articles\/s42003-019-0455-x<\/a><\/p>\n\n\n\n<p><a href=\"http:\/\/7thspace.com\/headlines\/851233\/cancer_fighting_combination_targets_glioblastoma.html\">http:\/\/7thspace.com\/headlines\/851233\/cancer_fighting_combination_targets_glioblastoma.html<\/a><\/p>\n\n\n\n<p>\u201c\u2026The researchers, probing a treatment modeled on&nbsp;<strong>evidence that glioblastoma is primarily a mitochondrial metabolic disease driven by fermentation<\/strong>, discovered the combination was able to penetrate the blood-brain barrier that shields the brain from both injury and interventions, they wrote in the article, titled \u201cTherapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma.\u201d<\/p>\n\n\n\n<p>\u201c\u2026<strong>The carbohydrate glucose and the amino acid glutamine are the two major fermentable fuels in the body that can drive the growth of glioblastoma, as well as most cancers<\/strong>, Seyfried said. Yet relatively few studies have simultaneously targeted these fuels as candidates for therapeutic management of glioblastoma. In a report last December, Seyfried and colleagues identified&nbsp;<strong>glutamine fermentation as the \u201cmissing link\u201d in the metabolic theory of cancer first posited by Nobel laureate Otto Warburg in 1931<\/strong>.&nbsp;<strong>Contrary to the theory that cancer is determined by genomic instability in the nucleus of a cell, the metabolic theory of cancer holds that cancer\u2019s deadly path begins in the mitochondria, where cells generate energy<\/strong>. In their new study,&nbsp;<strong>the researchers administered DON, a glutamine antagonist, in concert with a calorie-restricted, ketogenic diet to treat late-stage tumor growth in the brain. DON targets the biochemical \u201cmissing link\u201d \u2013 the reaction glutaminolysis \u2013 while the ketogenic diet both reduces glucose and elevates non-fermentable and neuroprotective ketone bodies<\/strong>, Seyfried said. \u201c<strong>The diet-drug therapeutic strategy killed tumor cells while reversing disease symptoms, and improving overall mouse survival<\/strong>,\u201d said Seyfried. \u201cThe therapeutic strategy also reduces edema, hemorrhage, and inflammation. Moreover, the calorie-restricted&nbsp;<strong>ketogenic diet facilitated DON delivery to the brain and allowed a lower dosage to achieve therapeutic effect<\/strong>.\u201d<\/p>\n\n\n\n<p>\u201c<strong>The findings support the importance of glucose and glutamine in driving glioblastoma growth and provide a therapeutic strategy for non-toxic metabolic management<\/strong>,\u201d said Seyfried, who has been searching for alternative cancer treatments throughout his career. Seyfried said next steps to further explore the combination would be to determine if&nbsp;<strong>the diet-drug therapeutic synergy found for glioblastoma could also be seen for other malignant cancers, as glucose and glutamine are the key fuels that drive most if not all malignant cancers regardless of cell or tissue origin<\/strong>.\u201d<\/p>\n\n\n\n<p>\u03a0\u03b7\u03b3\u03ae:<\/p>\n\n\n\n<p><a href=\"http:\/\/haidut.me\/?p=174\">http:\/\/haidut.me\/?p=174<\/a><\/p>\n\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/%d1%80%d0%b5%d0%b2%d0%be%d0%bb%d1%8e%d1%86%d0%b8%d0%be%d0%bd%d0%b5%d0%bd-%d0%bf%d0%be%d0%b3%d0%bb%d0%b5%d0%b4-%d0%b2%d1%8a%d1%80%d1%85%d1%83-%d1%80%d0%b0%d0%ba%d0%b0-%d0%bc%d0%b5%d1%82%d0%b0%d0%b1\/\">\u0420\u0435\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0433\u043b\u0435\u0434 \u0432\u044a\u0440\u0445\u0443 \u0440\u0430\u043a\u0430: \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d, \u0430 \u043d\u0435 \u0441\u0430\u043c\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u043d \u043f\u0440\u043e\u0431\u043b\u0435\u043c<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/hidroksiapatit-v-oralnata-grizha\/\">\u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0430\u043f\u0430\u0442\u0438\u0442 \u0432 \u043e\u0440\u0430\u043b\u043d\u0430\u0442\u0430 \u0433\u0440\u0438\u0436\u0430: \u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u043e\u043b\u0437\u0438\u0442\u0435, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430 \u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u0444\u043b\u0443\u043e\u0440\u0438\u0434\u0430<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/kolko-presni-portokala-sa-vi-neobhodimi-za-da-izchistite-chernia-si-drob-ot-maznini\/\">\u03a0\u03cc\u03c3\u03b1 \u03c6\u03c1\u03ad\u03c3\u03ba\u03b1 \u03c0\u03bf\u03c1\u03c4\u03bf\u03ba\u03ac\u03bb\u03b9\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c3\u03c4\u03b5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03ba\u03b1\u03b8\u03b1\u03c1\u03af\u03c3\u03b5\u03c4\u03b5 \u03c4\u03bf \u03c3\u03c5\u03ba\u03ce\u03c4\u03b9 \u03c3\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bb\u03af\u03c0\u03bf\u03c2;<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/hronichniyat-stres-ponizhava-dopamina-i-prichinyava-psihichni-zabolyavania\/\">\u03a4\u03bf \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bd\u03c4\u03bf\u03c0\u03b1\u03bc\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c8\u03c5\u03c7\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/estrogenat-i-kortizolat-a-ne-androgenite-potiskat-imuniteta\/\">\u03a4\u03b1 \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7, \u03cc\u03c7\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03af\u03b1<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u0418\u0437\u0433\u043b\u0435\u0436\u0434\u0430, \u0447\u0435 \u0442\u0440\u0430\u0434\u0438\u0446\u0438\u043e\u043d\u043d\u0430\u0442\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430 \u043d\u0430\u0439-\u043d\u0430\u043a\u0440\u0430\u044f \u0441\u0435 \u0435 \u043e\u0441\u044a\u0437\u043d\u0430\u043b\u0430 \u0437\u0430 \u043a\u043b\u0430\u043d\u0435\u0442\u043e, \u043a\u043e\u0435\u0442\u043e \u0435 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href=\"https:\/\/xenobg.com\/el\/category\/%d0%b0%d0%bd%d0%b0%d0%bb%d0%b8%d0%b7-%d0%bd%d0%b0-%d0%bd%d0%b0%d1%83%d1%87%d0%bd%d0%b8-%d0%b8%d0%b7%d1%81%d0%bb%d0%b5%d0%b4%d0%b2%d0%b0%d0%bd%d0%b8%d1%8f\/\" class=\"advgb-post-tax-term\">\u0445\u0430\u0439\u0434\u0443\u0442<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Haidut<\/span>","<span class=\"advgb-post-tax-term\">\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0430 \u0442\u0435\u043e\u0440\u0438\u044f<\/span>","<span class=\"advgb-post-tax-term\">\u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438<\/span>","<span class=\"advgb-post-tax-term\">\u0440\u0430\u043a<\/span>","<span class=\"advgb-post-tax-term\">\u0445\u0430\u0439\u0434\u0443\u0442<\/span>"]}},"comment_count":0,"relative_dates":{"created":"Posted 2 \u03ad\u03c4\u03b7 ago","modified":"Updated 2 \u03ad\u03c4\u03b7 ago"},"absolute_dates":{"created":"Posted on 04.09.2024","modified":"Updated on 04.09.2024"},"absolute_dates_time":{"created":"Posted on 04.09.2024 9:49 \u03c0\u03bc","modified":"Updated on 04.09.2024 9:53 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