{"id":23714,"date":"2024-09-11T11:09:06","date_gmt":"2024-09-11T08:09:06","guid":{"rendered":"https:\/\/xenobg.com\/?p=23714"},"modified":"2024-09-11T11:09:11","modified_gmt":"2024-09-11T08:09:11","slug":"sirt1-e-klyuchov-prichinitel-na-levkemiyata-i-drugi-vidove-rak-na-kravta","status":"publish","type":"post","link":"https:\/\/xenobg.com\/el\/sirt1-e-klyuchov-prichinitel-na-levkemiyata-i-drugi-vidove-rak-na-kravta\/","title":{"rendered":"SIRT1 \u0435 \u043a\u043b\u044e\u0447\u043e\u0432 \u043f\u0440\u0438\u0447\u0438\u043d\u0438\u0442\u0435\u043b \u043d\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f\u0442\u0430 \u0438 \u0434\u0440\u0443\u0433\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a \u043d\u0430 \u043a\u0440\u044a\u0432\u0442\u0430"},"content":{"rendered":"<p>SIRT1 (\u0435\u0434\u0438\u043d \u043e\u0442 \u0433\u0435\u043d\u0438\u0442\u0435 \u043d\u0430 \u0441\u0438\u0440\u0442\u0443\u0438\u043d\u0438\u0442\u0435) \u0432 \u043c\u043e\u043c\u0435\u043d\u0442\u0430 \u0435 \u0435\u0434\u043d\u0430 \u043e\u0442 \u0437\u0432\u0435\u0437\u0434\u0438\u0442\u0435 \u0432 \u0445\u0440\u0430\u043d\u0438\u0442\u0435\u043b\u043d\u0430\u0442\u0430\/\u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u0442\u0430 \u0431\u043b\u043e\u0433\u043e\u0441\u0444\u0435\u0440\u0430. \u041e\u0449\u0435 \u043f\u0440\u0435\u0437 2004 \u0433. SIRT1 \u0431\u0435\u0448\u0435 \u043f\u043e\u043f\u0443\u043b\u044f\u0440\u0438\u0437\u0438\u0440\u0430\u043d \u043a\u0430\u0442\u043e \u043a\u043b\u044e\u0447\u043e\u0432 \u0440\u0435\u0433\u0443\u043b\u0430\u0442\u043e\u0440 \u043d\u0430 \u0434\u044a\u043b\u0433\u043e\u043b\u0435\u0442\u0438\u0435\u0442\u043e \u0438 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0442\u043e\u0437\u0438 \u0433\u0435\u043d \u0431\u0435\u0448\u0435 \u0440\u0435\u043a\u043b\u0430\u043c\u0438\u0440\u0430\u043d\u043e \u043a\u0430\u0442\u043e \u0435\u0434\u0438\u043d \u043e\u0442 \u043d\u0430\u0439-\u043d\u0430\u0434\u0435\u0436\u0434\u043d\u0438\u0442\u0435 \u043d\u0430\u0447\u0438\u043d\u0438 \u0437\u0430 \u0443\u0432\u0435\u043b\u0438\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u0436\u0438\u0432\u043e\u0442\u0430. \u0420\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b\u044a\u0442 \u0431\u0435\u0448\u0435 \u0432\u044a\u0437\u0445\u0432\u0430\u043b\u044f\u0432\u0430\u043d \u043a\u0430\u0442\u043e \u0435\u0434\u0438\u043d \u043e\u0442 \u043d\u0430\u0439-\u043c\u043e\u0449\u043d\u0438\u0442\u0435 \u043f\u0440\u0438\u0440\u043e\u0434\u043d\u0438 \u0430\u043a\u0442\u0438\u0432\u0430\u0442\u043e\u0440\u0438 \u043d\u0430 SIRT1, \u0430 \u0425\u0430\u0440\u0432\u0430\u0440\u0434\u0441\u043a\u0438\u044f\u0442 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u043f\u0443\u0431\u043b\u0438\u043a\u0443\u0432\u0430 \u043c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f, \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0449\u0438 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0430\u043a\u0442\u0438\u0432\u0430\u0442\u043e\u0440\u0438 \u043d\u0430 SIRT1, \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043d\u0430 \u0440\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b \u0438 \u043d\u0435\u0433\u043e\u0432\u0438\u0442\u0435 \u043f\u0430\u0442\u0435\u043d\u0442\u043e\u0432\u0430\u043d\u0438 \u0440\u0430\u0437\u043d\u043e\u0432\u0438\u0434\u043d\u043e\u0441\u0442\u0438, \u043a\u043e\u0438\u0442\u043e \u0425\u0430\u0440\u0432\u0430\u0440\u0434 \u043f\u0440\u0438\u0442\u0435\u0436\u0430\u0432\u0430\u0448\u0435. \u0414-\u0440 \u0414\u0435\u0439\u0432\u0438\u0434 \u0421\u0438\u043d\u043a\u043b\u0435\u0440, \u0435\u0434\u0438\u043d \u043e\u0442 \u0433\u043b\u0430\u0432\u043d\u0438\u0442\u0435 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442\u0438 \u043f\u043e SIRT1\/\u0440\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b, \u043e\u0441\u043d\u043e\u0432\u0430\u0432\u0430 \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f, \u043d\u0430\u0440\u0435\u0447\u0435\u043d\u0430 Sirtris Pharmaceuticals.<\/p>\n\n\n\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Sirtris_Pharmaceuticals\">https:\/\/en.wikipedia.org\/wiki\/Sirtris_Pharmaceuticals<\/a><\/p>\n\n\n\n<p>\u0426\u0435\u043b\u0442\u0430 \u043d\u0430 \u0442\u0430\u0437\u0438 \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f \u0435 \u0434\u0430 \u043a\u043e\u043c\u0435\u0440\u0441\u0438\u0430\u043b\u0438\u0437\u0438\u0440\u0430 \u043f\u0430\u0442\u0435\u043d\u0442\u043e\u0432\u0430\u043d\u0438\u0442\u0435 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u043d\u0438 \u043d\u0430 \u0440\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b\u0430 \u0438 \u0434\u0430 \u043f\u0440\u043e\u0432\u0435\u0434\u0435 \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0438\u044f \u0432\u044a\u0440\u0445\u0443 \u0445\u043e\u0440\u0430, \u0442\u0430\u043a\u0430 \u0447\u0435 \u0442\u0435\u0437\u0438 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u043d\u0438 \u0434\u0430 \u0431\u044a\u0434\u0430\u0442 \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438 \u043a\u0430\u0442\u043e \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u043e\u0442 FDA. \u041f\u0440\u0435\u0437 2008 \u0433. \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u044f\u0442\u0430 \u0435 \u043f\u0440\u043e\u0434\u0430\u0434\u0435\u043d\u0430 \u0437\u0430 720 \u043c\u043b\u043d. \u0434\u043e\u043b\u0430\u0440\u0430 \u043d\u0430 GSK \u0438 \u0441\u043a\u043e\u0440\u043e \u0441\u043b\u0435\u0434 \u0442\u043e\u0432\u0430 \u0435 \u0437\u0430\u043a\u0440\u0438\u0442\u0430 \u043f\u043e\u0440\u0430\u0434\u0438 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430\u0442\u0430 \u0441\u043c\u044a\u0440\u0442\u043d\u043e\u0441\u0442 \u0432 \u0430\u043a\u0442\u0438\u0432\u043d\u0438\u0442\u0435 \u0433\u0440\u0443\u043f\u0438 \u043e\u0442 \u043a\u043b\u0438\u043d\u0438\u0447\u043d\u0438\u0442\u0435 \u0438\u0437\u043f\u0438\u0442\u0432\u0430\u043d\u0438\u044f \u0441 \u043f\u0430\u0442\u0435\u043d\u0442\u043e\u0432\u0430\u043d\u0438\u044f \u0440\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b \u043d\u0430 Sirtris. \u041d\u0430\u043a\u0440\u0430\u0442\u043a\u043e &#8211; \u0440\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b\u044a\u0442 \u0438 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 SIRT1 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043d\u0435 \u0441\u0430 \u043d\u0438\u0449\u043e \u0434\u0440\u0443\u0433\u043e \u043e\u0441\u0432\u0435\u043d \u0438\u0437\u043c\u0430\u043c\u0430. \u0412\u0441\u044a\u0449\u043d\u043e\u0441\u0442 \u0434-\u0440 \u041f\u0438\u0439\u0442 \u043f\u0443\u0431\u043b\u0438\u043a\u0443\u0432\u0430 \u0441\u0442\u0430\u0442\u0438\u044f, \u043d\u0430\u0440\u0435\u0447\u0435\u043d\u0430 &#8222;\u0418\u0437\u043c\u0430\u043c\u0430\u0442\u0430 \u0441 \u0440\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b&#8220;, \u0432 \u043a\u043e\u044f\u0442\u043e \u043f\u043e\u0434\u0440\u043e\u0431\u043d\u043e \u043e\u043f\u0438\u0441\u0432\u0430 \u043c\u043d\u043e\u0433\u043e \u043e\u0442 \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u043d\u0438\u0442\u0435 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 SIRT1 \u043a\u0430\u0442\u043e \u0446\u044f\u043b\u043e \u0438 \u043a\u043e\u043d\u043a\u0440\u0435\u0442\u043d\u043e \u043d\u0430 \u0440\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b\u0430. \u0417\u0430 \u0442\u0435\u0437\u0438, \u043a\u043e\u0438\u0442\u043e \u043d\u0435 \u0437\u043d\u0430\u044f\u0442, \u0440\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b\u044a\u0442 \u0435 \u0441\u0442\u0438\u043b\u0431\u0435\u043d\u043e\u0438\u0434 &#8211; \u0435\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043d\u043e \u0441\u0440\u0435\u0449\u0430\u0449\u0438 \u0441\u0435 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u0438 \u0441 \u043c\u043e\u0449\u043d\u043e \u0435\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043d\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435. \u0415\u0434\u0438\u043d \u043e\u0442 \u043d\u0430\u0439-\u0438\u0437\u0432\u0435\u0441\u0442\u043d\u0438\u0442\u0435 \u0441\u0442\u0438\u043b\u0431\u0435\u043d\u043e\u0438\u0434\u0438 \u0435 Vioxx &#8211; \u0438\u0437\u0442\u0435\u0433\u043b\u0435\u043d\u0438\u044f\u0442 \u043e\u0442 \u043f\u0430\u0437\u0430\u0440\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440 \u043d\u0430 \u0421\u041e\u0425, \u043a\u043e\u0439\u0442\u043e \u0443\u0431\u0438 \u0434\u043e\u0441\u0442\u0430 \u0445\u043e\u0440\u0430 \u0432 \u043d\u0430\u0447\u0430\u043b\u043e\u0442\u043e \u043d\u0430 2000 \u0433., \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043f\u043e\u0440\u0430\u0434\u0438 \u0441\u0438\u043b\u043d\u0430\u0442\u0430 \u0441\u0438 \u0435\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u043d\u043e\u0441\u0442, \u0430 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u0438 \u043f\u043e\u0440\u0430\u0434\u0438 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 SIRT1.<\/p>\n\n\n\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Rofecoxib\">https:\/\/en.wikipedia.org\/wiki\/Rofecoxib<\/a><\/p>\n\n\n\n<p>\u0412\u044a\u043f\u0440\u0435\u043a\u0438 \u0442\u043e\u0432\u0430 \u043f\u043e\u043f\u0443\u043b\u044f\u0440\u0438\u0437\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 SIRT1 \u043d\u0435 \u0441\u043f\u0438\u0440\u0430 \u0438 \u043d\u0430 \u043f\u0430\u0437\u0430\u0440\u0430 \u0432\u0441\u0435 \u043e\u0449\u0435 \u0441\u0435 \u043f\u0440\u0435\u0434\u043b\u0430\u0433\u0430\u0442 \u0434\u0440\u0443\u0433\u0438 \u0434\u043e\u0431\u0430\u0432\u043a\u0438 \u0437\u0430 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 SIRT1. \u041d\u043e \u0437\u0430\u0449\u043e \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 SIRT1 \u0435 \u043e\u043f\u0430\u0441\u043d\u043e? \u0415\u0434\u0438\u043d \u043e\u0442 \u043e\u0441\u043d\u043e\u0432\u043d\u0438\u0442\u0435 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 SIRT1 \u0435 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u043e\u0442\u043e \u0431\u0435\u0442\u0430-\u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435. \u0421 \u0434\u0440\u0443\u0433\u0438 \u0434\u0443\u043c\u0438, \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 SIRT1 \u0443\u0432\u0435\u043b\u0438\u0447\u0430\u0432\u0430 \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u043c\u0430\u0437\u043d\u0438\u043d\u0438\u0442\u0435 \u0438 \u043f\u043e \u0442\u043e\u0437\u0438 \u043d\u0430\u0447\u0438\u043d \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430\u0442\u0430 (\u0446\u0438\u043a\u044a\u043b \u043d\u0430 \u0420\u0430\u043d\u0434\u044a\u043b). \u041f\u0443\u0431\u043b\u0438\u043a\u0443\u0432\u0430\u0445 \u043d\u044f\u043a\u043e\u043b\u043a\u043e \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0438\u044f \u0437\u0430 \u0440\u043e\u043b\u044f\u0442\u0430 \u043d\u0430 SIRT1 \u0432 \u0440\u0430\u0441\u0442\u0435\u0436\u0430 \u043d\u0430 \u0440\u0430\u043a\u0430 \u0438 \u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u0438\u0442\u0435, \u043a\u0430\u043a\u0442\u043e \u0438 \u0437\u0430 \u0437\u0430\u0449\u0438\u0442\u043d\u0430\u0442\u0430 \u0440\u043e\u043b\u044f \u043d\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u0438\u0442\u0435 \u043d\u0430 SIRT1. \u041f\u0443\u0431\u043b\u0438\u043a\u0443\u0432\u0430\u0445 \u0441\u044a\u0449\u043e \u0442\u0430\u043a\u0430 \u0437\u0430 \u0440\u0435\u0448\u0430\u0432\u0430\u0449\u0430\u0442\u0430 \u0440\u043e\u043b\u044f \u043d\u0430 \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u043c\u0430\u0437\u043d\u0438\u043d\u0438\u0442\u0435 \u043f\u0440\u0438 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0438\u044f\u0442\u0430\/\u043c\u0435\u0442\u0430\u0441\u0442\u0430\u0437\u0438\u0442\u0435 \u043d\u0430 \u0440\u0430\u043a\u0430 \u0438 \u0437\u0430 \u0437\u0430\u0449\u0438\u0442\u043d\u0430\u0442\u0430 \u0440\u043e\u043b\u044f \u043d\u0430 \u043d\u0438\u0430\u0446\u0438\u043d\u0430\u043c\u0438\u0434\u0430\/\u043d\u0438\u043a\u043e\u0442\u0438\u043d\u0430\u043c\u0438\u0434\u0430. \u041d\u0430\u0439-\u0440\u0430\u0437\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u044f\u0442 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440 \u043d\u0430 SIRT1 \u0435 \u043d\u0438\u0430\u0446\u0438\u043d\u0430\u043c\u0438\u0434\u044a\u0442. \u0418 \u0441\u0435\u0433\u0430, \u0432 \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435\u0442\u043e \u043f\u043e-\u0434\u043e\u043b\u0443, \u0441\u0435 \u043f\u043e\u0442\u0432\u044a\u0440\u0436\u0434\u0430\u0432\u0430 \u043e\u0449\u0435 \u0432\u0435\u0434\u043d\u044a\u0436 \u0440\u043e\u043b\u044f\u0442\u0430 \u043d\u0430 SIRT1 \u043a\u0430\u0442\u043e \u043f\u0440\u043e\u043c\u043e\u0442\u043e\u0440 \u043d\u0430 \u0440\u0430\u043a\u0430. \u0422\u043e \u043f\u043e\u043a\u0430\u0437\u0432\u0430, \u0447\u0435 SIRT1 \u0435 \u0441\u0432\u0440\u044a\u0445\u0435\u043a\u0441\u043f\u0440\u0435\u0441\u0438\u0440\u0430\u043d \u0432 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u043d\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0430\u0442\u0430 \u043c\u0438\u0435\u043b\u043e\u0438\u0434\u043d\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f \u0438 \u0447\u0435 \u043d\u0435\u0433\u043e\u0432\u0430\u0442\u0430 \u0441\u0432\u0440\u044a\u0445\u0435\u043a\u0441\u043f\u0440\u0435\u0441\u0438\u044f \u0435 \u043e\u0442 \u043a\u043b\u044e\u0447\u043e\u0432\u043e \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u0437\u0430 \u0442\u043e\u0432\u0430 \u0440\u0430\u043a\u043e\u0432\u0438\u0442\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u0434\u0430 \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u0442 \u0441\u0432\u043e\u044f\u0442\u0430 &#8222;\u0441\u0442\u0432\u043e\u043b\u043e\u0432\u0430&#8220; \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0430 \u0438 \u043f\u043e \u0442\u043e\u0437\u0438 \u043d\u0430\u0447\u0438\u043d \u0434\u0430 \u0441\u0430 \u0443\u0441\u0442\u043e\u0439\u0447\u0438\u0432\u0438 \u043d\u0430 \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0417\u0430\u0433\u043b\u0443\u0448\u0430\u0432\u0430\u043d\u0435\u0442\u043e\/\u043e\u0442\u0441\u0442\u0440\u0430\u043d\u044f\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 SIRT1 \u043f\u0440\u0430\u0432\u0438 \u0440\u0430\u043a\u0430 \u043b\u0435\u0441\u043d\u043e \u043f\u043e\u0434\u0430\u0442\u043b\u0438\u0432 \u043d\u0430 \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0438 \u043f\u0440\u0435\u0434\u043e\u0442\u0432\u0440\u0430\u0442\u044f\u0432\u0430 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u0430\u0442\u0430 \u043f\u043e\u044f\u0432\u0430 \u043d\u0430 \u0431\u043e\u043b\u0435\u0441\u0442\u0442\u0430 \u0441\u043b\u0435\u0434 \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u0442\u043e. \u041e\u0441\u0432\u0435\u043d \u0442\u043e\u0432\u0430, \u0442\u044a\u0439 \u043a\u0430\u0442\u043e \u0440\u043e\u043b\u044f\u0442\u0430 \u043d\u0430 SIRT1 \u0437\u0430 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u043e\u043a\u0438\u0441\u043b\u044f\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u043c\u0430\u0437\u043d\u0438\u043d\u0438\u0442\u0435 \u0435 \u0442\u043e\u043b\u043a\u043e\u0432\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0430, \u043c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u043e\u0447\u0430\u043a\u0432\u0430, \u0447\u0435 \u0441\u0432\u0440\u044a\u0445\u0435\u043a\u0441\u043f\u0440\u0435\u0441\u0438\u044f\u0442\u0430 \u043d\u0430 SIRT1 \u0449\u0435 \u043d\u0430\u0441\u044a\u0440\u0447\u0438 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435\u0442\u043e \u043d\u0430 \u0434\u0440\u0443\u0433\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a. \u0422\u043e\u0447\u043d\u043e \u0442\u043e\u0432\u0430 \u043e\u0442\u043a\u0440\u0438\u0432\u0430\u0442\/\u0442\u0432\u044a\u0440\u0434\u044f\u0442 \u0438 \u0430\u0432\u0442\u043e\u0440\u0438\u0442\u0435 \u043d\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.jci.org\/articles\/view\/127080\">https:\/\/www.jci.org\/articles\/view\/127080<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.uab.edu\/news\/research\/item\/10534-sirt1-plays-key-role-in-chronic-myeloid-leukemia-by-aiding-persistence-of-leukemic-stem-cells\">https:\/\/www.uab.edu\/news\/research\/item\/10534-sirt1-plays-key-role-in-chronic-myeloid-leukemia-by-aiding-persistence-of-leukemic-stem-cells<\/a><\/p>\n\n\n\n<p>\u201c\u2026In a study published in the Journal of Clinical Investigation, Ajay Abraham, Ph.D., Shaowei Qiu, M.D., Ravi Bhatia, M.D., and colleagues at the&nbsp;<a href=\"http:\/\/www.uab.edu\/home\/\">University of Alabama at Birmingham<\/a>show how&nbsp;<strong>the stress-responsive protein SIRT1 plays important roles in maintaining the regenerative potential of CML leukemic stem cells and promoting leukemia development in CML<\/strong>. \u201cOur studies provide a conceptual advance and new biological insights regarding the activity of SIRT1 and its role in CML leukemic stem cells,\u201d said senior author Bhatia. At UAB, Bhatia is a professor of&nbsp;<a href=\"https:\/\/www.uab.edu\/medicine\/dom\/\">medicine<\/a>, director of the&nbsp;<a href=\"https:\/\/www.uab.edu\/medicine\/hemonc\/\">Division of Hematology and Oncology<\/a>, and interim director of the&nbsp;<a href=\"https:\/\/www.uab.edu\/onealcancercenter\/\">O\u2019Neal Comprehensive Cancer Center at UAB<\/a>. In 2012, Bhatia and colleagues reported that&nbsp;<strong>SIRT1 was overexpressed in CML leukemic stem cells compared to normal hematopoietic stem cells, and this overexpression contributed to CML leukemic stem cell maintenance and resistance to tyrosine kinase inhibitors<\/strong>. However, the underlying mechanisms were not known.\u201d<\/p>\n\n\n\n<p>\u201c\u2026Treatment with tyrosine kinase inhibitors is known to suppress leukemic hematopoiesis.&nbsp;<strong>When SIRT1-deleted mice were treated with tyrosine kinase inhibitors, the UAB researchers found an even greater suppression of leukemic hematopoiesis. The SIRT1 knock-out also impaired development of CML in the mouse model<\/strong>. Compared with the CML mice without SIRT1 knock-out, the researchers saw significant delays in developing increased numbers of leukocytes and neutrophils, and delayed enlargement of the spleen and time of death. The deletion also reversed redistribution of CML stem cells from the bone marrow to the spleen.\u201d<\/p>\n\n\n\n<p>\u201c\u2026<strong>Bhatia says the impact of this study extends to other hematological malignancies, including acute myeloid leukemia, myelodysplastic syndromes and myeloproliferative neoplasms<\/strong>. \u201cOur research reveals new knowledge and concepts regarding the&nbsp;<strong>role of SIRT1 in metabolic regulation of hematopoietic stem cell and leukemic stem cell maintenance, growth and resistance<\/strong>,\u201d Bhatia said. \u201cThis raises the possibility of developing improved strategies to target kinase-independent metabolic alterations.\u201d<\/p>\n\n\n\n<p>\u03a0\u03b7\u03b3\u03ae:<\/p>\n\n\n\n<p><a href=\"http:\/\/haidut.me\/?p=192\">http:\/\/haidut.me\/?p=192<\/a><\/p>\n\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/%d1%80%d0%b5%d0%b2%d0%be%d0%bb%d1%8e%d1%86%d0%b8%d0%be%d0%bd%d0%b5%d0%bd-%d0%bf%d0%be%d0%b3%d0%bb%d0%b5%d0%b4-%d0%b2%d1%8a%d1%80%d1%85%d1%83-%d1%80%d0%b0%d0%ba%d0%b0-%d0%bc%d0%b5%d1%82%d0%b0%d0%b1\/\">\u0420\u0435\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0433\u043b\u0435\u0434 \u0432\u044a\u0440\u0445\u0443 \u0440\u0430\u043a\u0430: \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d, \u0430 \u043d\u0435 \u0441\u0430\u043c\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u043d \u043f\u0440\u043e\u0431\u043b\u0435\u043c<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/hidroksiapatit-v-oralnata-grizha\/\">\u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0430\u043f\u0430\u0442\u0438\u0442 \u0432 \u043e\u0440\u0430\u043b\u043d\u0430\u0442\u0430 \u0433\u0440\u0438\u0436\u0430: \u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u043e\u043b\u0437\u0438\u0442\u0435, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430 \u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u0444\u043b\u0443\u043e\u0440\u0438\u0434\u0430<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/kolko-presni-portokala-sa-vi-neobhodimi-za-da-izchistite-chernia-si-drob-ot-maznini\/\">\u03a0\u03cc\u03c3\u03b1 \u03c6\u03c1\u03ad\u03c3\u03ba\u03b1 \u03c0\u03bf\u03c1\u03c4\u03bf\u03ba\u03ac\u03bb\u03b9\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c3\u03c4\u03b5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03ba\u03b1\u03b8\u03b1\u03c1\u03af\u03c3\u03b5\u03c4\u03b5 \u03c4\u03bf \u03c3\u03c5\u03ba\u03ce\u03c4\u03b9 \u03c3\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bb\u03af\u03c0\u03bf\u03c2;<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/hronichniyat-stres-ponizhava-dopamina-i-prichinyava-psihichni-zabolyavania\/\">\u03a4\u03bf \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bd\u03c4\u03bf\u03c0\u03b1\u03bc\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c8\u03c5\u03c7\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/estrogenat-i-kortizolat-a-ne-androgenite-potiskat-imuniteta\/\">\u03a4\u03b1 \u03bf\u03b9\u03c3\u03c4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bf\u03c1\u03c4\u03b9\u03b6\u03cc\u03bb\u03b7, \u03cc\u03c7\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03cc\u03bd\u03b1, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03af\u03b1<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>SIRT1 (\u0435\u0434\u0438\u043d \u043e\u0442 \u0433\u0435\u043d\u0438\u0442\u0435 \u043d\u0430 \u0441\u0438\u0440\u0442\u0443\u0438\u043d\u0438\u0442\u0435) \u0432 \u043c\u043e\u043c\u0435\u043d\u0442\u0430 \u0435 \u0435\u0434\u043d\u0430 \u043e\u0442 \u0437\u0432\u0435\u0437\u0434\u0438\u0442\u0435 \u0432 \u0445\u0440\u0430\u043d\u0438\u0442\u0435\u043b\u043d\u0430\u0442\u0430\/\u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u0442\u0430 \u0431\u043b\u043e\u0433\u043e\u0441\u0444\u0435\u0440\u0430. \u041e\u0449\u0435 \u043f\u0440\u0435\u0437 2004 \u0433. SIRT1 \u0431\u0435\u0448\u0435 \u043f\u043e\u043f\u0443\u043b\u044f\u0440\u0438\u0437\u0438\u0440\u0430\u043d \u043a\u0430\u0442\u043e \u043a\u043b\u044e\u0447\u043e\u0432 \u0440\u0435\u0433\u0443\u043b\u0430\u0442\u043e\u0440 \u043d\u0430 \u0434\u044a\u043b\u0433\u043e\u043b\u0435\u0442\u0438\u0435\u0442\u043e \u0438 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0442\u043e\u0437\u0438 \u0433\u0435\u043d \u0431\u0435\u0448\u0435 \u0440\u0435\u043a\u043b\u0430\u043c\u0438\u0440\u0430\u043d\u043e \u043a\u0430\u0442\u043e \u0435\u0434\u0438\u043d \u043e\u0442 \u043d\u0430\u0439-\u043d\u0430\u0434\u0435\u0436\u0434\u043d\u0438\u0442\u0435 \u043d\u0430\u0447\u0438\u043d\u0438 \u0437\u0430 \u0443\u0432\u0435\u043b\u0438\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u0436\u0438\u0432\u043e\u0442\u0430. \u0420\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b\u044a\u0442 \u0431\u0435\u0448\u0435 \u0432\u044a\u0437\u0445\u0432\u0430\u043b\u044f\u0432\u0430\u043d \u043a\u0430\u0442\u043e \u0435\u0434\u0438\u043d \u043e\u0442 \u043d\u0430\u0439-\u043c\u043e\u0449\u043d\u0438\u0442\u0435 \u043f\u0440\u0438\u0440\u043e\u0434\u043d\u0438 \u0430\u043a\u0442\u0438\u0432\u0430\u0442\u043e\u0440\u0438 \u043d\u0430 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[850,949,945],"tags":[1138,1137,329,1146,73,947,1001,201,802,1145,885],"class_list":["post-23714","post","type-post","status-publish","format-standard","hentry","category-haidut","category-949","category-945","tag-cox","tag-cox-lox","tag-haidut","tag-sirt1","tag-73","tag-947","tag-1001","tag-201","tag-802","tag-1145","tag-885"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>SIRT1 \u0435 \u043a\u043b\u044e\u0447\u043e\u0432 \u043f\u0440\u0438\u0447\u0438\u043d\u0438\u0442\u0435\u043b \u043d\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f\u0442\u0430 \u0438 \u0434\u0440\u0443\u0433\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a \u043d\u0430 \u043a\u0440\u044a\u0432\u0442\u0430 - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xenobg.com\/el\/sirt1-e-klyuchov-prichinitel-na-levkemiyata-i-drugi-vidove-rak-na-kravta\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SIRT1 \u0435 \u043a\u043b\u044e\u0447\u043e\u0432 \u043f\u0440\u0438\u0447\u0438\u043d\u0438\u0442\u0435\u043b \u043d\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f\u0442\u0430 \u0438 \u0434\u0440\u0443\u0433\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a \u043d\u0430 \u043a\u0440\u044a\u0432\u0442\u0430 - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\" \/>\n<meta property=\"og:description\" content=\"SIRT1 (\u0435\u0434\u0438\u043d \u043e\u0442 \u0433\u0435\u043d\u0438\u0442\u0435 \u043d\u0430 \u0441\u0438\u0440\u0442\u0443\u0438\u043d\u0438\u0442\u0435) \u0432 \u043c\u043e\u043c\u0435\u043d\u0442\u0430 \u0435 \u0435\u0434\u043d\u0430 \u043e\u0442 \u0437\u0432\u0435\u0437\u0434\u0438\u0442\u0435 \u0432 \u0445\u0440\u0430\u043d\u0438\u0442\u0435\u043b\u043d\u0430\u0442\u0430\/\u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u0442\u0430 \u0431\u043b\u043e\u0433\u043e\u0441\u0444\u0435\u0440\u0430. \u041e\u0449\u0435 \u043f\u0440\u0435\u0437 2004 \u0433. SIRT1 \u0431\u0435\u0448\u0435 \u043f\u043e\u043f\u0443\u043b\u044f\u0440\u0438\u0437\u0438\u0440\u0430\u043d \u043a\u0430\u0442\u043e \u043a\u043b\u044e\u0447\u043e\u0432 \u0440\u0435\u0433\u0443\u043b\u0430\u0442\u043e\u0440 \u043d\u0430 \u0434\u044a\u043b\u0433\u043e\u043b\u0435\u0442\u0438\u0435\u0442\u043e \u0438 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0442\u043e\u0437\u0438 \u0433\u0435\u043d \u0431\u0435\u0448\u0435 \u0440\u0435\u043a\u043b\u0430\u043c\u0438\u0440\u0430\u043d\u043e \u043a\u0430\u0442\u043e \u0435\u0434\u0438\u043d \u043e\u0442 \u043d\u0430\u0439-\u043d\u0430\u0434\u0435\u0436\u0434\u043d\u0438\u0442\u0435 \u043d\u0430\u0447\u0438\u043d\u0438 \u0437\u0430 \u0443\u0432\u0435\u043b\u0438\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u0436\u0438\u0432\u043e\u0442\u0430. \u0420\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b\u044a\u0442 \u0431\u0435\u0448\u0435 \u0432\u044a\u0437\u0445\u0432\u0430\u043b\u044f\u0432\u0430\u043d \u043a\u0430\u0442\u043e \u0435\u0434\u0438\u043d \u043e\u0442 \u043d\u0430\u0439-\u043c\u043e\u0449\u043d\u0438\u0442\u0435 \u043f\u0440\u0438\u0440\u043e\u0434\u043d\u0438 \u0430\u043a\u0442\u0438\u0432\u0430\u0442\u043e\u0440\u0438 \u043d\u0430 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/xenobg.com\/el\/sirt1-e-klyuchov-prichinitel-na-levkemiyata-i-drugi-vidove-rak-na-kravta\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/xenobg\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-11T08:09:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-11T08:09:11+00:00\" \/>\n<meta name=\"author\" content=\"\u0425\u0430\u0439\u0434\u0443\u0442\u0438\u043d\" \/>\n<meta name=\"twitter:label1\" content=\"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u0425\u0430\u0439\u0434\u0443\u0442\u0438\u043d\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 \u03bb\u03b5\u03c0\u03c4\u03ac\" \/>\n<script type=\"application\/ld+json\" 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