{"id":24346,"date":"2025-02-13T08:44:20","date_gmt":"2025-02-13T06:44:20","guid":{"rendered":"https:\/\/xenobg.com\/?p=24346"},"modified":"2025-02-13T09:46:21","modified_gmt":"2025-02-13T07:46:21","slug":"progesteronat-mozhe-da-se-svarzhe-i-deaktivira-direktno-endotoksina-lps","status":"publish","type":"post","link":"https:\/\/xenobg.com\/el\/progesteronat-mozhe-da-se-svarzhe-i-deaktivira-direktno-endotoksina-lps\/","title":{"rendered":"\u041f\u0440\u043e\u0433\u0435\u0441\u0442\u0435\u0440\u043e\u043d\u044a\u0442 \u043c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u0441\u0432\u044a\u0440\u0436\u0435 \u0438 \u0434\u0435\u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430 \u0434\u0438\u0440\u0435\u043a\u0442\u043d\u043e \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d\u0430 (LPS)"},"content":{"rendered":"\n<p>\u041d\u0430\u0441\u043a\u043e\u0440\u043e \u043d\u0430\u043f\u0438\u0441\u0430\u0445 \u043d\u044f\u043a\u043e\u043b\u043a\u043e \u043f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u0438, \u0432 \u043a\u043e\u0438\u0442\u043e \u043e\u0431\u0441\u044a\u0436\u0434\u0430\u0445 \u0431\u043b\u043e\u043a\u0438\u0440\u0430\u0449\u0438\u0442\u0435 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 <a href=\"https:\/\/xenobg.com\/produktov-etiket\/pregnenolone\/\">\u043f\u0440\u0435\u0433\u043d\u0435\u043d\u043e\u043b\u043e\u043d\u0430<\/a> \u0432\u044a\u0440\u0445\u0443 TLR4 \u0438 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438\u0442\u0435 \u043e\u0442 \u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u043e\u0442\u043e TLR \u043a\u0430\u0442\u043e \u0446\u044f\u043b\u043e, \u043a\u0430\u043a\u0442\u043e \u0438 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0442\u043e \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435, \u043f\u0440\u043e\u0438\u0437\u0442\u0438\u0447\u0430\u0449\u043e \u043e\u0442 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\u043a\u044a\u043c \u0430\u043d\u0442\u0430\u0433\u043e\u043d\u0438\u0437\u043c\u0430 \u043d\u0430 TLR4\/\u0445\u0438\u0441\u0442\u0430\u043c\u0438\u043d\/\u0441\u0435\u0440\u043e\u0442\u043e\u043d\u0438\u043d\/\u043f\u0440\u043e\u0441\u0442\u0430\u0433\u043b\u0430\u043d\u0434\u0438\u043d\/\u0442.\u043d., \u043a\u043e\u0439\u0442\u043e \u0442\u0435\u0437\u0438 \u0441\u0442\u0435\u0440\u043e\u0438\u0434\u0438 \u0432\u0435\u0447\u0435 \u043f\u0440\u0438\u0442\u0435\u0436\u0430\u0432\u0430\u0442, \u0438 \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430, \u0447\u0435 \u0438\u043c\u0435\u043d\u043d\u043e \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0438\u0442\u0435 \u0441\u0432\u043e\u0439\u0441\u0442\u0432\u0430 \u043d\u0430 \u0441\u0442\u0435\u0440\u043e\u0438\u0434\u0438\u0442\u0435 \u0421-21, \u0430 \u043d\u0435 \u0442\u0435\u0445\u043d\u0438\u0442\u0435 &#8222;\u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043d\u0438&#8220; \u0435\u0444\u0435\u043a\u0442\u0438, \u043c\u043e\u0433\u0430\u0442 \u0434\u0430 \u0431\u044a\u0434\u0430\u0442 \u043e\u0442\u0433\u043e\u0432\u043e\u0440\u043d\u0438 \u0437\u0430 \u043d\u044f\u043a\u043e\u0438 \u043e\u0442 \u0442\u0435\u0445\u043d\u0438\u0442\u0435 \u043f\u043e\u043b\u0437\u0438. \u041d\u0430\u0438\u0441\u0442\u0438\u043d\u0430 \u0437\u0430\u0431\u0435\u043b\u0435\u0436\u0438\u0442\u0435\u043b\u043d\u043e \u0438 \u043f\u043e\u0434\u043e\u0431\u043d\u043e \u043d\u0430 \u043e\u0431\u043e\u0441\u043d\u043e\u0432\u043a\u0430\u0442\u0430, \u043a\u043e\u044f\u0442\u043e Peat \u043f\u0440\u0435\u0434\u043e\u0441\u0442\u0430\u0432\u0438 \u0437\u0430 \u043f\u043e\u043b\u0437\u0438\u0442\u0435 \u043e\u0442 \u0433\u043b\u0438\u0446\u0438\u043d\u0430, \u043a\u043e\u0438\u0442\u043e \u043d\u0435 \u043c\u043e\u0433\u0430\u0442 \u0434\u0430 \u0431\u044a\u0434\u0430\u0442 \u043e\u0431\u044f\u0441\u043d\u0435\u043d\u0438 \u0441 \u043d\u0435\u0433\u043e\u0432\u0438\u0442\u0435 \u0433\u0435\u043d\u043e\u043c\u043d\u0438 \u0438\u043b\u0438 \u0435\u043d\u0437\u0438\u043c\u043d\u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/4959441\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/4959441<\/a><\/p>\n\n\n\n<p>\u201c\u2026<strong>We have found that progesterone markedly prolongs survival in cats that have been given endotoxin<\/strong>. The effect of progesterone on the course of endotoxic shock varied with the time the progesterone was given. Progesterone incubated with or given simultaneously with endotoxin lessened the initial and secondary fall in blood pressure seen in the control animals. Progesterone given 5 or 30 minutes after the endotoxin restored the initial falling blood pressure to near-normal levels and lessened the secondary hypotension which occurred at 1 to 1% hours in the control animals.&nbsp;<strong>The mechanism responsible for the initial hypotensive episode following the administration of endotoxin is thought to be related to the liberation of histamine or a similar vasoactive substance<\/strong>&nbsp;[3, 5].\u201d<\/p>\n\n\n\n<p>\u201c\u2026<strong>The preliminary results<\/strong>&nbsp;of our work with the ether and aqueous extracts of progesterone and endotoxin, and the increased survival obtained with prior incubation of endotoxin with progesterone,&nbsp;<strong>appear to indicate that progesterone may form an in vitro bond with the endotoxin compound<\/strong>. This has been suggested as a possible alternate explanation of the action of aldosterone and endotoxin [3, 4]. Whether this results in direct inhibition of the endotoxin or the inhibition is mediated through unknown substances in vivo is pure conjecture at this time.&nbsp;<strong>DeSaulles has demonstrated increased survival in animals given endotoxin and 19 oxoprogesterone<\/strong>&nbsp;[1].&nbsp;<strong>This compound reportedly has no antiinflammatory or mineralcorticoid effects and may indicate that the inhibition of endotoxin by the glucocorticoids, mineralcorticoids, and progesterone bears no relationship to their known physiological actions<\/strong>.\u201d<\/p>\n\n\n\n<p>\u0418\u0437\u0442\u043e\u0447\u043d\u0438\u043a:<\/p>\n\n\n\n<p><a href=\"http:\/\/haidut.me\/?p=441\">http:\/\/haidut.me\/?p=441<\/a><\/p>\n\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/%d1%80%d0%b5%d0%b2%d0%be%d0%bb%d1%8e%d1%86%d0%b8%d0%be%d0%bd%d0%b5%d0%bd-%d0%bf%d0%be%d0%b3%d0%bb%d0%b5%d0%b4-%d0%b2%d1%8a%d1%80%d1%85%d1%83-%d1%80%d0%b0%d0%ba%d0%b0-%d0%bc%d0%b5%d1%82%d0%b0%d0%b1\/\">\u0420\u0435\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0433\u043b\u0435\u0434 \u0432\u044a\u0440\u0445\u0443 \u0440\u0430\u043a\u0430: \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d, \u0430 \u043d\u0435 \u0441\u0430\u043c\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u043d \u043f\u0440\u043e\u0431\u043b\u0435\u043c<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/hidroksiapatit-v-oralnata-grizha\/\">\u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0430\u043f\u0430\u0442\u0438\u0442 \u0432 \u043e\u0440\u0430\u043b\u043d\u0430\u0442\u0430 \u0433\u0440\u0438\u0436\u0430: \u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u043e\u043b\u0437\u0438\u0442\u0435, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430 \u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u0444\u043b\u0443\u043e\u0440\u0438\u0434\u0430<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/el\/kolko-presni-portokala-sa-vi-neobhodimi-za-da-izchistite-chernia-si-drob-ot-maznini\/\">\u041a\u043e\u043b\u043a\u043e \u043f\u0440\u0435\u0441\u043d\u0438 \u043f\u043e\u0440\u0442\u043e\u043a\u0430\u043b\u0430 \u0441\u0430 \u0432\u0438 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438, \u0437\u0430 \u0434\u0430 \u0438\u0437\u0447\u0438\u0441\u0442\u0438\u0442\u0435 \u0447\u0435\u0440\u043d\u0438\u044f \u0441\u0438 \u0434\u0440\u043e\u0431 \u043e\u0442 \u043c\u0430\u0437\u043d\u0438\u043d\u0438?<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" 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\u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0442\u043e \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435, \u043f\u0440\u043e\u0438\u0437\u0442\u0438\u0447\u0430\u0449\u043e \u043e\u0442 \u0442\u043e\u0432\u0430 \u0431\u043b\u043e\u043a\u0438\u0440\u0430\u043d\u0435\/\u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d\u0435. http:\/\/haidut.me\/?p=17 \u0414\u043e\u0431\u0440\u0435 \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u043e \u0435, \u0447\u0435 \u0433\u043b\u044e\u043a\u043e\u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0438\u0434\u0438\u0442\u0435 \u0438 \u043c\u0438\u043d\u0435\u0440\u0430\u043b\u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0438\u0434\u0438\u0442\u0435 \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u0432\u0430\u0442 \u043e\u0442 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u0435\u043d \u0448\u043e\u043a, \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043f\u043e\u0440\u0430\u0434\u0438 \u0431\u043b\u043e\u043a\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0445\u0438\u043f\u043e\u0442\u0435\u043d\u0437\u0438\u0432\u043d\u0438\u0442\u0435 \u0438 \u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0438\u0442\u0435 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d\u0430. \u0412\u044a\u043f\u0440\u0435\u043a\u0438 \u0442\u043e\u0432\u0430 \u0432\u0441\u0435 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