{"id":17122,"date":"2020-03-18T09:08:45","date_gmt":"2020-03-18T07:08:45","guid":{"rendered":"https:\/\/xenobg.com\/?p=17122"},"modified":"2020-03-24T07:41:23","modified_gmt":"2020-03-24T05:41:23","slug":"antivirusni-efekti-na-voda-oxidal-methylene-blue","status":"publish","type":"post","link":"https:\/\/xenobg.com\/en\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/","title":{"rendered":"\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19)"},"content":{"rendered":"

\u0423\u0412\u041e\u0414<\/h3>\n\n\n\n

\u041a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u044a\u0442 COVID-19<\/strong> e \u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441. \u0422\u043e\u0439 \u0437\u0430\u043f\u043e\u0447\u0432\u0430 \u0440\u0430\u0437\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435\u0442\u043e \u0441\u0438 \u0432 \u043a\u0440\u0430\u044f \u043d\u0430 2019 \u0433. \u0438 \u043d\u0430\u0447\u0430\u043b\u043e\u0442\u043e \u043d\u0430 2020 \u0433. \u0432 \u041a\u0438\u0442\u0430\u0439 \u0438 \u0432\u043e\u0434\u0438 \u0434\u043e \u043e\u0441\u0442\u0440\u043e\u0442\u043e \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u0437\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435 2019-nCoV. \u0422\u043e\u0439 \u0435 \u0431\u043b\u0438\u0437\u044a\u043a \u0434\u043e Severe acute respiratory syndrome-related coronavirus<\/em> (SARSr-CoV<\/strong>) \u0438 \u043d\u043e\u0432\u0438\u044f\u0442 \u0432\u0438\u0440\u0443\u0441 \u0435 \u043e\u0437\u043d\u0430\u0447\u0435\u043d \u043a\u0430\u0442\u043e SARS-CoV-2. \u041d\u0435\u0433\u043e\u0432\u0438\u044f\u0442 \u0433\u0435\u043d\u043e\u043c \u0435 \u0435\u0434\u043d\u043e\u0432\u0435\u0440\u0438\u0436\u0435\u043d \u0441 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u0430 \u043f\u043e\u043b\u044f\u0440\u043d\u043e\u0441\u0442 ((+) \u0432\u0435\u0440\u0438\u0433\u0430). \u0421\u044a\u0434\u044a\u0440\u0436\u0430 \u043d\u0443\u043a\u043b\u0435\u043e\u0442\u0438\u0434\u0438 \u0441\u044a\u0441 \u0441\u043f\u0438\u0440\u0430\u043b\u043d\u0430 \u0441\u0438\u043c\u0435\u0442\u0440\u0438\u044f (1). \u041a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u044a\u0442 COVID-19<\/strong> \u0440\u0435\u043f\u043b\u0438\u0446\u0438\u0440\u0430 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u0438\u044f \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b \u0447\u0440\u0435\u0437 \u043a\u043e\u043f\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0435\u043d\u0437\u0438\u043c\u0430 RNA-dependent RNA polymerase<\/em> (2). \u0410\u0432\u0442\u043e\u0440\u044a\u0442 \u0440\u0430\u0437\u0433\u043b\u0435\u0436\u0434\u0430 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0435\u043d \u043c\u0435\u0442\u043e\u0434 \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 SARS-CoV, \u043a\u043e\u0439\u0442\u043e \u0432\u043a\u043b\u044e\u0447\u0432\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u043d\u0430 \u0430\u043b\u043a\u0430\u043b\u043d\u0430 \u0432\u043e\u0434\u0430 \u0441 \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u0435\u043d \u043e\u043a\u0438\u0441\u043b\u0438\u0442\u0435\u043b\u043d\u043e-\u0440\u0435\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b (ORP), \u0445\u0440\u0430\u043d\u0438\u0442\u0435\u043b\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430 Oxidal \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e.<\/p>\n\n\n\n

\u041a\u043b\u044e\u0447\u043e\u0432\u0438 \u0434\u0443\u043c\u0438:<\/strong> SARSr-CoV, \u0432\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442, Oxidal \u0441 \u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e, \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e<\/em><\/p>\n\n\n\n

* e-mail \u043d\u0430 \u0430\u0432\u0442\u043e\u0440\u0430 \u0437\u0430 \u043a\u043e\u0440\u0435\u0441\u043f\u043e\u043d\u0434\u0435\u043d\u0446\u0438\u044f: mbioph@abv.bg<\/a><\/p>\n\n\n\n

1. \u0412\u042a\u0412\u0415\u0414\u0415\u041d\u0418\u0415<\/h3>\n\n\n\n

\u041a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u044a\u0442 SARSr-CoV<\/strong> \u0438\u043c\u0430 \u0434\u0432\u0435 \u0430\u043c\u0438\u043d\u043e\u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438 valine<\/em> \u0438 leucine<\/em> (1). \u0422\u0435 \u0432\u043e\u0434\u044f\u0442 \u0434\u043e \u0441\u0438\u043b\u043d\u0430 \u0445\u0438\u0434\u0440\u043e\u0444\u043e\u0431\u043d\u043e\u0441\u0442. \u0412 SARSr-CoV<\/strong> \u0438\u043c\u0430 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u043c\u0435\u0436\u0434\u0443 E<\/em> and S<\/em> \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0438. \u0422\u043e\u0432\u0430 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0435 \u0441 \u0434\u0438\u0441\u0443\u043b\u0444\u0430\u0442\u043d\u0438 \u0432\u0440\u044a\u0437\u043a\u0438. \u0412\u0438\u0440\u0443\u0441\u043d\u0438\u0442\u0435 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442 \u043e\u0441\u043d\u043e\u0432\u043d\u0438 \u0447\u0440\u0435\u0437 C- \u0442\u0435\u0440\u043c\u0438\u043d\u0438\u0440\u0430\u043d\u0438 target proteins<\/em> (1). \u0422\u0435 \u0441\u0430 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u043e \u0437\u0430\u0440\u0435\u0434\u0435\u043d\u0438.
\u0412\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442 \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430 \u043f\u0440\u0438 \u0435\u043b\u0435\u043a\u0440\u043e\u043b\u0438\u0437\u0430 \u0432 \u043a\u0430\u0442\u043e\u0434\u043d\u043e\u0442\u043e \u043e\u0442\u0434\u0435\u043b\u0435\u043d\u0438e \u043d\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043b\u0430\u0439\u0437\u0435\u0440\u0430.
\u0412\u0430\u043b\u0438\u0434\u043d\u0430 \u0435 \u0440\u0435\u0430\u043a\u0446\u0438\u044f\u0442\u0430 \u0437\u0430 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u043d\u0430 \u0432\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442 \u0438 \u0441 \u0432\u0438\u0440\u0443\u0441\u0430 (3):
2\u041d2<\/sub>\u041e + 2\u0435–<\/sup>\u2192 H2<\/sub>+ 2\u041e\u041d–<\/sup><\/strong>
\u041e\u0442\u0434\u0435\u043b\u044f\u0442 \u0441\u0435 \u0441\u0432\u043e\u0431\u043e\u0434\u043d\u0438 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u0438, \u043a\u043e\u0438\u0442\u043e \u043d\u0435\u0443\u0442\u0440\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u0442 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u043e \u0437\u0430\u0440\u0435\u0434\u0435\u043d\u0438\u0442\u0435 \u0421-\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0438, \u043a\u043e\u0438\u0442\u043e \u0432\u043e\u0434\u044f\u0442 \u0434\u043e \u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438. \u0414\u043e\u0437\u0438\u0442\u0435 \u0441\u0430 \u0432\u0438\u0441\u043e\u043a\u0438 \u0438 \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442 \u0437\u043d\u0430\u0447\u0438\u043c\u0438 \u0435\u0444\u0435\u043a\u0442\u0438. \u041c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e\u0442\u043e \u0441\u0438\u043d\u044c\u043e \u0438\u043c\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0442\u043e\u0440\u043d\u043e\u0442\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 (Oz et al., 2011) (4). \u0422\u043e \u0435 \u0441 \u0445\u0438\u043c\u0438\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430: C16<\/sub>H18<\/sub>ClN13<\/sub>S<\/strong>. \u0418\u043c\u0430 \u0433\u043e\u043b\u044f\u043c \u0431\u0440\u043e\u0439 \u043d\u0430\u0443\u0447\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f Methylene blue<\/em> (MB) \u0441\u044a\u0441 \u0417\u0430\u043f\u0430\u0434\u043d\u043e-\u043d\u0438\u043b\u0441\u043a\u0438 \u0432\u0438\u0440\u0443\u0441 (5), \u0421\u041f\u0418\u041d \u2013 \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0430\u0442\u0430 \u0441\u0430\u0440\u043a\u043e\u043c\u0430 \u043d\u0430 \u041a\u0430\u043f\u043e\u0448\u0438 (6) \u0438 \u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441\u0438 (7). \u0418\u043c\u0430 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u0438 \u0440\u0435\u0437\u0443\u043b\u0442\u0430\u0442\u0438 \u0441 \u043f\u0440\u043e\u0433\u0435\u0440\u0438\u044f. \u0422\u0435 \u043f\u043e\u043a\u0430\u0437\u0432\u0430\u0442 \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u0430 \u043d\u0430 \u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e\u0442\u043e \u0441\u0438\u043d\u044c\u043e \u0437\u0430 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0441 \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u0430\u0442\u0430 \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0430 \u0441 \u0435\u0444\u0435\u043a\u0442\u0438 \u0432\u044a\u0440\u0445\u0443 \u0410\u0422\u0424 \u0438 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0440\u0438\u0438. Oxidal<\/em><\/strong> \u043d\u0435 \u0441\u0435 \u043d\u0443\u0436\u0434\u0430\u0435 \u043e\u0442 \u0444\u043e\u0442\u043e\u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u044f.
\u041a\u043e\u043b\u043e\u0438\u0434\u043d\u043e\u0442\u043e \u0441\u0440\u0435\u0431\u0440\u043e Ag+<\/sup><\/em><\/strong> \u0438\u043c\u0430 \u043f\u043e\u0434\u0442\u0438\u0441\u043a\u0430\u0449 \u0435\u0444\u0435\u043a\u0442 \u0432\u044a\u0440\u0445\u0443 \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u0438 \u0435\u043d\u0437\u0438\u043c\u0438. \u0422\u0430\u043a\u0430 \u0441\u0435 \u043f\u0440\u0430\u0432\u0438 \u043f\u0440\u0435\u0432\u0435\u043d\u0446\u0438\u044f \u0441\u0440\u0435\u0449\u0443 \u043f\u0440\u043e\u043c\u0435\u043d\u0438 \u043d\u0430 \u0435\u043d\u0437\u0438\u043c\u0438\u0442\u0435 (8). \u041a\u043e\u043b\u043e\u0438\u0434\u043d\u043e\u0442\u043e \u0441\u0440\u0435\u0431\u0440\u043e Ag+<\/sup><\/em><\/strong> \u043f\u043e\u0434\u0442\u0438\u0441\u043a\u0430 \u043a\u043e\u043f\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u0438 \u043f\u043e \u0442\u043e\u0437\u0438 \u043d\u0430\u0447\u0438\u043d \u043d\u0435\u0443\u0442\u0440\u0430\u043b\u0438\u0437\u0438\u0440\u0430 \u0435\u0444\u0435\u043a\u0442\u0438\u0442\u0435 \u043d\u0430 SARSr-CoV-2<\/strong>.<\/p>\n\n\n\n

2. MET\u041e\u0414\u0418 \u0418 \u041c\u0410\u0422\u0415\u0420\u0418\u0410\u041b\u0418<\/h3>\n\n\n\n

2.1. \u0415\u043b\u0435\u043a\u0442\u0440\u043e\u043b\u0430\u0439\u0437\u0435\u0440 \u0437\u0430 \u0432\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442<\/h4>\n\n\n\n

\u0415\u043b\u0435\u043a\u0442\u0440\u043e\u043b\u0430\u0439\u0437\u0435\u0440\u044a\u0442 \u0438\u043c\u0430 \u0434\u0432\u0435 \u0447\u0430\u0441\u0442\u0438, \u043a\u043e\u0438\u0442\u043e \u0441\u0430 \u0440\u0430\u0437\u0434\u0435\u043b\u0435\u043d\u0438 \u0441 \u043f\u043e\u043b\u0443\u043f\u0440\u043e\u043f\u0443\u0441\u043a\u043b\u0438\u0432\u0430 \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0430 (9). \u0410\u043d\u043e\u043b\u0438\u0442\u044a\u0442 \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430 \u043e\u0442 \u0430\u043d\u043e\u0434\u0430 \u0438 \u0435 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u043d\u0430 \u0444\u0440\u0430\u043a\u0446\u0438\u044f. \u041a\u0430\u0442\u043e\u043b\u0438\u0442\u044a\u0442 \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430 \u043f\u0440\u0438 \u043a\u0430\u0442\u043e\u0434\u0430 \u0438 \u0435 \u0430\u043b\u043a\u0430\u043b\u043d\u0430 \u0444\u0440\u0430\u043a\u0446\u0438\u044f. \u041a\u043e\u0433\u0430\u0442\u043e \u0435\u043b\u0435\u043a\u0442\u0440\u0438\u0447\u043d\u0438\u044f\u0442 \u0442\u043e\u043a \u043f\u0440\u0435\u043c\u0438\u043d\u0430\u0432\u0430 \u043f\u0440\u0435\u0437 \u0432\u043e\u0434\u0430\u0442\u0430 \u0438\u043c\u0430 \u0440\u0435\u0434\u043e\u043a\u0441 \u0440\u0435\u0430\u043a\u0446\u0438\u0438 \u0432\u044a\u0440\u0445\u0443 \u043f\u043e\u0432\u044a\u0440\u0445\u043d\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u0434\u0438\u0442\u0435. \u041a\u0430\u0442\u043e\u043b\u0438\u0442\u044a\u0442 \u0435 \u0441 \u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u0435\u043d \u043e\u043a\u0438\u0441\u043b\u0438\u0442\u0435\u043b\u043d\u043e-\u0440\u0435\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b \u0432 mV. \u0410\u043d\u043e\u043b\u0438\u0442\u044a\u0442 \u0435 \u0441 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u0435\u043d \u043e\u043a\u0438\u0441\u043b\u0438\u0442\u0435\u043b\u043d\u043e-\u0440\u0435\u0434\u0443\u043a\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b \u0432 mV. \u0424\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u043d\u0430\u0442\u0430 \u0441\u0445\u0435\u043c\u0430 \u0438 \u0440\u0435\u0430\u043a\u0446\u0438\u0438\u0442\u0435 \u0441\u0430 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438 \u043d\u0430 \u0424\u0438\u0433\u0443\u0440\u0430 1.<\/strong><\/p>\n\n\n\n

\"\u0424\u0438\u0433\u0443\u0440\u0430<\/figure>\n\n\n\n

\u0424\u0438\u0433\u0443\u0440\u0430 1. \u0421\u0445\u0435\u043c\u0430 \u043d\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043b\u0430\u0439\u0437\u0435\u0440<\/p>\n\n\n\n

2.2. Oxidal<\/a><\/em><\/h4>\n\n\n\n

Oxidal<\/a><\/em> \u0435 \u0441\u0442\u0435\u0440\u0438\u043b\u0435\u043d \u0442\u0435\u0447\u0435\u043d \u0440\u0430\u0437\u0442\u0432\u043e\u0440 \u0438 \u0441\u044a\u0434\u044a\u0440\u0436\u0430:
\u2013 1% \u201e\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e\u201d \u0441 \u0445\u0438\u043c\u0438\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430: C16<\/sub>H18<\/sub>ClN13<\/sub>S<\/strong>;
\u2013 1% \u043a\u0430\u0444\u0435\u0438\u043d;
\u2013 1% \u0431\u0435\u043d\u0437\u043e\u0435\u0432\u0430 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0430 \u0441 \u0445\u0438\u043c\u0438\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430: C6<\/sub>H5<\/sub>COOH<\/strong> (\u043a\u0430\u0442\u043e \u0441\u0442\u0430\u0431\u0438\u043b\u0438\u0437\u0430\u0442\u043e\u0440).<\/p>\n\n\n\n

2.3. \u041a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e<\/h4>\n\n\n\n

\u0417\u0430 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e \u0441\u0430 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438:
1. \u0421\u0440\u0435\u0431\u044a\u0440\u0435\u043d \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u0434 \u0441 \u0447\u0438\u0441\u043e\u0442\u0430 99.99%
2. Tetra-n-butylammonium bromide<\/em> (TBAB)-\u0430\u043c\u043e\u043d\u0438\u0435\u0432\u0430 \u0441\u043e\u043b \u0441 \u0431\u0440\u043e\u043c\u0438\u0434
3. Acetonitrile<\/em> \u2013 \u043e\u0446\u0432\u0435\u0442\u0435\u043d\u0430 \u0442\u0435\u0447\u043d\u043e\u0441\u0442 \u0441 \u0445\u0438\u043c\u0438\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430 CH3<\/sub>CN<\/strong><\/p>\n\n\n\n

\u041f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e \u043c\u043e\u0436\u0435 \u0434\u0430 \u0431\u044a\u0434\u0435 \u043f\u0440\u0438 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043b\u0438\u0437\u0430 (Mosin, Ignatov, 2013) (10). \u0418\u0437\u043f\u043e\u043b\u0437\u0432\u0430 \u0441\u0435 \u0442\u0435\u0442\u0440\u0430\u0431\u0443\u0442\u0438\u043b-\u0430\u043c\u043e\u043d\u0438\u0435\u0432 \u0431\u0440\u043e\u043c\u0438\u0434 \u0432 \u0430\u0446\u0435\u0442\u043e\u043d\u0438\u0442\u0440\u0438\u043b \u043a\u0430\u0442\u043e \u0442\u0435\u0447\u043d\u0430 \u0441\u0440\u0435\u0434\u0430 \u0437\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043b\u0438\u0437\u0430. \u041f\u0440\u0438 \u043c\u0435\u0442\u043e\u0434\u0430 \u043d\u0430 Mosin \u2013 Ignatov<\/em> \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e \u0441 \u0440\u0430\u0437\u043c\u0435\u0440\u0438 2\u20137 nm \u0432 \u0440\u0430\u0437\u0442\u0432\u043e\u0440 \u043e\u0442 Tetra-n-butylammonium bromide \u0432 acetonitrile<\/em>. \u0410\u043d\u043e\u0434\u044a\u0442 \u0435 \u0441\u0440\u0435\u0431\u044a\u0440\u0435\u043d, \u0430 \u043a\u0430\u0442\u043e\u0434\u044a\u0442 \u043e\u0442 \u0433\u0440\u0430\u0444\u0438\u0442.
\u0412 \u043f\u0440\u043e\u0446\u0435\u0441\u0430 \u043d\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043b\u0438\u0437\u0430 \u043d\u0430\u0441\u0442\u044a\u043f\u0432\u0430 \u0447\u0430\u0441\u0442\u0438\u0447\u043d\u043e\u0442\u043e \u0440\u0430\u0437\u0442\u0432\u0430\u0440\u044f\u043d\u0435 \u043d\u0430 \u0441\u0440\u0435\u0431\u044a\u0440\u043d\u0438\u044f \u0430\u043d\u043e\u0434, \u043a\u043e\u0435\u0442\u043e \u0432\u043e\u0434\u0438 \u0434\u043e \u043d\u0430\u0441\u0438\u0449\u0430\u043d\u0435 \u043d\u0430 \u0440\u0430\u0437\u0442\u0432\u043e\u0440\u0430 \u0441 Ag+<\/sup><\/em><\/strong>. \u041f\u0440\u0438 \u0437\u0430\u0434\u0430\u0434\u0435\u043d\u0438 \u043f\u0430\u0440\u0430\u043c\u0435\u0442\u0440\u0438 \u043d\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u0438\u0447\u043d\u0438\u044f \u0442\u043e\u043a \u0438 \u043d\u0430\u043f\u0440\u0435\u0436\u0435\u043d\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u0434\u0430. \u041a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u0440\u0430\u0437\u0442\u0432\u043e\u0440\u0430 Ag+<\/sup><\/em><\/strong> \u0441\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f \u043e\u0442 \u0432\u0440\u0435\u043c\u0435\u0442\u043e \u043d\u0430 \u0440\u0430\u0431\u043e\u0442\u0430 \u043d\u0430 \u0438\u0437\u0442\u043e\u0447\u043d\u0438\u043a\u0430 \u043d\u0430 \u0442\u043e\u043a \u0438 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e\u0442\u043e \u043d\u0430 \u0432\u043e\u0434\u043d\u0438\u044f \u0440\u0430\u0437\u0442\u0432\u043e\u0440.<\/p>\n\n\n\n

\"\u0424\u0438\u0433\u0443\u0440\u0430<\/figure>\n\n\n\n

\u0424\u0438\u0433\u0443\u0440\u0430 2. \u0417\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442 \u043c\u0435\u0436\u0434\u0443 \u0441\u0442\u043e\u0439\u043d\u043e\u0441\u0442\u0438\u0442\u0435
\u043d\u0430 pH \u0438 ORP \u0437\u0430 \u0441\u044a\u0449\u0435\u0441\u0442\u0432\u0443\u0432\u0430\u043d\u0435
\u043d\u0430 \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0438<\/p>\n\n\n\n

3. \u0420\u0415\u0417\u0423\u041b\u0422\u0410\u0422\u0418 \u0418 \u041c\u0410\u0422\u0415\u0420\u0418\u0410\u041b\u0418<\/h3>\n\n\n\n

3.1. A\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442<\/h4>\n\n\n\n

\u041d\u0430 \u0424\u0438\u0433\u0443\u0440\u0430 2<\/strong> \u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0430 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442 \u043c\u0435\u0436\u0434\u0443 \u0441\u0442\u043e\u0439\u043d\u043e\u0441\u0442\u0442\u0435 \u043d\u0430 pH and ORP (Karadzhov et al, 2014) \u0437\u0430 \u0441\u044a\u0449\u0435\u0441\u0442\u0432\u0443\u0432\u0430\u043d\u0435 \u043d\u0430 \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0438 (11). \u0421 \u0447\u0435\u0440\u0432\u0435\u043d\u0430\u0442\u0430 \u0444\u0438\u0433\u0443\u0440\u0430 \u0435 \u0443\u043a\u0430\u0437\u0430\u043d\u0430 \u0431\u0438\u043e\u0441\u0444\u0435\u0440\u0430\u0442\u0430 \u043d\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u043d\u0430 \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0432\u0438\u0442\u0435. \u0421\u044a\u0441 \u0441\u0438\u043d \u0446\u0432\u044f\u0442 \u0435 \u0443\u043a\u0430\u0437\u0430\u0442\u0430 \u0437\u043e\u043d\u0430\u0442\u0430 \u043d\u0430 \u043f\u043e\u0434\u0442\u0438\u0441\u043a\u0430\u043d\u0435 \u043d\u0430 \u0442\u044f\u0445\u043d\u043e\u0442\u043e \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435. \u0417\u0430 \u0432\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442 \u0437\u0430 \u0441\u0438\u043b\u0435\u043d \u0430\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u0435\u043d \u0435\u0444\u0435\u043a\u0442 \u0441\u0430 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438 \u0441\u043b\u0435\u0434\u043d\u0438\u0442\u0435 \u0441\u0442\u043e\u0439\u043d\u043e\u0441\u0442\u0438:
\u2013 \u0437\u0430 pH=9.5 ORP \u2265 (-650) mV;
\u2013 \u0437\u0430 pH=10.0 ORP \u2265 (-500) mV;
\u2013 \u0437\u0430 pH=10.5 ORP \u2265 (-450) mV<\/p>\n\n\n\n

\u041f\u044a\u0440\u0432\u0430\u0442\u0430 \u0434\u0438\u0430\u0433\u0440\u0430\u043c\u0430 \u043d\u0430 \u0424\u0438\u0433\u0443\u0440\u0430 3<\/strong> \u043f\u043e\u043a\u0430\u0437\u0432\u0430 \u043f\u0440\u043e\u0446\u0435\u043d\u0442\u044a\u0442 \u043d\u0430 \u0436\u0438\u0437\u043d\u0435\u043d\u043e\u0441\u043f\u043e\u0441\u043e\u0431\u043d\u0438\u0442\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u0432 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0432\u043e\u0434\u0438 (12) (Miloshev, Gluhchev et al. 2015). \u0411\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u0438\u0442\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u043d\u0430 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u044f\u0442\u0430 E. coli DH5a \u0432\u044a\u0432 \u0432\u043e\u0434\u0430 \u0441\u0430 100%. \u0412\u044a\u0432 \u0432\u043e\u0434\u0430 \u043a\u0430\u0442\u043e\u043b\u0438\u0442 \u043d\u0430 \u0432\u0442\u043e\u0440\u0430\u0442\u0430 \u0434\u0438\u0430\u0433\u0440\u0430\u043c\u0430 15.73 % \u043e\u0442 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u043d\u0430 E. coli \u0441\u044a\u0449\u0435\u0441\u0442\u0432\u0443\u0432\u0430\u0442. \u041f\u0440\u0438 \u0432\u043e\u0434\u0430 \u0430\u043d\u043e\u043b\u0438\u0442 73.60 % \u043e\u0442 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u0441\u0430 \u0436\u0438\u0437\u043d\u0435\u043d\u0438.
\u041f\u043e\u043b\u0443\u0447\u0435\u043d\u0438 \u0441\u0430 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u0438 \u0440\u0435\u0437\u0443\u043b\u0442\u0430\u0442\u0438 \u0441 \u0432\u043e\u0434\u0430 \u0430\u043d\u043e\u043b\u0438\u0442 \u043f\u0440\u0438 the Virus of Classical Swine Fever Virus <\/em>(Karadzhov, Ivanova et al., 2014) (13) \u0438 \u0431\u0438\u043e\u0446\u0438\u0434\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u0432\u044a\u0440\u0445\u0443 Gram-negative Pathogenic Bacteria<\/em> (14).<\/p>\n\n\n\n

\u0412\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442 \u0438\u043c\u0430 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0430 \u043d\u0430 \u0432\u043e\u0434\u043e\u0440\u043e\u0434\u043d\u0438\u0442\u0435 \u0432\u0440\u044a\u0437\u043a\u0438 \u043c\u0435\u0436\u0434\u0443 \u0432\u043e\u0434\u043d\u0438\u0442\u0435 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u0438 \u0441 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u0435\u043d \u0438 \u0430\u043d\u0442\u0438 \u0442\u0443\u043c\u043e\u0440\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438. (Ignatov, Mosin, 2013) (15). \u0412\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442 \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435 \u0438 \u0410\u0422\u0424 (Ignatov et al, 2019; 2020)(16, 17). \u041d\u0430\u043b\u0438\u0447\u0438\u0435\u0442\u043e \u043d\u0430 \u043d\u0430\u0441\u0446\u0435\u043d\u0442\u0435\u043d \u0432\u043e\u0434\u043e\u0440\u043e\u0434 \u0432 \u041a\u0430\u0442\u043e\u043b\u0438\u0442 \u0438\u043c\u0430 \u0430\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u043e \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 (Vassileva, Mehandjiev et al., 2019)<\/p>\n\n\n\n

\"\u0424\u0438\u0433\u0443\u0440\u0430<\/figure>\n\n\n\n

\u0424\u0438\u0433\u0443\u0440\u0430 3. \u041f\u0440\u043e\u0446\u0435\u043d\u0442 \u043d\u0430 \u0436\u0438\u0437\u043d\u0435\u043d\u043e\u0441\u043f\u043e\u0441\u043e\u0431\u043d\u0438
\u043a\u043b\u0435\u0442\u043a\u0438 E. coli DH5a \u0441\u043b\u0435\u0434
\u0435\u043b\u0435\u043a\u0442\u0440\u043e\u0445\u0438\u043c\u0438\u0447\u043d\u043e \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0441
\u0432\u043e\u0434\u0438 \u041a\u0430\u0442\u043e\u043b\u0438\u0442 \u0438 \u0410\u043d\u043e\u043b\u0438\u0442 \u043f\u043e \u043e\u0442\u043d\u043e\u0448\u0435\u043d\u0438\u0435 \u043d\u0430 \u0432\u043e\u0434\u0430,
\u043a\u043e\u044f\u0442\u043e \u043d\u0435 \u0435 \u0435 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u0445\u0438\u043c\u0438\u0447\u043d\u043e \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0430(18). \u0418\u043c\u0430 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430 \u0437\u0430 \u0435\u0444\u0435\u043a\u0442\u0438 \u0432\u044a\u0440\u0445\u0443 Graffi tumor \u043d\u0430 \u0445\u0430\u043c\u0441\u0442\u0435\u0440\u0438 \u0441 \u043f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u043a\u0440\u044a\u0432\u043d\u0438 \u0438 \u0438\u043c\u0443\u043d\u043d\u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0438 (19, 20, 21).<\/p>\n\n\n\n

3.2. \u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 Oxidal<\/em><\/strong><\/h4>\n\n\n\n

\u041a\u043e\u0433\u0430\u0442\u043e \u043d\u0430\u0432\u043b\u0438\u0437\u0430 \u0432 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435 \u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e\u0442\u043e \u0441\u0438\u043d\u044c\u043e (methylene blue, MB) \u0434\u0435\u0439\u0441\u0442\u0432\u0430 \u043a\u0430\u0442\u043e \u0434\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u0435\u043d \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u0435\u043d \u0438\u0437\u0442\u043e\u0447\u043d\u0438\u043a. MB \u0440\u0435\u0430\u0433\u0438\u0440\u0430 \u043a\u0430\u0442\u043e \u0434\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u0435\u043d \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u0435\u043d \u0438\u0437\u0442\u043e\u0447\u043d\u0438\u043a. \u0422\u043e \u043f\u044a\u0440\u0432\u043e \u0441\u0435 \u0440\u0435\u0434\u0443\u0446\u0438\u0440\u0430 \u0434\u043e MBH 2 \u0447\u0440\u0435\u0437 NADH-dehydrogenase \u0432 complex I \u0438 \u0441\u043b\u0435\u0434 \u0442\u043e\u0432\u0430 \u0441\u0435 \u0440\u0435\u043e\u043a\u0441\u0438\u0434\u0438\u0440\u0430 \u0434\u043e MB \u0447\u0440\u0435\u0437 cytochrome c. \u0426\u0438\u043a\u043b\u0438\u0447\u043d\u043e\u0441\u0442\u0442\u0442\u0430 \u043c\u0435\u0436\u0434\u0443 \u0442\u0435\u0437\u0438 \u0434\u0432\u0435 \u0444\u043e\u0440\u043c\u0438 \u0441\u044a\u0437\u0434\u0430\u0432\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u0435\u043d \u043f\u0440\u0435\u043d\u043e\u0441 \u0437\u0430 \u0441\u0438\u043d\u0442\u0435\u0437 \u043d\u0430 \u0410\u0422\u0424 \u043a\u0430\u0442\u043e \u043e\u0441\u043d\u043e\u0432\u043d\u0430 \u0444\u0443\u043d\u043a\u0438\u0446\u0438\u044f \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435 (22). \u041e\u0449\u0435 \u043f\u043e-\u0432\u0430\u0436\u043d\u043e \u0435, \u0447\u0435 \u0441\u0435 \u043f\u0440\u0435\u0434\u043e\u0442\u0432\u0440\u0430\u0442\u044f\u0432\u0430 \u0437\u0430\u0433\u0443\u0431\u0430\u0442\u0430 \u043d\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u0438 \u0438 \u043e\u0431\u0440\u0430\u0437\u0443\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0438 \u0444\u043e\u0440\u043c\u0430\u0446\u0438\u0438, \u043a\u043e\u0438\u0442\u043e \u0441\u0430 \u0442\u043e\u043a\u0441\u0438\u0447\u043d\u0438 \u0437\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435 (23). MB \u0441\u044a\u0449\u043e \u043f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0430\u0442\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0441 \u0432\u043a\u043b\u044e\u0447\u0432\u0430\u043d\u0435 \u043d\u0430 PGC1\u03b1 \u043a\u0430\u0442\u043e \u0446\u0435\u043d\u0442\u0440\u0430\u043b\u0435\u043d \u043c\u0435\u0434\u0438\u0430\u0442\u043e\u0440 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0438\u044f \u0431\u0438\u043e\u0433\u0435\u043d\u0435\u0437\u0438\u0441 (24) \u0438 \u043a\u0430\u0442\u043e \u043d\u044f\u043a\u043e\u043b\u043a\u043e \u043a\u043b\u044e\u0447\u043e\u0432\u0438 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u043e \u043f\u0440\u0435\u043d\u0430\u0441\u044f\u0449\u0438 \u0432\u0435\u0440\u043b\u0438\u0433\u0438 (ETC). \u041a\u043e\u043c\u043f\u043e\u043d\u0435\u0442\u0438\u0442\u0435 cytochrome oxidase (COX II \u0438 COX IV (23) . \u0418\u0437\u0432\u043e\u0434\u044a\u0442 \u0435, \u0447\u0435 \u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e\u0442\u043e \u0441\u0438\u043d\u044c\u043e \u0441\u044a\u0434\u0435\u0439\u0441\u0442\u0432\u0430 \u0437\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435 \u0438 ROS \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438\u0442\u0435.
\u041f\u043e\u0432\u0438\u0448\u0435\u043d\u0438\u0442\u0435 ROS \u0441\u0430 \u0434\u043e\u043a\u043b\u0430\u0434\u0432\u0430\u043d\u0438 \u0437\u0430 \u043a\u043b\u0435\u0442\u043a\u0438 \u043f\u0440\u0438 Hutchinson\u2013Gilford progeria syndrome (HGPS) (Viteri et al.,  2010 ) (25); Lattanzi et al., 2012) (26). \u0414\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u043d\u043e \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 \u0440\u0435\u0433\u0443\u043b\u0430\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0438\u0442\u0435 \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0438 oxidative phosphorylation proteins, \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u0449\u0438 \u043d\u0438\u0432\u0430\u0442\u0430 \u043d\u0430 AT\u0424 \u0438 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0430\u0442\u0430 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0431\u0435 \u0434\u043e\u043a\u043b\u0430\u0434\u0432\u0430\u043d\u0430 \u0437\u0430 HGPS fibroblasts \u0438 \u0441\u044a\u0449\u043e \u0437\u0430 HGPS \u043c\u043e\u0434\u0435\u043b\u0438 \u0441 \u043c\u0438\u0448\u043a\u0438 (Rivera-Torres et al., 2013)(27), Villa-Bellosta et al., 2013) (28). \u0422\u0435\u0437\u0438 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430 \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430\u0442 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0438 \u0434\u0435\u0444\u0435\u043a\u0442\u0438 \u0432 HGPS.
\u0412\u0441\u0435 \u043e\u0449\u0435 \u043e\u0431\u0430\u0447\u0435 \u043d\u0435 \u0435 \u044f\u0441\u043d\u043e \u0434\u043e \u043a\u0430\u043a\u0432\u0430 \u0441\u0442\u0435\u043f\u0435\u043d \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0430\u0442\u0430 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0434\u043e\u043f\u0440\u0438\u043d\u0430\u0441\u044f \u0437\u0430 \u0444\u0435\u043d\u043e\u0442\u0438\u043f\u0438\u0442\u0435 \u043d\u0430 \u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u0441\u0442\u0430\u0440\u0435\u0435\u043d\u0435, \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0438 \u0441 HGPS. \u0412 \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435 \u0441\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0438\u0440\u0430 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u0438 \u0437\u0430 HGPS \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0438 \u0434\u0435\u0444\u0435\u043a\u0442\u0438 \u0438 \u0441\u0430 \u043f\u0440\u043e\u0443\u0447\u0435\u043d\u0438 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0438\u0442\u0435, \u0437\u0430\u043b\u0435\u0433\u043d\u0430\u043b\u0438 \u0432 \u043e\u0441\u043d\u043e\u0432\u0430\u0442\u0430 \u043d\u0430 \u0442\u0435\u0437\u0438 \u0430\u043d\u043e\u043c\u0430\u043b\u0438\u0438.<\/p>\n\n\n\n

\"\u0424\u0438\u0433\u0443\u0440\u0430<\/figure>\n\n\n\n

\u0424\u0438\u0433\u0443\u0440\u0430 4.<\/strong> \u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u043d\u0430
Ag+<\/sup><\/em><\/strong> \u0439\u043e\u043d\u0438 \u0432 \u043c\u0438\u043a\u0440\u043e\u0431\u043d\u0430 \u043a\u043b\u0435\u0442\u043a\u0430:
a)<\/strong> \u2013 \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0435\u043d \u043f\u0440\u043e\u0442\u0435\u0438\u043d peptidoglycan<\/em> \u0438
\u043d\u0435\u0433\u043e\u0432\u043e\u0442\u043e \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0441 Ag+<\/sup><\/em><\/strong> \u0439\u043e\u043d\u0438;
b)<\/strong> \u2013 \u043f\u0440\u043e\u0446\u0435\u0441 \u043d\u0430 \u043f\u0440\u043e\u043d\u0438\u043a\u0432\u0430\u043d\u0435 \u043d\u0430 Ag+<\/sup><\/em><\/strong> \u0439\u043e\u043d\u0438
\u0432 \u043c\u0438\u043a\u0440\u043e\u0431\u043d\u0430\u0442\u0430 \u043a\u043b\u0435\u0442\u043a\u0430 (Dondysh, 1964).<\/p>\n\n\n\n

\u041e\u0441\u0432\u0435\u043d \u0442\u043e\u0432\u0430 \u0435 \u0442\u0435\u0441\u0442\u0432\u0430\u043d\u043e \u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e (MB), \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u043e \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u0435, \u0437\u0430 \u043a\u043e\u0435\u0442\u043e \u0441\u0435 \u0437\u043d\u0430\u0435, \u0447\u0435 \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0430\u0442\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f. \u0420\u0435\u0437\u0443\u043b\u0442\u0430\u0442\u0438\u0442\u0435 \u043f\u043e\u043a\u0430\u0437\u0432\u0430\u0442, \u0447\u0435 \u043b\u0435\u0447\u0435\u043d\u0438\u0435\u0442\u043e \u0441 MB \u043f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430 \u043d\u0435 \u0441\u0430\u043c\u043e \u043c\u043e\u0440\u0444\u043e\u043b\u043e\u0433\u0438\u044f\u0442\u0430 \u0438 \u0444\u0443\u043d\u043a\u0446\u0438\u0438\u0442\u0435 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435, \u043d\u043e \u0441\u044a\u0449\u043e \u0442\u0430\u043a\u0430 \u0438\u0437\u0433\u043b\u0435\u0436\u0434\u0430, \u0447\u0435 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u043e \u0441\u043f\u0430\u0441\u044f\u0432\u0430 \u0444\u0435\u043d\u043e\u0442\u0438\u043f\u0438\u0442\u0435 \u043d\u0430 \u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u0441\u0442\u0430\u0440\u0435\u0435\u043d\u0435 \u0432 HGPS \u044f\u0434\u0440\u0430. \u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e \u0441\u043e\u0447\u0438 \u043d\u043e\u0432\u043e \u043e\u0431\u0435\u0449\u0430\u0432\u0430\u0449\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0437\u0430 HGPS.<\/p>\n\n\n\n

3.3. \u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e\u0442\u043e \u0441\u0440\u0435\u0431\u0440\u043e<\/h4>\n\n\n\n

\u041a\u043e\u043b\u043e\u0438\u0434\u043d\u043e\u0442\u043e \u0441\u0440\u0435\u0431\u0440\u043e Ag+<\/sup><\/em><\/strong> \u0438\u043c\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u0449 \u0435\u0444\u0435\u043a\u0442 \u0432\u044a\u0440\u0445\u0443 \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u0438 \u0435\u043d\u0437\u0438\u043c\u0438 \u043d\u0430 \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0438\u0442\u0435. Ag+<\/sup><\/em><\/strong> \u0441\u0435 \u0432\u0433\u0440\u0430\u0436\u0434\u0430 \u0432 \u0440\u0435\u0430\u043a\u0446\u0438\u043e\u043d\u043d\u0438\u044f \u0446\u0435\u043d\u0442\u044a\u0440 \u043d\u0430 \u0435\u043d\u0437\u0438\u043c\u0438. \u0422\u043e\u0432\u0430 \u0432\u044a\u0437\u043f\u0440\u0435\u043f\u044f\u0441\u0442\u0432\u0430 \u043f\u043e- \u043d\u0430\u0442\u0430\u0442\u044a\u0448\u043d\u043e\u0442\u043e \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u043d\u0430 \u0435\u043d\u0437\u0438\u043c\u0438\u0442\u0435. \u0422\u044a\u0439 \u043a\u0430\u0442\u043e \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0430\u0442\u0430 \u043d\u0430 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u043d\u0430 \u0431\u043e\u0437\u0430\u0439\u043d\u0438\u0446\u0438\u0442\u0435 \u043d\u0435 \u0441\u044a\u0434\u044a\u0440\u0436\u0430 \u043f\u0435\u043f\u0442\u0438\u0434\u043e\u0433\u043b\u0438\u043a\u0430\u043d\u0438 Ag+<\/sup><\/em><\/strong> \u043d\u044f\u043c\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u0449 \u0435\u0444\u0435\u043a\u0442 (32, 33). \u041d\u0430 \u0444\u0438\u0433. 4 \u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u044a\u0442 (Dondysh, 1964) (32).
\u041a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u044a\u0442 \u0441\u0435 \u0440\u0435\u043f\u043b\u0438\u0446\u0438\u0440\u0430 \u0447\u0440\u0435\u0437 \u043a\u043e\u043f\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u0438\u044f \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b \u0447\u0440\u0435\u0437 \u0435\u043d\u0437\u0438\u043c RNA- dependent RNA polymerase. \u041a\u043e\u043b\u043e\u0438\u0434\u043d\u043e\u0442\u043e \u0441\u0440\u0435\u0431\u0440\u043e Ag + \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430 \u0442\u043e\u0432\u0430 \u043a\u043e\u043f\u0438\u0440\u0430\u043d\u0435 \u0438 \u0442\u0430\u043a\u0430 \u0441\u0435 \u043d\u0435\u0443\u0442\u0440\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u0442 \u0435\u0444\u0435\u043a\u0442\u0438\u0442\u0435 \u043d\u0430 COVID-2019<\/strong>.<\/p>\n\n\n\n

\u041f\u043e\u043b\u0443\u0447\u0435\u043d\u0438 \u0441\u0430 \u0440\u0435\u0437\u0443\u043b\u0442\u0430\u0442\u0438 \u0437\u0430 SARS-CoV<\/strong>, \u0447\u0435 \u0432\u0438\u0440\u0443\u0441\u044a\u0442 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435, \u0437\u0430 \u0434\u0430 \u0434\u0430 \u043d\u0430\u043c\u0430\u043b\u0438 \u0438\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u0430 \u043d\u0430 \u0447\u043e\u0432\u0435\u043a\u0430 (Shi, 2014)(29)(Nelemans, 2019) (30). Oxidal<\/a><\/em><\/strong> \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435 \u0438 \u0410\u0422\u0424. \u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u0442\u0435 \u0449\u0430\u043c\u043e\u0432\u0435 \u043d\u0430 S. aureus \u0438 E. coli \u043f\u043e\u043a\u0430\u0437\u0432\u0430\u0442 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0430 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u043d\u043e\u0441\u0442 \u043a\u044a\u043c Oxidal<\/em><\/strong> \u0432 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u0431\u0438\u043e\u0442\u0438\u043a Thiamphenicol, \u043d\u043e \u0440\u0430\u0437\u043b\u0438\u043a\u0438\u0442\u0435 \u043d\u0435 \u0441\u0430 \u0437\u043d\u0430\u0447\u0438\u043c\u0438 (Popova, Petrova, Ignatov, Karadzhov, 2020) (31).<\/p>\n\n\n\n

\u0424\u0438\u0433\u0443\u0440\u0430 5<\/strong> \u043f\u043e\u043a\u0430\u0437\u0432\u0430 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u043d\u0430 \u0444\u043e\u0442\u043e\u0433\u0440\u0430\u0444\u0438\u044f \u043d\u0430 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e (34) (Darroudi et al., 2011)<\/p>\n\n\n\n

\"\u0424\u0438\u0433\u0443\u0440\u0430<\/figure>\n\n\n\n

\u0424\u0438\u0433\u0443\u0440\u0430 5. \u0415\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u043d\u0430 \u0444\u043e\u0442\u043e\u0433\u0440\u0430\u0444\u0438\u044f \u043d\u0430 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e
\u0441\u0440\u0435\u0431\u0440\u043e \u0441 \u0440\u0430\u0437\u043c\u0435\u0440 5 nm (Darroudi et al., 2011)<\/p>\n\n\n\n

3.4. \u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0434\u043e\u0437\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442, Oxidal<\/em><\/strong> \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e<\/h4>\n\n\n\n

\u041f\u0440\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u043d\u0430 \u0432\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442 \u0441\u0435 \u043f\u0440\u0435\u043f\u043e\u0440\u044a\u0447\u0432\u0430 \u0442\u043e\u0432\u0430 \u0434\u0430 \u0431\u044a\u0434\u0435 \u0435\u0434\u0438\u043d \u0447\u0430\u0441 \u043f\u0440\u0435\u0434\u0438 \u0438\u043b\u0438 \u0441\u043b\u0435\u0434 \u0445\u0440\u0430\u043d\u0430. \u041d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u0435 pH \u0434\u0430 \u0431\u044a\u0434\u0435 \u043d\u0430\u0434 9.5 \u0438 ORP \u0432 \u0438\u043d\u0442\u0435\u0440\u0432\u0430\u043b\u0430 (-700 – -400) mV. \u0421 \u0443\u0432\u0435\u043b\u0438\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 pH \u043c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 ORP \u0438 \u0442\u043e\u0432\u0430 \u0443\u0432\u0435\u043b\u0438\u0447\u0430\u0432\u0430 \u0435\u0444\u0435\u043a\u0442\u0430 \u043d\u0430 \u0432\u043e\u0434\u0430 \u041a\u0430\u0442\u043e\u043b\u0438\u0442. Oxidal<\/em><\/strong> <\/a>\u043c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u043f\u0440\u0438\u043b\u0430\u0433\u0430 \u0432 \u0434\u043e\u0441\u0442\u0430 \u0433\u043e\u043b\u0435\u043c\u0438 \u0434\u043e\u0437\u0438, \u043d\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f\u0442\u0430 \u0441 \u0445\u043e\u0440\u0430 \u043f\u043e\u043a\u0430\u0437\u0432\u0430\u0442, \u0447\u0435 \u043e\u043f\u0442\u0438\u043c\u0430\u043b\u043d\u0438\u0442\u0435 \u0434\u043e\u0437\u0438 \u043d\u0430 „methylene blue“ \u0437\u0430 \u0447\u043e\u0432\u0435\u043a \u043d\u0430 \u0434\u0435\u043d \u0441\u0430 \u043e\u043a\u043e\u043b\u043e 15 mg-16 mg. \u041f\u0440\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430\u0442\u0430 \u043d\u0430 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u043d\u0430\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e \u0434\u043e\u0437\u0438\u0442\u0435 \u0435 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e \u0434\u0430 \u0431\u044a\u0434\u0430\u0442 \u0442\u043e\u0447\u043d\u043e \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u043d\u0438 \u0414\u043e\u0437\u0430 \u0437\u0430 \u0435\u0434\u0438\u043d \u0434\u0435\u043d: 5 \u00b5g \u043c\u0438\u043a\u0440\u043e\u0433\u0440\u0430\u043c\u0430 \u043d\u0430 1 \u043a\u0433 \u0442\u0435\u043b\u0435\u0441\u043d\u0430 \u043c\u0430\u0441\u0430 5 \u00b5g x70 kg body weight=350 \u00b5g = 0.00035 g<\/p>\n\n\n\n

4. \u0417\u0410\u041a\u041b\u042e\u0427\u0415\u041d\u0418\u0415<\/h3>\n\n\n\n

\u0410\u0432\u0442\u043e\u0440\u044a\u0442 \u043f\u0440\u0435\u0434\u043b\u0430\u0433\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430\u0442\u0430 \u043d\u0430 \u0442\u0440\u0438 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0430 water \u2013 Catholyte, Oxidal<\/a><\/em><\/strong> and Colloidal Silver \u043f\u0440\u0438 \u043f\u0440\u0435\u0432\u0435\u043d\u0446\u0438\u044f \u0438 \u0434\u043e\u043f\u044a\u043b\u043d\u0438\u0442\u0435\u043b\u0435\u043d \u043c\u0435\u0442\u043e\u0434 \u0437\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u043f\u0440\u0438 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u0437\u043d\u043e\u0442\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435 2019-nCoV \u043f\u0440\u0435\u0434\u0438\u0437\u0432\u0438\u043a\u0430\u0442\u043e \u043e\u0442 \u0432\u0438\u0440\u0443\u0441\u0430 (SARSr-CoV<\/strong>). \u0415\u0444\u0435\u043a\u0433\u0438\u0442\u0435 \u0441\u0430 \u0432\u044a\u0440\u0445\u0443 \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u0430\u0442 \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0430, \u0410\u0422\u0424 \u0438 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438.<\/p>\n\n\n\n

\u0422\u043e\u0447\u043d\u043e\u0442\u043e \u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u0432\u043e\u0434\u0438 \u0434\u043e \u0441\u043b\u0435\u0434\u043d\u0438\u0442\u0435 \u0435\u0444\u0435\u043a\u0442\u0438:
1. \u041e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u043d\u0438\u0442\u0435 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u0438 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u0442 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u0438\u044f \u0437\u0430\u0440\u044f\u0434 \u043d\u0430 C \u043f\u0440\u043e\u0442\u0435\u043d\u0435\u0438\u043d\u0430 \u0438 \u0442\u0430\u043a\u0430 \u0441\u0435 \u041d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 \u0431\u0440\u043e\u044f\u0442 \u043d\u0430 \u043d\u0430\u0432\u043b\u0435\u0437\u043b\u0438\u0442\u0435 \u0432\u0438\u0440\u0443\u0441\u0438 \u0432 \u043a\u043b\u0435\u0442\u043a\u0430\u0442\u0430.
2. \u0412\u0438\u0440\u0443\u0441\u044a\u0442 SARS-CoV \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435, \u0437\u0430 \u0434\u0430 \u0434\u0430 \u043d\u0430\u043c\u0430\u043b\u0438 \u0438\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u0430 \u043d\u0430 \u0447\u043e\u0432\u0435\u043a\u0430. Oxidal<\/a><\/em><\/strong> \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0438\u0442\u0435 \u0438 \u0410\u0422\u0424.
3. \u041a\u043e\u043b\u043e\u0438\u0434\u043d\u043e\u0442\u043e \u0441\u0440\u0435\u0431\u0440\u043e Ag+<\/sup><\/em><\/strong> \u0438\u043c\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u0449 \u0435\u0444\u0435\u043a\u0442 \u0432\u044a\u0440\u0445\u0443 \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u0438 \u0435\u043d\u0437\u0438\u043c\u0438 \u043d\u0430 \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0438\u0442\u0435. Ag+<\/sup><\/em><\/strong> \u0441\u0435 \u0432\u0433\u0440\u0430\u0436\u0434\u0430 \u0432 \u0440\u0435\u0430\u043a\u0446\u0438\u043e\u043d\u043d\u0438\u044f \u0446\u0435\u043d\u0442\u044a\u0440 \u043d\u0430 \u0435\u043d\u0437\u0438\u043c\u0430. \u0422\u043e\u0432\u0430 \u0432\u044a\u0437\u043f\u0440\u0435\u043f\u044f\u0441\u0442\u0432\u0430 \u043f\u043e- \u043d\u0430\u0442\u0430\u0442\u044a\u0448\u043d\u043e\u0442\u043e \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u043d\u0430 \u0435\u043d\u0437\u0438\u043c\u0430. \u0422\u044a\u0439 \u043a\u0430\u0442\u043e \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u0430\u0442\u0430 \u043d\u0430 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u043d\u0430 \u0431\u043e\u0437\u0430\u0439\u043d\u0438\u0446\u0438\u0442\u0435 \u043d\u0435 \u0441\u044a\u0434\u044a\u0440\u0436\u0430 \u043f\u0435\u043f\u0442\u0438\u0434\u043e\u0433\u043b\u0438\u043a\u0430\u043d\u0438 Ag+<\/sup><\/em><\/strong> \u043d\u044f\u043c\u0430 \u0438\u043d\u0445\u0438\u0431\u0438\u0440\u0430\u0449 \u0435\u0444\u0435\u043a\u0442.<\/p>\n\n\n\n

\u041f\u0440\u0435\u043f\u043e\u0440\u044a\u0447\u0438\u0442\u0435\u043b\u043d\u0438 \u0441\u0430 \u0438 \u0432\u0438\u0441\u043e\u043a\u0438 \u0434\u043e\u0437\u0438 \u0432\u0438\u0442\u0430\u043c\u0438\u043d \u0421.<\/p>\n\n\n\n

\u0415\u0434\u0438\u043d \u043e\u0442 \u0438\u0437\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0438\u0442\u0435 Wolfgang Luepke \u043f\u0440\u0435\u0434\u043b\u0430\u0433\u0430 \u0445\u0438\u043f\u0435\u0440 \u0438\u043c\u0443\u043d\u0438\u0437\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0442\u0435\u043b\u0435\u0442\u0430 \u0441 SARS-CoV-2. \u0422\u0430\u043a\u0430 \u043c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0438 \u0441\u0435\u0440\u0443\u043c \u0441 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430. \u0422\u043e\u0439 \u0435 \u043f\u043e\u0434 \u0444\u043e\u0440\u043c\u0430\u0442\u0430 \u043d\u0430 \u0430\u0435\u0440\u043e\u0437\u043e\u043b \u0437\u0430 \u0432\u0434\u0438\u0448\u0432\u0430\u043d\u0435 \u0438 \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430 \u043f\u0430\u0441\u0438\u0432\u0435\u043d \u0418\u043c\u0443\u043d\u0438\u0442\u0435\u0442. \u0412 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u0441\u0435 \u043e\u0431\u0440\u0430\u0437\u0443\u0432\u0430\u0442 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u0438 \u043e\u0442 \u043f\u0430\u0441\u0438\u0432\u0435\u043d \u0438\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u044a\u0442 \u043c\u0438\u043d\u0430\u0432\u0430 \u0432 \u043f\u0430\u0441\u0438\u0432\u0435\u043d.<\/p>\n\n\n\n

\u0420\u0435\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0438:<\/p>\n\n\n\n

1. Lai, J., Luo, S., Ho, L. Signaling Pathways of SARS-CoV In Vitro and In Vivo , Analysis of Proteins that Interact with Nucleocapsid Protein of SARS-CoV using 15-mer Phage-displayed Library , Biochem. Pharmacol., 2018; 156:348-356.
2. Kim, S.; Kim, D.; Lee, B. Insufficient Sensitivity of RNA Dependent RNA Polymerase Gene of SARS- CoV-2 Viral Genome as Confirmatory Test using Korean COVID-19 Cases. Preprints 2020.
3. Ignatov, I., Gluhchev, G., Karadzhov, G., Yaneva, I., Valcheva, N., Dinkov, G,, Popova, T., Petrova, T., Mehandjiev, D., Akszjonovich, I. Dynamic Nano Clusters of Water on Waters Catholyte and Anolyte: Electrolysis with Nano Membranes, Physical Science International Journal, 2020, 24 (1): 46-54.
4. Oz, M. et al. Cellular and Molecular Actions of Methylene Blue in the Nervous System, Medicinal Research Reviews, 2011; 31 (1): 93-117.
5. Papin J.F.; Floyd R.A.; Dittmer D.P., Methylene Blue Photoinactivation Abolishes West Nile Virus Infectivity in Vivo. Antiviral Research; 2005; 68 (2): 84\u20137.
6. Tardivo, J.P.; Del Giglio, A.; Paschoal, L.H.; Baptista, M.S. New Photodynamic Therapy Protocol to Treat AIDS-related Kaposi’s Sarcoma, Photomedical Laser Surgery, 2006; 24 (4): 528\u201331.
7. Floyd R.A.; Schneider J.E.; Dittmer D.P. Methylene blue Photoinactivation of RNA Viruses, Antiviral Research, 2004; 61 (3): 141\u201351.
8. Ignatov, I., Mosin, O.V. Methods for the Preparation of Colloidal Silver Nanoparticles and Spheres of Their Practical Application Field, Bulletin of Science and Education, 2013:;3; 30\u201342.
9. Bahir, V.M., Liakumovich, A.G., Kirpichnikov, P.A., Spector, L.E., Mamajanov, U.D. The Physical Nature of the Phenomenon of Activation Substances. Izv. UzSSR. Ser. Tehn. Sciences, (1983)1: 60\u201364.
10. Mosin, O. V., Ignatov, I. Preparation of Nanoparticles of Colloid Silver and Spheres of Their Practical Using, Nanoengeneering, 2013; 5: 23-30.
11. Karadzov, S., Atanasov, A., Ivanova, E., Mosin, O. V., Ignatov, I. Mathematical Models of Electrochemical Aqueous Sodium Chloride Solutions (Anolyte and Catolyte) as Types of Water. Study of the Effects of Anolyte on the Virus of Classical Swine Fever Virus, Journal of Health, Medicine and Nursing, 2014; 5: 30-55.
12. Gluhchev, G., Ignatov, I., Karadzhov, S., Miloshev, G., Ivanov, N., Mosin, O. V. Studying of Virucidal and Biocidal Effects of Electrochemically Activated Anolyte and Catholyte Types of Water on Classical Swine Fever Virus (CSF) and Bacterium E. coli DH5, Journal of Medicine, Physiology and Biophysics. 2015; 13: 1-17.
13. Ignatov, I., Karadzhov, S., Atanasov, A., Ivanova, E., Mosin, O. V. Electrochemical Aqueous Sodium Chloride Solution (Anolyte and Catholyte) as Types of Water. Mathematical Models. Study of Effects of Anolyte on the Virus of Classical Swine Fever Virus, Journal of Health, Medicine and Nursing, 2014; 8: 1-28.
14. Popova, T., Petrova, T., Karadzhov, S. Investigation of the Biocidal Effect of Electrochemically Activated Aqueous Sodium Chloride Solution on Gram-negative Pathogenic Bacteria, Int. J. Curr. Microbiol. App. Sci. 2016; 5(1): 624-632.
15. Ignatov, I., Mosin, O. V. Structural Mathematical Models Describing Water Clusters, Journal of Mathematical Theory and Modeling, 2013; 3 (11): 72-87.
16. Ignatov, I. Electrochemically Activated Water Catholyte for Activation of Shape and Recovery in the Sport, Int. Conference on Medicine and Football, Sofia, Bulgaria, Journal of Medicine and Sport, 2019; 3-4.
17. Ignatov, I., Gencheva, N., Marinov, T., Yaneva, I., Angelcheva, M., Dinkov, G., Angushev, I. Electrochemically Activated Water Catholyte for the Activation of Hydrogen Ions and ATP for Sport\u2019s Shape and Recovery, International Journal of Medical and Pharmaceutical Case Reports, 2020.
18. Vassileva, P., Voykova, D., Ignatov, I., Karadzhov, S., Gluhchev, S., Ivanov, N., Mehandjiev, D. Results from the Research of Water Catholyte with Nascent (Atomic) Hydrogen, Journal of Medicine, Physiology and Biophysics, 2019; 52: 7-11.
19. Toshkova, R., Ignatov, I., Zvetkova, E., Gluhchev, G. Effects of Catholyte Water on the Development of Experimental Graffi Tumor on Hamsters, European Journal of Medicine, 2019; 7(1): 45-56.
20. Toshkova, R., Zvetkova, E., Ignatov, I., Gluhchev, G. Effects of Catholyte Water on the Development of Experimental Graffi Tumor on Hamsters, Bulgarian Journal of Public Health, 2019 11, (3): 60-73.
21. Ignatov, I., Toshkova, R.,Gluhchev, G., Zvetkova, E. Results with IR Spectroscopy of CortiNon+ on the Development of Experimental Graffi Tumor on Hamsters, European Reviews of Chemical Research, 2019; 6( 2): 61-67.
22. Tardivo, J. Methylene Blue in Photodynamic Therapy: From Basic Mechanisms to Clinical Applications, Photodiagnosis and Photodynamic Therapy, 2005; 2 (3): 175-191.
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24. Xiong, Z. M. et al. Methylene Blue Alleviates Nuclear and Mitochondrial Abnormalities in Progeria, Aging Cell, 2016; 15: 279\u2013290.
25. Viteri G, Chung YW, Stadtman ER (2010) Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients. Mech. Ageing Dev. 2010; 131: 2\u20138.
26. Lattanzi G, Marmiroli S, Facchini A, Maraldi N.M. Nuclear Damages and Oxidative Stress: New Perspectives for Laminopathies, Eur. J. Histochem, 2012; 56: 284\u2013288.
27. Rivera\u2010Torres J, et al, Identification of Mitochondrial Dysfunction in Hutchinson\u2010Gilford Progeria Syndrome through Use of Stable Isotope Labeling with Amino Acids in Cell Culture. J. Proteomics. 2013; 91:466\u2013477.
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32. Dondysh, L.M. Inhibitory Effect of Silver on Some Enzymatic Systems. Questions and Exogenous Organic Neuropsychiatric Disorders\/ in Materials of Scientific Conf., State Institute of Psychiatry USSR, Ministry of Health. \u2013 Moscow: State. Institute of Psychiatry USSR Ministry of Health, 1964; 2: 143\u2013165.
33. Mosin, O.V., Ignatov, I. Methods for the Preparation of Colloidal Silver Nanoparticles, Nano and Microsystems, 2014; 2: 46\u201352. 34. Darroudi, M., Ahmad, M.B., Zamiri, R. Time-dependent effect in green synthesis of silver nanoparticles. International Journal of Nanomedicine, 2011; 6: 677\u2013681.
<\/p>\n\n\n\n

Source: http:\/\/www.medicalbiophysics.bg\/bg\/covid-19.html<\/a> <\/p>\n\n\n\n

\u043f\u0440\u043e\u0444. \u0418\u0433\u043d\u0430\u0442 \u0418\u0433\u043d\u0430\u0442\u043e\u0432<\/h2>\n\n\n\n

\u041d\u0430\u0443\u0447\u043d\u043e\u0438\u0437\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0441\u043a\u0438 \u0446\u0435\u043d\u0442\u044a\u0440 \u043f\u043e \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430 \u0431\u0438\u043e\u0444\u0438\u0437\u0438\u043a\u0430, \u0421\u043e\u0444\u0438\u044f, \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f<\/h3>","protected":false},"excerpt":{"rendered":"

\u0423\u0412\u041e\u0414 \u041a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u044a\u0442 COVID-19 e \u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441. \u0422\u043e\u0439 \u0437\u0430\u043f\u043e\u0447\u0432\u0430 \u0440\u0430\u0437\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435\u0442\u043e \u0441\u0438 \u0432 \u043a\u0440\u0430\u044f \u043d\u0430 2019 \u0433. \u0438 \u043d\u0430\u0447\u0430\u043b\u043e\u0442\u043e \u043d\u0430 2020 \u0433. \u0432 \u041a\u0438\u0442\u0430\u0439 \u0438 \u0432\u043e\u0434\u0438 \u0434\u043e \u043e\u0441\u0442\u0440\u043e\u0442\u043e \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u0437\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435 2019-nCoV. \u0422\u043e\u0439 \u0435 \u0431\u043b\u0438\u0437\u044a\u043a \u0434\u043e Severe acute respiratory syndrome-related coronavirus (SARSr-CoV) \u0438 \u043d\u043e\u0432\u0438\u044f\u0442 \u0432\u0438\u0440\u0443\u0441 \u0435 \u043e\u0437\u043d\u0430\u0447\u0435\u043d \u043a\u0430\u0442\u043e SARS-CoV-2. \u041d\u0435\u0433\u043e\u0432\u0438\u044f\u0442 \u0433\u0435\u043d\u043e\u043c \u0435 \u0435\u0434\u043d\u043e\u0432\u0435\u0440\u0438\u0436\u0435\u043d \u0441 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u0430 \u043f\u043e\u043b\u044f\u0440\u043d\u043e\u0441\u0442 ((+) \u0432\u0435\u0440\u0438\u0433\u0430). \u0421\u044a\u0434\u044a\u0440\u0436\u0430 \u043d\u0443\u043a\u043b\u0435\u043e\u0442\u0438\u0434\u0438 \u0441\u044a\u0441 \u0441\u043f\u0438\u0440\u0430\u043b\u043d\u0430 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[949],"tags":[185,887,196],"class_list":["post-17122","post","type-post","status-publish","format-standard","hentry","category-949","tag-oxidal","tag-887","tag-196"],"yoast_head":"\n\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19) - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xenobg.com\/en\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19) - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\" \/>\n<meta property=\"og:description\" content=\"\u0423\u0412\u041e\u0414 \u041a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u044a\u0442 COVID-19 e \u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441. \u0422\u043e\u0439 \u0437\u0430\u043f\u043e\u0447\u0432\u0430 \u0440\u0430\u0437\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435\u0442\u043e \u0441\u0438 \u0432 \u043a\u0440\u0430\u044f \u043d\u0430 2019 \u0433. \u0438 \u043d\u0430\u0447\u0430\u043b\u043e\u0442\u043e \u043d\u0430 2020 \u0433. \u0432 \u041a\u0438\u0442\u0430\u0439 \u0438 \u0432\u043e\u0434\u0438 \u0434\u043e \u043e\u0441\u0442\u0440\u043e\u0442\u043e \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u0437\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435 2019-nCoV. \u0422\u043e\u0439 \u0435 \u0431\u043b\u0438\u0437\u044a\u043a \u0434\u043e Severe acute respiratory syndrome-related coronavirus (SARSr-CoV) \u0438 \u043d\u043e\u0432\u0438\u044f\u0442 \u0432\u0438\u0440\u0443\u0441 \u0435 \u043e\u0437\u043d\u0430\u0447\u0435\u043d \u043a\u0430\u0442\u043e SARS-CoV-2. \u041d\u0435\u0433\u043e\u0432\u0438\u044f\u0442 \u0433\u0435\u043d\u043e\u043c \u0435 \u0435\u0434\u043d\u043e\u0432\u0435\u0440\u0438\u0436\u0435\u043d \u0441 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u0430 \u043f\u043e\u043b\u044f\u0440\u043d\u043e\u0441\u0442 ((+) \u0432\u0435\u0440\u0438\u0433\u0430). \u0421\u044a\u0434\u044a\u0440\u0436\u0430 \u043d\u0443\u043a\u043b\u0435\u043e\u0442\u0438\u0434\u0438 \u0441\u044a\u0441 \u0441\u043f\u0438\u0440\u0430\u043b\u043d\u0430 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/xenobg.com\/en\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/xenobg\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-18T07:08:45+00:00\" 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\u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19)\",\"datePublished\":\"2020-03-18T07:08:45+00:00\",\"dateModified\":\"2020-03-24T05:41:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/\"},\"wordCount\":2565,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/www.medicalbiophysics.bg\\\/images\\\/Elctrolyzer.png\",\"keywords\":[\"Oxidal\",\"\u0432\u043e\u0434\u0430\",\"\u041c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e\"],\"articleSection\":[\"\u0410\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043d\u0430\u0443\u0447\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/\",\"url\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/\",\"name\":\"\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19) - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/www.medicalbiophysics.bg\\\/images\\\/Elctrolyzer.png\",\"datePublished\":\"2020-03-18T07:08:45+00:00\",\"dateModified\":\"2020-03-24T05:41:23+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/#\\\/schema\\\/person\\\/73533c05ea5a71c6062caaab75d737e0\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/#primaryimage\",\"url\":\"http:\\\/\\\/www.medicalbiophysics.bg\\\/images\\\/Elctrolyzer.png\",\"contentUrl\":\"http:\\\/\\\/www.medicalbiophysics.bg\\\/images\\\/Elctrolyzer.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/antivirusni-efekti-na-voda-oxidal-methylene-blue\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u041d\u0430\u0447\u0430\u043b\u043e\",\"item\":\"https:\\\/\\\/xenobg.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/#website\",\"url\":\"https:\\\/\\\/xenobg.com\\\/\",\"name\":\"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\",\"description\":\"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439 \u0441 \u0412\u0435\u0441\u0435\u043b\u0438\u043d \u0438 IdeaLabs \u0438 LSlabs\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/xenobg.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/#\\\/schema\\\/person\\\/73533c05ea5a71c6062caaab75d737e0\",\"name\":\"\u0425\u0430\u0439\u0434\u0443\u0442\u0438\u043d\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8b1215eb0750ccd786b177586445c9d7f806cb30bf775a2d539d8a574ee17b26?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8b1215eb0750ccd786b177586445c9d7f806cb30bf775a2d539d8a574ee17b26?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8b1215eb0750ccd786b177586445c9d7f806cb30bf775a2d539d8a574ee17b26?s=96&d=mm&r=g\",\"caption\":\"\u0425\u0430\u0439\u0434\u0443\u0442\u0438\u043d\"},\"url\":\"https:\\\/\\\/xenobg.com\\\/en\\\/author\\\/xenobg\\\/\"}]}<\/script>\n<!-- 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\u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/xenobg.com\/en\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/","og_locale":"en_GB","og_type":"article","og_title":"\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19) - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439","og_description":"\u0423\u0412\u041e\u0414 \u041a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u044a\u0442 COVID-19 e \u0420\u041d\u041a \u0432\u0438\u0440\u0443\u0441. \u0422\u043e\u0439 \u0437\u0430\u043f\u043e\u0447\u0432\u0430 \u0440\u0430\u0437\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435\u0442\u043e \u0441\u0438 \u0432 \u043a\u0440\u0430\u044f \u043d\u0430 2019 \u0433. \u0438 \u043d\u0430\u0447\u0430\u043b\u043e\u0442\u043e \u043d\u0430 2020 \u0433. \u0432 \u041a\u0438\u0442\u0430\u0439 \u0438 \u0432\u043e\u0434\u0438 \u0434\u043e \u043e\u0441\u0442\u0440\u043e\u0442\u043e \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u043e\u0437\u043d\u043e \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435 2019-nCoV. \u0422\u043e\u0439 \u0435 \u0431\u043b\u0438\u0437\u044a\u043a \u0434\u043e Severe acute respiratory syndrome-related coronavirus (SARSr-CoV) \u0438 \u043d\u043e\u0432\u0438\u044f\u0442 \u0432\u0438\u0440\u0443\u0441 \u0435 \u043e\u0437\u043d\u0430\u0447\u0435\u043d \u043a\u0430\u0442\u043e SARS-CoV-2. \u041d\u0435\u0433\u043e\u0432\u0438\u044f\u0442 \u0433\u0435\u043d\u043e\u043c \u0435 \u0435\u0434\u043d\u043e\u0432\u0435\u0440\u0438\u0436\u0435\u043d \u0441 \u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u0430 \u043f\u043e\u043b\u044f\u0440\u043d\u043e\u0441\u0442 ((+) \u0432\u0435\u0440\u0438\u0433\u0430). \u0421\u044a\u0434\u044a\u0440\u0436\u0430 \u043d\u0443\u043a\u043b\u0435\u043e\u0442\u0438\u0434\u0438 \u0441\u044a\u0441 \u0441\u043f\u0438\u0440\u0430\u043b\u043d\u0430 […]","og_url":"https:\/\/xenobg.com\/en\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/","og_site_name":"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439","article_publisher":"https:\/\/www.facebook.com\/xenobg","article_published_time":"2020-03-18T07:08:45+00:00","article_modified_time":"2020-03-24T05:41:23+00:00","og_image":[{"url":"http:\/\/www.medicalbiophysics.bg\/images\/Elctrolyzer.png","type":"","width":"","height":""}],"author":"\u0425\u0430\u0439\u0434\u0443\u0442\u0438\u043d","twitter_misc":{"Written by":"\u0425\u0430\u0439\u0434\u0443\u0442\u0438\u043d","Estimated reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/#article","isPartOf":{"@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/"},"author":{"name":"\u0425\u0430\u0439\u0434\u0443\u0442\u0438\u043d","@id":"https:\/\/xenobg.com\/#\/schema\/person\/73533c05ea5a71c6062caaab75d737e0"},"headline":"\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19)","datePublished":"2020-03-18T07:08:45+00:00","dateModified":"2020-03-24T05:41:23+00:00","mainEntityOfPage":{"@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/"},"wordCount":2565,"commentCount":0,"image":{"@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/#primaryimage"},"thumbnailUrl":"http:\/\/www.medicalbiophysics.bg\/images\/Elctrolyzer.png","keywords":["Oxidal","\u0432\u043e\u0434\u0430","\u041c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e"],"articleSection":["\u0410\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043d\u0430\u0443\u0447\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/","url":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/","name":"\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19) - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439","isPartOf":{"@id":"https:\/\/xenobg.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/#primaryimage"},"image":{"@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/#primaryimage"},"thumbnailUrl":"http:\/\/www.medicalbiophysics.bg\/images\/Elctrolyzer.png","datePublished":"2020-03-18T07:08:45+00:00","dateModified":"2020-03-24T05:41:23+00:00","author":{"@id":"https:\/\/xenobg.com\/#\/schema\/person\/73533c05ea5a71c6062caaab75d737e0"},"breadcrumb":{"@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/#primaryimage","url":"http:\/\/www.medicalbiophysics.bg\/images\/Elctrolyzer.png","contentUrl":"http:\/\/www.medicalbiophysics.bg\/images\/Elctrolyzer.png"},{"@type":"BreadcrumbList","@id":"https:\/\/xenobg.com\/antivirusni-efekti-na-voda-oxidal-methylene-blue\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u041d\u0430\u0447\u0430\u043b\u043e","item":"https:\/\/xenobg.com\/"},{"@type":"ListItem","position":2,"name":"\u0410\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438 \u043d\u0430 \u0432\u043e\u0434\u0430, Oxidal \u0441 Methylene Blue (\u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e) \u0438 \u043a\u043e\u043b\u043e\u0438\u0434\u043d\u043e \u0441\u0440\u0435\u0431\u0440\u043e. \u0412\u044a\u0437\u043c\u043e\u0436\u0435\u043d \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u0437\u0430 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441 SARSr-CoV \u0438 SARSr-CoV-2 (COVID-19)"}]},{"@type":"WebSite","@id":"https:\/\/xenobg.com\/#website","url":"https:\/\/xenobg.com\/","name":"Feel, think, act","description":"Feel, think, act with Veselin and IdeaLabs and 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href=\"https:\/\/xenobg.com\/en\/category\/%d0%b0%d0%bd%d0%b0%d0%bb%d0%b8%d0%b7-%d0%bd%d0%b0-%d0%bd%d0%b0%d1%83%d1%87%d0%bd%d0%b8-%d0%b8%d0%b7%d1%81%d0%bb%d0%b5%d0%b4%d0%b2%d0%b0%d0%bd%d0%b8%d1%8f\/\" class=\"advgb-post-tax-term\">\u0410\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043d\u0430\u0443\u0447\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">\u0410\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043d\u0430\u0443\u0447\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/xenobg.com\/en\/category\/%d0%b0%d0%bd%d0%b0%d0%bb%d0%b8%d0%b7-%d0%bd%d0%b0-%d0%bd%d0%b0%d1%83%d1%87%d0%bd%d0%b8-%d0%b8%d0%b7%d1%81%d0%bb%d0%b5%d0%b4%d0%b2%d0%b0%d0%bd%d0%b8%d1%8f\/\" class=\"advgb-post-tax-term\">Oxidal<\/a>","<a 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ago"},"absolute_dates":{"created":"Posted on 18.03.2020","modified":"Updated on 24.03.2020"},"absolute_dates_time":{"created":"Posted on 18.03.2020 9:08 am","modified":"Updated on 24.03.2020 7:41 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