{"id":23866,"date":"2024-10-14T13:22:46","date_gmt":"2024-10-14T10:22:46","guid":{"rendered":"https:\/\/xenobg.com\/?p=23866"},"modified":"2024-10-14T13:23:05","modified_gmt":"2024-10-14T10:23:05","slug":"als-e-svarzana-s-povisheno-okislenie-na-mazninite-fao-kato-povishavaneto-na-glyukozata-mozhe-da-ya-lekuva","status":"publish","type":"post","link":"https:\/\/xenobg.com\/en\/als-e-svarzana-s-povisheno-okislenie-na-mazninite-fao-kato-povishavaneto-na-glyukozata-mozhe-da-ya-lekuva\/","title":{"rendered":"ALS is associated with increased fat oxidation (FAO), and raising glucose can treat it"},"content":{"rendered":"\n<p>\u0412 \u043c\u0438\u043d\u0430\u043b\u043e\u0442\u043e \u043d\u0430\u043f\u0440\u0430\u0432\u0438\u0445 \u043d\u044f\u043a\u043e\u043b\u043a\u043e \u043f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u0438 \u0437\u0430 ALS (\u0430\u043c\u0438\u043e\u0442\u0440\u043e\u0444\u0438\u0447\u043d\u0430 \u043b\u0430\u0442\u0435\u0440\u0430\u043b\u043d\u0430 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\u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0430 \u0434\u043d\u0435\u0432\u043d\u043e \u043e\u043a\u043e\u043b\u043e 6 \u043c\u0435\u0441\u0435\u0446\u0430 \u043f\u043e-\u043a\u044a\u0441\u043d\u043e \u0438 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0430\u0432\u0430 \u0434\u0430 \u043f\u0440\u0438\u0435\u043c\u0430 \u043f\u043e 1 \u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0430 \u0434\u043d\u0435\u0432\u043d\u043e \u0434\u043e \u0434\u043d\u0435\u0441. \u041f\u043e\u043a\u043e\u0439\u043d\u0438\u044f\u0442 \u0421\u0442\u0438\u0432\u044a\u043d \u0425\u043e\u043a\u0438\u043d\u0433 \u0435 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0446\u0438\u0440\u0430\u043d \u0441 ALS \u043f\u0440\u0435\u0437 60-\u0442\u0435 \u0433\u043e\u0434\u0438\u043d\u0438 \u043d\u0430 \u043c\u0438\u043d\u0430\u043b\u0438\u044f \u0432\u0435\u043a \u0438 \u043e\u0446\u0435\u043b\u044f\u0432\u0430 \u0432 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0435\u043d\u0438\u0435 \u043d\u0430 \u0434\u0435\u0441\u0435\u0442\u0438\u043b\u0435\u0442\u0438\u044f, \u043c\u0430\u043a\u0430\u0440 \u0438 \u0441 \u0442\u0435\u0436\u043a\u0438 \u0434\u0432\u0438\u0433\u0430\u0442\u0435\u043b\u043d\u0438 \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0438. \u041f\u043e-\u043a\u044a\u0441\u043d\u043e \u043f\u0440\u0435\u0437 \u0436\u0438\u0432\u043e\u0442\u0430 \u043c\u0443 \u043b\u0435\u043a\u0430\u0440\u0438\u0442\u0435 \u0437\u0430\u043f\u043e\u0447\u0432\u0430\u0442 \u0434\u0430 \u0441\u0435 \u043f\u0438\u0442\u0430\u0442 \u0434\u0430\u043b\u0438 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u0435\u0442\u043e \u043c\u0443 \u043d\u0435 \u0435 ALS, \u0437\u0430\u0449\u043e\u0442\u043e, \u0437\u043d\u0430\u0435\u0442\u0435, \u043d\u0438\u043a\u043e\u0439 \u043d\u0435 \u043c\u043e\u0436\u0435 \u0434\u0430 \u043e\u0446\u0435\u043b\u0435\u0435 \u0441 ALS \u0442\u043e\u043b\u043a\u043e\u0432\u0430 \u0434\u044a\u043b\u0433\u043e. \u0427\u0443\u0434\u044f \u0441\u0435 \u0434\u0430\u043b\u0438 \u0441\u0430\u043c\u043e\u043f\u0440\u0438\u0437\u043d\u0430\u0442\u0438\u044f\u0442 \u043d\u0430\u0432\u0438\u043a \u043d\u0430 \u0433-\u043d \u0425\u043e\u043a\u0438\u043d\u0433 \u0434\u0430 \u0432\u0437\u0435\u043c\u0430 \u043f\u043e \u0435\u0434\u043d\u0430 \u0442\u0430\u0431\u043b\u0435\u0442\u043a\u0430 \u0430\u0441\u043f\u0438\u0440\u0438\u043d \u0434\u0432\u0430 \u043f\u044a\u0442\u0438 \u0441\u0435\u0434\u043c\u0438\u0447\u043d\u043e \u0438\u043c\u0430 \u043d\u0435\u0449\u043e \u043e\u0431\u0449\u043e \u0441 \u0442\u043e\u0432\u0430&#8230;<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29057168\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29057168<\/a><\/p>\n\n\n\n<p>\u201c\u2026These models provide the tools for genetic and dietary interventions that can distinguish between cause and consequence. For example, although the primary cause remains unknown,&nbsp;<strong>in ALS muscles, there seems to be a reduction in glycolysis that is compensated by utilization of alternate fuels such as fatty acids<\/strong>&nbsp;(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5647833\/figure\/F1\/\">Figure 1<\/a>). In contrast, in motor neurons, the impairment in mitochondrial function may lead to compensatory mechanisms that counterbalance the defects in oxidative phosphorylation such as increased glycolysis as reported in cultured cells, or altered interactions with lactate producing glial cells.&nbsp;<\/p>\n\n\n\n<p>Another study using asymptomatic SOD1G86R mice indicated decreased glucose handling in glycolytic muscles of the diseased animals [43]. This is due to concerted effects caused by downregulation of the key glycolytic enzyme phosphofructokinase 1 (PFK 1), and upregulation of pyruvate dehydrogenase kinase 4 (PDK4), an enzyme that inhibits pyruvate dehydrogenase complex through phosphorylation, thus blocking conversion of pyruvate into acetyl-coA. As a consequence, the lipid pathway was stimulated in these animals as early as during the pre-symptomatic stage, and remained active till end stage of the disease, thus switching the fuel preference towards fatty acids by suppressing glucose utilization. Consistent with this,&nbsp;<strong>treatment with DCA, a specific inhibitor of PDK, restored normal mRNA expression of Pdk and Pfk1 mRNAs, and resulted in decreased expression of denervation and atrophy markers. This was further translated at the functional level by restoration of muscle strength, larger muscle fibers and overall weight gain in DCA-treated animals compared to non-treated<\/strong>&nbsp;SOD1G86R mice. Thus altogether, this and previous reports show that as the glycolytic muscles progressively lose their ability to utilize glucose, they switch to lipids as an alternate energy source, and that, this metabolic switch happens largely in the early pre-symptomatic stage.<\/p>\n\n\n\n<p><a href=\"https:\/\/elifesciences.org\/articles\/45114\">https:\/\/elifesciences.org\/articles\/45114<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/uanews.arizona.edu\/story\/people-als-may-benefit-more-glucose\">https:\/\/uanews.arizona.edu\/story\/people-als-may-benefit-more-glucose<\/a><\/p>\n\n\n\n<p>\u201c\u2026<strong>Increased glucose, transformed into energy, could give people with amyotrophic lateral sclerosis, or ALS, improved mobility and a longer life<\/strong>, according to new findings by a University of Arizona-led research team.\u201d<\/p>\n\n\n\n<p><strong>People with ALS use more energy while resting than those without the disease, while simultaneously they often struggle to effectively make use of glucose<\/strong>, the precise ingredient a body needs to make more energy. Experts have not known exactly what happens in a patient\u2019s cells to cause this dysfunction or how to alleviate it.&nbsp;\u201cThis project was a way to parse out those details,\u201d said Manzo, who described&nbsp;<strong>the results<\/strong>, published online in&nbsp;<a href=\"https:\/\/elifesciences.org\/articles\/45114\" target=\"_blank\" rel=\"noreferrer noopener\">eLife<\/a>, as \u201c<strong>truly shocking<\/strong>.\u201d<\/p>\n\n\n\n<p>\u201c\u2026<strong>The study revealed that when ALS-affected neurons are given more glucose, they turn that power source into energy. With that energy, they\u2019re able to survive longer and function better<\/strong>. Increasing glucose delivery to the cells, then, may be one way to meet the abnormally high energy demands of ALS patients. \u201c<strong>These neurons were finding some relief by breaking down glucose and getting more cellular energy<\/strong>,\u201d Manzo said.\u201d<\/p>\n\n\n\n<p>\u201cThe fact that we uncovered a compensatory mechanism surprised me,\u201d Zarnescu said. \u201c<strong>These desperate, degenerating neurons showed incredible resilience. It is an example of how amazing cells are at dealing with stress<\/strong>.\u201d The novelty of the findings partially lies in the fact that metabolism in ALS patients has remained poorly understood, Zarnescu said.\u201d<\/p>\n\n\n\n<p>\u201c\u2026Their findings were consistent with&nbsp;<strong>a pilot clinical trial, which found a high carbohydrate diet was one possible intervention for ALS patients with gross metabolic dysfunction<\/strong>. \u201cOur data essentially provide an explanation for why that approach might work,\u201d Zarnescu said. \u201cMy goal is to convince clinicians to perform a larger clinical trial to test this idea.\u201d<\/p>\n\n\n\n<p>\u0418\u0437\u0442\u043e\u0447\u043d\u0438\u043a:<\/p>\n\n\n\n<p><a href=\"http:\/\/haidut.me\/?p=239\">http:\/\/haidut.me\/?p=239<\/a><\/p>\n\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/%d1%80%d0%b5%d0%b2%d0%be%d0%bb%d1%8e%d1%86%d0%b8%d0%be%d0%bd%d0%b5%d0%bd-%d0%bf%d0%be%d0%b3%d0%bb%d0%b5%d0%b4-%d0%b2%d1%8a%d1%80%d1%85%d1%83-%d1%80%d0%b0%d0%ba%d0%b0-%d0%bc%d0%b5%d1%82%d0%b0%d0%b1\/\">\u0420\u0435\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0433\u043b\u0435\u0434 \u0432\u044a\u0440\u0445\u0443 \u0440\u0430\u043a\u0430: \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d, \u0430 \u043d\u0435 \u0441\u0430\u043c\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u043d \u043f\u0440\u043e\u0431\u043b\u0435\u043c<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/hidroksiapatit-v-oralnata-grizha\/\">\u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0430\u043f\u0430\u0442\u0438\u0442 \u0432 \u043e\u0440\u0430\u043b\u043d\u0430\u0442\u0430 \u0433\u0440\u0438\u0436\u0430: \u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u043e\u043b\u0437\u0438\u0442\u0435, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430 \u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u0444\u043b\u0443\u043e\u0440\u0438\u0434\u0430<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/kolko-presni-portokala-sa-vi-neobhodimi-za-da-izchistite-chernia-si-drob-ot-maznini\/\">\u041a\u043e\u043b\u043a\u043e \u043f\u0440\u0435\u0441\u043d\u0438 \u043f\u043e\u0440\u0442\u043e\u043a\u0430\u043b\u0430 \u0441\u0430 \u0432\u0438 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438, \u0437\u0430 \u0434\u0430 \u0438\u0437\u0447\u0438\u0441\u0442\u0438\u0442\u0435 \u0447\u0435\u0440\u043d\u0438\u044f \u0441\u0438 \u0434\u0440\u043e\u0431 \u043e\u0442 \u043c\u0430\u0437\u043d\u0438\u043d\u0438?<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/hronichniyat-stres-ponizhava-dopamina-i-prichinyava-psihichni-zabolyavania\/\">\u0425\u0440\u043e\u043d\u0438\u0447\u043d\u0438\u044f\u0442 \u0441\u0442\u0440\u0435\u0441 \u043f\u043e\u043d\u0438\u0436\u0430\u0432\u0430 \u0434\u043e\u043f\u0430\u043c\u0438\u043d\u0430 \u0438 \u043f\u0440\u0438\u0447\u0438\u043d\u044f\u0432\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/estrogenat-i-kortizolat-a-ne-androgenite-potiskat-imuniteta\/\">\u0415\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u044a\u0442 \u0438 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u044a\u0442, \u0430 \u043d\u0435 \u0430\u043d\u0434\u0440\u043e\u0433\u0435\u043d\u0438\u0442\u0435, \u043f\u043e\u0442\u0438\u0441\u043a\u0430\u0442 \u0438\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u0430<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u0412 \u043c\u0438\u043d\u0430\u043b\u043e\u0442\u043e \u043d\u0430\u043f\u0440\u0430\u0432\u0438\u0445 \u043d\u044f\u043a\u043e\u043b\u043a\u043e \u043f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u0438 \u0437\u0430 ALS (\u0430\u043c\u0438\u043e\u0442\u0440\u043e\u0444\u0438\u0447\u043d\u0430 \u043b\u0430\u0442\u0435\u0440\u0430\u043b\u043d\u0430 \u0441\u043a\u043b\u0435\u0440\u043e\u0437\u0430), \u043a\u043e\u0439\u0442\u043e \u0441\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0438\u0440\u0430 \u0441 \u0445\u0438\u043f\u0435\u0440\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442 \u043d\u0430 \u043d\u0430\u0434\u0431\u044a\u0431\u0440\u0435\u0447\u043d\u0438\u0442\u0435 \u0436\u043b\u0435\u0437\u0438 \u0438 \u043f\u043e\u0442\u0438\u0441\u043d\u0430\u0442\u0430 \u0433\u043e\u043d\u0430\u0434\u043d\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f, \u043a\u0430\u043a\u0442\u043e \u0438 \u0441 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u043d\u0430 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0438 \u043d\u0435\u0434\u043e\u0441\u0442\u0438\u0433 \u043d\u0430 \u043c\u0435\u0434. \u0421\u044a\u0449\u043e \u0442\u0430\u043a\u0430 \u0435 \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u043e, \u0447\u0435 \u043d\u0435\u0444\u0430\u043c\u0438\u043b\u043d\u0430\u0442\u0430 \u0410\u041b\u0421 \u0441\u0435 \u0441\u0440\u0435\u0449\u0430 4-5 \u043f\u044a\u0442\u0438 \u043f\u043e-\u0447\u0435\u0441\u0442\u043e \u043f\u0440\u0438 \u0430\u043a\u0442\u0438\u0432\u043d\u0438\/\u043f\u0435\u043d\u0441\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0438 \u0435\u043b\u0438\u0442\u043d\u0438 \u0441\u043f\u043e\u0440\u0442\u0438\u0441\u0442\u0438. \u0412\u0441\u0438\u0447\u043a\u0438 \u0442\u0435\u0437\u0438 \u043e\u0442\u043a\u0440\u0438\u0442\u0438\u044f \u043a\u0430\u0442\u0435\u0433\u043e\u0440\u0438\u0447\u043d\u043e \u0441\u043e\u0447\u0430\u0442, \u0447\u0435 \u0410\u041b\u0421 \u0435 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":23867,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[850,949,968],"tags":[1173,329,803,199,1172,1038,89,1001,201,802,885],"class_list":["post-23866","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-haidut","category-949","category-968","tag-als","tag-haidut","tag-ray-peat","tag-199","tag-1172","tag-1038","tag-89","tag-1001","tag-201","tag-802","tag-885"],"yoast_head":"<!-- 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