{"id":24881,"date":"2025-05-19T15:54:23","date_gmt":"2025-05-19T12:54:23","guid":{"rendered":"https:\/\/xenobg.com\/?p=24881"},"modified":"2025-05-19T15:54:29","modified_gmt":"2025-05-19T12:54:29","slug":"vitamin-k-mozhe-da-lekuva-levkemia","status":"publish","type":"post","link":"https:\/\/xenobg.com\/en\/vitamin-k-mozhe-da-lekuva-levkemia\/","title":{"rendered":"Vitamin K can cure leukemia"},"content":{"rendered":"<p>\u041e\u0449\u0435 \u0435\u0434\u043d\u043e \u0447\u0443\u0434\u0435\u0441\u043d\u043e \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435, \u043a\u043e\u0435\u0442\u043e \u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u0430 \u043a\u0430\u043a\u0442\u043e \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u043d\u0438\u044f \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b \u043d\u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0438\u0442\u0435, \u0442\u0430\u043a\u0430 \u0438 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href=\"https:\/\/www.alternativehealthscience.com\/apatone-for-cancer-the-clinical-trial-results-may-surprise-you\">https:\/\/www.alternativehealthscience.com\/apatone-for-cancer-the-clinical-trial-results-may-surprise-you<\/a><\/p>\n\n\n\n<p>\u0412 \u0442\u043e\u0432\u0430 \u043d\u043e\u0432\u043e \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435 \u0435 \u0434\u043e\u043a\u0430\u0437\u0430\u043d\u043e, \u0447\u0435 \u0432\u0438\u0442\u0430\u043c\u0438\u043d \u041a3 \u0435\u043b\u0438\u043c\u0438\u043d\u0438\u0440\u0430 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u0438\u0442\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u043d\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f\u0442\u0430 (\u043a\u043e\u0435\u0442\u043e \u043f\u0440\u0435\u0434\u043e\u0442\u0432\u0440\u0430\u0442\u044f\u0432\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435\u0442\u043e \u043d\u0430 \u0440\u0430\u043a\u0430), \u0434\u043e\u0440\u0438 \u043a\u043e\u0433\u0430\u0442\u043e \u0441\u0435 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\u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430, \u043a\u043e\u0438\u0442\u043e \u0434\u0430 \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430\u0442, \u0447\u0435 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u0447\u043d\u0438\u0442\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u0441\u0430 \u043f\u043e \u043d\u044f\u043a\u0430\u043a\u044a\u0432 \u043d\u0430\u0447\u0438\u043d \u0443\u043d\u0438\u043a\u0430\u043b\u043d\u0438 \u0438 \u043d\u044f\u043c\u0430 \u0434\u0430 \u0440\u0435\u0430\u0433\u0438\u0440\u0430\u0442 \u043d\u0430 \u0441\u044a\u0449\u0438\u044f \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u044a\u043c \u043d\u0430 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 &#8211; \u0433\u0435\u043d\u0435\u0440\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 ROS \u0438 \u0438\u0437\u043c\u0435\u0441\u0442\u0432\u0430\u043d\u0435 \u043d\u0430 \u0440\u0435\u0434\u043e\u043a\u0441 \u0431\u0430\u043b\u0430\u043d\u0441\u0430 \u0432 \u043f\u043e\u0441\u043e\u043a\u0430 \u043d\u0430 \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2214854X15300066\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2214854X15300066<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.omicsonline.org\/vitamin-c-and-k-combination-causes-enhanced-anticancer-activity-against-rt-bladder-cancer-cells-1948-5956.1000223.php?aid=19597\">https:\/\/www.omicsonline.org\/vitamin-c-and-k-combination-causes-enhanced-anticancer-activity-against-rt-bladder-cancer-cells-1948-5956.1000223.php?aid=19597<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/etd.ohiolink.edu\/!etd.send_file?accession=kent1334356592&amp;disposition=inline\">https:\/\/etd.ohiolink.edu\/!etd.send_file?accession=kent1334356592&amp;disposition=inline<\/a><\/p>\n\n\n\n<p>\u041f\u043e\u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u043c \u043e\u0431\u0430\u0447\u0435 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\u0414\u043e\u0431\u0440\u0430\u0442\u0430 \u043d\u043e\u0432\u0438\u043d\u0430 \u0435, \u0447\u0435 \u0432\u043c\u0435\u0441\u0442\u043e \u0432\u0438\u0442\u0430\u043c\u0438\u043d \u041a3 \u043c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d \u041a2 (MK-4) \u0438 \u0442\u043e\u0439 \u0432\u0441\u0435 \u043e\u0449\u0435 \u0449\u0435 \u043e\u0441\u0438\u0433\u0443\u0440\u044f\u0432\u0430 \u0441\u044a\u0449\u0438\u0442\u0435 \u043f\u043e\u043b\u0437\u0438, \u043f\u043e\u0447\u0442\u0438 \u0431\u0435\u0437 \u0440\u0438\u0441\u043a \u043e\u0442 \u0441\u0442\u0440\u0430\u043d\u0438\u0447\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438. \u0422\u0430\u043a\u0430 \u0447\u0435 \u0437\u0430\u0431\u0440\u0430\u043d\u0430\u0442\u0430 \u043d\u0430 FDA \u0437\u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d \u041a3 \u0432 \u043d\u0430\u0439-\u0434\u043e\u0431\u0440\u0438\u044f \u0441\u043b\u0443\u0447\u0430\u0439 \u043d\u0435 \u043f\u043e\u0441\u0442\u0438\u0433\u0430 \u043d\u0438\u0449\u043e, \u0430 \u0432 \u043d\u0430\u0439-\u043b\u043e\u0448\u0438\u044f &#8211; \u043f\u0440\u0435\u0434\u0438\u0437\u0432\u0438\u043a\u0432\u0430 \u0441\u043f\u0435\u043a\u0443\u043b\u0430\u0446\u0438\u0438 \u0437\u0430\u0449\u043e \u0430\u0433\u0435\u043d\u0446\u0438\u044f\u0442\u0430 \u0437\u0430\u0431\u0440\u0430\u043d\u044f\u0432\u0430 \u043f\u0440\u043e\u0434\u0430\u0436\u0431\u0430\u0442\u0430 \u043d\u0430 \u043f\u0440\u043e\u0434\u0443\u043a\u0442, \u0441\u0447\u0438\u0442\u0430\u043d \u0437\u0430 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u0435\u043d \u0432 \u043f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u0434\u0440\u0443\u0433\u0438 \u0441\u0442\u0440\u0430\u043d\u0438, \u043a\u0430\u0442\u043e \u0432 \u0441\u044a\u0449\u043e\u0442\u043e \u0432\u0440\u0435\u043c\u0435 \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0432\u0430 \u043d\u0430 \u0447\u0430\u0441\u0442\u043d\u0438 \u043a\u043e\u043c\u043f\u0430\u043d\u0438\u0438 \u0434\u0430 \u0433\u043e \u043f\u0440\u043e\u0434\u0430\u0432\u0430\u0442 \u043a\u0430\u0442\u043e \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043e \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u0430 \u0440\u0430\u043a \u043d\u0430 \u0431\u0435\u0437\u0443\u043c\u043d\u043e \u0437\u0430\u0432\u0438\u0448\u0435\u043d\u0430 \u0446\u0435\u043d\u0430\u2026<\/p>\n\n\n\n<p><a href=\"https:\/\/ashpublications.org\/blood\/article-abstract\/doi\/10.1182\/blood.2018875922\/374983\/KLF4-Represses-DYRK2-Inhibition-of-Self-renewal?redirectedFrom=fulltext\">https:\/\/ashpublications.org\/blood\/article-abstract\/doi\/10.1182\/blood.2018875922\/374983\/KLF4-Represses-DYRK2-Inhibition-of-Self-renewal?redirectedFrom=fulltext<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/medicalxpress.com\/news\/2019-11-cancer-roots.html\">https:\/\/medicalxpress.com\/news\/2019-11-cancer-roots.html<\/a><\/p>\n\n\n\n<p>\u201c\u2026The findings suggested that KLF4 promotes disease progression in this mouse model by repressing the production of the DYRK2 enzyme. The results also suggested that it was possible that doing the opposite, elevating the production of DYRK2 enzyme, would reduce or inhibit leukemia stem cell survival and self-renewal. Looking to translate these results to the clinic, the researchers searched for a possible pharmacological means to enhance the stability of the DYRK2 enzyme. Searching the literature revealed a potential way to achieve this goal. They found that <strong>vitamin K3 inhibits SIAH2, an enzyme that is implicated in the degradation of DYRK2. \u201cWe hypothesized that if we inhibited SIAH2 with vitamin K3, we would prevent or reduce the degradation of DYRK2, and therefore likely increase the levels of DYRK2, which would trigger inhibition of survival and self-renewal of leukemia stem cells<\/strong>,\u201d Lacorazza said. The researchers tested this strategy in chronic myeloid leukemia cell lines, in their\u00a0<a href=\"https:\/\/medicalxpress.com\/tags\/mouse+model\/\">mouse model<\/a> and in patient samples in the lab. The results were encouraging. They saw that treatment with <strong>vitamin K3 increased DYRK2 and inhibited the expansion of the leukemia stem cells<\/strong>. \u201cVitamin K3 may be toxic to humans. Although in our view<strong> vitamin K3<\/strong> is not going to be the drug to treat leukemia stem cells, it has proved the concept that stabilizing DYRK2 enzyme <strong>could help eliminate the leukemic stem cell population<\/strong>,\u201d Lacorazza said.\u201d<\/p>\n\n\n\n<p>Source:<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-to-extract-knowledge-from-matter wp-block-embed-to-extract-knowledge-from-matter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"7lytNWIr3d\"><a href=\"https:\/\/haidut.me\/?p=694\">Vitamin K may treat leukemia<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Vitamin K may treat leukemia&#8221; &#8212; To Extract Knowledge from Matter\" src=\"https:\/\/haidut.me\/?p=694&#038;embed=true#?secret=Z49x9nr2iV#?secret=7lytNWIr3d\" data-secret=\"7lytNWIr3d\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/%d1%80%d0%b5%d0%b2%d0%be%d0%bb%d1%8e%d1%86%d0%b8%d0%be%d0%bd%d0%b5%d0%bd-%d0%bf%d0%be%d0%b3%d0%bb%d0%b5%d0%b4-%d0%b2%d1%8a%d1%80%d1%85%d1%83-%d1%80%d0%b0%d0%ba%d0%b0-%d0%bc%d0%b5%d1%82%d0%b0%d0%b1\/\">\u0420\u0435\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0433\u043b\u0435\u0434 \u0432\u044a\u0440\u0445\u0443 \u0440\u0430\u043a\u0430: \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d, \u0430 \u043d\u0435 \u0441\u0430\u043c\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u043d \u043f\u0440\u043e\u0431\u043b\u0435\u043c<\/a><div class=\"wp-block-latest-posts__post-excerpt\">\u0421\u043f\u043e\u0440\u0435\u0434 \u0413\u0435\u043e\u0440\u0433\u0438 \u0414\u0438\u043d\u043a\u043e\u0432 \u0425\u0430\u0439\u0434\u0443\u0442, \u0431\u0438\u043e\u0445\u0438\u043c\u0438\u043a \u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b \u0432 \u043e\u0431\u043b\u0430\u0441\u0442\u0442\u0430 \u043d\u0430\u2026 <a class=\"wp-block-latest-posts__read-more\" href=\"https:\/\/xenobg.com\/en\/%d1%80%d0%b5%d0%b2%d0%be%d0%bb%d1%8e%d1%86%d0%b8%d0%be%d0%bd%d0%b5%d0%bd-%d0%bf%d0%be%d0%b3%d0%bb%d0%b5%d0%b4-%d0%b2%d1%8a%d1%80%d1%85%d1%83-%d1%80%d0%b0%d0%ba%d0%b0-%d0%bc%d0%b5%d1%82%d0%b0%d0%b1\/\" rel=\"noopener noreferrer\">Read more<span class=\"screen-reader-text\">: \u0420\u0435\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0433\u043b\u0435\u0434 \u0432\u044a\u0440\u0445\u0443 \u0440\u0430\u043a\u0430: \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d, \u0430 \u043d\u0435 \u0441\u0430\u043c\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u043d \u043f\u0440\u043e\u0431\u043b\u0435\u043c<\/span><\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/hidroksiapatit-v-oralnata-grizha\/\">\u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0430\u043f\u0430\u0442\u0438\u0442 \u0432 \u043e\u0440\u0430\u043b\u043d\u0430\u0442\u0430 \u0433\u0440\u0438\u0436\u0430: \u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u043e\u043b\u0437\u0438\u0442\u0435, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430 \u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u0444\u043b\u0443\u043e\u0440\u0438\u0434\u0430<\/a><div class=\"wp-block-latest-posts__post-excerpt\">\u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0430\u043f\u0430\u0442\u0438\u0442\u044a\u0442 (HAP), \u0441 \u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430 Ca\u2081\u2080(PO\u2084)\u2086(OH)\u2082, \u0435 \u043e\u0441\u043d\u043e\u0432\u043d\u0438\u044f\u0442 \u043c\u0438\u043d\u0435\u0440\u0430\u043b\u0435\u043d \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442\u2026 <a class=\"wp-block-latest-posts__read-more\" href=\"https:\/\/xenobg.com\/en\/hidroksiapatit-v-oralnata-grizha\/\" rel=\"noopener noreferrer\">Read more<span class=\"screen-reader-text\">: \u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0430\u043f\u0430\u0442\u0438\u0442 \u0432 \u043e\u0440\u0430\u043b\u043d\u0430\u0442\u0430 \u0433\u0440\u0438\u0436\u0430: \u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u043e\u043b\u0437\u0438\u0442\u0435, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430 \u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u0444\u043b\u0443\u043e\u0440\u0438\u0434\u0430<\/span><\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/kolko-presni-portokala-sa-vi-neobhodimi-za-da-izchistite-chernia-si-drob-ot-maznini\/\">How many fresh oranges do you need to cleanse your liver of fat?<\/a><div class=\"wp-block-latest-posts__post-excerpt\">\u0410\u043a\u043e \u0438\u043c\u0430\u0442\u0435 \u043e\u043c\u0430\u0437\u043d\u0435\u043d \u0447\u0435\u0440\u0435\u043d \u0434\u0440\u043e\u0431, \u0432\u043a\u043b\u044e\u0447\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u043f\u0440\u0435\u0441\u043d\u0438 \u043f\u043e\u0440\u0442\u043e\u043a\u0430\u043b\u0438 \u0432\u2026 <a class=\"wp-block-latest-posts__read-more\" href=\"https:\/\/xenobg.com\/en\/kolko-presni-portokala-sa-vi-neobhodimi-za-da-izchistite-chernia-si-drob-ot-maznini\/\" rel=\"noopener noreferrer\">Read more<span class=\"screen-reader-text\">: \u041a\u043e\u043b\u043a\u043e \u043f\u0440\u0435\u0441\u043d\u0438 \u043f\u043e\u0440\u0442\u043e\u043a\u0430\u043b\u0430 \u0441\u0430 \u0432\u0438 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u0438, \u0437\u0430 \u0434\u0430 \u0438\u0437\u0447\u0438\u0441\u0442\u0438\u0442\u0435 \u0447\u0435\u0440\u043d\u0438\u044f \u0441\u0438 \u0434\u0440\u043e\u0431 \u043e\u0442 \u043c\u0430\u0437\u043d\u0438\u043d\u0438?<\/span><\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/hronichniyat-stres-ponizhava-dopamina-i-prichinyava-psihichni-zabolyavania\/\">Chronic stress lowers dopamine and causes mental illness<\/a><div class=\"wp-block-latest-posts__post-excerpt\">\u0414\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430\u0442\u0430 \u0437\u0430 \u0440\u043e\u043b\u044f\u0442\u0430 \u043d\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0438\u044f \u0441\u0442\u0440\u0435\u0441 \u0432 \u043f\u043e\u0447\u0442\u0438 \u0432\u0441\u0438\u0447\u043a\u0438 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u0438\u2026 <a class=\"wp-block-latest-posts__read-more\" href=\"https:\/\/xenobg.com\/en\/hronichniyat-stres-ponizhava-dopamina-i-prichinyava-psihichni-zabolyavania\/\" rel=\"noopener noreferrer\">Read more<span class=\"screen-reader-text\">: \u0425\u0440\u043e\u043d\u0438\u0447\u043d\u0438\u044f\u0442 \u0441\u0442\u0440\u0435\u0441 \u043f\u043e\u043d\u0438\u0436\u0430\u0432\u0430 \u0434\u043e\u043f\u0430\u043c\u0438\u043d\u0430 \u0438 \u043f\u0440\u0438\u0447\u0438\u043d\u044f\u0432\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f<\/span><\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/en\/estrogenat-i-kortizolat-a-ne-androgenite-potiskat-imuniteta\/\">Estrogen and cortisol, not androgens, suppress immunity<\/a><div class=\"wp-block-latest-posts__post-excerpt\">\u0412 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u044f\u0442\u0430 \u043d\u0430 \u0432\u044a\u0437\u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0441\u0442\u0432\u043e\u0442\u043e \u0438\u043c\u0430 \u0435\u0434\u043d\u0430 \u043c\u043d\u043e\u0433\u043e \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u0430 \u0442\u0435\u043e\u0440\u0438\u044f, \u043a\u043e\u044f\u0442\u043e\u2026 <a class=\"wp-block-latest-posts__read-more\" href=\"https:\/\/xenobg.com\/en\/estrogenat-i-kortizolat-a-ne-androgenite-potiskat-imuniteta\/\" rel=\"noopener noreferrer\">Read more<span class=\"screen-reader-text\">: \u0415\u0441\u0442\u0440\u043e\u0433\u0435\u043d\u044a\u0442 \u0438 \u043a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u044a\u0442, \u0430 \u043d\u0435 \u0430\u043d\u0434\u0440\u043e\u0433\u0435\u043d\u0438\u0442\u0435, \u043f\u043e\u0442\u0438\u0441\u043a\u0430\u0442 \u0438\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u0430<\/span><\/a><\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u041e\u0449\u0435 \u0435\u0434\u043d\u043e \u0447\u0443\u0434\u0435\u0441\u043d\u043e \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435, \u043a\u043e\u0435\u0442\u043e \u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u0430 \u043a\u0430\u043a\u0442\u043e \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u043d\u0438\u044f \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b \u043d\u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0438\u0442\u0435, \u0442\u0430\u043a\u0430 \u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0438\u044f\/\u0440\u0435\u0434\u043e\u043a\u0441 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440 \u043d\u0430 \u0440\u0430\u043a\u0430. \u041a\u0430\u043a\u0442\u043e \u0441\u043f\u043e\u043c\u0435\u043d\u0430\u0445 \u0432 \u043d\u044f\u043a\u043e\u0438 \u043e\u0442 \u043c\u043e\u0438\u0442\u0435 \u043f\u043e\u0434\u043a\u0430\u0441\u0442\u0438, \u0432\u0438\u0442\u0430\u043c\u0438\u043d \u041a2 (MK-4) \u043f\u043e\u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u043c \u0435 \u0432 \u043f\u0440\u043e\u0446\u0435\u0441 \u043d\u0430 \u043a\u043b\u0438\u043d\u0438\u0447\u043d\u0438 \u0438\u0437\u043f\u0438\u0442\u0432\u0430\u043d\u0438\u044f \u0437\u0430 \u043b\u0435\u0447\u0435\u043d\u0438\u0435\/\u043f\u0440\u0435\u0434\u043e\u0442\u0432\u0440\u0430\u0442\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0440\u0435\u0434\u0438\u0446\u0430 \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a, \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u0440\u0430\u043a \u043d\u0430 \u0447\u0435\u0440\u043d\u0438\u044f \u0434\u0440\u043e\u0431 \u0438 \u0442.\u043d\u0430\u0440. \u043c\u0438\u0435\u043b\u043e\u0434\u0438\u0441\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u043d\u0438 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043e\u0431\u0445\u0432\u0430\u0449\u0430\u0442 \u0432\u0441\u0438\u0447\u043a\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a 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