{"id":9671,"date":"2019-08-28T09:03:12","date_gmt":"2019-08-28T06:03:12","guid":{"rendered":"https:\/\/xenobg.com\/?p=9671"},"modified":"2020-01-15T22:23:39","modified_gmt":"2020-01-15T20:23:39","slug":"pufa-%d0%bf%d1%80%d0%b8-%d1%85%d1%80%d0%b0%d0%bd%d0%b5%d0%bd%d0%b5-%d1%81-%d0%b0%d0%b4%d0%b0%d0%bf%d1%82%d0%b8%d1%80%d0%b0%d0%bd%d0%be-%d0%bc%d0%bb%d1%8f%d0%ba%d0%be-%d0%b8%d0%bb%d0%b8-%d0%b7%d0%b0","status":"publish","type":"post","link":"https:\/\/xenobg.com\/en\/pufa-%d0%bf%d1%80%d0%b8-%d1%85%d1%80%d0%b0%d0%bd%d0%b5%d0%bd%d0%b5-%d1%81-%d0%b0%d0%b4%d0%b0%d0%bf%d1%82%d0%b8%d1%80%d0%b0%d0%bd%d0%be-%d0%bc%d0%bb%d1%8f%d0%ba%d0%be-%d0%b8%d0%bb%d0%b8-%d0%b7%d0%b0\/","title":{"rendered":"PUFA, \u043f\u0440\u0438 \u0445\u0440\u0430\u043d\u0435\u043d\u0435 \u0441 \u0430\u0434\u0430\u043f\u0442\u0438\u0440\u0430\u043d\u043e \u043c\u043b\u044f\u043a\u043e \u0438\u043b\u0438 \u0437\u0430\u0442\u043b\u044a\u0441\u0442\u044f\u0432\u0430\u043d\u0435 \u043f\u0440\u0438 \u043c\u0430\u0439\u043a\u0430\u0442\u0430, \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u0440\u0438\u0447\u0438\u043d\u0438 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f"},"content":{"rendered":"\n<p>\u041e\u0449\u0435 \u0435\u0434\u043d\u043e \u0433\u043e\u043b\u044f\u043c\u043e \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435 \u0438 \u0435\u0434\u043d\u043e \u043e\u0442 \u043c\u0430\u043b\u043a\u043e\u0442\u043e, \u043a\u043e\u0438\u0442\u043e \u0441\u0435 \u043e\u0441\u043c\u0435\u043b\u044f\u0432\u0430\u0442 \u0434\u0430 \u043d\u0430\u0441\u043e\u0447\u0430\u0442 \u043f\u0440\u044a\u0441\u0442\u0430 \u0441\u0438 \u043a\u044a\u043c \u0441\u0432\u0435\u0449\u0435\u043d\u0438\u044f \u0413\u0440\u0430\u0430\u043b \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430\u0442\u0430 &#8211; \u201e\u0435\u0441\u0435\u043d\u0446\u0438\u0430\u043b\u043d\u0438\u0442\u0435 \u043c\u0430\u0441\u0442\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438\u201c. \u041a\u0430\u043a\u0442\u043e \u043f\u0440\u0430\u0432\u0438\u043b\u043d\u043e \u043a\u0430\u0437\u0432\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e, \u0432\u0438\u0441\u043e\u043a\u0438\u0442\u0435 \u043d\u0438\u0432\u0430 \u043d\u0430 <a href=\"https:\/\/xenobg.com\/omega-3-ne-sa-poleznite-maznini\/\">PUFA(\u041f\u043e\u043b\u0438 \u043d\u0435\u043d\u0430\u0441\u0438\u0442\u0435\u043d\u0438 \u043c\u0430\u0441\u0442\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438)<\/a> \u0432 \u043a\u0440\u044a\u0432\u0442\u0430 \u0438 \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438\u0442\u0435 \u043d\u0438\u0432\u0430 \u043d\u0430 \u043b\u0438\u043d\u043e\u043b\u043e\u0432\u0430 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0430 \u043f\u0440\u0435\u0434\u0441\u043a\u0430\u0437\u0432\u0430\u0442 \u043f\u043e\u0441\u043b\u0435\u0434\u0432\u0430\u0449\u043e \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u043d\u0430 \u043e\u0441\u0442\u0440\u0430 \u043b\u0438\u043c\u0444\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f (\u0412\u0421\u0418\u0427\u041a\u0418) \u043f\u0440\u0438 \u0434\u0435\u0446\u0430. \u0412\u044a\u043f\u0440\u0435\u043a\u0438 \u0447\u0435 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e \u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0442\u0435\u043b\u043d\u043e, \u0430\u0432\u0442\u043e\u0440\u0438\u0442\u0435 \u0437\u0430\u044f\u0432\u044f\u0432\u0430\u0442 \u0434\u043e\u0441\u0442\u0430 \u043a\u0430\u0442\u0435\u0433\u043e\u0440\u0438\u0447\u043d\u043e, \u0447\u0435 \u0441\u043c\u044f\u0442\u0430\u0442, \u0447\u0435 \u0432\u0440\u044a\u0437\u043a\u0430\u0442\u0430 \u0435 \u043f\u0440\u0438\u0447\u0438\u043d\u043d\u0430 \u0438 \u0441\u043f\u043e\u043c\u0435\u043d\u0430\u0432\u0430\u0442 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430, \u0447\u0435 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0438\u0442\u0435 \u043d\u0438\u0432\u0430 \u043d\u0430 PUFA \u043c\u043e\u0433\u0430\u0442 \u0434\u0430 \u043f\u0440\u0435\u0434\u0441\u043a\u0430\u0437\u0432\u0430\u0442 \u0434\u0440\u0443\u0433\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a \u043a\u0430\u043a\u0442\u043e \u043f\u0440\u0438 \u0434\u0435\u0446\u0430 \u0442\u0430\u043a\u0430 \u0438 \u043f\u0440\u0438 \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438. \u0421\u044a\u0449\u043e \u0442\u043e\u043b\u043a\u043e\u0432\u0430 \u0432\u0430\u0436\u043d\u043e, \u0442\u0435 \u043e\u0442\u043a\u0440\u0438\u0432\u0430\u0442, \u0447\u0435 \u043d\u0438\u0432\u0430\u0442\u0430 \u043d\u0430 PUFA \u0441\u0430 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438 \u0432 \u043a\u0440\u044a\u0432\u0442\u0430 \u043d\u0430 \u0434\u0435\u0446\u0430, \u0445\u0440\u0430\u043d\u0435\u043d\u0438 \u0441 \u0430\u0434\u0430\u043f\u0442\u0438\u0440\u0430\u043d\u043e \u043c\u043b\u044f\u043a\u043e, \u043e\u0442\u043a\u043e\u043b\u043a\u043e\u0442\u043e \u043d\u0430 \u043a\u044a\u0440\u043c\u0435\u043d\u0438\u0442\u0435. \u0410\u043a\u043e \u0434\u0435\u0446\u0430\u0442\u0430 \u0441\u0430 \u0431\u0438\u043b\u0438 \u043a\u044a\u0440\u043c\u0435\u043d\u0438, \u0442\u0435\u0437\u0438 \u0441\u044a\u0441 \u0437\u0430\u0442\u043b\u044a\u0441\u0442\u0435\u043b\u0438 \u043c\u0430\u0439\u043a\u0438 \u0441\u0430 \u0438\u043c\u0430\u043b\u0438 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438 \u043d\u0438\u0432\u0430 \u043d\u0430 PUFA \u0432 \u043a\u0440\u044a\u0432\u0442\u0430, \u043a\u043e\u0435\u0442\u043e \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430, \u0447\u0435 \u0437\u0430\u0442\u043b\u044a\u0441\u0442\u044f\u0432\u0430\u043d\u0435\u0442\u043e \u043f\u0440\u0438 \u043c\u0430\u0439\u043a\u0430\u0442\u0430 \u0441\u044a\u0449\u043e \u0441\u0435 \u0437\u0430\u0434\u0432\u0438\u0436\u0432\u0430 \u043e\u0442 PUFA (\u0438\u043b\u0438 \u043f\u043e\u043d\u0435 \u0441\u0438\u043b\u043d\u043e \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u043e \u0441 \u043d\u0435\u0433\u043e). \u0422\u0430\u043a\u0430 \u0447\u0435, \u0441\u0430\u043c\u043e \u0432 \u0435\u0434\u043d\u043e \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435 \u0438\u043c\u0430\u043c\u0435 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430, \u0447\u0435 \u0442\u0430\u043a\u0430 \u043d\u0430\u0440\u0435\u0447\u0435\u043d\u0438\u0442\u0435 \u201e\u0435\u0441\u0435\u043d\u0446\u0438\u0430\u043b\u043d\u0438\u201c \u043c\u0430\u0441\u0442\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438 \u043c\u043e\u0433\u0430\u0442 \u0434\u0430 \u043f\u0440\u0438\u0447\u0438\u043d\u044f\u0442 \u043a\u0430\u043a\u0442\u043e \u0437\u0430\u0442\u043b\u044a\u0441\u0442\u044f\u0432\u0430\u043d\u0435 \u043f\u0440\u0438 \u043c\u0430\u0439\u043a\u0430\u0442\u0430, \u0442\u0430\u043a\u0430 \u0438 \u0441\u043c\u044a\u0440\u0442\u043e\u043d\u043e\u0441\u043d\u0430 \u0434\u0435\u0442\u0441\u043a\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f, \u0430 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u0438 \u0434\u0440\u0443\u0433\u0438 \u0432\u0438\u0434\u043e\u0432\u0435 \u0440\u0430\u043a, \u043a\u0430\u043a\u0442\u043e \u0438 \u043f\u0440\u0438 \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u043d\u0438.<br><a rel=\"noreferrer noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30904619?fbclid=IwAR1Rx8wAPYvRFTRgi3_ZmfPTaqgWjtgXyeodkRe73qn-74XgL9wmMdPLvOQ\" target=\"_blank\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30904619<\/a><\/p>\n\n\n\n<p>\u201c\u2026Because ALL risks had previously been shown to be affected by age at diagnosis[10\u201313], we stratified cases by early (1-5 years) and late diagnosis (6-14 years) and, indeed, discovered mutually exclusive sets of predictive metabolomic features (Table 1). These 28 metabolites were mainly putative lipids (Table 1), some of which have been found to be perturbed in diagnostic blood for a number of malignancies [31,32] including childhood and adult acute leukemias [33,34]. Our study is unique in that the findings are based on pre-diagnostic blood collected at birth.\u201d<\/p>\n\n\n\n<p><a href=\"https:\/\/factor.niehs.nih.gov\/2019\/8\/papers\/dert\/\">https:\/\/factor.niehs.nih.gov\/2019\/8\/papers\/dert\/<\/a><\/p>\n\n\n\n<p>\u201c\u2026NIEHS grantees revealed associations between the presence of certain metabolites shortly after birth and childhood diagnosis of acute lymphoblastic leukemia (ALL). Notably, late-onset ALL patients exhibited more abundant metabolites linked to formula feeding rather than breast milk, indicating a possible role of nutrition in late-onset ALL risk. Using archived neonatal blood spots, the researchers compared 332 children who later developed ALL with 324 healthy children. The newborn blood spots were typically obtained between 24 and 48 hours post-delivery, generally after infants had received multiple feedings. Children diagnosed with ALL were separated by age at diagnosis into two groups: early, 1-5 years; and late, 6-14 years. The researchers identified metabolic features exclusive to each of the two groups of cases compared with controls. Nine metabolites predicted early ALL diagnosis and 19 different metabolites predicted late diagnosis. In the late-diagnosis group, they found a cluster of metabolites that indicated linoleic acid, an essential nutrient, was more abundant in these children than in either the early-onset cases or controls. Linoleic acid metabolites were also greater in infants fed formula rather than breast milk, in the form of colostrum, in the first few days of life. Levels of the metabolites increased with the mother\u2019s pre-pregnancy body mass index, suggesting that mother\u2019s weight may also be involved in late-diagnosis ALL risk.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u041e\u0449\u0435 \u0435\u0434\u043d\u043e \u0433\u043e\u043b\u044f\u043c\u043e \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435 \u0438 \u0435\u0434\u043d\u043e \u043e\u0442 \u043c\u0430\u043b\u043a\u043e\u0442\u043e, \u043a\u043e\u0438\u0442\u043e \u0441\u0435 \u043e\u0441\u043c\u0435\u043b\u044f\u0432\u0430\u0442 \u0434\u0430 \u043d\u0430\u0441\u043e\u0447\u0430\u0442 \u043f\u0440\u044a\u0441\u0442\u0430 \u0441\u0438 \u043a\u044a\u043c \u0441\u0432\u0435\u0449\u0435\u043d\u0438\u044f \u0413\u0440\u0430\u0430\u043b \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430\u0442\u0430 &#8211; \u201e\u0435\u0441\u0435\u043d\u0446\u0438\u0430\u043b\u043d\u0438\u0442\u0435 \u043c\u0430\u0441\u0442\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438\u201c. \u041a\u0430\u043a\u0442\u043e \u043f\u0440\u0430\u0432\u0438\u043b\u043d\u043e \u043a\u0430\u0437\u0432\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e, \u0432\u0438\u0441\u043e\u043a\u0438\u0442\u0435 \u043d\u0438\u0432\u0430 \u043d\u0430 PUFA(\u041f\u043e\u043b\u0438 \u043d\u0435\u043d\u0430\u0441\u0438\u0442\u0435\u043d\u0438 \u043c\u0430\u0441\u0442\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438) \u0432 \u043a\u0440\u044a\u0432\u0442\u0430 \u0438 \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438\u0442\u0435 \u043d\u0438\u0432\u0430 \u043d\u0430 \u043b\u0438\u043d\u043e\u043b\u043e\u0432\u0430 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0430 \u043f\u0440\u0435\u0434\u0441\u043a\u0430\u0437\u0432\u0430\u0442 \u043f\u043e\u0441\u043b\u0435\u0434\u0432\u0430\u0449\u043e \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u043d\u0430 \u043e\u0441\u0442\u0440\u0430 \u043b\u0438\u043c\u0444\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f (\u0412\u0421\u0418\u0427\u041a\u0418) \u043f\u0440\u0438 \u0434\u0435\u0446\u0430. \u0412\u044a\u043f\u0440\u0435\u043a\u0438 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9688,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[850,184,851,726,949,198,945],"tags":[329,946,872,803,948,947],"class_list":["post-9671","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-haidut","category-idealabs","category-science","category-xenobg","category-949","category-198","category-945","tag-haidut","tag-mufa","tag-pufa","tag-ray-peat","tag-948","tag-947"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PUFA, \u043f\u0440\u0438 \u0445\u0440\u0430\u043d\u0435\u043d\u0435 \u0441 \u0430\u0434\u0430\u043f\u0442\u0438\u0440\u0430\u043d\u043e \u043c\u043b\u044f\u043a\u043e \u0438\u043b\u0438 \u0437\u0430\u0442\u043b\u044a\u0441\u0442\u044f\u0432\u0430\u043d\u0435 \u043f\u0440\u0438 \u043c\u0430\u0439\u043a\u0430\u0442\u0430, \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u0440\u0438\u0447\u0438\u043d\u0438 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xenobg.com\/en\/pufa-\u043f\u0440\u0438-\u0445\u0440\u0430\u043d\u0435\u043d\u0435-\u0441-\u0430\u0434\u0430\u043f\u0442\u0438\u0440\u0430\u043d\u043e-\u043c\u043b\u044f\u043a\u043e-\u0438\u043b\u0438-\u0437\u0430\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PUFA, \u043f\u0440\u0438 \u0445\u0440\u0430\u043d\u0435\u043d\u0435 \u0441 \u0430\u0434\u0430\u043f\u0442\u0438\u0440\u0430\u043d\u043e \u043c\u043b\u044f\u043a\u043e \u0438\u043b\u0438 \u0437\u0430\u0442\u043b\u044a\u0441\u0442\u044f\u0432\u0430\u043d\u0435 \u043f\u0440\u0438 \u043c\u0430\u0439\u043a\u0430\u0442\u0430, \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u0440\u0438\u0447\u0438\u043d\u0438 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f - \u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\" \/>\n<meta property=\"og:description\" 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\u0432\u0438\u0441\u043e\u043a\u0438\u0442\u0435 \u043d\u0438\u0432\u0430 \u043d\u0430 PUFA(\u041f\u043e\u043b\u0438 \u043d\u0435\u043d\u0430\u0441\u0438\u0442\u0435\u043d\u0438 \u043c\u0430\u0441\u0442\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438) \u0432 \u043a\u0440\u044a\u0432\u0442\u0430 \u0438 \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438\u0442\u0435 \u043d\u0438\u0432\u0430 \u043d\u0430 \u043b\u0438\u043d\u043e\u043b\u043e\u0432\u0430 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0430 \u043f\u0440\u0435\u0434\u0441\u043a\u0430\u0437\u0432\u0430\u0442 \u043f\u043e\u0441\u043b\u0435\u0434\u0432\u0430\u0449\u043e \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435 \u043d\u0430 \u043e\u0441\u0442\u0440\u0430 \u043b\u0438\u043c\u0444\u043e\u0431\u043b\u0430\u0441\u0442\u043d\u0430 \u043b\u0435\u0432\u043a\u0435\u043c\u0438\u044f (\u0412\u0421\u0418\u0427\u041a\u0418) \u043f\u0440\u0438 \u0434\u0435\u0446\u0430. 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