{"id":18194,"date":"2021-05-11T23:55:55","date_gmt":"2021-05-11T20:55:55","guid":{"rendered":"https:\/\/xenobg.com\/?p=18194"},"modified":"2021-05-12T00:01:56","modified_gmt":"2021-05-11T21:01:56","slug":"deficit-na-nikotinamide-shizofrenia","status":"publish","type":"post","link":"https:\/\/xenobg.com\/ro\/deficit-na-nikotinamide-shizofrenia\/","title":{"rendered":"\u0414\u0435\u0444\u0438\u0446\u0438\u0442 \u043d\u0430 \u043d\u0438\u0430\u0446\u0438\u043d\u0430\u043c\u0438\u0434 (\u0432\u0438\u0442\u0430\u043c\u0438\u043d B3) \u0432 \u0445\u0440\u0430\u043d\u0430\u0442\u0430 \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u0440\u0438\u0447\u0438\u043d\u0438 \u0448\u0438\u0437\u043e\u0444\u0440\u0435\u043d\u0438\u044f"},"content":{"rendered":"<p>\u041a\u0430\u043a\u0442\u043e \u0437\u043d\u0430\u044f\u0442 \u043f\u043e\u0432\u0435\u0447\u0435\u0442\u043e \u043c\u0438 \u0447\u0438\u0442\u0430\u0442\u0435\u043b\u0438, \u0432\u0440\u044a\u0437\u043a\u0430\u0442\u0430 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\u043f\u0441\u0438\u0445\u0438\u0447\u043d\u0438\u0442\u0435 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f \u0435 \u0433\u0440\u0435\u0448\u043d\u0430, \u0430 \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u043d\u0430\u0442\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u2013 \u043d\u0435\u0435\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430.<\/p>\n\n\n\n<p>\u0415, \u0446\u0438\u0442\u0438\u0440\u0430\u043d\u043e\u0442\u043e \u043f\u043e-\u0434\u043e\u043b\u0443 \u043f\u0440\u043e\u0443\u0447\u0432\u0430\u043d\u0435 \u043c\u043e\u0436\u0435 \u0434\u0430 \u043e\u043d\u0435\u0432\u0438\u043d\u0438 \u0425\u043e\u0444\u044a\u0440, \u0430\u043a\u043e \u043d\u0435 \u0432\u044f\u0440\u0430\u0442\u0430 \u043c\u0443 \u0432 \u201e\u0430\u0434\u0440\u0435\u043d\u043e\u0445\u0440\u043e\u043c\u201c, \u0442\u043e \u043f\u043e\u043d\u0435 \u0443\u0431\u0435\u0436\u0434\u0435\u043d\u0438\u0435\u0442\u043e \u043c\u0443, \u0447\u0435 \u043d\u0438\u0430\u0446\u0438\u043d\u0430\u043c\u0438\u0434\u044a\u0442 \u0435 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u043d. \u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e \u0438\u043c\u0430 \u043f\u043e-\u043f\u0440\u0430\u0432\u0434\u043e\u043f\u043e\u0434\u043e\u0431\u043d\u043e \u043e\u0431\u044f\u0441\u043d\u0435\u043d\u0438\u0435, \u0434\u043e\u0431\u0440\u0435 \u043f\u043e\u0437\u043d\u0430\u0442\u043e \u043d\u0430 \u043f\u043e\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0438\u0442\u0435 \u043d\u0430 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0430\u0442\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0410 \u0442\u043e \u0435, \u0447\u0435 \u0448\u0438\u0437\u043e\u0444\u0440\u0435\u043d\u0438\u044f\u0442\u0430 \u0441\u0435 \u043f\u0440\u0438\u0447\u0438\u043d\u044f\u0432\u0430 \u043e\u0442 \u0435\u043d\u0435\u0440\u0433\u0435\u0442\u0438\u0447\u043d\u0438 \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0438, \u043d\u0430\u0439-\u0432\u0435\u0447\u0435 \u0432 \u0440\u0435\u0437\u0443\u043b\u0442\u0430\u0442 \u043e\u0442 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e\u0442\u043e \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0441\u0442\u0432\u043e \u043d\u0430 NAD. \u0421\u043f\u043e\u0440\u0435\u0434 \u0430\u0432\u0442\u043e\u0440\u0438\u0442\u0435 \u043d\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e \u0442\u0435\u0437\u0438 \u043f\u043e\u043d\u0438\u0436\u0435\u043d\u0438 \u043d\u0438\u0432\u0430 \u043d\u0430 NAD \u0441\u0435 \u043f\u043e\u043b\u0443\u0447\u0430\u0432\u0430\u0442 \u043f\u0440\u043e\u0441\u0442\u043e \u043e\u0442 \u043d\u0435\u0434\u043e\u0441\u0442\u0438\u0433 \u043d\u0430 \u043d\u0438\u0430\u0446\u0438\u043d\u0430\u043c\u0438\u0434. \u0417\u0430\u0442\u043e\u0432\u0430, \u043f\u043e\u043d\u0435 \u043f\u043e \u043f\u0440\u0438\u043d\u0446\u0438\u043f, 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\u0447\u0435 \u0432\u0435\u0433\u0430\u043d\u0441\u043a\u0430\u0442\u0430 \u0434\u0438\u0435\u0442\u0430 \u0435 \u043d\u0435 \u0441\u0430\u043c\u043e \u043d\u0435\u043e\u043f\u0442\u0438\u043c\u0430\u043b\u043d\u0430 \u0437\u0430 \u0437\u0434\u0440\u0430\u0432\u0435\u0442\u043e, \u043d\u043e \u0438 \u043c\u043e\u0436\u0435 \u0434\u0430 \u0434\u043e\u043f\u0440\u0438\u043d\u0435\u0441\u0435 \u0437\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435\u0442\u043e \u043d\u0430 \u0448\u0438\u0437\u043e\u0444\u0440\u0435\u043d\u0438\u044f \u0438\u043b\u0438 \u0434\u0440\u0443\u0433\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f, \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u043d\u0438 \u043a\u044a\u043c \u0438\u0437\u0447\u0435\u0440\u043f\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 NAD (\u0430 \u0432\u0441\u0438\u0447\u043a\u0438 \u0432\u0441\u044a\u0449\u043d\u043e\u0441\u0442 \u0441\u0430 \u0442\u0430\u043a\u0438\u0432\u0430).<\/p>\n\n\n\n<p><a href=\"https:\/\/researchmatters.in\/news\/two-decade-long-study-links-lack-vitamin-b3-schizophrenia-among-indians\">https:\/\/researchmatters.in\/news\/two-decade-long-study-links-lack-vitamin-b3-schizophrenia-among-indians<\/a><\/p>\n\n\n\n<p>\u201c\u2026<strong>This enzyme helps in the process of converting niacin into nicotinamide adenine dinucleotide (NAD), which is essential for many biochemical processes in the body, like the aerobic respiration in cells<\/strong>. Interestingly, the amount of NAPRT1 enzyme in the brain changes with age. The study found that&nbsp;<strong>the amount of NAPRT1 in the brain is highest before birth, and decreases thereafter<\/strong>. It functions during a critical time window when the young brain is forming, implying that there may be differences in brain development in healthy people and those who have schizophrenia.\u201d<\/p>\n\n\n\n<p>\u201c\u2026 They suggest that&nbsp;<strong>vitamin B3 is linked with schizophrenia since the pathway for synthesising NAD uses NAPRT1 and vitamin B3<\/strong>.&nbsp;<strong>A disturbance in either the level of vitamin B3 or the enzyme metabolising it might increase the risk for schizophrenia<\/strong>.\u201d<\/p>\n\n\n\n<p>\u201c\u2026Since the\u00a0<strong>diet is an external factor contributing to schizophrenia<\/strong>, the researchers analysed the participants who had lower levels of NAPRT1 based on whether they were vegetarians or non-vegetarians. Interestingly,\u00a0<strong>a higher number of schizophrenia patients had a vegetarian diet<\/strong>.\u00a0<strong>A vegetarian diet lacks tryptophan \u2060\u2014 an amino acid used by the body to produce NAD without using vitamin B3. A gene-linked deficiency of NAPRT1 and the lack of tryptophan in the diet may aggravate the overall scarcity of NAD<\/strong>. This condition could lead to developmental anomalies and increase the risk of schizophrenia, say the researchers. \u201c<strong>In principle, niacin supplementation can increase NAD levels<\/strong>. However, we are uncertain whether this will improve health outcomes,\u201d remarks Dr Periyasamy. \u201cSince schizophrenia has a developmental origin, the effects of the risk factors during prenatal stages can be permanent, and these treatments may not work in such cases,\u201d he adds. As a next step, the researchers plan to conduct clinical trials to test if niacin supplements can reverse the symptoms. \u201c<strong>These supplements might have to be prescribed during pregnancy, similar to how folic acid is being prescribed<\/strong>,\u201d suggests Dr Periyasamy.\u201d<\/p>\n\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/hronichniyat-stres-ponizhava-dopamina-i-prichinyava-psihichni-zabolyavania\/\">Stresul cronic scade dopamina \u0219i provoac\u0103 boli mintale<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/estrogenat-i-kortizolat-a-ne-androgenite-potiskat-imuniteta\/\">Estrogenul \u0219i cortizolul, nu androgenii, suprim\u0103 imunitatea<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/inhibiraneto-na-aromatazata-za-namalyavane-na-estrogena-mozhe-da-dovede-do-lechenie-na-rak-na-stomaha\/\">Inhibarea aromatazei (pentru a reduce estrogenul) poate duce la tratamentul cancerului de stomac.<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/potisnatiyat-imunitet-a-ne-virusite-hpv-mozhe-da-e-prichina-za-raka-na-kozhata\/\">Imunitatea suprimat\u0103, nu virusurile (HPV), poate fi cauza cancerului de piele<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/vitamin-k-mozhe-da-lekuva-levkemia\/\">Vitamina K poate vindeca leucemia<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/vitamin-d-mozhe-da-spre-rastezha-na-melanoma\/\">Vitamina D poate opri cre\u0219terea melanomului<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/povisheniyat-sintez-na-mastni-kiselini-fas-e-prosto-priznak-za-nedostig-na-kislorod-nisak-metabolizam\/\">Sinteza crescut\u0103 a acizilor gra\u0219i (FAS) este pur \u0219i simplu un semn de deficit de oxigen \/ metabolism sc\u0103zut<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/pnmk-sa-imunosupresivni-a-gladuvaneto-i-ogranichavaneto-na-proteinite-veroyatno-nanasyat-oshte-po-golyama-vreda\/\">AINS sunt imunosupresoare, iar postul \u0219i restric\u021bia proteic\u0103 (probabil) fac \u0219i mai mult r\u0103u<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/horata-imat-podobna-na-salamandar-sposobnost-da-vazstanovyavat-hrushtyali\/\">Oamenii au o capacitate asem\u0103n\u0103toare cu a salamandrelor de a repara cartilajele<\/a><\/li>\n<\/ul>\n\n\n<div class=\"wp-block-advgb-search-bar advgb-search-bar-wrapper undefined\"><form method=\"get\" 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\u0415\u0439\u0431\u0440\u0430\u0445\u0430\u043c \u0425\u043e\u0444\u044a\u0440, \u0435\u0434\u0438\u043d \u043e\u0442 \u043e\u0441\u043d\u043e\u0432\u0430\u0442\u0435\u043b\u0438\u0442\u0435 \u043d\u0430 \u043e\u0440\u0442\u043e\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0438\u044f \u043f\u043e\u0434\u0445\u043e\u0434, \u0435 \u0431\u0438\u043b \u0443\u0431\u0435\u0434\u0435\u043d, \u0447\u0435 \u0441\u0442\u0440\u0435\u0441\u044a\u0442 \u0435 \u043e\u0433\u0440\u043e\u043c\u0435\u043d \u0444\u0430\u043a\u0442\u043e\u0440 \u0437\u0430 \u043f\u0441\u0438\u0445\u0438\u0447\u0435\u0441\u043a\u0438\u0442\u0435 \u0431\u043e\u043b\u0435\u0441\u0442\u0438 \u0438 \u0435 \u043d\u0430\u043f\u0440\u0430\u0432\u0438\u043b \u043d\u044f\u043a\u043e\u043b\u043a\u043e \u0443\u0441\u043f\u0435\u0448\u043d\u0438 \u0438\u0437\u043f\u0438\u0442\u0430\u043d\u0438\u044f \u0441 \u0432\u0438\u0441\u043e\u043a\u0438 \u0434\u043e\u0437\u0438 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