{"id":22682,"date":"2024-03-04T22:19:57","date_gmt":"2024-03-04T20:19:57","guid":{"rendered":"https:\/\/xenobg.com\/?p=22682"},"modified":"2024-03-04T23:13:32","modified_gmt":"2024-03-04T21:13:32","slug":"kortizolat-stresat-direktna-prichina-za-depresiya","status":"publish","type":"post","link":"https:\/\/xenobg.com\/ro\/kortizolat-stresat-direktna-prichina-za-depresiya\/","title":{"rendered":"\u041a\u043e\u0440\u0442\u0438\u0437\u043e\u043b\u044a\u0442 (\u0441\u0442\u0440\u0435\u0441\u044a\u0442) \u0434\u0438\u0440\u0435\u043a\u0442\u043d\u0430 \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u0437\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f"},"content":{"rendered":"\n

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\u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u0437\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f. \u0422\u044f \u043e\u0431\u044f\u0441\u043d\u044f\u0432\u0430 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u0435\u0442\u043e \u043a\u0430\u0442\u043e „\u0441\u043b\u043e\u0436\u043d\u0430“ \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u043e\u0442 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u0438 \u043f\u0440\u0435\u0434\u0440\u0430\u0437\u043f\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u044f, \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e „\u043f\u043e\u0434\u043f\u043e\u043c\u043e\u0433\u043d\u0430\u0442\u0438“ \u043e\u0442 \u043e\u043a\u043e\u043b\u043d\u0430\u0442\u0430 \u0441\u0440\u0435\u0434\u0430. \u0412\u0441\u0435 \u043f\u0430\u043a, \u0432\u044a\u0432 \u0432\u0441\u0435\u043a\u0438 \u043e\u043f\u0438\u0442 \u0441 \u0436\u0438\u0432\u043e\u0442\u043d\u0438, \u0438\u043c\u0430\u0449 \u0437\u0430 \u0446\u0435\u043b  \u0438\u0437\u0443\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f\u0442\u0430, \u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b\u0438 \u043a\u0430\u0442\u043e chronic unpredictable mild stress (CUMS) \u0438 chronic social defeat (CSD)  \u0441\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u0442 \u043a\u0430\u0442\u043e \u0435\u0434\u0438\u043d\u0441\u0442\u0432\u0435\u043d\u0438 \u0438 \u0434\u0438\u0440\u0435\u043a\u0442\u043d\u0438 \u043f\u0440\u0438\u0447\u0438\u043d\u0438 \u0437\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f\u0442\u0430 \u043f\u0440\u0438 \u0436\u0438\u0432\u043e\u0442\u043d\u0438\u0442\u0435. \u041d\u0438\u043a\u044a\u0434\u0435 \u043d\u0435 \u0441\u0435 \u0441\u0440\u0435\u0449\u0430 \u0438 \u0434\u0443\u043c\u0430 \u0437\u0430 \u0433\u0435\u043d\u0438\u0442\u0435 \u0432 \u0442\u0435\u0437\u0438 \u043e\u043f\u0438\u0442\u0438 \u0441 \u0436\u0438\u0432\u043e\u0442\u043d\u0438. 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\u043b\u0438\u043f\u0441\u0430\u0442\u0430 \u043d\u0430 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430, \u043a\u043e\u0438\u0442\u043e \u0441\u043e\u0447\u0430\u0442 \u0441\u0442\u0440\u0435\u0441\u0430 \u043a\u0430\u0442\u043e \u043e\u0441\u043d\u043e\u0432\u043d\u0430 \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u0437\u0430 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u044f. \u0415, \u0432\u0435\u0447\u0435 \u043d\u0435. \u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e \u043f\u043e-\u0434\u043e\u043b\u0443 \u043f\u0440\u0435\u043c\u0430\u0445\u0432\u0430 CUMS\/CSD \u0438 \u0432\u043c\u0435\u0441\u0442\u043e \u0434\u0430 \u043f\u043e\u0434\u043b\u0430\u0433\u0430 \u0436\u0438\u0432\u043e\u0442\u043d\u0438\u0442\u0435 \u043d\u0430 \u0441\u0442\u0440\u0435\u0441 \u0433\u0438 \u043f\u0440\u0430\u0432\u0438 \u0434\u0435\u043f\u0440\u0435\u0441\u0438\u0440\u0430\u043d\u0438, \u043a\u0430\u0442\u043e \u0438\u043c 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https:\/\/science.sciencemag.org\/content\/364\/6436\/eaat8078<\/a><\/p>\n\n\n\n

\u201c\u2026We began by testing whether the induction of depression-related behavior in chronic stress models is associated with targeted effects on specific dendritic spine populations. To this end, we imaged the PFC through a prism (13<\/em><\/a>, 16<\/em><\/a>) chronically implanted in the contralateral hemisphere (Fig. 1A<\/a>). Using two-photon (2P) laser-scanning microscopy, we obtained high-resolution images of the apical dendrites of yellow fluorescent protein (YFP)\u2013expressing projection neurons in the medial PFC (mPFC) [in Thy1\/YFP-H mice (Jackson Labs)] before and after 21 days of exposure to corticosterone (CORT) (0.10 mg\/ml in the drinking water)<\/strong> (21<\/em><\/a>), the principal murine stress hormone (Fig. 1A<\/a>). CORT is a critical mediator of chronic stress effects on behavior, and chronic CORT treatment recapitulates important aspects of the neuroendocrine response to chronic stress <\/strong>(21<\/em><\/a>\u201326<\/em><\/a>).\u201d<\/p>\n\n\n\n

https:\/\/www.npr.org\/sections\/health-shots\/2019\/04\/11\/712295937\/ketamine-may-relieve-depression-by-repairing-damaged-brain-circuits<\/a><\/p>\n\n\n\n

\u201c\u2026So Liston and a team of scientists from the U.S. and Japan gave mice a stress hormone that caused them to act depressed<\/strong>. For example, the animals lost interest in favorite activities like eating sugar and exploring a maze. Then the team used a special laser microscope to study the animals\u2019 brains. The researchers were looking for changes to synapses. \u201cStress is associated with a loss of synapses in this region of the brain that we think is important in depression,\u201d Liston says. And sure enough, the stressed-out mice lost a lot of synapses<\/strong>. Next, the scientists gave the animals a dose of ketamine. And Liston says that\u2019s when they noticed something surprising. \u201cKetamine was actually restoring many of the exact same synapses in their exact same configuration that existed before the animal was exposed to chronic stress<\/strong>,\u201d he says. In other words, the drug seemed to be repairing brain circuits that had been damaged by stress<\/strong>.\u201d<\/p>\n\n\n\n

Moreover, the study exposes another fraudulent meme commonly propagated by doctors \u2013 i.e. that steroids are not effective when administered orally \u2013 by causing depression through administration of cortisol in the drinking water. The study also suggests that the rapid antidepressant effects of the recently approved ketamine are likely due to being a functional or maybe even direct glucocorticoid antagonist. This is a mechanism of action for ketamine I have never heard discussed officially, possibly because it may undermine steroid sales and widespread use in hospitals. Instead, we are being fed the usual crap of ketamine having a \u201ccomplex\u201d mechanism of action that is mostly unknown at this point.
https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166432818314451<\/a>)<\/p>\n\n\n\n

And if all the above damning findings were not enough, there is evidence that ketamine also acts against another major mediator of stress \u2013 serotonin. The very chemical that we have been told for decades is a \u201ccure\u201d for depression, a \u201chappiness hormone\u201d that tens of millions of people in the US alone are prescribed for life in the form of toxic serotonergic (SSRI) drugs.
https:\/\/www.researchgate.net\/publication\/22985524_Possible_role_of_brain_serotonin_in_the_central_effects_of_ketamine<\/a><\/p>\n\n\n\n

\u0418\u0437\u0442\u043e\u0447\u043d\u0438\u043a:<\/p>\n\n\n\n

http:\/\/haidut.me\/?p=38<\/a><\/p>\n\n\n