{"id":23452,"date":"2024-07-20T14:34:08","date_gmt":"2024-07-20T11:34:08","guid":{"rendered":"https:\/\/xenobg.com\/?p=23452"},"modified":"2024-07-20T14:42:05","modified_gmt":"2024-07-20T11:42:05","slug":"blokiraneto-na-endotoksin-mozhe-da-lekuva-diabet-tip-1-insulinozavisim","status":"publish","type":"post","link":"https:\/\/xenobg.com\/ro\/blokiraneto-na-endotoksin-mozhe-da-lekuva-diabet-tip-1-insulinozavisim\/","title":{"rendered":"\u0411\u043b\u043e\u043a\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d (LPS) \u043c\u043e\u0436\u0435 \u0434\u0430 \u043b\u0435\u043a\u0443\u0432\u0430 \u0434\u0438\u0430\u0431\u0435\u0442 \u0442\u0438\u043f 1 (\u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0437\u0430\u0432\u0438\u0441\u0438\u043c)"},"content":{"rendered":"<p>\u041e\u0449\u0435 \u0435\u0434\u043d\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435, \u043a\u043e\u0435\u0442\u043e \u0440\u0430\u0437\u043a\u0440\u0438\u0432\u0430 \u043a\u043b\u044e\u0447\u043e\u0432\u0430\u0442\u0430 \u0440\u043e\u043b\u044f \u043d\u0430 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d \u0432 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f\u0442\u0430 \u043d\u0430 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043d\u0430\u0439-\u0448\u0438\u0440\u043e\u043a\u043e \u0440\u0430\u0437\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0430\u0442\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0430 \u0431\u043e\u043b\u0435\u0441\u0442 \u0432 \u0434\u043d\u0435\u0448\u043d\u043e \u0432\u0440\u0435\u043c\u0435 &#8211; \u0434\u0438\u0430\u0431\u0435\u0442\u044a\u0442. \u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e \u043f\u043e-\u0434\u043e\u043b\u0443 \u043e\u0442\u043a\u0440\u0438\u0432\u0430, \u0447\u0435 \u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u0431\u0435\u0442\u0430-\u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435, \u043f\u0440\u043e\u0438\u0437\u0432\u0435\u0436\u0434\u0430\u0449\u0438 \u0438\u043d\u0441\u0443\u043b\u0438\u043d \u0432 \u043f\u0430\u043d\u043a\u0440\u0435\u0430\u0441\u0430, \u0435 \u043f\u043e\u0447\u0442\u0438 \u043d\u0430\u043f\u044a\u043b\u043d\u043e \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0438\u0440\u0430\u043d\u0430 \u043e\u0442 \u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u043e\u0442\u043e \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438 TLR4\/TLR2. \u0410\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0442\u0435\u0437\u0438 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438 \u0432\u043e\u0434\u0438 \u0434\u043e \u0431\u044a\u0440\u0437\u0430 \u0441\u043c\u044a\u0440\u0442 \u043d\u0430 \u0431\u0435\u0442\u0430-\u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u0438, \u043e\u0431\u0440\u0430\u0442\u043d\u043e, \u0438\u0437\u0442\u0440\u0438\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438\u0442\u0435 TLR4\/TLR2 \u0432\u043e\u0434\u0438 \u0434\u043e \u0431\u044a\u0440\u0437\u043e \u0432\u044a\u0437\u0441\u0442\u0430\u043d\u043e\u0432\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0431\u0435\u0442\u0430-\u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435, \u0434\u043e\u0440\u0438 \u043f\u0440\u0438 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u043e \u0445\u0440\u0430\u043d\u0435\u043d\u0435 \u043d\u0430 \u0432\u0438\u0441\u043e\u043a\u043e\u043c\u0430\u0437\u043d\u0438\u043d\u043d\u0430 (PUFA) \u0434\u0438\u0435\u0442\u0430!<\/p>\n\n\n\n<p>\u0421\u0430\u043c\u043e\u0442\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435 \u0438\u043c\u0430 \u0435\u043a\u0441\u0442\u0440\u0435\u043c\u0435\u043d \u043f\u043e\u0434\u0445\u043e\u0434, \u0441\u044a\u0437\u0434\u0430\u0432\u0430\u0439\u043a\u0438 \u043c\u0438\u0448\u043a\u0438 \u0441 \u043d\u0430\u043f\u044a\u043b\u043d\u043e \u043b\u0438\u043f\u0441\u0432\u0430\u0449\u0438 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438 TLR4\/TLR2. \u0412\u044a\u043f\u0440\u0435\u043a\u0438 \u0442\u043e\u0432\u0430, \u0441\u0430\u043c\u043e\u0442\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435 \u0434\u043e\u043a\u0430\u0437\u0432\u0430, \u0447\u0435 \u0431\u043b\u043e\u043a\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 TLR4\/TLR2 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u0435 \u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e, \u0437\u0430 \u0434\u0430 \u0441\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0430\u0432\u0430 \u0441\u044a\u0449\u0438\u044f\u0442 \u0435\u0444\u0435\u043a\u0442. \u0421 \u043e\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u043d\u0430\u0442\u0430 \u0440\u043e\u043b\u044f \u043d\u0430 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0438\u0442\u0435 FFA \u043f\u0440\u0438 \u0434\u0438\u0430\u0431\u0435\u0442\u0430, \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u043e\u0442 \u043d\u0438\u0430\u0446\u0438\u043d\u0430\u043c\u0438\u0434 (\u0438\u043b\u0438 \u0430\u0441\u043f\u0438\u0440\u0438\u043d \u0438\u043b\u0438 \u0432\u0438\u0442\u0430\u043c\u0438\u043d \u0415) \u0438 \u0431\u043b\u043e\u043a\u0435\u0440 \u043d\u0430 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d, \u043a\u0430\u0442\u043e \u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440 \u043d\u0430\u043b\u0442\u0440\u0435\u043a\u0441\u043e\u043d, \u0446\u0438\u043f\u0440\u043e\u0445\u0435\u043f\u0442\u0430\u0434\u0438\u043d, \u0411\u0435\u043d\u0430\u0434\u0440\u0438\u043b, \u043f\u0440\u043e\u0433\u0435\u0441\u0442\u0435\u0440\u043e\u043d \u0438 \u0434\u0440., \u043c\u043e\u0436\u0435 \u0434\u0430 \u0431\u044a\u0434\u0435 \u0435\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0438 \u0437\u0430 \u0414\u0412\u0410\u0422\u0410 \u0412\u0418\u0414\u0410 \u0434\u0438\u0430\u0431\u0435\u0442 (I \u0438 II). \u0412\u0435\u0447\u0435 \u0438\u043c\u0430 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430, \u0447\u0435 \u043d\u0438\u0430\u0446\u0438\u043d\u0430\u043c\u0438\u0434 \u0441\u0430\u043c \u043f\u043e \u0441\u0435\u0431\u0435 \u0441\u0438 \u043c\u043e\u0436\u0435 \u0434\u0430 \u043e\u0431\u044a\u0440\u043d\u0435 (\u043d\u0430 \u0440\u0430\u043d\u043d\u0438 \u0441\u0442\u0430\u0434\u0438\u0438) \u0434\u0438\u0430\u0431\u0435\u0442 I \u043f\u0440\u0438 \u0434\u0435\u0446\u0430, \u043a\u043e\u0435\u0442\u043e \u043f\u043e\u0442\u0432\u044a\u0440\u0436\u0434\u0430\u0432\u0430 \u0440\u0435\u0437\u0443\u043b\u0442\u0430\u0442\u0438\u0442\u0435 \u043e\u0442 \u0442\u043e\u0432\u0430 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435. \u0422\u0430\u043a\u0430 \u0447\u0435, \u0442\u043e\u043b\u043a\u043e\u0432\u0430 \u0437\u0430 \u043d\u0435\u043e\u0431\u0440\u0430\u0442\u0438\u043c\u0438\u044f \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0437\u0430\u0432\u0438\u0441\u0438\u043c \u0434\u0438\u0430\u0431\u0435\u0442&#8230;<\/p>\n\n\n\n<p>\u0411\u0435\u0437\u0443\u043c\u043d\u043e \u0435, \u0447\u0435 \u0432\u044a\u043f\u0440\u0435\u043a\u0438 \u043e\u0442\u043a\u0440\u0438\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0440\u043e\u043b\u044f\u0442\u0430 \u043d\u0430 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d \u0432 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f\u0442\u0430 \u043d\u0430 \u0434\u0438\u0430\u0431\u0435\u0442\u0430, \u0430\u0432\u0442\u043e\u0440\u0438\u0442\u0435 \u043f\u0440\u0430\u0432\u044f\u0442 \u0437\u0430\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u0435\u0442\u043e, \u0447\u0435 &#8222;\u043d\u0435\u0449\u043e&#8220; \u0432 \u0445\u0440\u0430\u043d\u0435\u043d\u0435\u0442\u043e \u0441 \u0432\u0438\u0441\u043e\u043a\u043e\u043c\u0430\u0437\u043d\u0438\u043d\u043d\u0430 \u0445\u0440\u0430\u043d\u0430, \u043f\u0440\u0435\u0434\u0438\u0437\u0432\u0438\u043a\u0432\u0430 \u0434\u0438\u0430\u0431\u0435\u0442, \u043d\u043e \u0442\u043e\u0447\u043d\u0430\u0442\u0430 \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u0435 &#8222;\u043d\u0435\u0438\u0437\u0432\u0435\u0441\u0442\u043d\u0430&#8220;. \u0421\u0438\u0433\u0443\u0440\u043d\u043e \u0441\u0435 \u0448\u0435\u0433\u0443\u0432\u0430\u0442! \u0410\u043c\u0438 \u0430\u0433\u0435\u043d\u0442\u044a\u0442, \u0438\u0437\u0432\u0435\u0441\u0442\u0435\u043d \u0441 \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 TLR4\/TLR2? \u0415\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d (LPS), \u043d\u044f\u043a\u043e\u0439? \u0410\u043c\u0438 \u0434\u043e\u0431\u0440\u0435 \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u0430\u0442\u0430 \u0432\u0440\u044a\u0437\u043a\u0430 \u043c\u0435\u0436\u0434\u0443 \u0432\u0438\u0441\u043e\u043a\u043e\u043c\u0430\u0437\u043d\u0438\u043d\u043d\u0430\u0442\u0430 \u0434\u0438\u0435\u0442\u0430 \u0438 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d? \u0410\u043c\u0438 \u0438\u0437\u0432\u0435\u0441\u0442\u043d\u0430\u0442\u0430 \u0432\u0440\u044a\u0437\u043a\u0430 \u043c\u0435\u0436\u0434\u0443 \u0432\u0438\u0441\u043e\u043a\u043e\u043c\u0430\u0437\u043d\u0438\u043d\u043d\u0430\u0442\u0430 \u0434\u0438\u0435\u0442\u0430 \u0438 \u043f\u043e-\u0441\u0438\u043b\u043d\u043e\u0442\u043e \u0441\u044a\u0434\u043e\u0432\u043e \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435 \u043f\u043e\u0440\u0430\u0434\u0438 \u043f\u0440\u0435\u0432\u0440\u044a\u0449\u0430\u043d\u0435\u0442\u043e \u043d\u0430 PUFA \u0432 \u043f\u0440\u043e\u0441\u0442\u0430\u0433\u043b\u0430\u043d\u0434\u0438\u043d\u0438, \u043b\u0435\u0432\u043a\u043e\u0442\u0440\u0438\u0435\u043d\u0438 \u0438 \u0434\u0440.? \u0418\u043b\u0438 \u0447\u0443\u0434\u043e\u0432\u0438\u0449\u043d\u0430 \u0433\u043b\u0443\u043f\u043e\u0441\u0442, \u0438\u043b\u0438 \u043e\u0442\u043a\u0440\u0438\u0442\u0430 \u043a\u043e\u0440\u0443\u043f\u0446\u0438\u044f \u0441\u0430 \u043e\u043a\u0443\u043f\u0438\u0440\u0430\u043b\u0438 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u0442\u0430 \u043f\u0440\u043e\u0444\u0435\u0441\u0438\u044f, \u0437\u0430 \u0434\u0430 \u0431\u044a\u0434\u0435 \u0441\u043b\u044f\u043f\u0430 \u0437\u0430 \u0442\u0430\u043a\u0438\u0432\u0430 \u043e\u0447\u0435\u0432\u0438\u0434\u043d\u043e\u0441\u0442\u0438.<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26130764\">https:\/\/pubmed.ncbi.nlm.nih.gov\/26130764<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.medicalnewstoday.com\/articles\/278289\">https:\/\/www.medicalnewstoday.com\/articles\/278289<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41590-019-0396-z?_ga=2.225718682.1673049787.1558602635-227900212.1558602635\">https:\/\/www.nature.com\/articles\/s41590-019-0396-z?_ga=2.225718682.1673049787.1558602635-227900212.1558602635<\/a><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-gen-genetic-engineering-and-biotechnology-news wp-block-embed-gen-genetic-engineering-and-biotechnology-news\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"vMkX1TbWYW\"><a href=\"https:\/\/www.genengnews.com\/news\/insulin-producing-beta-cells-proliferate-when-the-brakes-are-off\/\">Insulin-Producing Beta Cells Proliferate When the Brakes Are Off<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Insulin-Producing Beta Cells Proliferate When the Brakes Are Off&#8221; &#8212; GEN - Genetic Engineering and Biotechnology News\" src=\"https:\/\/www.genengnews.com\/news\/insulin-producing-beta-cells-proliferate-when-the-brakes-are-off\/embed\/#?secret=bfHo0Rbf6w#?secret=vMkX1TbWYW\" data-secret=\"vMkX1TbWYW\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>\u201c\u2026Western-type diets that are laden with carbohydrates and fats put extra demand on the body\u2019s pancreatic islets to produce enough insulin to control blood sugar levels. If this demand can\u2019t be met, then diabetes can result. Research by a University of Michigan-headed team of scientists has now suggested that&nbsp;<strong>it may be possible to trigger increased production of insulin. Their studies in mice showed that switching off two toll-like receptors (TLRs) effectively takes the brakes of islet cell expansion in the pancreas, and allows pancreatic islets to ramp up production of insulin-producing \u03b2 cells, but only in response to a high-fat diet (HFD)<\/strong>.<\/p>\n\n\n\n<p>\u201c\u2026The researchers say the discovery that&nbsp;<strong>TLR2, TLR4, and HFD play a combined role in regulating \u03b2 cell production could lead to new approaches for treating diabetes and obesity<\/strong>. \u201cThese data reveal a regulatory mechanism controlling the proliferation of \u03b2 cells in diet-induced obesity and suggest that&nbsp;<strong>selective targeting of the TLR2\/TLR4 pathways may reverse \u03b2 cell failure in patients with diabetes<\/strong>,\u201d they concluded in their published paper in&nbsp;<em>Nature Immunology<\/em>, which is titled, \u201c<a href=\"https:\/\/www.nature.com\/articles\/s41590-019-0396-z?_ga=2.225718682.1673049787.1558602635-227900212.1558602635\" target=\"_blank\" rel=\"noreferrer noopener\">Toll-like receptors TLR2 and TLR4 block the replication of pancreatic \u03b2 cells in diet-induced obesity<\/a>.\u201d<\/p>\n\n\n\n<p>\u201c\u2026The researchers made the discovery on the back of experiments that were originally designed to investigate the role of the immune system, and TLR2 and TLR4, in the development of adipose tissue inflammation in obese mice. The team\u2019s subsequent&nbsp;<strong>studies in the TLR2- and TLR4-deficient mice found that loss of both of the proteins effectively removed a block on \u03b2 cell proliferation in animals fed a high-fat diet. Encouragingly, \u03b2 cell function was maintained and blood sugar controlled in the HFD-fed mice that lacked TLR2 and TLR4<\/strong>.\u201d<\/p>\n\n\n\n<p>\u201c\u2026Qi and his team are now working to identify the role that a high-fat diet plays in islet expansion in the context of TLR2 and TLR4. \u201c<strong>Something associated with high-fat-induced obesity plays a key role in this process, but we don\u2019t yet know what<\/strong>,\u201d he said. Qi also suggested that the discovery that negative factors can block \u03b2 cell expansion indicates that approaches to boosting \u03b2 cell numbers that focus solely on amplifying positive factors may not be effective.\u201d<\/p>\n\n\n\n<p>\u201c\u2026<strong>Both the proteins had to be disabled to unlock diet-related \u03b2 cell proliferation. If either TLR2 or TLR4 was present the islets didn\u2019t expand or generate additional \u03b2 cells<\/strong>&nbsp;\u201c\u2026&nbsp;<strong>activation of either TLR2 or TLR4 was sufficient to suppress \u03b2 cell proliferation in mice<\/strong>,\u201d the scientists wrote. Further experiments ruled out a potential role for any factors circulating in the blood in allowing islet expansion, and suggested that \u201c<strong>TLR2 and TLR4 deficiency affected HFD-induced \u03b2 cell replication in an islet-intrinsic manner<\/strong>,\u201d they continued. Pathway analysis indicated that in parallel with chronic consumption of high-fat foods, signaling pathways mediated by&nbsp;<strong>TLR2 and TLR4 downregulated the activation of MEK\/Erk kinases, which blocked key molecules involved in cell replication from entering the nucleus, and so prevented \u03b2 cell proliferation<\/strong>.\u201d<\/p>\n\n\n\n<p>Surs\u0103:<\/p>\n\n\n\n<p><a href=\"http:\/\/haidut.me\/?p=144\">http:\/\/haidut.me\/?p=144<\/a><\/p>\n\n\n<ul class=\"wp-block-latest-posts__list wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/%d1%80%d0%b5%d0%b2%d0%be%d0%bb%d1%8e%d1%86%d0%b8%d0%be%d0%bd%d0%b5%d0%bd-%d0%bf%d0%be%d0%b3%d0%bb%d0%b5%d0%b4-%d0%b2%d1%8a%d1%80%d1%85%d1%83-%d1%80%d0%b0%d0%ba%d0%b0-%d0%bc%d0%b5%d1%82%d0%b0%d0%b1\/\">\u0420\u0435\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u0435\u043d \u043f\u043e\u0433\u043b\u0435\u0434 \u0432\u044a\u0440\u0445\u0443 \u0440\u0430\u043a\u0430: \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d, \u0430 \u043d\u0435 \u0441\u0430\u043c\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u043d \u043f\u0440\u043e\u0431\u043b\u0435\u043c<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/hidroksiapatit-v-oralnata-grizha\/\">\u0425\u0438\u0434\u0440\u043e\u043a\u0441\u0438\u0430\u043f\u0430\u0442\u0438\u0442 \u0432 \u043e\u0440\u0430\u043b\u043d\u0430\u0442\u0430 \u0433\u0440\u0438\u0436\u0430: \u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u043e\u043b\u0437\u0438\u0442\u0435, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0430 \u0438 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u0444\u043b\u0443\u043e\u0440\u0438\u0434\u0430<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/kolko-presni-portokala-sa-vi-neobhodimi-za-da-izchistite-chernia-si-drob-ot-maznini\/\">De c\u00e2te portocale proaspete ai nevoie pentru a-\u021bi cur\u0103\u021ba ficatul de gr\u0103simi?<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/hronichniyat-stres-ponizhava-dopamina-i-prichinyava-psihichni-zabolyavania\/\">Stresul cronic scade dopamina \u0219i provoac\u0103 boli mintale<\/a><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/xenobg.com\/ro\/estrogenat-i-kortizolat-a-ne-androgenite-potiskat-imuniteta\/\">Estrogenul \u0219i cortizolul, nu androgenii, suprim\u0103 imunitatea<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u041e\u0449\u0435 \u0435\u0434\u043d\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435, \u043a\u043e\u0435\u0442\u043e \u0440\u0430\u0437\u043a\u0440\u0438\u0432\u0430 \u043a\u043b\u044e\u0447\u043e\u0432\u0430\u0442\u0430 \u0440\u043e\u043b\u044f \u043d\u0430 \u0435\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043d \u0432 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f\u0442\u0430 \u043d\u0430 \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043d\u0430\u0439-\u0448\u0438\u0440\u043e\u043a\u043e \u0440\u0430\u0437\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0430\u0442\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0430 \u0431\u043e\u043b\u0435\u0441\u0442 \u0432 \u0434\u043d\u0435\u0448\u043d\u043e \u0432\u0440\u0435\u043c\u0435 &#8211; \u0434\u0438\u0430\u0431\u0435\u0442\u044a\u0442. \u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435\u0442\u043e \u043f\u043e-\u0434\u043e\u043b\u0443 \u043e\u0442\u043a\u0440\u0438\u0432\u0430, \u0447\u0435 \u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u0431\u0435\u0442\u0430-\u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435, \u043f\u0440\u043e\u0438\u0437\u0432\u0435\u0436\u0434\u0430\u0449\u0438 \u0438\u043d\u0441\u0443\u043b\u0438\u043d \u0432 \u043f\u0430\u043d\u043a\u0440\u0435\u0430\u0441\u0430, \u0435 \u043f\u043e\u0447\u0442\u0438 \u043d\u0430\u043f\u044a\u043b\u043d\u043e \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0438\u0440\u0430\u043d\u0430 \u043e\u0442 \u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u043e\u0442\u043e \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438 TLR4\/TLR2. \u0410\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0442\u0435\u0437\u0438 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0438 \u0432\u043e\u0434\u0438 \u0434\u043e \u0431\u044a\u0440\u0437\u0430 \u0441\u043c\u044a\u0440\u0442 \u043d\u0430 \u0431\u0435\u0442\u0430-\u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u0438, \u043e\u0431\u0440\u0430\u0442\u043d\u043e, \u0438\u0437\u0442\u0440\u0438\u0432\u0430\u043d\u0435\u0442\u043e \u043d\u0430 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[850,949],"tags":[872,1124,876,597,877,89,1116,885],"class_list":["post-23452","post","type-post","status-publish","format-standard","hentry","category-haidut","category-949","tag-pufa","tag-tlr2","tag-tlr4","tag-597","tag-877","tag-89","tag-1116","tag-885"],"yoast_head":"<!-- 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