{"id":35,"date":"2014-02-23T22:26:42","date_gmt":"2014-02-23T22:26:42","guid":{"rendered":"http:\/\/xenobg.com\/?p=35"},"modified":"2014-05-13T09:39:43","modified_gmt":"2014-05-13T06:39:43","slug":"xenoandrogeni-in-profesional-cu","status":"publish","type":"post","link":"https:\/\/xenobg.com\/ro\/%d0%ba%d1%81%d0%b5%d0%bd%d0%be%d0%b0%d0%bd%d0%b4%d1%80%d0%be%d0%b3%d0%b5%d0%bd%d0%b8%d1%82%d0%b5-%d0%b2-%d0%bf%d1%80%d0%be%d1%84%d0%b5%d1%81%d0%b8%d0%be%d0%bd%d0%b0%d0%bb%d0%bd%d0%b8%d1%8f-%d1%81\/","title":{"rendered":"XENOANDROGENII \u00ceN SPORTUL PROFESIONIST"},"content":{"rendered":"<p>P\u00e2n\u0103 de cur\u00e2nd, nimeni nu auzise de xenoandrogeni. Sticlu\u021bele cu nume care aminteau de cele ale steroizilor anabolizan\u021bi au \u00eenceput s\u0103 apar\u0103 \u00een 2011 \u0219i majoritatea dintre noi am crezut c\u0103 sunt steroizi interzi\u0219i. C\u00e2nd a devenit clar c\u0103 aceste substan\u021be erau de fapt tocoferoli modifica\u021bi, categorisi\u021bi legal ca suplimente alimentare, nu am avut de ales dec\u00e2t s\u0103 l\u0103s\u0103m sportivii s\u0103 le foloseasc\u0103 chiar \u0219i cu cinci minute \u00eenainte de competi\u021biile importante. Au trecut doi ani \u0219i jum\u0103tate de atunci \u0219i am \u00eenv\u0103\u021bat multe despre ac\u021biunea \u0219i efectele secundare ale acestor substan\u021be, numite uneori xenohormoni.<\/p>\n<p>Ce sunt xenoandrogenii?<\/p>\n<p>Orice substan\u021b\u0103 care nu este un hormon androgenic, dar ac\u021biunea sa este similar\u0103, poate fi numit\u0103 xenoandrogen. \u00cen acest caz avem de-a face cu foarte complexe \u0219i la nivel molecular. Astfel de manipul\u0103ri pot schimba afinitatea moleculelor pentru diferi\u021bi receptori din organism.<\/p>\n<p>Cercet\u0103rile ini\u021biale sugereaz\u0103 c\u0103 xenoandrogenii utiliza\u021bi ca stimulen\u021bi se pot lega de receptorii importan\u021bi: receptorii androgeni, receptorii catecolaminelor, receptorii estrogeni. Unele efecte sunt declan\u0219ate prin activarea acestor receptori, altele - prin ocuparea acestor receptori f\u0103r\u0103 activarea lor (ceea ce blocheaz\u0103 procese specifice).<\/p>\n<p>Cum ac\u021bioneaz\u0103 xenoadrogenii?<\/p>\n<p>Exist\u0103 dou\u0103 caracteristici care sunt caracteristice tocoferolilor modifica\u021bi \u0219i nicotinamidei care disting aceste substan\u021be de testosteron \u0219i de deriva\u021bii s\u0103i, steroizii anabolico-androgenici.<\/p>\n<p>Xenoandrogenii au un timp de \u00eenjum\u0103t\u0103\u021bire semnificativ mai lung. \u00cen cazul AAS, esterificarea prelunge\u0219te efectul (\u0219i, prin urmare, probabilitatea unui e\u0219antion pozitiv), dar moleculele de xenoandrogeni prezint\u0103 perioade de \u00eenjum\u0103t\u0103\u021bire lungi, de c\u00e2teva luni, chiar \u0219i f\u0103r\u0103 esterificare.<\/p>\n<p>Xenoandrogenii sunt preparate mai bl\u00e2nde. \u00cen plus, ac\u021biunea lor nu este imediat\u0103.  Prima faz\u0103 p\u00e2n\u0103 la satura\u021bia complet\u0103 poate dura c\u00e2teva s\u0103pt\u0103m\u00e2ni. C\u00e2nd organismul este saturat, ac\u021biunile \u0219i efectele secundare \u00eencep s\u0103 se manifeste.<\/p>\n<p>Mul\u021bi sportivi compar\u0103 efectul xenoandrogenilor cu creatina: este necesar\u0103 o faz\u0103 de realimentare la \u00eenceput \u0219i o cur\u0103\u021bare dup\u0103 sf\u00e2r\u0219itul cursului. Aceasta este, de asemenea, principala diferen\u021b\u0103 cu AAS.<\/p>\n<p>&nbsp;<\/p>\n<p>Efectele \u0219i efectele secundare ale xenoandrogenilor<\/p>\n<p>Unele modific\u0103ri ale tocoferolului \u0219i nicotinamidei par s\u0103 prezinte ac\u021biuni similare cu cele ale AAS, inclusiv cre\u0219terea sintezei proteinelor \u00een fibrele musculare, sc\u0103derea proceselor catabolice (cel mai probabil prin ocuparea receptorilor de catecolamine) \u0219i cre\u0219terea sintezei proteinelor \u00een \u021besutul conjunctiv.<\/p>\n<p>Unii xenoandrogeni cauzeaz\u0103 probabil reten\u021bie de ap\u0103 \u0219i apari\u021bia acneei. Nu este clar dac\u0103 xenoandrogenii suprim\u0103 propria lor produc\u021bie de testosteron. P\u00e2n\u0103 \u00een prezent nu s-a observat a\u0219a ceva, dar studiile au fost efectuate numai pe sportivi profesioni\u0219ti cu un regim strict \u0219i cuno\u0219tin\u021be privind aportul adecvat (a\u0219a-numitele \u201ecicluri\u201d). Trebuie avut \u00een vedere faptul c\u0103 xenoandrogenii sunt cunoscu\u021bi de prea pu\u021bin timp \u0219i este imposibil s\u0103 se stabileasc\u0103 toate efectele secundare asupra celulelor \u0219i echilibrului hormonal. Posibilele modific\u0103ri negative ale colesterolului reprezint\u0103 o preocupare major\u0103 pentru medicii practicieni, de\u0219i acestea nu au fost observate p\u00e2n\u0103 \u00een prezent.<\/p>\n<p>&nbsp;<\/p>\n<p>Problem\u0103 etic\u0103<\/p>\n<p>Dincolo de problemele medicale, exist\u0103 \u0219i cele etice. Principalul motiv pentru interzicerea unui produs este avantajul nedrept pe care \u00eel ofer\u0103 sportivului. Sus\u021bin\u0103torii modific\u0103rilor de tocoferol \u0219i nicotinamid\u0103 subliniaz\u0103 faptul c\u0103 exist\u0103 \u0219i alte preparate, cum ar fi creatina, care au, de asemenea, un efect pozitiv asupra cre\u0219terii musculare, dar sunt considerate un supliment alimentar.<\/p>\n<p>Cu toate acestea, exist\u0103 o diferen\u021b\u0103 profund\u0103 \u00eentre creatin\u0103, proteine \u0219i suplimente similare, pe de o parte, \u0219i xenoandrogeni, pe de alt\u0103 parte. Primul grup este prezent \u00een mod natural \u00een alimentele noastre, \u00een timp ce nu putem g\u0103si versiuni modificate ale tocoferolului \u00een natur\u0103. Manipul\u0103rile moleculare dau o diferen\u021b\u0103 important\u0103 \u00een structura substan\u021bei originale. \u00cen acest caz, principala problem\u0103 este c\u0103 xenoandrogenii nu sunt clasifica\u021bi ca o clas\u0103 separat\u0103 de preparate. De\u0219i v\u00e2ndute legal ca tocoferol \u0219i nicotinamid\u0103, faptul este c\u0103 substan\u021bele originale nu ar produce niciodat\u0103 un rezultat similar asupra unui atlet.<\/p>\n<p>Trebuie remarcat faptul c\u0103, deoarece xenoandrogenii nu sunt interzi\u0219i, nu exist\u0103 niciun test antidoping stabilit pentru ace\u0219tia. \u00cen viitor, este de a\u0219teptat ca toate acestea s\u0103 fie clasificate \u0219i analizate, inclusiv de c\u0103tre Asocia\u021bia Interna\u021bional\u0103 Anti-Doping.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u0414\u043e \u0441\u043a\u043e\u0440\u043e \u043d\u0438\u043a\u043e\u0439 \u043d\u0435 \u0431\u0435\u0448\u0435 \u0447\u0443\u0432\u0430\u043b \u0437\u0430 \u043a\u0441\u0435\u043d\u043e\u0430\u043d\u0434\u0440\u043e\u0433\u0435\u043d\u0438\u0442\u0435. \u041c\u0430\u043b\u043a\u0438\u0442\u0435 \u0448\u0438\u0448\u0435\u043d\u0446\u0430 \u0441 \u0438\u043c\u0435\u043d\u0430 \u043d\u0430\u043f\u043e\u043c\u043d\u044f\u0449\u0438 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2900,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[15],"tags":[25,69],"class_list":["post-35","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-15","tag-25","tag-69"],"yoast_head":"<!-- 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