{"id":23962,"date":"2024-11-08T00:51:12","date_gmt":"2024-11-07T22:51:12","guid":{"rendered":"https:\/\/xenobg.com\/produkt\/pyruaceto-%d1%82%d0%b5%d1%87%d0%b5%d0%bd-%d0%bf%d0%b8%d1%80%d1%83%d0%b2%d0%b0%d1%82-%d0%b0%d1%86%d0%b5%d0%b0%d1%82%d0%be%d0%b0%d1%86%d0%b5%d1%82%d0%b0%d1%82-%d0%bc%d0%b8%d0%ba%d1%81\/"},"modified":"2026-01-05T23:31:28","modified_gmt":"2026-01-05T21:31:28","slug":"pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs","status":"publish","type":"product","link":"https:\/\/xenobg.com\/ro\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/","title":{"rendered":"Pyruaceto - amestec lichid de piruvat\/acetoacetat"},"content":{"rendered":"<p data-start=\"0\" data-end=\"64\">A\u043d\u0430\u043b\u043e\u0433 \u043d\u0430 <a href=\"https:\/\/xenobg.com\/pyrucet-idealabs\/\">Pyrucet<\/a>\u00a0 \u043d\u0430 Idealabs<\/p>\n<p data-start=\"0\" data-end=\"64\"><strong data-start=\"0\" data-end=\"64\">Pyruaceto \u2013 \u0415\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f\u0442 \u043a\u0430\u0442\u0430\u043b\u0438\u0437\u0430\u0442\u043e\u0440 \u0437\u0430 \u043e\u043f\u0442\u0438\u043c\u0430\u043b\u0435\u043d \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c<\/strong><\/p>\n<p data-start=\"66\" data-end=\"293\"><strong data-start=\"66\" data-end=\"91\">\u041e\u043f\u0438\u0441\u0430\u043d\u0438\u0435 \u043d\u0430 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0430:<\/strong> Pyruaceto \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430, \u0441\u044a\u0447\u0435\u0442\u0430\u0432\u0430\u0449\u0430 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u2013 \u0434\u0432\u0435 \u043c\u043e\u0449\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u043e\u0442\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430.<\/p>\n<p data-start=\"295\" data-end=\"332\"><strong data-start=\"295\" data-end=\"332\">\u041a\u043b\u044e\u0447\u043e\u0432\u0438 \u0441\u044a\u0441\u0442\u0430\u0432\u043a\u0438 \u0438 \u0442\u0435\u0445\u043d\u0438\u0442\u0435 \u043f\u043e\u043b\u0437\u0438:<\/strong><\/p>\n<ol data-start=\"334\" data-end=\"1046\">\n<li data-start=\"334\" data-end=\"699\">\n<p data-start=\"337\" data-end=\"353\"><strong data-start=\"337\" data-end=\"353\">\u0415\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442<\/strong><\/p>\n<ul data-start=\"357\" data-end=\"699\">\n<li data-start=\"357\" data-end=\"558\"><strong data-start=\"359\" data-end=\"395\">\u041f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c:<\/strong> \u0415\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442\u044a\u0442 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430 \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435\u0442\u043e \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430\u0442\u0430, \u043a\u0430\u0442\u043e \u043e\u0433\u0440\u0430\u043d\u0438\u0447\u0430\u0432\u0430 \u043f\u0440\u0435\u043a\u043e\u043c\u0435\u0440\u043d\u0430\u0442\u0430 \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435 \u043d\u0430 \u043c\u0430\u0441\u0442\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438, \u043a\u043e\u0435\u0442\u043e \u0432\u043e\u0434\u0438 \u0434\u043e \u043f\u043e-\u0435\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0441\u0442\u0432\u043e \u043d\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f.<\/li>\n<li data-start=\"562\" data-end=\"699\"><strong data-start=\"564\" data-end=\"592\">\u0410\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0438 \u0441\u0432\u043e\u0439\u0441\u0442\u0432\u0430:<\/strong> \u0422\u043e\u0439 \u043f\u0440\u0438\u0442\u0435\u0436\u0430\u0432\u0430 \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438, \u043a\u043e\u0438\u0442\u043e \u043c\u043e\u0433\u0430\u0442 \u0434\u0430 \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u044f\u0442 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u043e\u0442 \u043e\u043a\u0441\u0438\u0434\u0430\u0442\u0438\u0432\u0435\u043d \u0441\u0442\u0440\u0435\u0441 \u0438 \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u044f.<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"701\" data-end=\"1046\">\n<p data-start=\"704\" data-end=\"724\"><strong data-start=\"704\" data-end=\"724\">\u0415\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442<\/strong><\/p>\n<ul data-start=\"728\" data-end=\"1046\">\n<li data-start=\"728\" data-end=\"902\"><strong data-start=\"730\" data-end=\"758\">\u041a\u0435\u0442\u043e\u043d\u043d\u043e \u0442\u044f\u043b\u043e \u0437\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f:<\/strong> \u0415\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442\u044a\u0442 \u0435 \u043a\u0435\u0442\u043e\u043d\u043d\u043e \u0442\u044f\u043b\u043e, \u043a\u043e\u0435\u0442\u043e \u0441\u043b\u0443\u0436\u0438 \u043a\u0430\u0442\u043e \u0430\u043b\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u0435\u043d \u0438\u0437\u0442\u043e\u0447\u043d\u0438\u043a \u043d\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f \u0437\u0430 \u043c\u043e\u0437\u044a\u043a\u0430 \u0438 \u043c\u0443\u0441\u043a\u0443\u043b\u0438\u0442\u0435, \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043f\u0440\u0438 \u043d\u0438\u0441\u043a\u0438 \u043d\u0438\u0432\u0430 \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430.<\/li>\n<li data-start=\"906\" data-end=\"1046\"><strong data-start=\"908\" data-end=\"943\">\u041f\u043e\u0434\u0434\u044a\u0440\u0436\u0430 \u0447\u0435\u0440\u043d\u043e\u0434\u0440\u043e\u0431\u043d\u0430\u0442\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f:<\/strong> \u0422\u043e\u0439 \u0438\u0433\u0440\u0430\u0435 \u0440\u043e\u043b\u044f \u0432 \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u0430 \u0447\u0435\u0440\u043d\u043e\u0434\u0440\u043e\u0431\u043d\u0430 \u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u043d\u0430 \u043c\u0430\u0441\u0442\u043d\u0438\u0442\u0435 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p data-start=\"1048\" data-end=\"1079\"><strong data-start=\"1048\" data-end=\"1079\">\u0417\u0430\u0449\u043e \u0434\u0430 \u0438\u0437\u0431\u0435\u0440\u0435\u0442\u0435 Pyruaceto?<\/strong><\/p>\n<ul data-start=\"1080\" data-end=\"1469\">\n<li data-start=\"1080\" data-end=\"1205\"><strong data-start=\"1082\" data-end=\"1102\">\u0415\u043d\u0435\u0440\u0433\u0438\u0435\u043d \u0431\u0443\u0441\u0442\u0435\u0440:<\/strong> \u041f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0441\u0442\u0432\u043e\u0442\u043e \u043d\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f \u043d\u0430 \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u043e \u043d\u0438\u0432\u043e, \u043a\u043e\u0435\u0442\u043e \u0432\u043e\u0434\u0438 \u0434\u043e \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430 \u0438\u0437\u0434\u0440\u044a\u0436\u043b\u0438\u0432\u043e\u0441\u0442 \u0438 \u0436\u0438\u0437\u043d\u0435\u043d\u043e\u0441\u0442.<\/li>\n<li data-start=\"1206\" data-end=\"1356\"><strong data-start=\"1208\" data-end=\"1233\">\u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0430 \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0430:<\/strong> \u041d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430\u0442\u0430 \u0438 \u043c\u0430\u0441\u0442\u043d\u0438\u0442\u0435 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438, \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0439\u043a\u0438 \u043e\u043f\u0442\u0438\u043c\u0430\u043b\u043d\u043e\u0442\u043e \u0442\u0435\u043b\u0435\u0441\u043d\u043e \u0442\u0435\u0433\u043b\u043e \u0438 \u043a\u043e\u043c\u043f\u043e\u0437\u0438\u0446\u0438\u044f.<\/li>\n<li data-start=\"1357\" data-end=\"1469\"><strong data-start=\"1359\" data-end=\"1385\">\u0410\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0430 \u0437\u0430\u0449\u0438\u0442\u0430:<\/strong> \u041f\u0440\u0435\u0434\u043f\u0430\u0437\u0432\u0430 \u043a\u043b\u0435\u0442\u043a\u0438\u0442\u0435 \u043e\u0442 \u043e\u043a\u0441\u0438\u0434\u0430\u0442\u0438\u0432\u0435\u043d \u0441\u0442\u0440\u0435\u0441, \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u0439\u043a\u0438 \u0440\u0438\u0441\u043a\u0430 \u043e\u0442 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f.<\/li>\n<li data-start=\"1357\" data-end=\"1469\">\n<h1 dir=\"ltr\" data-pm-slice=\"1 1 []\">\u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e &#8211; \u0422\u0435\u0447\u043d\u0430 \u0421\u043c\u0435\u0441 \u043e\u0442 \u0415\u0442\u0438\u043b \u041f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0415\u0442\u0438\u043b \u0410\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442<\/h1>\n<h2 dir=\"ltr\">\u041f\u0440\u0435\u0433\u043b\u0435\u0434 \u043d\u0430 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0430<\/h2>\n<p dir=\"ltr\">\u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0435 \u0440\u0435\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430, \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0430 \u0434\u0430 \u043e\u043f\u0442\u0438\u043c\u0438\u0437\u0438\u0440\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u0434\u0430 \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430 \u0446\u044f\u043b\u043e\u0441\u0442\u043d\u043e\u0442\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u0447\u0440\u0435\u0437 \u0443\u043d\u0438\u043a\u0430\u043b\u043d\u0430 \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u043e\u0442 <strong>\u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442<\/strong> \u0438 <strong>\u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442<\/strong> \u2013 \u0434\u0432\u0430 \u043c\u043e\u0449\u043d\u0438 \u0435\u0441\u0442\u0435\u0440\u0430 \u043d\u0430 \u0435\u043d\u0434\u043e\u0433\u0435\u043d\u043d\u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0438, \u043a\u043e\u0438\u0442\u043e \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u0442 \u043a\u043b\u044e\u0447\u043e\u0432\u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0438 \u043f\u044a\u0442\u0438\u0449\u0430. \u0412\u0434\u044a\u0445\u043d\u043e\u0432\u0435\u043d \u043e\u0442 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f\u0442\u0430 \u043d\u0430 \u0434-\u0440 \u0420\u0435\u0439 \u041f\u0438\u044a\u0442 \u0438 \u0441\u044a\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0438\u0442\u0435 \u043f\u0440\u043e\u0437\u0440\u0435\u043d\u0438\u044f \u0437\u0430 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0430\u0442\u0430 \u0442\u0435\u043e\u0440\u0438\u044f \u043d\u0430 \u0437\u0434\u0440\u0430\u0432\u0435\u0442\u043e, \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0441\u0435 \u0444\u043e\u043a\u0443\u0441\u0438\u0440\u0430 \u0432\u044a\u0440\u0445\u0443 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u043d\u043e\u0442\u043e \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435 \u0438 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0438\u0437\u043b\u0438\u0448\u043d\u043e\u0442\u043e \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435 \u043d\u0430 \u043c\u0430\u0441\u0442\u043d\u0438 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0438 (FAO), \u043a\u043e\u0435\u0442\u043e \u0435 \u0441\u0432\u044a\u0440\u0437\u0430\u043d\u043e \u0441 \u0440\u0435\u0434\u0438\u0446\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u044f, \u0432\u043a\u043b\u044e\u0447\u0438\u0442\u0435\u043b\u043d\u043e \u0434\u0438\u0430\u0431\u0435\u0442, \u0440\u0430\u043a \u0438 \u043d\u0435\u0432\u0440\u043e\u0434\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f. \u0422\u0430\u0437\u0438 \u0444\u043e\u0440\u043c\u0443\u043b\u0430 \u0435 \u0438\u0434\u0435\u0430\u043b\u043d\u0430 \u0437\u0430 \u0445\u043e\u0440\u0430, \u043a\u043e\u0438\u0442\u043e \u0438\u0441\u043a\u0430\u0442 \u0434\u0430 \u043f\u043e\u0434\u043e\u0431\u0440\u044f\u0442 \u0443\u043c\u0441\u0442\u0432\u0435\u043d\u0430\u0442\u0430 \u044f\u0441\u043d\u043e\u0442\u0430, \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0430\u0442\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f \u0438 \u0443\u0441\u0442\u043e\u0439\u0447\u0438\u0432\u043e\u0441\u0442\u0442\u0430 \u043a\u044a\u043c \u0441\u0442\u0440\u0435\u0441, \u043a\u0430\u0442\u043e \u0441\u044a\u0449\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u044f\u0442 \u0437\u0434\u0440\u0430\u0432\u0435\u0442\u043e \u043d\u0430 \u0441\u044a\u0440\u0446\u0435\u0442\u043e, \u0447\u0435\u0440\u043d\u0438\u044f \u0434\u0440\u043e\u0431 \u0438 \u043c\u043e\u0437\u044a\u043a\u0430.<\/p>\n<p dir=\"ltr\">\u0412\u0441\u044f\u043a\u0430 \u0434\u043e\u0437\u0430 \u043e\u0442 \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0434\u043e\u0441\u0442\u0430\u0432\u044f <strong>500 \u043c\u0433 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442<\/strong> \u0438 <strong>500 \u043c\u0433 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442<\/strong> \u0432 \u0441\u0442\u0430\u0431\u0438\u043b\u043d\u0430, \u043b\u0438\u043f\u043e\u0444\u0438\u043b\u043d\u0430 \u0444\u043e\u0440\u043c\u0430, \u043a\u043e\u044f\u0442\u043e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0432\u0430 \u0434\u043e 100 \u043f\u044a\u0442\u0438 \u043f\u043e-\u0433\u043e\u043b\u044f\u043c\u0430 \u0435\u0444\u0438\u043a\u0430\u0441\u043d\u043e\u0441\u0442 \u0432 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0435 \u0441 \u043e\u0431\u0438\u043a\u043d\u043e\u0432\u0435\u043d\u0438\u044f \u043f\u0438\u0440\u0443\u0432\u0430\u0442, \u0431\u043b\u0430\u0433\u043e\u0434\u0430\u0440\u0435\u043d\u0438\u0435 \u043d\u0430 \u043f\u043e\u0434\u043e\u0431\u0440\u0435\u043d\u043e\u0442\u043e \u0443\u0441\u0432\u043e\u044f\u0432\u0430\u043d\u0435. \u041e\u043f\u0430\u043a\u043e\u0432\u0430\u043d \u0432 \u0443\u0434\u043e\u0431\u043d\u0430 \u0431\u0443\u0442\u0438\u043b\u043a\u0430 \u0441 \u043a\u0430\u043f\u043a\u043e\u043c\u0435\u0440, \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u044a\u0442 \u043e\u0441\u0438\u0433\u0443\u0440\u044f\u0432\u0430 \u043e\u043a\u043e\u043b\u043e 30 \u0434\u043e\u0437\u0438, \u043a\u0430\u0442\u043e \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u0430\u0442\u0430 \u0434\u043e\u0437\u0430 \u0435 20 \u043a\u0430\u043f\u043a\u0438. \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0435 \u043f\u0440\u0435\u0434\u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d \u0437\u0430 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u043d\u0430 \u0438\u043b\u0438 \u043b\u043e\u043a\u0430\u043b\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430, \u043a\u0430\u0442\u043e \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0438\u0442\u0435 \u043c\u043e\u0433\u0430\u0442 \u0434\u0430 \u0433\u043e \u043f\u0440\u0438\u0435\u043c\u0430\u0442 \u0441 \u0432\u043e\u0434\u0430, \u0441\u043e\u043a \u0438\u043b\u0438 \u0434\u0430 \u0433\u043e \u043d\u0430\u043d\u0430\u0441\u044f\u0442 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0436\u0430\u0442\u0430 \u0437\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u0438 \u0435\u0444\u0435\u043a\u0442\u0438. \u041d\u0435\u0433\u043e\u0432\u0438\u044f\u0442 \u043b\u0435\u043a\u043e \u043f\u043b\u043e\u0434\u043e\u0432 \u0430\u0440\u043e\u043c\u0430\u0442 \u0438 \u043b\u0435\u0441\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0433\u043e \u043f\u0440\u0430\u0432\u044f\u0442 \u0438\u0434\u0435\u0430\u043b\u0435\u043d \u0437\u0430 \u0435\u0436\u0435\u0434\u043d\u0435\u0432\u043d\u0430 \u0438\u043d\u0442\u0435\u0433\u0440\u0430\u0446\u0438\u044f \u0432 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u0438 \u0440\u0443\u0442\u0438\u043d\u0438.<\/p>\n<h2 dir=\"ltr\">\u041e\u0441\u043d\u043e\u0432\u043d\u0438 \u043f\u043e\u043b\u0437\u0438<\/h2>\n<p dir=\"ltr\">\u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0435 \u0444\u043e\u0440\u043c\u0443\u043b\u0438\u0440\u0430\u043d \u0434\u0430 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430 \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0434\u0435\u0445\u0438\u0434\u0440\u043e\u0433\u0435\u043d\u0430\u0437\u0430\u0442\u0430 (PDH), \u043a\u043b\u044e\u0447\u043e\u0432 \u0435\u043d\u0437\u0438\u043c \u0437\u0430 \u043f\u0440\u0435\u0432\u0440\u044a\u0449\u0430\u043d\u0435\u0442\u043e \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430\u0442\u0430 \u0432 \u0435\u043d\u0435\u0440\u0433\u0438\u044f, \u043a\u0430\u0442\u043e \u0441\u044a\u0449\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u043f\u043e\u0442\u0438\u0441\u043a\u0430 \u0438\u0437\u043b\u0438\u0448\u043d\u043e\u0442\u043e \u0438\u0437\u0433\u0430\u0440\u044f\u043d\u0435 \u043d\u0430 \u043c\u0430\u0437\u043d\u0438\u043d\u0438, \u043a\u043e\u0435\u0442\u043e \u043c\u043e\u0436\u0435 \u0434\u0430 \u0434\u043e\u0432\u0435\u0434\u0435 \u0434\u043e \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u0435\u043d \u0441\u0442\u0440\u0435\u0441. \u041e\u0441\u043d\u043e\u0432\u043d\u0438\u0442\u0435 \u043f\u043e\u043b\u0437\u0438, \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0435\u043d\u0438 \u043e\u0442 \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0441\u043a\u0438 \u043e\u0442\u0437\u0438\u0432\u0438 \u0438 \u043d\u0430\u0443\u0447\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f, \u0432\u043a\u043b\u044e\u0447\u0432\u0430\u0442:<\/p>\n<ul class=\"tight\" dir=\"ltr\" data-tight=\"true\">\n<li>\n<p dir=\"ltr\"><strong>\u041f\u043e\u0434\u043e\u0431\u0440\u0435\u043d \u0435\u043d\u0435\u0440\u0433\u0438\u0435\u043d \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c<\/strong>: \u0415\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442\u044a\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442\u044a\u0442 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0433\u043b\u044e\u043a\u043e\u0437\u043d\u043e\u0442\u043e \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435, \u043a\u043e\u0435\u0442\u043e \u0432\u043e\u0434\u0438 \u0434\u043e \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f \u0438 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0443\u043c\u043e\u0440\u0430\u0442\u0430. \u041f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0438 \u0441\u044a\u043e\u0431\u0449\u0430\u0432\u0430\u0442 \u0437\u0430 \u0443\u0441\u0435\u0449\u0430\u043d\u0435 \u0437\u0430 \u201e\u043b\u0435\u043a\u043e\u0442\u0430 \u0438 \u043f\u044a\u0440\u0433\u0430\u0432\u0438\u043d\u0430\u201c \u0438 \u043f\u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0430 \u0438\u0437\u0434\u0440\u044a\u0436\u043b\u0438\u0432\u043e\u0441\u0442 \u043f\u0440\u0438 \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0438 \u0443\u043f\u0440\u0430\u0436\u043d\u0435\u043d\u0438\u044f, \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043f\u043e\u0440\u0430\u0434\u0438 \u043d\u0430\u043c\u0430\u043b\u0435\u043d\u043e\u0442\u043e \u043d\u0430\u0442\u0440\u0443\u043f\u0432\u0430\u043d\u0435 \u043d\u0430 \u043c\u043b\u0435\u0447\u043d\u0430 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0430.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u041a\u043e\u0433\u043d\u0438\u0442\u0438\u0432\u043d\u0430 \u044f\u0441\u043d\u043e\u0442\u0430 \u0438 \u0444\u043e\u043a\u0443\u0441<\/strong>: \u041c\u043d\u043e\u0437\u0438\u043d\u0430 \u043e\u0442\u0431\u0435\u043b\u044f\u0437\u0432\u0430\u0442 \u043f\u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0430 \u0443\u043c\u0441\u0442\u0432\u0435\u043d\u0430 \u044f\u0441\u043d\u043e\u0442\u0430, \u043d\u0430\u043c\u0430\u043b\u0435\u043d\u0430 \u043c\u043e\u0437\u044a\u0447\u043d\u0430 \u043c\u044a\u0433\u043b\u0430 \u0438 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442 \u0437\u0430 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f, \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043f\u0440\u0438 \u0445\u043e\u0440\u0430 \u0441 ADD \u0438\u043b\u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0430 \u0443\u043c\u043e\u0440\u0430. \u0415\u0434\u0438\u043d \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b \u043e\u043f\u0438\u0441\u0432\u0430 \u201e\u043e\u0441\u0432\u0435\u0442\u043b\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0441\u044a\u0437\u043d\u0430\u043d\u0438\u0435\u0442\u043e\u201c \u0438 \u201e\u0441\u043f\u043e\u043a\u043e\u0439\u0441\u0442\u0432\u0438\u0435\u201c, \u043f\u043e\u0434\u043e\u0431\u043d\u043e \u043d\u0430 \u0435\u0444\u0435\u043a\u0442\u0430 \u043d\u0430 GABA-\u0430\u0433\u043e\u043d\u0438\u0441\u0442\u0438, \u0441\u043b\u0435\u0434 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u0435\u043d \u043f\u0440\u0438\u0435\u043c.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u0410\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0430 \u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0430 \u0437\u0430\u0449\u0438\u0442\u0430<\/strong>: \u0415\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442\u044a\u0442 \u043f\u0440\u043e\u044f\u0432\u044f\u0432\u0430 \u043c\u043e\u0449\u043d\u0438 \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0438 \u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0438 \u0441\u0432\u043e\u0439\u0441\u0442\u0432\u0430, \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u0432\u0430\u0439\u043a\u0438 \u043c\u043e\u0437\u044a\u043a\u0430, \u0441\u044a\u0440\u0446\u0435\u0442\u043e \u0438 \u0447\u0435\u0440\u043d\u0438\u044f \u0434\u0440\u043e\u0431 \u043e\u0442 \u043e\u043a\u0441\u0438\u0434\u0430\u0442\u0438\u0432\u0435\u043d \u0441\u0442\u0440\u0435\u0441 \u0438 \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435. \u0418\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u043f\u043e\u043a\u0430\u0437\u0432\u0430\u0442, \u0447\u0435 \u0442\u043e\u0439 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430 \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u0441\u0442\u0432\u043e\u0442\u043e \u043d\u0430 \u043d\u0438\u0442\u0440\u0438\u0447\u0435\u043d \u043e\u043a\u0441\u0438\u0434 \u0438 \u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0438 \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u0438 \u043a\u0430\u0442\u043e TNF-\u03b1, \u043a\u043e\u0435\u0442\u043e \u0433\u043e \u043f\u0440\u0430\u0432\u0438 \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b\u043d\u043e \u043f\u043e\u043b\u0435\u0437\u0435\u043d \u043f\u0440\u0438 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u044f \u043a\u0430\u0442\u043e \u0441\u0435\u043f\u0441\u0438\u0441 \u0438 COVID-19.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u041f\u043e\u0434\u043a\u0440\u0435\u043f\u0430 \u0437\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u044f<\/strong>: \u041f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0438 \u0441 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0430 \u0443\u043c\u043e\u0440\u0430 (CFS), \u043f\u043e\u0441\u0442\u0443\u0440\u0430\u043b\u043d\u0430 \u0442\u0430\u0445\u0438\u043a\u0430\u0440\u0434\u0438\u044f (POTS) \u0438\u043b\u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f \u0441\u044a\u043e\u0431\u0449\u0430\u0432\u0430\u0442 \u0437\u0430 \u043e\u0431\u043b\u0435\u043a\u0447\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0438 \u043a\u0430\u0442\u043e \u0441\u044a\u0440\u0446\u0435\u0431\u0438\u0435\u043d\u0435 \u0441\u043b\u0435\u0434 \u043f\u0440\u0438\u0435\u043c \u043d\u0430 \u0432\u044a\u0433\u043b\u0435\u0445\u0438\u0434\u0440\u0430\u0442\u0438 \u0438 \u043c\u0443\u0441\u043a\u0443\u043b\u043d\u0430 \u0431\u043e\u043b\u043a\u0430. \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u043e\u043c\u043e\u0433\u043d\u0435 \u0437\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043a\u0440\u044a\u0432\u043d\u0430\u0442\u0430 \u0437\u0430\u0445\u0430\u0440, \u043a\u0430\u0442\u043e \u0435\u0434\u0438\u043d \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b \u043e\u0442\u0431\u0435\u043b\u044f\u0437\u0432\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u043d\u0438 \u043d\u0438\u0432\u0430 \u043f\u043e\u0434 110 mg\/dL \u0441\u043b\u0435\u0434 \u043a\u043e\u043d\u0441\u0443\u043c\u0430\u0446\u0438\u044f \u043d\u0430 \u043f\u043b\u043e\u0434\u043e\u0432\u0435.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u041f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0441\u043f\u043e\u0440\u0442\u043d\u0438\u0442\u0435 \u043f\u043e\u0441\u0442\u0438\u0436\u0435\u043d\u0438\u044f<\/strong>: \u0410\u043b\u043f\u0438\u043d\u0438\u0441\u0442\u0438 \u0438 \u0430\u0442\u043b\u0435\u0442\u0438, \u0442\u0440\u0435\u043d\u0438\u0440\u0430\u0449\u0438 \u0432 \u0435\u043a\u0441\u0442\u0440\u0435\u043c\u043d\u0438 \u0443\u0441\u043b\u043e\u0432\u0438\u044f, \u043e\u0442\u0431\u0435\u043b\u044f\u0437\u0432\u0430\u0442 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430 \u0438\u0437\u0434\u0440\u044a\u0436\u043b\u0438\u0432\u043e\u0441\u0442 \u0438 \u043d\u0430\u043c\u0430\u043b\u0435\u043d\u0430 \u043c\u0443\u0441\u043a\u0443\u043b\u043d\u0430 \u0443\u043c\u043e\u0440\u0430 \u043f\u0440\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u043d\u0430 \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e, \u043a\u043e\u0435\u0442\u043e \u0433\u043e \u043f\u0440\u0430\u0432\u0438 \u0446\u0435\u043d\u0435\u043d \u0437\u0430 \u0441\u043f\u043e\u0440\u0442\u0438\u0441\u0442\u0438, \u0442\u044a\u0440\u0441\u0435\u0449\u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0430 \u043e\u043f\u0442\u0438\u043c\u0438\u0437\u0430\u0446\u0438\u044f.<\/p>\n<\/li>\n<\/ul>\n<h2 dir=\"ltr\">\u041a\u0430\u043a \u0434\u0430 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430\u0442\u0435 \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e<\/h2>\n<p dir=\"ltr\">\u0413\u044a\u0432\u043a\u0430\u0432\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u043f\u043e\u0437\u0432\u043e\u043b\u044f\u0432\u0430 \u043f\u0435\u0440\u0441\u043e\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u0430\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u0432 \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442 \u043e\u0442 \u0446\u0435\u043b\u0438\u0442\u0435 \u043d\u0430 \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u044f. \u0415\u0442\u043e \u043d\u0430\u0439-\u0447\u0435\u0441\u0442\u043e \u0441\u0440\u0435\u0449\u0430\u043d\u0438\u0442\u0435 \u043c\u0435\u0442\u043e\u0434\u0438, \u0438\u0437\u0432\u043b\u0435\u0447\u0435\u043d\u0438 \u043e\u0442 \u043e\u0431\u0440\u0430\u0442\u043d\u0430 \u0432\u0440\u044a\u0437\u043a\u0430 \u043e\u0442 \u043e\u0431\u0449\u043d\u043e\u0441\u0442\u0442\u0430:<\/p>\n<ul class=\"tight\" dir=\"ltr\" data-tight=\"true\">\n<li>\n<p dir=\"ltr\"><strong>\u041f\u0435\u0440\u043e\u0440\u0430\u043b\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430<\/strong>: \u0421\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u0430\u0442\u0430 \u0434\u043e\u0437\u0430 \u0435 20 \u043a\u0430\u043f\u043a\u0438, \u0441\u043c\u0435\u0441\u0435\u043d\u0438 \u0441 \u0432\u043e\u0434\u0430, \u0441\u043e\u043a \u0438\u043b\u0438 \u0437\u0430\u0445\u0430\u0440, \u0437\u0430 \u0434\u0430 \u0441\u0435 \u043d\u0430\u043c\u0430\u043b\u0438 \u043b\u0435\u043a\u0438\u044f\u0442 \u0438\u0437\u0433\u0430\u0440\u044f\u0449 \u0432\u043a\u0443\u0441, \u043d\u0430\u043f\u043e\u0434\u043e\u0431\u044f\u0432\u0430\u0449 \u0441\u0438\u043b\u0435\u043d \u0430\u043b\u043a\u043e\u0445\u043e\u043b. \u041f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0438\u0442\u0435 \u043f\u0440\u0435\u043f\u043e\u0440\u044a\u0447\u0432\u0430\u0442 \u043f\u0440\u0438\u0435\u043c \u0441\u043b\u0435\u0434 \u0445\u0440\u0430\u043d\u0435\u043d\u0435, \u0437\u0430 \u0434\u0430 \u0441\u0435 \u0438\u0437\u0431\u0435\u0433\u043d\u0435 \u043f\u043e\u0432\u0438\u0448\u0435\u043d\u0430 \u043d\u0443\u0436\u0434\u0430 \u043e\u0442 \u0432\u044a\u0433\u043b\u0435\u0445\u0438\u0434\u0440\u0430\u0442\u0438, \u0442\u044a\u0439 \u043a\u0430\u0442\u043e \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0443\u0432\u0435\u043b\u0438\u0447\u0430\u0432\u0430 \u0442\u044a\u0440\u0441\u0435\u043d\u0435\u0442\u043e \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430. \u0417\u0430 \u043d\u0430\u0447\u0438\u043d\u0430\u0435\u0449\u0438 5\u201310 \u043a\u0430\u043f\u043a\u0438 \u0434\u043d\u0435\u0432\u043d\u043e \u0441\u0430 \u043f\u043e\u0434\u0445\u043e\u0434\u044f\u0449\u0438 \u0437\u0430 \u043e\u0446\u0435\u043d\u043a\u0430 \u043d\u0430 \u043f\u043e\u043d\u043e\u0441\u0438\u043c\u043e\u0441\u0442\u0442\u0430.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u041b\u043e\u043a\u0430\u043b\u043d\u043e \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u0435<\/strong>: \u041d\u0430\u043d\u0435\u0441\u0435\u0442\u0435 10\u201320 \u043a\u0430\u043f\u043a\u0438 \u0432\u044a\u0440\u0445\u0443 \u043a\u043e\u0436\u0430\u0442\u0430 (\u043d\u0430\u043f\u0440. \u043a\u043e\u0440\u0435\u043c, \u043a\u0438\u0442\u043a\u0438 \u0438\u043b\u0438 \u0431\u0435\u0434\u0440\u0430) \u0437\u0430 \u043f\u043e-\u0431\u0430\u0432\u043d\u043e, \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u043e \u0443\u0441\u0432\u043e\u044f\u0432\u0430\u043d\u0435. \u0415\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442\u044a\u0442 \u043f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430 \u043f\u0440\u043e\u043d\u0438\u043a\u0432\u0430\u043d\u0435\u0442\u043e \u043f\u0440\u0435\u0437 \u043a\u043e\u0436\u0430\u0442\u0430, \u043a\u0430\u0442\u043e \u0435\u0444\u0435\u043a\u0442\u0438\u0442\u0435 \u0441\u0435 \u043f\u0440\u043e\u044f\u0432\u044f\u0432\u0430\u0442 \u0441\u043b\u0435\u0434 \u043e\u043a\u043e\u043b\u043e 30 \u043c\u0438\u043d\u0443\u0442\u0438. \u0422\u043e\u0432\u0430 \u0435 \u043f\u0440\u0435\u0434\u043f\u043e\u0447\u0438\u0442\u0430\u043d \u043c\u0435\u0442\u043e\u0434 \u0437\u0430 \u0442\u0435\u0437\u0438, \u043a\u043e\u0438\u0442\u043e \u0438\u0437\u043f\u0438\u0442\u0432\u0430\u0442 \u0441\u0442\u043e\u043c\u0430\u0448\u043d\u043e \u0440\u0430\u0437\u0434\u0440\u0430\u0437\u043d\u0435\u043d\u0438\u0435 \u043e\u0442 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u0435\u043d \u043f\u0440\u0438\u0435\u043c.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u041a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u044f \u0441 \u0434\u0440\u0443\u0433\u0438 \u0434\u043e\u0431\u0430\u0432\u043a\u0438<\/strong>: \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0441\u0435 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u0430 \u0434\u043e\u0431\u0440\u0435 \u0441 \u043d\u0438\u0430\u0446\u0438\u043d\u0430\u043c\u0438\u0434, \u0442\u0438\u0430\u043c\u0438\u043d \u0438\u043b\u0438 \u0430\u0441\u043f\u0438\u0440\u0438\u043d \u0437\u0430 \u0443\u0441\u0438\u043b\u0432\u0430\u043d\u0435 \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u043d\u043e\u0442\u043e \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435 \u0438 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435\u0442\u043e. \u041f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0438 \u0441 CFS\/POTS \u0441\u044a\u043e\u0431\u0449\u0430\u0432\u0430\u0442 \u0437\u0430 \u0441\u0438\u043d\u0435\u0440\u0433\u0438\u044f \u0441 \u043c\u0435\u0442\u0438\u043b\u0435\u043d\u043e\u0432\u043e \u0441\u0438\u043d\u044c\u043e \u0438 \u0442\u0438\u0430\u043c\u0438\u043d \u0437\u0430 \u043f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f\u0442\u0430 \u0438 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u043c\u043b\u0435\u0447\u043d\u0430\u0442\u0430 \u043a\u0438\u0441\u0435\u043b\u0438\u043d\u0430.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u0414\u043e\u0437\u0438 \u0437\u0430 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u0438 \u0446\u0435\u043b\u0438<\/strong>: \u0417\u0430 \u0441\u043f\u043e\u0440\u0442\u0438\u0441\u0442\u0438 \u0438\u043b\u0438 \u0445\u043e\u0440\u0430 \u0441 \u0432\u0438\u0441\u043e\u043a\u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0438 \u0438\u0437\u0438\u0441\u043a\u0432\u0430\u043d\u0438\u044f \u0434\u043e\u0437\u0430\u0442\u0430 \u043c\u043e\u0436\u0435 \u0434\u0430 \u0441\u0435 \u0443\u0432\u0435\u043b\u0438\u0447\u0438 \u0434\u043e 20 \u043a\u0430\u043f\u043a\u0438 2\u20133 \u043f\u044a\u0442\u0438 \u0434\u043d\u0435\u0432\u043d\u043e, \u043d\u043e \u0441\u0430\u043c\u043e \u0441\u043b\u0435\u0434 \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0430\u0446\u0438\u044f \u0441 \u043b\u0435\u043a\u0430\u0440. \u0417\u0430 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043a\u0440\u044a\u0432\u043d\u0430\u0442\u0430 \u0437\u0430\u0445\u0430\u0440 \u043c\u0430\u043b\u043a\u0438 \u0434\u043e\u0437\u0438 (5 \u043a\u0430\u043f\u043a\u0438) \u0441\u0443\u0442\u0440\u0438\u043d \u0441\u0430 \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u0438 \u0435\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442.<\/p>\n<\/li>\n<\/ul>\n<p dir=\"ltr\"><strong>\u0417\u0430\u0431\u0435\u043b\u0435\u0436\u043a\u0430<\/strong>: \u041a\u043e\u043d\u0441\u0443\u043b\u0442\u0438\u0440\u0430\u0439\u0442\u0435 \u0441\u0435 \u0441 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442 \u043f\u0440\u0435\u0434\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430, \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043f\u0440\u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f, \u0434\u0438\u0430\u0431\u0435\u0442 \u0438\u043b\u0438 \u043f\u0440\u0438\u0435\u043c \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430 \u043a\u0430\u0442\u043e \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u043e\u0432\u043b\u0438\u044f\u0435 \u043d\u0430 \u0433\u043b\u0443\u0442\u0430\u0442\u0438\u043e\u043d\u043e\u0432\u0438\u0442\u0435 \u043d\u0438\u0432\u0430, \u043a\u043e\u0435\u0442\u043e \u0438\u0437\u0438\u0441\u043a\u0432\u0430 \u0432\u043d\u0438\u043c\u0430\u0442\u0435\u043b\u043d\u043e \u0434\u043e\u0437\u0438\u0440\u0430\u043d\u0435 \u043f\u0440\u0438 \u043d\u0435\u0440\u0430\u043a\u043e\u0432\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438.<\/p>\n<h2 dir=\"ltr\">\u041f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0441\u043a\u0438 \u043e\u043f\u0438\u0442<\/h2>\n<p dir=\"ltr\">\u041e\u0431\u0449\u043d\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0441\u043f\u043e\u0434\u0435\u043b\u044f \u0435\u043d\u0442\u0443\u0441\u0438\u0430\u0437\u0438\u0440\u0430\u043d\u0438 \u043e\u0442\u0437\u0438\u0432\u0438, \u043f\u043e\u0434\u0447\u0435\u0440\u0442\u0430\u0432\u0430\u0449\u0438 \u043d\u0435\u0433\u043e\u0432\u0438\u0442\u0435 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0438 \u0438 \u043a\u043e\u0433\u043d\u0438\u0442\u0438\u0432\u043d\u0438 \u043f\u043e\u043b\u0437\u0438, \u043a\u0430\u043a\u0442\u043e \u0438 \u043d\u044f\u043a\u043e\u0438 \u043f\u0440\u0435\u0434\u0438\u0437\u0432\u0438\u043a\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430:<\/p>\n<ul class=\"tight\" dir=\"ltr\" data-tight=\"true\">\n<li>\n<p dir=\"ltr\"><strong>\u0415\u043d\u0435\u0440\u0433\u0438\u044f \u0438 \u0438\u0437\u0434\u0440\u044a\u0436\u043b\u0438\u0432\u043e\u0441\u0442<\/strong>: \u041f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b \u043d\u0430 62 \u0433\u043e\u0434\u0438\u043d\u0438 \u0441\u044a\u043e\u0431\u0449\u0430\u0432\u0430 \u0437\u0430 \u201e\u0443\u0434\u0432\u043e\u044f\u0432\u0430\u043d\u0435, \u0434\u043e\u0440\u0438 \u0443\u0442\u0440\u043e\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u044f\u0442\u0430\u201c \u0438 \u043f\u043e\u0434\u043e\u0431\u0440\u0435\u043d \u0444\u043e\u043a\u0443\u0441 \u0441\u043b\u0435\u0434 20 \u043a\u0430\u043f\u043a\u0438 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u043d\u043e, \u043a\u0430\u0442\u043e \u043e\u0442\u0431\u0435\u043b\u044f\u0437\u0432\u0430 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0441\u0442 \u043e\u0442 \u0437\u0430\u043a\u0443\u0441\u043a\u0438 \u0437\u0430 \u043f\u043e\u0434\u0434\u044a\u0440\u0436\u0430\u043d\u0435 \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430\u0442\u0430. \u0414\u0440\u0443\u0433 \u043e\u043f\u0438\u0441\u0432\u0430 \u043d\u0430\u043c\u0430\u043b\u0435\u043d\u0430 \u0443\u043c\u043e\u0440\u0430 \u043f\u043e \u0432\u0440\u0435\u043c\u0435 \u043d\u0430 \u0442\u0440\u0435\u043d\u0438\u0440\u043e\u0432\u043a\u0438 \u0438 \u201e\u0443\u0441\u0435\u0449\u0430\u043d\u0435 \u0437\u0430 \u043b\u0435\u043a\u043e\u0442\u0430\u201c.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u041a\u043e\u0433\u043d\u0438\u0442\u0438\u0432\u043d\u0438 \u043f\u043e\u043b\u0437\u0438<\/strong>: \u041f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b \u0441 ADD \u043e\u0442\u0431\u0435\u043b\u044f\u0437\u0432\u0430 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u043d\u043e \u043f\u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438\u0435 \u0432 \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f\u0442\u0430 \u0438 \u043d\u0430\u043c\u0430\u043b\u0435\u043d\u0430 \u0442\u0440\u0435\u0432\u043e\u0436\u043d\u043e\u0441\u0442 \u0441\u043b\u0435\u0434 5 \u043a\u0430\u043f\u043a\u0438 \u0434\u043d\u0435\u0432\u043d\u043e, \u043e\u043f\u0438\u0441\u0432\u0430\u0439\u043a\u0438 \u201e\u0441\u043f\u043e\u043a\u043e\u0435\u043d \u0443\u043c \u0438 \u0442\u044f\u043b\u043e\u201c. \u0414\u0440\u0443\u0433 \u0441\u044a\u043e\u0431\u0449\u0430\u0432\u0430 \u0437\u0430 \u043f\u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0430 \u043f\u0430\u043c\u0435\u0442, \u043d\u043e \u043e\u0442\u0431\u0435\u043b\u044f\u0437\u0432\u0430 \u0443\u043c\u043e\u0440\u0430 \u043f\u0440\u0438 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438 \u0434\u043e\u0437\u0438, \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u043f\u043e\u0440\u0430\u0434\u0438 \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442\u043d\u0438\u044f \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u043d\u043e\u0441\u0442<\/strong>: \u0425\u043e\u0440\u0430 \u0441 \u0440\u0435\u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u0445\u0438\u043f\u043e\u0433\u043b\u0438\u043a\u0435\u043c\u0438\u044f \u0441\u044a\u043e\u0431\u0449\u0430\u0432\u0430\u0442 \u0437\u0430 \u0441\u0442\u0430\u0431\u0438\u043b\u0438\u0437\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043a\u0440\u044a\u0432\u043d\u0430\u0442\u0430 \u0437\u0430\u0445\u0430\u0440 \u0441\u043b\u0435\u0434 \u043c\u0430\u043b\u043a\u0438 \u0434\u043e\u0437\u0438, \u0441 \u0431\u044a\u0440\u0437 \u0441\u043f\u0430\u0434 \u043e\u0442 \u043f\u0438\u043a\u043e\u0432\u0435 (\u043d\u0430\u043f\u0440. \u043e\u0442 170 \u0434\u043e 120 mg\/dL \u0437\u0430 \u0447\u0430\u0441). \u0422\u043e\u0432\u0430 \u043f\u0440\u0435\u0434\u043f\u043e\u043b\u0430\u0433\u0430, \u0447\u0435 \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c, \u0431\u0435\u0437 \u0434\u0430 \u043f\u0440\u0435\u0434\u0438\u0437\u0432\u0438\u043a\u0432\u0430 \u0445\u0438\u043f\u043e\u0433\u043b\u0438\u043a\u0435\u043c\u0438\u044f.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u041f\u0440\u0435\u0434\u0438\u0437\u0432\u0438\u043a\u0430\u0442\u0435\u043b\u0441\u0442\u0432\u0430<\/strong>: \u041d\u044f\u043a\u043e\u0438 \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0438 \u0438\u0437\u043f\u0438\u0442\u0432\u0430\u0442 \u0443\u043c\u043e\u0440\u0430, \u0441\u044a\u043d\u043b\u0438\u0432\u043e\u0441\u0442 \u0438\u043b\u0438 \u0441\u0432\u0435\u0442\u043e\u0432\u044a\u0440\u0442\u0435\u0436 \u043f\u0440\u0438 \u043f\u043e-\u0432\u0438\u0441\u043e\u043a\u0438 \u0434\u043e\u0437\u0438, \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u0430\u043a\u043e \u043d\u0435 \u043f\u0440\u0438\u0435\u043c\u0430\u0442 \u0434\u043e\u0441\u0442\u0430\u0442\u044a\u0447\u043d\u043e \u0432\u044a\u0433\u043b\u0435\u0445\u0438\u0434\u0440\u0430\u0442\u0438. \u0414\u0440\u0443\u0433\u0438 \u043e\u0442\u0431\u0435\u043b\u044f\u0437\u0432\u0430\u0442 \u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e \u043f\u043e\u0432\u0438\u0448\u0430\u0432\u0430\u043d\u0435 \u043d\u0430 \u0433\u043b\u0430\u0434\u0430 \u0438\u043b\u0438 \u0441\u0442\u043e\u043c\u0430\u0448\u043d\u043e \u0440\u0430\u0437\u0434\u0440\u0430\u0437\u043d\u0435\u043d\u0438\u0435 \u043e\u0442 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u043d\u0438\u044f \u043f\u0440\u0438\u0435\u043c, \u043a\u043e\u0435\u0442\u043e \u0441\u0435 \u0438\u0437\u0431\u044f\u0433\u0432\u0430 \u0441 \u043b\u043e\u043a\u0430\u043b\u043d\u043e \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u0435.<\/p>\n<\/li>\n<li>\n<p dir=\"ltr\"><strong>\u0412\u043a\u0443\u0441 \u0438 \u0443\u0441\u0435\u0449\u0430\u043d\u0435<\/strong>: \u0412\u043a\u0443\u0441\u044a\u0442 \u0435 \u043e\u043f\u0438\u0441\u0430\u043d \u043a\u0430\u0442\u043e \u201e\u0438\u0437\u0433\u0430\u0440\u044f\u0449\u201c \u0438 \u043f\u043e\u0434\u043e\u0431\u0435\u043d \u043d\u0430 \u0441\u0438\u043b\u0435\u043d \u0430\u043b\u043a\u043e\u0445\u043e\u043b, \u043d\u043e \u043d\u044f\u043a\u043e\u0438 \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0438 \u0433\u043e \u043d\u0430\u043c\u0438\u0440\u0430\u0442 \u0437\u0430 \u043f\u0440\u0438\u044f\u0442\u0435\u043d \u0441\u043b\u0435\u0434 \u0430\u0434\u0430\u043f\u0442\u0430\u0446\u0438\u044f. \u041b\u043e\u043a\u0430\u043b\u043d\u043e\u0442\u043e \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u0435 \u0435 \u043f\u0440\u0435\u0434\u043f\u043e\u0447\u0438\u0442\u0430\u043d\u043e \u0437\u0430 \u0438\u0437\u0431\u044f\u0433\u0432\u0430\u043d\u0435 \u043d\u0430 \u0443\u0441\u0442\u043d\u0438\u044f \u0434\u0438\u0441\u043a\u043e\u043c\u0444\u043e\u0440\u0442.<\/p>\n<\/li>\n<\/ul>\n<h2 dir=\"ltr\">\u0411\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442 \u0438 \u043f\u0440\u0435\u0434\u043f\u0430\u0437\u043d\u0438 \u043c\u0435\u0440\u043a\u0438<\/h2>\n<p dir=\"ltr\">\u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0435 \u0444\u043e\u0440\u043c\u0443\u043b\u0438\u0440\u0430\u043d \u0441 \u0445\u0440\u0430\u043d\u0438\u0442\u0435\u043b\u043d\u0438 \u0441\u044a\u0441\u0442\u0430\u0432\u043a\u0438, \u043d\u043e \u043d\u0435\u0433\u043e\u0432\u043e\u0442\u043e \u043c\u043e\u0449\u043d\u043e \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0432\u044a\u0440\u0445\u0443 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u043c\u0430 \u0438\u0437\u0438\u0441\u043a\u0432\u0430 \u0432\u043d\u0438\u043c\u0430\u0442\u0435\u043b\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430. \u0412\u0438\u0441\u043e\u043a\u0438 \u0434\u043e\u0437\u0438 \u0438\u043b\u0438 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u043d\u0430 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u043c\u043e\u0433\u0430\u0442 \u0434\u0430 \u0434\u043e\u0432\u0435\u0434\u0430\u0442 \u0434\u043e \u0438\u0437\u0447\u0435\u0440\u043f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0433\u043b\u0443\u0442\u0430\u0442\u0438\u043e\u043d\u0430, \u043a\u043e\u0435\u0442\u043e \u043c\u043e\u0436\u0435 \u0434\u0430 \u0431\u044a\u0434\u0435 \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u043d\u043e \u0437\u0430 \u043d\u0435\u0440\u0430\u043a\u043e\u0432\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438. \u0425\u043e\u0440\u0430 \u0441 \u0434\u0438\u0430\u0431\u0435\u0442, \u0440\u0430\u043a \u0438\u043b\u0438 \u0430\u0432\u0442\u043e\u0438\u043c\u0443\u043d\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f \u0442\u0440\u044f\u0431\u0432\u0430 \u0434\u0430 \u0441\u0435 \u043a\u043e\u043d\u0441\u0443\u043b\u0442\u0438\u0440\u0430\u0442 \u0441 \u043b\u0435\u043a\u0430\u0440, \u0442\u044a\u0439 \u043a\u0430\u0442\u043e \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u044a\u0442 \u043c\u043e\u0436\u0435 \u0434\u0430 \u043f\u043e\u0432\u043b\u0438\u044f\u0435 \u043d\u0430 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u0442\u0435 \u043f\u044a\u0442\u0438\u0449\u0430 \u0438 \u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0438\u0442\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u0438. \u0418\u0437\u0431\u044f\u0433\u0432\u0430\u0439\u0442\u0435 \u043a\u043e\u043d\u0442\u0430\u043a\u0442 \u0441 \u043e\u0447\u0438\u0442\u0435 \u043f\u0440\u0438 \u043b\u043e\u043a\u0430\u043b\u043d\u043e \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u0435 \u0438 \u0441\u044a\u0445\u0440\u0430\u043d\u044f\u0432\u0430\u0439\u0442\u0435 \u043d\u0430 \u0445\u043b\u0430\u0434\u043d\u043e, \u0442\u044a\u043c\u043d\u043e \u043c\u044f\u0441\u0442\u043e, \u0437\u0430 \u0434\u0430 \u0437\u0430\u043f\u0430\u0437\u0438\u0442\u0435 \u0441\u0442\u0430\u0431\u0438\u043b\u043d\u043e\u0441\u0442\u0442\u0430 \u043d\u0430 \u0435\u0441\u0442\u0435\u0440\u0438\u0442\u0435.<\/p>\n<h2 dir=\"ltr\">\u0417\u0430\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u0435<\/h2>\n<p dir=\"ltr\">\u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430, \u043a\u043e\u044f\u0442\u043e \u0442\u0440\u0430\u043d\u0441\u0444\u043e\u0440\u043c\u0438\u0440\u0430 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u043e\u0442\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u0447\u0440\u0435\u0437 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u043d\u043e\u0442\u043e \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435 \u0438 \u043d\u0430\u043c\u0430\u043b\u044f\u0432\u0430\u043d\u0435 \u043d\u0430 \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435\u0442\u043e. \u0421\u044a\u0441 \u0441\u0432\u043e\u0438\u0442\u0435 \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0438, \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0438 \u0438 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438 \u043f\u043e\u043b\u0437\u0438, \u0442\u043e\u0439 \u0435 \u0438\u0434\u0435\u0430\u043b\u0435\u043d \u0437\u0430 \u0445\u043e\u0440\u0430, \u0442\u044a\u0440\u0441\u0435\u0449\u0438 \u043a\u043e\u0433\u043d\u0438\u0442\u0438\u0432\u043d\u0430 \u044f\u0441\u043d\u043e\u0442\u0430, \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0430 \u0438\u0437\u0434\u0440\u044a\u0436\u043b\u0438\u0432\u043e\u0441\u0442 \u0438 \u0437\u0430\u0449\u0438\u0442\u0430 \u0441\u0440\u0435\u0449\u0443 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u044f. \u041d\u0435\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e \u0434\u0430\u043b\u0438 \u0441\u0435 \u0438\u0437\u043f\u043e\u043b\u0437\u0432\u0430 \u043f\u0435\u0440\u043e\u0440\u0430\u043b\u043d\u043e \u0437\u0430 \u0431\u044a\u0440\u0437\u0438 \u0440\u0435\u0437\u0443\u043b\u0442\u0430\u0442\u0438 \u0438\u043b\u0438 \u043b\u043e\u043a\u0430\u043b\u043d\u043e \u0437\u0430 \u043f\u0440\u043e\u0434\u044a\u043b\u0436\u0438\u0442\u0435\u043b\u0435\u043d \u0435\u0444\u0435\u043a\u0442, \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e \u0434\u0430\u0432\u0430 \u0432\u044a\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442 \u043d\u0430 \u043f\u043e\u0442\u0440\u0435\u0431\u0438\u0442\u0435\u043b\u0438\u0442\u0435 \u0434\u0430 \u043e\u043f\u0442\u0438\u043c\u0438\u0437\u0438\u0440\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u0435\u0442\u043e \u0441\u0438 \u0441 \u043d\u0430\u0443\u0447\u043d\u043e \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0435\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430.<\/p>\n<p dir=\"ltr\">\n<\/li>\n<\/ul>\n<p><a href=\"https:\/\/lowtoxinforum.com\/threads\/pyrucet-liquid-ethyl-pyruvate-aceatoacetate-mix.27487\/\">https:\/\/lowtoxinforum.com\/threads\/pyrucet-liquid-ethyl-pyruvate-aceatoacetate-mix.27487\/<\/a><\/p>\n<p>\u0420\u0435\u0444\u0435\u0440\u043d\u0446\u0438\u0438:<\/p>\n<p>1. <b><u>Miscellaneous<\/u><\/b><\/p>\n<div class=\"bbCodeBlock bbCodeBlock--unfurl js-unfurl fauxBlockLink\" data-unfurl=\"true\" data-result-id=\"37383\" data-url=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4732204\/\" data-host=\"www.ncbi.nlm.nih.gov\" data-pending=\"false\">\n<div class=\"contentRow\">\n<div class=\"contentRow-figure contentRow-figure--fixedSmall js-unfurl-figure\"><img decoding=\"async\" src=\"https:\/\/lowtoxinforum.com\/proxy.php?image=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fcorehtml%2Fpmc%2Fpmcgifs%2Fpmc-card-share.jpg%3F_%3D0&amp;hash=e34873217a3509b209b110d231d166fb&amp;return_error=1\" alt=\"www.ncbi.nlm.nih.gov\" data-onerror=\"hide-parent\" \/><\/div>\n<div class=\"contentRow-main\">\n<h3 class=\"contentRow-header js-unfurl-title\"><a class=\"link link--external fauxBlockLink-blockLink\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4732204\/\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4732204%2F&amp;hash=323be0d0fe507501084f279ace9830f5\"> Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice <\/a><\/h3>\n<div class=\"contentRow-snippet js-unfurl-desc\">Acetoacetate (AA) is a ketone body and acts as a fuel to supply energy for cellular activity of various tissues. Here, we uncovered a novel function of AA in promoting muscle cell proliferation. Notably, the functional role of AA in regulating muscle &#8230;<\/div>\n<div class=\"contentRow-minor contentRow-minor--hideLinks\"><span class=\"js-unfurl-favicon\"> <img decoding=\"async\" class=\"bbCodeBlockUnfurl-icon\" src=\"https:\/\/lowtoxinforum.com\/proxy.php?image=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fcoreutils%2Fnwds%2Fimg%2Ffavicons%2Ffavicon.png&amp;hash=78667591a96ab09efe3eb2c1bcac7c98&amp;return_error=1\" alt=\"www.ncbi.nlm.nih.gov\" data-onerror=\"hide-parent\" \/> <\/span> www.ncbi.nlm.nih.gov<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6537353\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F6537353&amp;hash=b70e929abd2f199ececaee79c49698d5\">Mutagenic investigation of flavourings: dimethyl succinate, ethyl pyruvate and aconitic acid are negative in the Salmonella\/mammalian-microsome test. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1521830\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F1521830&amp;hash=b44ad4687819ca60b4c1ef8385745555\">A 28-day feeding study with ethyl acetoacetate in rats. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29355144\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29355144&amp;hash=e3dc90671fb0e630bda91664699fa55d\">Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29259719\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29259719&amp;hash=6fb948ff8e1867583f8e4baf629127da\">Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026 <b><u>Due to poor solubility and stability, therapeutic potential of pyruvate is limited. Ethyl pyruvate (EP) is now considered as a suitable replacement of pyruvate<\/u><\/b>. In this paper, we will try to focus the effect of NO and EP in Schwann cell dedifferentiation, proliferation, nerve degeneration, and regeneration during Wallerian degeneration (WD) of peripheral nerve injury along with their neuroprotective effects, cardiovascular functioning, support in hepatic complication, etc.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28427942\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28427942&amp;hash=658cf350d225ccd2ce6bc1ef6ad5615c\">Inhibitory effects of ethyl pyruvate on platelet aggregation and phosphatidylserine exposure. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026<b><u>Ethyl pyruvate (EP) is a stable lipophilic pyruvate derivative. Studies demonstrated that EP shows potent anti-oxidation, anti-inflammatory and anti-coagulant effects<\/u><\/b>. Inflammation and coagulation are closely interacted with platelet activation.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/en.wikipedia.org\/wiki\/Acetoacetic_acid\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FAcetoacetic_acid&amp;hash=643061f24d09977e90ea593b14ed50ce\">Acetoacetic acid &#8211; Wikipedia<\/a><br \/>\n&#8222;&#8230;<b><u>Acetoacetic acid (also diacetic acid)<\/u><\/b> is the organic compound with the formula CH3COCH2COOH. It is the simplest beta-keto acid group, and like other members of this class, it <b><u>is unstable<\/u><\/b>. <b><u>The methyl and ethyl esters,<\/u><\/b> which <b><u>are quite stable<\/u><\/b>, are produced on a large scale industrially as precursors to dyes.&#8220;<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27980458\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27980458&amp;hash=89a98018d71f41d4ca9e5161ef6997be\">Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<div class=\"bbImageWrapper js-lbImage\" title=\"ethyl_pyruvate_inflammation_targets.png\" data-src=\"https:\/\/lowtoxinforum.com\/attachments\/ethyl_pyruvate_inflammation_targets-png.12033\/\" data-lb-sidebar-href=\"\" data-lb-caption-extra-html=\"\" data-single-image=\"1\"><img decoding=\"async\" class=\"bbImage\" title=\"ethyl_pyruvate_inflammation_targets.png\" src=\"https:\/\/lowtoxinforum.com\/attachments\/ethyl_pyruvate_inflammation_targets-png.12033\/\" alt=\"ethyl_pyruvate_inflammation_targets.png\" width=\"717\" height=\"557\" data-url=\"\" data-zoom-target=\"1\" \/><\/div>\n<p><a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22348679\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22348679&amp;hash=4e2ed19a478acd01023d579675153940\">Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine? &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026<b><u>Pyruvate, however, is unstable in aqueous solutions due to a rapid aldol-like condensation reaction forming parapyruvate, a potent inhibitor of the Krebs cycle blocking the \u03b1-ketoglutaric dehydrogenase<\/u><\/b> [7]. <b><u>This problem can be circumvented by using the ethanol ester of pyruvate (that is, EP) &#8211; the effects of which qualitatively resemble that of pyruvate, but which only require molar doses that are lower by one to two orders of magnitude<\/u><\/b> [7]. In addition to the properties of pyruvate, EP also exerts anti-apoptotic effects, increases heme oxygenase-1 expression, attenuates peroxynitrite-related DNA damage, and stabilizes the hypoxia-inducible factor 1\u03b1 via stimulation of the Krebs cycle.\u201d<br \/>\n\u201c\u2026Ethyl pyruvate (EP) is a simple derivative of pyruvic acid, which is an important endogenous metabolite that can scavenge reactive oxygen species (ROS). <b><u>Treatment with EP is able to ameliorate systemic inflammation and multiple organ dysfunctions in multiple animal models, such as acute pancreatitis, alcoholic liver injury, acute respiratory distress syndrome (ARDS), acute viral myocarditis, acute kidney injury and sepsis. Recent studies have demonstrated that prolonged treatment with EP can ameliorate experimental ulcerative colitis and slow multiple tumor growth<\/u><\/b>. It has become evident that EP has pharmacological anti-inflammatory effect to inhibit multiple early inflammatory cytokines and the late inflammatory cytokine HMGB1 release, and the anti-tumor activity is likely associated with its anti-inflammatory effect. <b><u>EP has been tested in human volunteers and in a clinical trial of patients undergoing cardiac surgery in USA and shown to be safe at clinical relevant doses<\/u><\/b>\u2026\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21389621\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21389621&amp;hash=2dc8b7833fa3aa8f3e1fa93318ac9bcf\">Higher hypochlorous acid scavenging activity of ethyl pyruvate compared to its sodium salt. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026The potential effect of ethanol was also evaluated, and hypochlorous acid was used as an oxidant. Our data indicate the <b><u>concentration-dependent scavenging potency of both sodium and ethyl pyruvate, with the ester having higher activity<\/u><\/b>. <b><u>This effect was not related to the presence of ethanol<\/u><\/b>. <b><u>Better protection of the liver homogenate by ethyl pyruvate was also apparent<\/u><\/b>, despite the fact that cell membrane transport was omitted.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18443482\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18443482&amp;hash=f3010e4d19a5963df7a1f58aa16f77e2\">Ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a><br \/>\n\u201c\u2026<b><u>This ester was originally regarded as a way to administer pyruvate, while avoiding some of the problems associated with the instability of pyruvate<\/u><\/b> in aqueous solutions. Increasingly, however, <b><u>it is becoming apparent that certain pyruvate esters, including ethyl pyruvate, have pharmacological effects, such as suppression of inflammation, which are distinct from those exerted by pyruvate anion<\/u><\/b>. <b><u>Ethyl pyruvate has been tested in human volunteers and shown to be safe<\/u><\/b> at clinically relevant doses. Ethyl pyruvate is a simple molecule that has been shown to have salutary effects in numerous large and small animal models of critical illness. It remains to be determined whether this ester can be used successfully to treat human diseases.\u201d<\/p>\n<p>2. <b><u>Metabolism<\/u><\/b><br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/5497217\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F5497217&amp;hash=b63d3c384f63c771248755798fa3c00f\">Inhibition of free fatty acid oxidation by acetoacetate in normal dogs. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n\u201c\u2026The rate of turnover and oxidation of plasma free fatty acids (FFA) waa measured in 7 normal anaesthetized dogs infused at a constant rate with 1-W-palmitate for 5 h. After a control period, sustained hyperketonaemia was induced by <b><u>infusing sodium aceto-acetate (AA). This produced a fall in plasma FFA (33%) and in blood sugar (24%)<\/u><\/b>, without changes in immuno-reactive insulin (IRI) concentrations. During the control period, the turnover rate of carbon of <b><u>FFA<\/u><\/b> averaged 131 uat.C\/kg\/min, 32% of which were oxidized, thus <b><u>supplying 17.7% of the total CO, production<\/u><\/b>. <b><u>At the end of the AA infusion<\/u><\/b>, the mean turnover rate of FFA was reduced to 75 uat. C\/kg\/min; since <b><u>only 13.9% of these were oxidized, the contribution of FFA to total CO, production was reduced to 4.3%<\/u><\/b> .\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14481944\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F14481944&amp;hash=39f4429ed26405cdf8bc8f93828f4f01\">Effect of pyruvate and acetoacetate on the metabolism of fatty acids by the perfused rat heart. &#8211; PubMed &#8211; NCBI<\/a> (EA + P)<br \/>\n\u201c\u2026About <b><u>75% of the fatty acids removed were oxidized to carbon dioxide accounting<\/u><\/b>, at this concentration of fatty acids in the perfusate, <b><u>for<\/u><\/b> <b><u>37% of oxygen consumption of the heart<\/u><\/b>\u2026<b><u>In the presence of 10mM pyruvate or acetoacetate, the uptake of fatty acids from the medium was reduced approximately 50% and the oxidation of the extracted acids was reduced further so that only 25% of the fatty acids oxidized by the control group appeared as carbon dioxide<\/u><\/b> in the presence of competing substrate\u2026<b><u>The competing substrates<\/u><\/b>, thus, contributed 75%-85% to the fuel of the respiration and <b><u>reduced the contribution of the fatty acids to 8%-9% of the total respiration of the heart<\/u><\/b>\u2026It may be of considerable interest to examine the <b><u>competition between pyruvate and free fatty acid<\/u><\/b> over a range of concentrations bracketing physiological concentrations of both substances\u2026<b><u>Both acetoacetate and pyruvate<\/u><\/b> can enter the tricarboxylic acid cycle without resort to a kinase, and this may be one reason why they <b><u>compete successfully with fatty acids<\/u><\/b> which require the action of adenosine triphosphate and a thiokinase.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14249143\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F14249143&amp;hash=9d0e226f218ecab50238c2cce9871206\">EFFECT OF CARNITINE ON THE OXIDATION OF ALPHA-OXOGLUTARATE TO SUCCINATE IN THE PRESENCE OF ACETOACETATE OR PYRUVATE. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3999980\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F3999980&amp;hash=a28dadacaee5704484bb11baff54226c\">Inhibition of palmitoylcarnitine oxidation by pyruvate in rat heart mitochondria. &#8211; PubMed &#8211; NCBI<\/a> (P)<br \/>\n\u201c\u2026The oxidation of 1 -\u20184C-palmitoylcarnitine by rat heart mitochondria has bean measured by assessing both the disappearance of substrata and the appearance of labelled products. <b><u>Pyruvate inhibited palmitoylcarnitine oxidation by about 40%. Fifty percent inhibition occurred at about 20 umol\/L pyruvate<\/u><\/b>. The inhibitory effect of pyruvate required entry of pyruvate into mitochondria since it did not occur in the presence of a-cyano4hydroxycinnamic acid, an inhibitor of the mitochondrial pyruvate transporter. \u201c<br \/>\n\u201c\u2026Earlier work by Olson and by Evans et al had demonstrated <b><u>significant inhibition (40% to 50%) of palmitate oxidation in the retrogradely perfused heart by<\/u><\/b> lactate and by <b><u>pyruvate<\/u><\/b>. In addition, experiments by Harris et al5 and by Hirche and Langor have shown that lactate could compete effectively with fatty acids for oxidation by the heart in vivo. These observations have led us to investigate the possible inhibition of fatty acid oxidation by pyruvate in isolated rat heart mitochondria. <b><u>We have demonstrated a significant inhibition of fatty acid oxidation by pyruvate<\/u><\/b>.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1811059\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F1811059&amp;hash=c75765671349c6d1fbdb95840bb79be1\">Fatty acid accumulation during ischemia and reperfusion: effects of pyruvate and POCA, a carnitine palmitoyltransferase I inhibitor. &#8211; PubMed &#8211; NCBI<\/a> (P)<br \/>\n\u201c\u2026During reperfusion, however, the tissue FA level dramatically increases, indicating that <b><u>the inhibitory effects of pyruvate and POCA on FA utilization are additive<\/u><\/b>. <b><u>Pyruvate is known to activate pyruvate dehydrogenase and, hence, to stimulate its own conversion to acetyl-CoA<\/u><\/b> (Kobayashi and Neely, 1983). <b><u>As a consequence, the availability of mitochondrial free CoA will be diminished and beta-oxidation becomes inhibited<\/u><\/b> (Brosnan and Reid, 1985). In this manner pyruvate probably inhibits the removal of FAs released from endogenous lipid pools during reperfusion.\u201d<br \/>\n\u201c\u2026In summary, the present findings show that POCA and <b><u>pyruvate markedly increase the FA content of reperfused hearts, most likely through inhibition of the oxidation of FAs<\/u><\/b> released from endogenous lipid pools.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/838728\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F838728&amp;hash=78b24fc5916d17e3c55c8f35940294f9\">Studies on inactivation of pyruvate dehydrogenase by palmitoylcarnitine oxidation in isolated rat heart mitochondria. &#8211; PubMed &#8211; NCBI<\/a> (P)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25701336\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25701336&amp;hash=59f9e516458a32ccbf248836c0a9b7f5\">Single pyruvate intake induces blood alkalization and modification of resting metabolism in humans. &#8211; PubMed &#8211; NCBI<\/a> (P)<br \/>\n\u201c\u2026CONCLUSION: <b><u>Pyruvate intake<\/u><\/b> induced mild alkalization in a sex-dependent fashion. Moreover, it <b><u>accelerated carbohydrate metabolism and delayed the rate of glycerol appearance in the blood<\/u><\/b>, but had no effect on the resting energy expenditure. Furthermore, sodium salt seems to have had a greater effect on the blood buffering level than calcium salt.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21802492\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21802492&amp;hash=e331d754893b2d2a2ec1bc685c21028b\">Supplementation of pyruvate prevents palmitate-induced impairment of glucose uptake in C2 myotubes. &#8211; PubMed &#8211; NCBI<\/a> (P)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9074701\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F9074701&amp;hash=905bb8fd5334e3e5af2eb4333dfd1fa8\">Pyruvate reverses fatty-acid-induced depression of ventricular function and calcium overload after hypothermia in guinea pig hearts. &#8211; PubMed &#8211; NCBI<\/a> (P)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/4331324\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F4331324&amp;hash=71a46618dbb5bae0cbae035f5397d74b\">The action of pyruvate on ethanol oxidation by intact isolated liver cells. &#8211; PubMed &#8211; NCBI<\/a> (P)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/13816296\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F13816296&amp;hash=004b5ac3cba3d3209cf876ade097a4bf\">Stimulation by acetoacetate of DPNH oxidation by liver mitochondria. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/13816295\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F13816295&amp;hash=7ac776bd70e1cffa472289c3362cda7d\">Effect of acetoacetate on the oxidation of reduced diphosphopyridine nucleotide by intact rat liver mitochondria. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n\u201c\u2026<b><u>The oxidation of DPNH (NADH) by intact rat liver mitochondria, isolated in 0.25 M sucrose or 2.5% polyvinylpyrrolidone-0.25 M sucrose, was found to be stimulated 4 to 6 times by catalytic quantities (0.3 to 1.0 uM) of acetoacetate<\/u><\/b> or D-b-hydroxybutyrate. <b><u>Coupled phosphorylation was also stimulated, with P:O ratios in the range of 1.5 to 2.2<\/u><\/b>. The increased respiration was completely inhibited by Amytal and antimycin A, and phosphate uptake abolished by 2,4-dinitrophenol. Catalytic quantities of succinate, a-ketoglutarate, malate, citrate, glutamate, and pyruvate stimulated the endogenous respiration, but had no effect on DPNH oxidation.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/13485090\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F13485090&amp;hash=b7a39b6592d747123c710b07426ec858\">Acetoacetate induced dehydroascorbic acid accumulation in blood and tissues and its prevention by glucose-cyclo-acetoacetate. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n\u201c\u2026<b><u>The effect of acetoacetate injections in doses of 500 mg\/kg on ascorbic and dehydroascorbic acid contents of blood and tissues, and their excretion in urine, was studied. 2. Animals injected with aceto-acetate excrete more dehydroascorbic acid and less ascorbic acid. Their tissues (liver, kidney, spleen and adrenal) also accumulate more dehydroascorbic acid, and the amount of ascorbic acid in them is diminished<\/u><\/b>. 3. Glucose-cyclo-acetoacetate or its hydrolysed product has been found to prevent this increased accumulation of dehydroascorbic acid in blood and tissues. 4. Acetoacetate has been shown to cause oxidation of ascorbic acid to dehydroascorbic acid in vitro in presence of a few drops of CuSO4 solution at a faster rate than that in the control. 5. The mechanism for prevention of acetoacetate induced accumulation of dehydroascorbic acid by hydrolysed glucose-cyclo-acetoacetate has been suggested.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/13032097\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F13032097&amp;hash=28c6b53de0a9973757514d6d5ee72f55\">Progressive depletion in the reduced glutathione content of the blood following acetoacetate injections. &#8211; PubMed &#8211; NCBI<\/a><br \/>\n\u201c\u2026<b><u>The experimental data presented indicate that acetoacetate causes a fall in the blood GSH content<\/u><\/b>, although it is not as sharp and rapid as is reported in the case of alloxan (Leech &amp; Bailey, 1945). It is only natural that this should be so since acetoacetate is an intermediary fat metabolite which normally occurs in very minute proportions in the system. <b><u>Repeated daily injection brings the blood GSH value to zero in 3-5 days, less time being required with higher dose<\/u><\/b>.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14569076\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F14569076&amp;hash=244720e650e3ef7d9de331917c32150f\">Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-s&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026<b><u>Although NAC increased GSH levels, EP had the opposite effect<\/u><\/b>. The anti-inflammatory effects of EP were partially reversed when RAW 264.7 cells were treated with a cell-permeable GSH analog, glutathione ethyl ester. These data support the view that the <b><u>anti-inflammatory effects of EP are mediated<\/u><\/b>, at least in part, <b><u>by the ability of EP to deplete cellular GSH stores<\/u><\/b>. Moreover, the findings presented here suggest that an unusual combination of biochemical effects (inhibition of lipid peroxidation and <b><u>GSH depletion) might account for the anti-inflammatory effects of EP<\/u><\/b>.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/13061411\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F13061411&amp;hash=15968ee9ba38bb2869a0c6570196f60a\">Effect of acetoacetate upon utilization of carbohydrate. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15305018\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15305018&amp;hash=aca66bd656882774dfd0c2fbe71ea073\">Hypochlorous acid inhibition by acetoacetate: implications on neutrophil functions. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12709664\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12709664&amp;hash=d2059db6af801a2f45f2af8cd7d58739\">Osmotonicity of acetoacetate: possible implications for cerebral edema in diabetic ketoacidosis. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1898011\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F1898011&amp;hash=ca69e96772c05b851f68081893661e49\">Acetoacetate and malate effects on succinate and energy production by O2-deprived liver mitochondria supplied with 2-oxoglutarate. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3238802\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F3238802&amp;hash=0cbbfd3a3e0dc1983cdf089b9e195f98\">[The effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria]. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/4259412\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F4259412&amp;hash=84a8e01360cac3ae6dd1f9f483b80b1e\">The effect of acetoacetate on plasma insulin concentration. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23857218\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23857218&amp;hash=6774bc72d00b49599ed6f3c4a346595f\">Effect of ethyl pyruvate on skeletal muscle metabolism in rats fed on a high fat diet. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21106878\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21106878&amp;hash=61598bd0ac63bccb6553d4515ecf1235\">Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20338685\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20338685&amp;hash=77ad0524341ecb1932afcedb4da43389\">Ethyl pyruvate stabilizes hypoxia-inducible factor 1 alpha via stimulation of the TCA cycle. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18821148\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18821148&amp;hash=c9ba0c6216eaff6c8c4d58ff572a7a05\">The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<p>3. <b><u>Inflammation\/Endotoxin\/Sepsis\/Trauma<\/u><\/b><br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17430122\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17430122&amp;hash=42fac5a57734e9763ba157015337883c\">Ethyl pyruvate: a novel treatment for sepsis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17391109\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17391109&amp;hash=2ad8c1c69a0bb8729e5b5ca30030f53f\">Ethyl pyruvate: a novel anti-inflammatory agent. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15181417\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15181417&amp;hash=b2188ce8012ebad71ecb6aa5bdd070e5\">Ethyl pyruvate: a novel treatment for sepsis and shock. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28987932\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28987932&amp;hash=78a0851a7f143f4a4194aa46da9ac7e8\">Ethyl pyruvate ameliorates inflammatory arthritis in mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28965011\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28965011&amp;hash=61b0c59c0e78dd4ea7a7ed64638dfaac\">Anti-encephalitogenic effects of ethyl pyruvate are reflected in the central nervous system and the gut. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28863323\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28863323&amp;hash=e63846a33d54ef68b7bf81465f654bcb\">Ethyl pyruvate reverses development of Pseudomonas aeruginosa pneumonia during sepsis-induced immunosuppression. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27865166\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27865166&amp;hash=67dbbb0e78cfec8fe83d496c8ef75f2a\">Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1\/STAT signaling in LPS-activated RAW264.7 cells and peritoneal mac&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27567422\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27567422&amp;hash=57dbc96f7801eeaf69a3ed6d7d1b832b\">Effects of insulin combined with ethyl pyruvate on inflammatory response and oxidative stress in multiple-organ dysfunction syndrome rats with seve&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27085456\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27085456&amp;hash=a56eb941dccd4e9c424f598ec85c4101\">Effects of N-acetylcysteine and ethyl pyruvate on ischemia-reperfusion injury in experimental electrical burn model. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26966369\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26966369&amp;hash=345a86faadc896e56ac79662080b7bc5\">Ethyl pyruvate protects against sepsis by regulating energy metabolism. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026<b>RESULTS<\/b>: Our results demonstrated that the administration of EP significantly improved the survival rate and reduced intestinal histological alterations. EP inhibited the plasma levels of IL-1\u03b2, IL-6, and tumor necrosis factor-\u03b1 and increased the IL-10 level. EP significantly inhibited the elevation of the malondialdehyde, lactate, and lactate\/pyruvate levels and enhanced the total antioxidative capacity levels in the liver tissues. <b><u>The downregulation of the adenosine triphosphate (ATP)<\/u><\/b>, total adenylate, and <b><u>energy charge levels<\/u><\/b> in the liver tissues <b><u>was reversed in the septic mice treated with EP<\/u><\/b>. <b>CONCLUSION<\/b>:<br \/>\nThe results suggest that <b><u>EP administration effectively modulates the energy metabolism, which may be an important component in treatment of sepsis<\/u><\/b>.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26339342\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26339342&amp;hash=b70c1441ffec780c4e099902f19a0404\">Ethyl pyruvate reduces hepatic mitochondrial swelling and dysfunction in a rat model of sepsis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26222821\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26222821&amp;hash=cbf8b0d4ca5166c3eeda71d32ce9cc05\">Effects of ethyl pyruvate on leukocyte-endothelial interactions in the mesenteric microcirculation during early sepsis treatment. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25681468\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25681468&amp;hash=6d761b82d65085734f618e6c5af0bb0a\">Ethyl pyruvate attenuates murine allergic rhinitis partly by decreasing high mobility group box 1 release. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25681336\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25681336&amp;hash=bef502e07e40e3345ae4d0a480ad0c33\">A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026<b><u>Production of two other proinflammatory cytokines, IL-6 and TNF, and NO was suppressed by EP<\/u><\/b> in macrophages and microglia. Reactive oxygen species production in macrophages, microglia activation, and the development of Ag-presenting phenotype in microglia and macrophages were constrained by EP. The release of IL-6 was reduced in astrocytes. Finally, EP inhibited the activation of transcription factor NF-\u03baB in microglia and astrocytes. Most of these effects were also found for DMF, implying that EP and DMF share common targets and mechanisms of action. Importantly, EP had in vivo impact on experimental autoimmune encephalomyelitis, an animal model of MS. <b><u>Treatment with EP resulted in delay and shortening of the first relapse, and lower clinical scores, whereas the second attack was annihilated<\/u><\/b>. Further studies on the possibility to use EP as an MS therapeutic are warranted.\u201d<br \/>\n\u201c\u2026Our results speak in favor of this possibility. <b><u>Maybe the most favorable facts are that EP<\/u><\/b> reduced IFN-\u03b3 and IL-17 generation in human PBMCs, alleviated EAE in rats, and even more it <b><u>practically prevented the second relapse<\/u><\/b>.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25470819\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25470819&amp;hash=3fd7e0629afa4f892369fdf62e01041a\">Endoplasmic reticulum stress mediates the anti-inflammatory effect of ethyl pyruvate in endothelial cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25333921\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25333921&amp;hash=dca4ad65281f67d3233f9889e9a3bba2\">Ethyl pyruvate inhibits HMGB1 phosphorylation and release by chelating calcium. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24819717\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24819717&amp;hash=6036358ad36f2225d62d9fb6b9a2fd85\">Ethyl pyruvate decreases airway neutrophil infiltration partly through a high mobility group box 1-dependent mechanism in a chemical-induced murine&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22943507\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22943507&amp;hash=114cd8e07dbdcb6953d656b1e7e38d15\">Ethyl pyruvate diminishes the inflammatory response to lipopolysaccharide infusion in horses. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22918642\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22918642&amp;hash=4d4390a68b846d12ced076c1f61d2f2b\">Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22640699\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22640699&amp;hash=65a4e8ba35c081c07e20d5ceb21dc24b\">Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22369644\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22369644&amp;hash=8c861d649c2909486718a97d57b0f7d7\">Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and &#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22152811\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22152811&amp;hash=6347526fff8fc54620847e05b593ff41\">[Ethyl pyruvate inhibited HMGB1 expression induced by LPS in macrophages]. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21551413\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21551413&amp;hash=14a88eecf6f9d1bac86aa1165448ca3f\">Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21492212\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21492212&amp;hash=9d1d2c4209d0f37e14623a4441536f8d\">Preliminary safety and biological efficacy studies of ethyl pyruvate in normal mature horses. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21419499\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21419499&amp;hash=6194ddd44efbcc819eddd467b27159e1\">Ethyl pyruvate decreases proinflammatory gene expression in lipopolysaccharide-stimulated equine monocytes. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21396682\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21396682&amp;hash=64d99ee5395fa2046a531bad488f6386\">In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21244758\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21244758&amp;hash=4c95411f08858063a46ce4e99cb3ce67\">Ethyl pyruvate therapy attenuates experimental severe arthritis caused by type II collagen (CII) in the mouse (CIA). &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20969857\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20969857&amp;hash=fae0c3a28eefa27b4d7ac93f05d76b43\">Interaction of ethyl pyruvate in vitro with NF-\u03baB subunits, RelA and p50. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20965334\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20965334&amp;hash=27cfb0e2489bddfd9b3a9a9a1e05cd12\">Ethyl pyruvate diminishes the endotoxin-induced inflammatory response of bovine mammary endothelial cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20495301\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20495301&amp;hash=c9ea8e2d2ad53f549b8349d891d183b1\">Ethyl pyruvate downregulates tumor necrosis factor alpha and interleukin (IL)-6 and upregulates IL-10 in lipopolysaccharide-stimulated canine perip&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20302967\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20302967&amp;hash=a943aa6d40b7eb56cafcc02fa9cd153f\">Inhibition by ethyl pyruvate of the nuclear translocation of nuclear factor-kappaB in cultured lung epithelial cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19953001\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19953001&amp;hash=ce8d45635849e6d3e402200baa56dd87\">Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19695165\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19695165&amp;hash=ab09f86fc620c78312d7cb810860d345\">[Effects of ethyl pyruvate on injuries of sepsis in mice]. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19555300\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19555300&amp;hash=ffca8820b4e6e2ab97b66424156531ab\">Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19454652\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19454652&amp;hash=fec7d6cf536eea6bfae9db2fcd9d916a\">Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19430239\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19430239&amp;hash=1d14b546e9c529695ef0b20b35ebede9\">Effect of ethyl pyruvate on physical and immunological barriers of the small intestine in a rat model of sepsis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19172241\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19172241&amp;hash=97d6096fd497b4ee30564d4be2e48b1b\">Ethyl pyruvate improves survival in awake hemorrhage. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19050619\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19050619&amp;hash=10354abceef1c4aa703b20b931875bfc\">Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18625205\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18625205&amp;hash=c47db220b00d9c8161d0fb8a430b9c8b\">Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18500358\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18500358&amp;hash=2f200c06640491f23e9c4716c1a190e3\">Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18480149\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18480149&amp;hash=9eb86e0dabc95dfce644cb04bc6d68ad\">Protective effects of ethyl pyruvate treatment on paraquat-intoxicated rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18344089\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18344089&amp;hash=105db6df566f70d7e161a064262d0bd3\">[Protective effect of ethyl pyruvate on barrier function of intestinal mucosa in dogs with septic shock]. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18199399\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18199399&amp;hash=f02661283f7fa51ca37d66664ad362d3\">[Effect of ethyl pyruvate on indices of tissue oxygenation and perfusion in dogs with septic shock]. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17973549\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17973549&amp;hash=b6d4f67785927c048c5e44c66054ffd2\">Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17351912\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17351912&amp;hash=7e665fc6e37c692bd78f6cfb4f3290a7\">Protective effect of ethyl pyruvate on msP rat leukocytes damaged by alcohol intake. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17309968\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17309968&amp;hash=fe2215ce77519afbbe27667775c05a03\">Beneficial effects of ethyl pyruvate in septic shock from peritonitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17139374\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17139374&amp;hash=172e3ef5bdeb71b0bb37d91360a19544\">Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16524498\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16524498&amp;hash=5cd9d09e6bd5db1f683e288df3eccd18\">[Effect of treatment with ethyl pyruvate on multiple organ dysfunction and mortality following delayed resuscitation after burn injury in rat]. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16148477\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16148477&amp;hash=2df0f3b8087b1cdbeac1d352626000dc\">Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic &#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16004772\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16004772&amp;hash=613eb391d9573bd7702cd9e5f0227975\">[Effects of ethyl pyruvate on splenocyte proliferation and apoptosis in burn rats with delayed resuscitation]. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15636704\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15636704&amp;hash=6ace2aa81b2ddd0bda8643dfbef9bd0e\">[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury]. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15525791\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15525791&amp;hash=76d8b5c38cc952df9e11937bc7b97b06\">Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12768116\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12768116&amp;hash=e04421f792be2c20e77d2f367e5b01c0\">Ringer&#8217;s ethyl pyruvate solution: a novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12544977\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12544977&amp;hash=157cdabf30ac6cb407f17b1c59ed2f12\">Ethyl pyruvate: a novel anti-inflammatory agent. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12490623\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12490623&amp;hash=966b05ce381533b1004f3e050759034c\">Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12462557\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12462557&amp;hash=c470d826f34f8607921b3b4365ab6330\">Resuscitation with Ringer&#8217;s ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite\/nitrate concentrations in a rat mod&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12209006\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12209006&amp;hash=ba0c1753be567bae4d1b96066213c078\">Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12069183\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12069183&amp;hash=8ca12b1b35350dfd1ed0798a52b47415\">Resuscitation from hemorrhagic shock with Ringer&#8217;s ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability i&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12065309\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12065309&amp;hash=6d45152963069e017d4699274ae4fad8\">Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11844984\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F11844984&amp;hash=4e86a299d2c8dfa6854b1773ed0c6da2\">Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential be&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11376508\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F11376508&amp;hash=6b7530fed6e05f8e82cc9b53433262ed\">Ringer&#8217;s ethyl pyruvate solution: a novel resuscitation fluid. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<p>4. <b><u>CVD<\/u><\/b><br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12595283\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12595283&amp;hash=dea207582e48b51d161575349b9bbcb3\">Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29885697\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29885697&amp;hash=63a50ecdf641968d4021505c97a2ce67\">Ethyl pyruvate: A promising feasible therapeutic approach for myocardial ischemia-reperfusion injury under both normoglycemia and hyperglycemia. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29169909\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29169909&amp;hash=10a6ef2e9b3396a9c404b00813cf0250\">Ethyl pyruvate attenuates myocardial ischemia-reperfusion injury exacerbated by hyperglycemia via retained inhibitory effect on HMGB1. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29370236\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29370236&amp;hash=8a51494fae7ed0a1d7c3aa301f38666b\">Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28538193\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28538193&amp;hash=eadf0e4bdd9f0dcde83be6875e920c07\">Ethyl pyruvate protects PC12 cells from oxygen-glucose deprivation: A potential role in ischemic cerebrovascular disease. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27995262\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27995262&amp;hash=f352aa3c7141f85a632db6ab84b4d74f\">Anti-apoptotic and myocardial protective effects of ethyl pyruvate after regional ischaemia\/reperfusion myocardial damage in an in vivo rat model. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27882138\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27882138&amp;hash=5875deb5cc66c481d019bbd5ce88670e\">Impact of ethyl pyruvate on Adriamycin-induced cardiomyopathy in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26696442\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26696442&amp;hash=35c3720e330984c08e287f7e156b1d01\">Effects of Ethyl Pyruvate in Preventing the Development of Diet-induced Atherosclerosis by Blocking the HMGB1 Expression in ApoE-Deficient Mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25780465\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25780465&amp;hash=06d759f5f1478192c064a3feee164771\">Role of high-mobility group box-1 in myocardial ischemia\/reperfusion injury and the effect of ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24940411\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24940411&amp;hash=2c81edeb2beb32449ae9e7f29f7466f9\">Effects of ethyl pyruvate on cardiac function recovery and apoptosis reduction after global cold ischemia and reperfusion. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23671872\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23671872&amp;hash=35925e0738eac1d4b730940bf50148e5\">Ethyl pyruvate prevents methyglyoxal-induced retinal vascular injury in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21556772\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21556772&amp;hash=d91832b5873f6ab9c25a73a1bec1c658\">Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20879048\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20879048&amp;hash=e07455f42afdaf3a069cb9bb21f4c861\">Ethyl pyruvate has anti-inflammatory and delayed myocardial protective effects after regional ischemia\/reperfusion injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19818545\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19818545&amp;hash=7db9f219fe6c2084f98eeb5b273d4399\">Ethyl pyruvate enhances intra-resuscitation hemodynamics in prolonged ventricular fibrillation arrest. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18563323\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18563323&amp;hash=915515bc87c813c0187c594f3ab56208\">Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl-2 and Bax proteins after ischemia-reperfusion in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16352248\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16352248&amp;hash=8b0478b63dbbd4ca1fe193ae7f5e790a\">Ethyl pyruvate enhances ATP levels, reduces oxidative stress and preserves cardiac function in a rat model of off-pump coronary bypass. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15115981\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15115981&amp;hash=2e4584a3c8d01355da651ed440cc163f\">Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<p>5. <b><u>GI\/Liver\/Kidney\/Pancreas\/Lungs<\/u><\/b><br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7395994\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F7395994&amp;hash=163416ca0b7bc6243db11343d9d7c34a\">Prevention of maleate-induced tubular dysfunction by acetoacetate. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30611702\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30611702&amp;hash=4de99175a29bc0ad450cbefe95e30bc5\">Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of in vitro and in vivo studies. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30382544\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30382544&amp;hash=52fd365b9029c9e9c4c531624397ec89\">Prophylactic effect of ethyl pyruvate on renal ischemia\/reperfusion injury mediated through oxidative stress. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30352436\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30352436&amp;hash=23a906b22d78e6917c83edb22cea0bbc\">Ethyl Pyruvate Attenuates CaCl2-Induced Tubular Epithelial Cell Injury by Inhibiting Autophagy and Inflammatory Responses. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29725369\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29725369&amp;hash=73561c117c8e156e36652553020cf052\">Ethyl pyruvate can alleviate alcoholic liver disease through inhibiting Nrf2 signaling pathway. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29560444\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29560444&amp;hash=2fa1afb5f7a78158c504df29710ca525\">Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced by N-acetyl-p-benzoquinone imine. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29526883\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29526883&amp;hash=6d0a396792a122987efa2035b88f7513\">Ethyl Pyruvate Improves Pulmonary Function in Mice with Bleomycin-induced Lung Injury as Monitored with Hyperpolarized 129Xe MR Imaging. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29420582\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29420582&amp;hash=63bf2dcfa860e79bdb8c9b114c490b15\">Ethyl pyruvate ameliorates hepatic injury following blunt chest trauma and hemorrhagic shock by reducing local inflammation, NF-kappaB activation a&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29195627\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29195627&amp;hash=b90708360cabb06cbf0f4988e2a49936\">Ethyl pyruvate is renoprotective against ischemia-reperfusion injury under hyperglycemia. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29102048\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29102048&amp;hash=c96a84fefd4375fe6f8e7a9c4d3d7ca2\">Ethyl pyruvate reduces acute lung damage following trauma and hemorrhagic shock via inhibition of NF-\u03baB and HMGB1. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28601590\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28601590&amp;hash=aa7d32a16f874b7fb65135160032d4bc\">Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4\/NF-\u03baB signaling and up-regulation of MMPs\/T&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28570981\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28570981&amp;hash=734ed4c2ac489bc2ecc862ed8fd760d8\">Ethyl pyruvate alleviates radiation-induced lung injury in mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28155974\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28155974&amp;hash=500c47c8ae1fb1fd8a2e943b81b302cf\">The potential beneficial effects of ethyl pyruvate on diabetic nephropathy: an experimental and ultrastructural study. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28098908\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28098908&amp;hash=c2870033d676648869fd9e957494dff1\">Protective effects of ethyl pyruvate on lipopolysaccharide\u2011induced acute lung injury through inhibition of autophagy in neutrophils. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27689918\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27689918&amp;hash=eacb06e1f1cdbd33679dc2032d22a6a8\">Treatment response of ethyl pyruvate in a mouse model of chronic obstructive pulmonary disease studied by hyperpolarized 129 Xe MRI. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27354791\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27354791&amp;hash=23819211ca1f12d3a7b352e9b6c0c5a7\">Intratracheal instillation of ethyl pyruvate nanoparticles prevents the development of shunt-flow-induced pulmonary arterial hypertension in a rat &#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27010523\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27010523&amp;hash=3e561d1b897b598d8a61622b1f394fb7\">Preventive Effect of Ethyl Pyruvate on Postoperative Adhesion Formation Following Abdominal Surgery. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26541861\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26541861&amp;hash=f34b9bf222fe9427cb835cd7bad06335\">Ethyl pyruvate ameliorates experimental colitis in mice by inhibiting the HMGB1-Th17 and Th1\/Tc1 responses. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26019553\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26019553&amp;hash=d84b8b3867e1f7818a19510d2a2d704f\">Protective effects of ethyl pyruvate in cisplatin-induced nephrotoxicity. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25954992\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25954992&amp;hash=0e7ec81da1e49d3a1c4f9abf9f216721\">Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by &#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25530684\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25530684&amp;hash=714bbd8f52795ac5e4ef3c9bd8b91796\">Decreased inflammatory responses of human lung epithelial cells after ethanol exposure are mimicked by ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25126977\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25126977&amp;hash=8e23fbb17d570d729e901f1e24308968\">Preventing intraperitoneal adhesions with ethyl pyruvate and hyaluronic acid\/carboxymethylcellulose: a comparative study in an experimental model. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24575415\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24575415&amp;hash=55523e598f4ee161475b59c3f2ebd5a0\">Role of ethyl pyruvate in systemic inflammatory response and lung injury in an experimental model of ruptured abdominal aortic aneurysm. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24498418\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24498418&amp;hash=a7db759a535eac5024f92c8bc6f9e896\">Ethyl pyruvate pretreatment attenuates concanavalin a-induced autoimmune hepatitis in mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24492475\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24492475&amp;hash=6b6eb09da6fecfa750a2611c642595d4\">Ethyl pyruvate ameliorates monocrotaline-induced pulmonary arterial hypertension in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24453420\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24453420&amp;hash=83d1b8e02d36f83bb6184a5a9d93cae7\">Ethyl pyruvate ameliorates hepatic ischemia-reperfusion injury by inhibiting intrinsic pathway of apoptosis and autophagy. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24361892\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24361892&amp;hash=636fc11c923bbe8bb1ad8deb62a78c1a\">Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23896834\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23896834&amp;hash=e20178a1d5da644939fb7375ecd28f11\">Ethyl-pyruvate reduces lung injury matrix metalloproteinases and cytokines and improves survival in experimental model of severe acute pancreatitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23883694\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23883694&amp;hash=4e6615a177a6b7b82788681db581ad00\">The effect of ethyl pyruvate supplementation on rat fatty liver induced by a high-fat diet. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23600830\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23600830&amp;hash=0094ce217dcbb084234330f7097ff292\">Ethyl pyruvate significantly inhibits tumour necrosis factor-\u03b1, interleukin-1\u03b2 and high mobility group box 1 releasing and attenuates sodium tauroc&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23558073\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23558073&amp;hash=116b4e44ce97529202ea058d042873e6\">Ethyl pyruvate prevents inflammatory factors release and decreases intestinal permeability in rats with D-galactosamine-induced acute liver failure. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23155311\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23155311&amp;hash=b55bb8e108141fdad3c9a1bfe21234e1\">Ethyl pyruvate protects against experimental acute-on-chronic liver failure in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23082705\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23082705&amp;hash=cb9725ad1f349ebbc0a1e6dea4f3de26\">Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22717227\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22717227&amp;hash=0296ed7cf6f9dea1c7cf5e8730ad6eb9\">Protective effect of ethyl pyruvate on pancreas injury in rats with severe acute pancreatitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22715434\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22715434&amp;hash=58d41ec3656fee72ffac5621565f79f7\">Ethyl pyruvate reduces ventilation-induced neutrophil infiltration and oxidative stress. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22699144\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22699144&amp;hash=90b8462e66e3a8eb69d235071b5d748c\">Therapeutic treatment with ethyl pyruvate attenuates the severity of liver injury in rats with severe acute pancreatitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22298750\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22298750&amp;hash=4d405ed2fe3c898117e6f86e7d3571ab\">Ethyl pyruvate improves healing of colonic anastomosis in a rat model of peritonitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22129969\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22129969&amp;hash=00db11c1081be098b029e086bce48c97\">Ethyl pyruvate ameliorates albuminuria and glomerular injury in the animal model of diabetic nephropathy. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21818760\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21818760&amp;hash=9cba092e116e33709588d6c20f1d14ed\">Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase2 and inducible nitric oxide synthase expression. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21324485\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21324485&amp;hash=be3c8cd1cd80bb9b72128c6d2f967345\">Ethyl pyruvate reduces acute lung injury via regulation of iNOS and HO-1 expression in endotoxemic rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21190605\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21190605&amp;hash=f28851f1c5d5798f32c007f7ce5ef2eb\">[Effect of ethyl pyruvate on expression of inflammatory factors and mitogen-activated protein kinase proteins in renal ischemic\/reperfusion injury &#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19959189\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19959189&amp;hash=8d07ee1b72620bf878fe4a26f1ff5692\">Effects of ethyl pyruvate and other \u03b1-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19799777\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19799777&amp;hash=494d11e4c8f20d9ffb5fa09c080541f4\">Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19628226\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19628226&amp;hash=551f92ef7cc3a66af52a863aa14935d1\">Ethyl pyruvate prevents intestinal inflammatory response and oxidative stress in a rat model of extrahepatic cholestasis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19345231\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19345231&amp;hash=33ef8c8753e936d50110ecf65ab62707\">Ethyl pyruvate modulates adhesive and secretory reactions in human lung epithelial cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19064591\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19064591&amp;hash=47e57c201323841f9d75127caf8c79e7\">Ethyl pyruvate protects colonic anastomosis from ischemia-reperfusion injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19027919\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19027919&amp;hash=284099a46adb7056f45c409880cc25b2\">Ethyl pyruvate ameliorates liver injury secondary to severe acute pancreatitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18790172\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18790172&amp;hash=80181d4a0ad5f788f0c6c77f57fd0d4e\">The role of high-mobility group box-1 in renal ischemia and reperfusion injury and the effect of ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18680237\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18680237&amp;hash=af5a5db0aac4650d3d3da800af259e1c\">Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18067720\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18067720&amp;hash=48a5a0fb61aa242c80d58bbce35d0ee0\">[Effect of ethyl pyruvate on renal high mobility group box-1 protein expression and acute kidney injury in rats with delayed resuscitation after th&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17914505\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17914505&amp;hash=6d603273dce78bcc4194446f87d72b5a\">The protective effect of ethyl pyruvate on lung injury after burn in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17895847\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17895847&amp;hash=93a5cb5bb2dbabffcfa6afd761db14a1\">Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17577142\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17577142&amp;hash=a57b2f5a2e0e866f34c7a5fd1f540b00\">Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17574585\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17574585&amp;hash=9ffa3c4ea7d6703ebeeeb8a70c4daf31\">Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17574580\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17574580&amp;hash=6152c1759204594aab58934d4114eb8e\">The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16524507\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16524507&amp;hash=5b4d80e3f2343a83ae4004ebf007262c\">[Effect of ethyl pyruvate on peroxidation injury of intestinal mucosa in rats with severe abdominal infection]. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16356237\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16356237&amp;hash=8242956c314147e8301148971befc063\">Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16213909\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16213909&amp;hash=f14719f4fb4acf336bc04ccdf9d244af\">Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15665768\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15665768&amp;hash=84692d022877c99aff0be6aa6f364cf7\">Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15377894\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15377894&amp;hash=79dd5d3d9385a6340c6091db690acff1\">Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15241088\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15241088&amp;hash=64159a7c0fc508433fecb6807e7d628d\">Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14647036\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F14647036&amp;hash=7810c74676b96c63153f7d09ecd2fcc5\">Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14625476\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F14625476&amp;hash=0113dfbc92b448fe91786c923fddf2a4\">Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14531793\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F14531793&amp;hash=da9e024ef22da17f59f769109f4f2eca\">Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12955182\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12955182&amp;hash=e15fc635fcaaa71ddf80f78847b42afb\">Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11505117\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F11505117&amp;hash=187525f5b708c5e0759d66af0af0865c\">Ringer&#8217;s ethyl pyruvate solution ameliorates ischemia\/reperfusion-induced intestinal mucosal injury in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<p>6. <b><u>Brain\/CNS\/Mood\/Muscle\/Vision<\/u><\/b><br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28294308\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28294308&amp;hash=ff29dd6e0307a143db4a7eb1c6221680\">Neuronal inhibition and seizure suppression by acetoacetate and its analog, 2-phenylbutyrate. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26645687\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26645687&amp;hash=ab6052334d3b7c5041c399a79c74f73d\">Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16435389\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16435389&amp;hash=f7149ba5801b097560b72aaf179270b6\">Acetoacetate protects neuronal cells from oxidative glutamate toxicity. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12890508\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F12890508&amp;hash=54cd5447a74a11ff752d6d2587bd3e80\">Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6733142\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F6733142&amp;hash=ce2c9ef38436c8b3a17707af8bd40ae9\">Acetoacetate is a cholesterogenic precursor for myelinating rat brain and spinal cord. Incorporation of label from [3-14C]acetoacetate, [14C]glucos&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30160153\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30160153&amp;hash=210037d75fe6fcac2cd08d8db8135a38\">Ethyl pyruvate prevents from chronic cerebral hypoperfusion via preserving cognitive function and decreasing oxidative stress, caspase 3 activation&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28836378\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28836378&amp;hash=ffc27226cc1e6bc32aaf14f95b869aab\">Ethyl pyruvate does not require microglia for mediating neuroprotection after excitotoxic injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28236213\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28236213&amp;hash=1077e6ee12a116c9362bb924b1b05bf0\">Ethyl Pyruvate Attenuates Early Brain Injury Following Subarachnoid Hemorrhage in the Endovascular Perforation Rabbit Model Possibly Via Anti-infla&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27776698\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27776698&amp;hash=c50e2bbccd875904ca72b4c0b32bda67\">Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27324856\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27324856&amp;hash=6dab318b6c7e638c89c9d2c321c0b038\">The effect of ethyl pyruvate and N-acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic stroke. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27072679\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27072679&amp;hash=125627d32c78873c11609061c1c978ca\">Ethyl pyruvate alleviates early brain injury following subarachnoid hemorrhage in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26850126\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26850126&amp;hash=75731b0deb321fce7204f1d7f8f58ccd\">Neuroprotective effect of ethyl pyruvate against Zn(2+) toxicity via NAD replenishment and direct Zn(2+) chelation. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026However, when cortical neurons were exposed to acute treatment of Zn(2+) (400 \u03bcM, 15 min),<b><u> EP, but not pyruvate, significantly suppressed neuronal death<\/u><\/b>, despite the fact that NAD replenishment by EP was weaker than that by pyruvate. Spectrophotometric studies revealed that EP directly chelates Zn(2+), and this was confirmed in physiological contexts, such as, NMDA-treated primary cortical cultures and OGD-subjected hippocampal slice cultures, in which EP suppressed intracellular Zn(2+) elevation and neuronal cell death. In addition, EP markedly reduced the expressions of PARP-1 and of the NADPH oxidase subunit in Zn(2+)-treated primary cortical neurons, well known Zn(2+)-induced downstream processes. Together, these results show <b><u>EP suppresses Zn(2+) induced neurotoxicity via dual functions, chelating Zn(2+) and promoting NAD replenishment<\/u><\/b>.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26054669\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26054669&amp;hash=f62a89c811cdb4b977c0d08500796f7b\">Short term exposure to ethyl pyruvate has long term anti-inflammatory effects on microglial cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25999282\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25999282&amp;hash=f7f788742fae870857593cd5d0d6cdee\">Combination treatment with ethyl pyruvate and IGF-I exerts neuroprotective effects against brain injury in a rat model of neonatal hypoxic-ischemic&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25533312\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25533312&amp;hash=cf362376b80c6cc0a141970f06403196\">Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24576481\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24576481&amp;hash=7dda8bdc3a239c676678376c94145163\">Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24371837\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24371837&amp;hash=4de52c2ff7f0b71f26d99a1ce86045df\">Ethyl pyruvate inhibits retinal pathogenic neovascularization by downregulating HMGB1 expression. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24246904\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24246904&amp;hash=bd3d2eca18e4db5535810c66d9623f29\">Ethyl pyruvate inhibits HMGB1 phosphorylation and secretion in activated microglia and in the postischemic brain. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23821591\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23821591&amp;hash=2204a3d12603d6f80124a12671c38431\">Neuroprotective effects of \u03b1-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23805037\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23805037&amp;hash=fb2af4dcfb5ee4f06198d0eb37dd96cc\">Ethyl pyruvate treatment mitigates oxidative stress damage in cultured trabecular meshwork cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23624063\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23624063&amp;hash=6b95751bf47829676652f1530ed2b56b\">Ethyl pyruvate ameliorates intracerebral hemorrhage-induced brain injury through anti-cell death and anti-inflammatory mechanisms. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23614074\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23614074&amp;hash=27ce2444b742f484888feacdef0a58f4\">Effect of ethyl pyruvate on Paclitaxel-induced neuropathic pain in rats. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23471594\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23471594&amp;hash=7f8bed766d01e2bcae0960f922f34511\">Improvement of hypoxia-ischemia-induced white matter injury in immature rat brain by ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23280059\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23280059&amp;hash=f2caedc9c6b76602228e43c6c79a9a1a\">Ethyl pyruvate protects against lipopolysaccharide-induced white matter injury in the developing rat brain. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23091681\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23091681&amp;hash=45a55b4292ac427950f3c790fb2683ca\">Effects of Ethyl Pyruvate on Allodynia, TNF-\u03b1 Expression, and Apoptosis in the Dorsal Root Ganglion after Spinal Nerve Ligation Injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22142175\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22142175&amp;hash=78912897723538c521c6fa1c2cc4a92b\">Ethyl pyruvate promotes spinal cord repair by ameliorating the glial microenvironment. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21772666\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21772666&amp;hash=fff49128ec8be9e572cb247ec433d987\">Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4\/NF-\u03baB pathway after traumatic brain injury in&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21685323\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21685323&amp;hash=ca717f99c4f3931ac7e1297ba0d531c6\">Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson&#8217;s disease. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21316417\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21316417&amp;hash=282509ad54b676ce54bd099d712c9dd4\">Inhibitory mechanism of MMP-9 gene expression by ethyl pyruvate in lipopolysaccharide-stimulated BV2 microglial cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21217488\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21217488&amp;hash=a66c5f03cf61e09b2d808475fcccc09a\">Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murin&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20670624\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20670624&amp;hash=f80b37342deb698a98d891f687ddfc5f\">Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20307492\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20307492&amp;hash=642c291ed9c116fc7e6ec6a8a0e95cd2\">Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson&#8217;s disease model. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20053976\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20053976&amp;hash=a700057ea475c63c82a87785626c2d38\">Responses of cultured human keratocytes and myofibroblasts to ethyl pyruvate: a microarray analysis of gene expression. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20026271\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20026271&amp;hash=b8b47c562be6adf299d270f1b5252100\">Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19768540\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19768540&amp;hash=d87d621e740086f26ad101dab770d8b1\">Ethyl pyruvate inhibits peroxynitrite-induced DNA damage and hydroxyl radical generation: implications for neuroprotection. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19636661\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19636661&amp;hash=a15d171536c66fd9728f64fc323a7621\">Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19417608\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19417608&amp;hash=3e1722a700b2482cdc0b126a11a3b38b\">Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19041675\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19041675&amp;hash=90c66b1253bd57603837a4be2bdc3488\">Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18985448\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18985448&amp;hash=d5406982b03860dda7755de2df7941ab\">Neuroprotective effects of ethyl pyruvate on brain energy metabolism after ischemia-reperfusion injury: a 31P-nuclear magnetic resonance study. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18948848\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18948848&amp;hash=e5086fce3733a799dec5a17f2d852f83\">Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18625301\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18625301&amp;hash=368d72574742b613ef8560d8a57f998d\">Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17893460\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17893460&amp;hash=ea34b3aa59a904a2f889a936f191bd2f\">Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16958132\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16958132&amp;hash=a9891a27a54e29bdb1a65095456bd4e3\">Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16374049\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16374049&amp;hash=55424726b0e5255ad69536f59fb864d0\">Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16226231\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16226231&amp;hash=245a4297e319914a156a23eee33c8578\">Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16141417\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F16141417&amp;hash=d39abaf3f1562dc6ba780bbfed321516\">Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15680254\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F15680254&amp;hash=bf3549159ccf24511d43db4b2e1c809d\">Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10569189\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F10569189&amp;hash=a7d93ef67ef60104bb9e11fb74f3f135\">Attenuation of sugar cataract by ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<p>7. <b><u>Sexuality\/Reproduction<\/u><\/b><br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27441057\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27441057&amp;hash=b5340ebfd14b99a3b2e52afd3b5d4d57\">Attenuation of Methotrexate-Induced Embryotoxicity and Oxidative Stress by Ethyl Pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27226889\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27226889&amp;hash=a178439ad25332ddbe86b8a2c6810044\">Protective effect of ethyl pyruvate on mice sperm parameters in phenylhydrazine induced hemolytic anemia. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27123204\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27123204&amp;hash=585a1b72ea5501730f8bedf2950a9d44\">Ethyl Pyruvate Ameliorates The Damage Induced by Cyclophosphamide on Adult Mice Testes. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26221128\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26221128&amp;hash=6ddedf8fed01df8a7e62ed7c021ddb60\">Protective effects of ethyl pyruvate on sperm quality in cyclophosphamide treated mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25291349\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F25291349&amp;hash=85d6d3289a6b9970250794e3c20566ca\">Protective effect of ethyl pyruvate on ischemia-reperfusion injury in rat ovary: biochemical and histopathological evaluation. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24551573\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24551573&amp;hash=9510a244bd06896d87c30ac82eae3f52\">Protective effect of ethyl pyruvate on epididymal sperm characteristics, oxidative stress and testosterone level in methotrexate treated mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22717346\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22717346&amp;hash=2d4d37742526f5ae72a870c261743d97\">A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18405719\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18405719&amp;hash=58f216cdfd77811a6814716ced240726\">Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion\/detorsion. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<p>8. <b><u>Cancer<\/u><\/b><br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30417494\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30417494&amp;hash=1b0a0b50fd954a6f672553336ff0751b\">Pyruvic acid\/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K\/AKT, GSK3\u03b2, and ROS-ERK signaling pathways. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30008929\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30008929&amp;hash=ffe78b00793bd4a0c04d447c86a24dda\">Suppressed epithelial-mesenchymal transition and cancer stem cell properties mediate the anti-cancer effects of ethyl pyruvate via regulation of th&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28186988\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28186988&amp;hash=6e34587b3807a2a01c91280cbc4dfd9d\">HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27579985\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27579985&amp;hash=fca7bfc818a02026b2cacac7dccc4881\">Ethyl Pyruvate Combats Human Leukemia Cells but Spares Normal Blood Cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24288766\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24288766&amp;hash=7f0fdf79e3fbc8a4d5d6243c0e944cee\">Immunomodulating effect of ethyl pyruvate on nonsyngenic transplanted tumor in mice. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24105621\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24105621&amp;hash=9cf6009256ddaf127526674de2b11e77\">Exploring glyoxalase 1 expression in prostate cancer tissues: targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23298486\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23298486&amp;hash=51609b7e789477dff0d8f7d4f1403c19\">Ethyl pyruvate administration suppresses growth and invasion of gallbladder cancer cells via downregulation of HMGB1-RAGE axis. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22453153\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22453153&amp;hash=3f89ba421d384b84c3092d4454d5fcb1\">Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyru&#8230; &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21333439\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21333439&amp;hash=d912d70fe865eb73a259327b44582cf1\">Ethyl pyruvate, an anti-inflammatory agent, inhibits tumor angiogenesis through inhibition of the NF-\u03baB signaling pathway. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20160032\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F20160032&amp;hash=e27dfd17e06875b412328149169a1277\">Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026Our findings that <b><u>IDO is effectively blocked by EP treatment<\/u><\/b> deepens emerging links between IDO and inflammatory processes. Further, these findings rationalize oncological applications for this agent, by providing a <b><u>compelling basis to reposition EP as a low cost immunochemotherapy for clinical evaluation in cancer patients<\/u><\/b>.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19584311\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F19584311&amp;hash=2ad219724263b7d02b41940d6fdc94d9\">Ethyl pyruvate administration inhibits hepatic tumor growth. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17611636\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17611636&amp;hash=76c8de4042ba25de328184191754b78e\">Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<p>9. <b><u>Infection\/Pathogen<\/u><\/b><br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29341217\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F29341217&amp;hash=47e25a5f9e0ae16f8e9e23335963b837\">Acetoacetate and ethyl acetoacetate as novel inhibitors of bacterial biofilm. &#8211; PubMed &#8211; NCBI<\/a> (EA)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30623442\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F30623442&amp;hash=a354996408d54eaa9dc80b28c8848659\">Ethyl pyruvate (EP) suppressed postharvest blue mold of sweet cherry fruit by inhibiting the growth of Penicillium oxalicum. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27658257\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27658257&amp;hash=33d60fba6100a6602154e63adebf906d\">Ethyl Pyruvate: An Anti-Microbial Agent that Selectively Targets Pathobionts and Biofilms. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n\u201c\u2026The microbiota has a strong influence on health and disease in humans. A causative shift favoring pathobionts is strongly linked to diseases. Therefore, anti-microbial agents selectively targeting potential pathogens as well as their biofilms are urgently demanded. Here we demonstrate the impact of ethyl pyruvate, so far known as ROS scavenger and anti-inflammatory agent, on planktonic microbes and biofilms. <b><u>Ethyl pyruvate combats preferably the growth of pathobionts belonging to bacteria and fungi independent of the genera and prevailing drug resistance. Surprisingly, this anti-microbial agent preserves symbionts like Lactobacillus species. Moreover, ethyl pyruvate prevents the formation of biofilms and promotes matured biofilms dissolution. This potentially new anti-microbial and anti-biofilm agent could have a tremendous positive impact on human<\/u><\/b>, veterinary medicine and technical industry as well.\u201d<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27026909\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27026909&amp;hash=d01b86e8c5843290970bfeb3621f5f84\">Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1\/RAGE\/NF-\u039aB pathway. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26340747\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26340747&amp;hash=ec6286f408e4e31d2339127e153f3397\">Ethyl Pyruvate Emerges as a Safe and Fast Acting Agent against Trypanosoma brucei by Targeting Pyruvate Kinase Activity. &#8211; PubMed &#8211; NCBI<\/a> (EP)<br \/>\n<a class=\"link link--external\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22691467\" target=\"_blank\" rel=\"nofollow ugc noopener\" data-proxy-href=\"\/proxy.php?link=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22691467&amp;hash=5a1806ff798a4632920207b46341effd\">Decontamination of green onions and baby spinach by vaporized ethyl pyruvate. &#8211; PubMed &#8211; NCBI<\/a> (EP)<\/p>\n<p><strong>\u041e\u0442\u043a\u0430\u0437 \u043e\u0442 \u043e\u0442\u0433\u043e\u0432\u043e\u0440\u043d\u043e\u0441\u0442<\/strong>: \u0422\u0430\u0437\u0438 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f \u0435 \u0441\u0430\u043c\u043e \u0437\u0430 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u0438 \u0446\u0435\u043b\u0438 \u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u0441\u0442\u0432\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u0441\u044a\u0432\u0435\u0442. \u041a\u043e\u043d\u0441\u0443\u043b\u0442\u0438\u0440\u0430\u0439\u0442\u0435 \u0441\u0435 \u0441 \u043b\u0435\u043a\u0430\u0440 \u043f\u0440\u0435\u0434\u0438 \u0443\u043f\u043e\u0442\u0440\u0435\u0431\u0430 \u043d\u0430 \u041f\u0418\u0420\u0423\u0410\u0426\u0415\u0422\u041e, \u043e\u0441\u043e\u0431\u0435\u043d\u043e \u043f\u0440\u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f \u0438\u043b\u0438 \u043f\u0440\u0438\u0435\u043c \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A\u043d\u0430\u043b\u043e\u0433 \u043d\u0430 Pyrucet\u00a0 \u043d\u0430 Idealabs Pyruaceto \u2013 \u0415\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f\u0442 \u043a\u0430\u0442\u0430\u043b\u0438\u0437\u0430\u0442\u043e\u0440 \u0437\u0430 \u043e\u043f\u0442\u0438\u043c\u0430\u043b\u0435\u043d \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u041e\u043f\u0438\u0441\u0430\u043d\u0438\u0435 \u043d\u0430 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0430: Pyruaceto \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430, \u0441\u044a\u0447\u0435\u0442\u0430\u0432\u0430\u0449\u0430 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u2013 \u0434\u0432\u0435 \u043c\u043e\u0449\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u043e\u0442\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430. \u041a\u043b\u044e\u0447\u043e\u0432\u0438 \u0441\u044a\u0441\u0442\u0430\u0432\u043a\u0438 \u0438 \u0442\u0435\u0445\u043d\u0438\u0442\u0435 \u043f\u043e\u043b\u0437\u0438: \u0415\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u041f\u043e\u0434\u043e\u0431\u0440\u044f\u0432\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c: \u0415\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442\u044a\u0442 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430 \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435\u0442\u043e \u043d\u0430 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24560,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"product_brand":[],"product_cat":[845,1021,1134],"product_tag":[1348,1345,1346,1344,987,1347,1351,1340,1354,1333,1353,1349,861,1352,1099,1342,1350],"woo-feed-brand":[],"class_list":{"0":"post-23962","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-haidut","7":"product_cat-lslabs","8":"product_cat-1134","9":"product_tag-1348","10":"product_tag-1345","11":"product_tag-1346","12":"product_tag-1344","13":"product_tag-987","14":"product_tag-1347","15":"product_tag-1351","16":"product_tag-1340","17":"product_tag-1354","18":"product_tag-1333","19":"product_tag-1353","20":"product_tag-1349","21":"product_tag-861","22":"product_tag-1352","23":"product_tag-1099","24":"product_tag-1342","25":"product_tag-1350","27":"first","28":"instock","29":"taxable","30":"shipping-taxable","31":"purchasable","32":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u0415\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430 \u0437\u0430 \u0447\u0440\u0435\u0432\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u2013 \u041a\u0430\u043c\u0444\u0440\u0438\u0441\u0430\u043b<\/title>\n<meta name=\"description\" content=\"Pyruaceto \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430, \u0441\u044a\u0447\u0435\u0442\u0430\u0432\u0430\u0449\u0430 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u2013 \u0434\u0432\u0435 \u043c\u043e\u0449\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u043e\u0442\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xenobg.com\/ro\/produs\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0415\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430 \u0437\u0430 \u0447\u0440\u0435\u0432\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u2013 \u041a\u0430\u043c\u0444\u0440\u0438\u0441\u0430\u043b\" \/>\n<meta property=\"og:description\" content=\"Pyruaceto \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430, \u0441\u044a\u0447\u0435\u0442\u0430\u0432\u0430\u0449\u0430 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u2013 \u0434\u0432\u0435 \u043c\u043e\u0449\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u043e\u0442\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/xenobg.com\/ro\/produs\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/xenobg\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-05T21:31:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/xenobg.com\/wp-content\/uploads\/2025\/03\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:label1\" content=\"Timp estimat pentru citire\" \/>\n\t<meta name=\"twitter:data1\" content=\"43 de minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/produkt\\\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\\\/\",\"url\":\"https:\\\/\\\/xenobg.com\\\/produkt\\\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\\\/\",\"name\":\"\u0415\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430 \u0437\u0430 \u0447\u0440\u0435\u0432\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u2013 \u041a\u0430\u043c\u0444\u0440\u0438\u0441\u0430\u043b\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/produkt\\\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/produkt\\\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/xenobg.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg\",\"datePublished\":\"2024-11-07T22:51:12+00:00\",\"dateModified\":\"2026-01-05T21:31:28+00:00\",\"description\":\"Pyruaceto \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430, \u0441\u044a\u0447\u0435\u0442\u0430\u0432\u0430\u0449\u0430 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u2013 \u0434\u0432\u0435 \u043c\u043e\u0449\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u043e\u0442\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/xenobg.com\\\/produkt\\\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\\\/#breadcrumb\"},\"inLanguage\":\"ro-RO\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/xenobg.com\\\/produkt\\\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ro-RO\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/produkt\\\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\\\/#primaryimage\",\"url\":\"https:\\\/\\\/xenobg.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg\",\"contentUrl\":\"https:\\\/\\\/xenobg.com\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg\",\"width\":1080,\"height\":1080,\"caption\":\"Pyruaceto \u043e\u0442 LSLabs \u043c\u0438\u043a\u0441 \u043e\u0442 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/produkt\\\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u041d\u0430\u0447\u0430\u043b\u043e\",\"item\":\"https:\\\/\\\/xenobg.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u041c\u0430\u0433\u0430\u0437\u0438\u043d\",\"item\":\"https:\\\/\\\/xenobg.com\\\/magazin\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Pyruaceto -\u0442\u0435\u0447\u0435\u043d \u043f\u0438\u0440\u0443\u0432\u0430\u0442\\\/\u0430\u0446\u0435\u0430\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u043c\u0438\u043a\u0441\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/xenobg.com\\\/#website\",\"url\":\"https:\\\/\\\/xenobg.com\\\/\",\"name\":\"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439\",\"description\":\"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439 \u0441 \u0412\u0435\u0441\u0435\u043b\u0438\u043d \u0438 IdeaLabs \u0438 LSlabs\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/xenobg.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ro-RO\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u0415\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430 \u0437\u0430 \u0447\u0440\u0435\u0432\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u2013 \u041a\u0430\u043c\u0444\u0440\u0438\u0441\u0430\u043b","description":"Pyruaceto \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430, \u0441\u044a\u0447\u0435\u0442\u0430\u0432\u0430\u0449\u0430 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u2013 \u0434\u0432\u0435 \u043c\u043e\u0449\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u043e\u0442\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/xenobg.com\/ro\/produs\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/","og_locale":"ro_RO","og_type":"article","og_title":"\u0415\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430 \u0437\u0430 \u0447\u0440\u0435\u0432\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u2013 \u041a\u0430\u043c\u0444\u0440\u0438\u0441\u0430\u043b","og_description":"Pyruaceto \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430, \u0441\u044a\u0447\u0435\u0442\u0430\u0432\u0430\u0449\u0430 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u2013 \u0434\u0432\u0435 \u043c\u043e\u0449\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u043e\u0442\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430.","og_url":"https:\/\/xenobg.com\/ro\/produs\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/","og_site_name":"\u0423\u0441\u0435\u0442\u0438, \u043c\u0438\u0441\u043b\u0438, \u0434\u0435\u0439\u0441\u0442\u0432\u0430\u0439","article_publisher":"https:\/\/www.facebook.com\/xenobg","article_modified_time":"2026-01-05T21:31:28+00:00","og_image":[{"width":1080,"height":1080,"url":"https:\/\/xenobg.com\/wp-content\/uploads\/2025\/03\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg","type":"image\/jpeg"}],"twitter_misc":{"Timp estimat pentru citire":"43 de minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/xenobg.com\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/","url":"https:\/\/xenobg.com\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/","name":"\u0415\u0441\u0442\u0435\u0441\u0442\u0432\u0435\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430 \u0437\u0430 \u0447\u0440\u0435\u0432\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435 \u2013 \u041a\u0430\u043c\u0444\u0440\u0438\u0441\u0430\u043b","isPartOf":{"@id":"https:\/\/xenobg.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/xenobg.com\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/#primaryimage"},"image":{"@id":"https:\/\/xenobg.com\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/#primaryimage"},"thumbnailUrl":"https:\/\/xenobg.com\/wp-content\/uploads\/2025\/03\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg","datePublished":"2024-11-07T22:51:12+00:00","dateModified":"2026-01-05T21:31:28+00:00","description":"Pyruaceto \u0435 \u0438\u043d\u043e\u0432\u0430\u0442\u0438\u0432\u043d\u0430 \u0442\u0435\u0447\u043d\u0430 \u0444\u043e\u0440\u043c\u0443\u043b\u0430, \u0441\u044a\u0447\u0435\u0442\u0430\u0432\u0430\u0449\u0430 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u2013 \u0434\u0432\u0435 \u043c\u043e\u0449\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0434\u043f\u043e\u043c\u0430\u0433\u0430\u0442 \u0435\u043d\u0435\u0440\u0433\u0438\u0439\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c \u0438 \u043d\u0430\u0441\u044a\u0440\u0447\u0430\u0432\u0430\u0442 \u0437\u0434\u0440\u0430\u0432\u043e\u0441\u043b\u043e\u0432\u043d\u043e\u0442\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430.","breadcrumb":{"@id":"https:\/\/xenobg.com\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/#breadcrumb"},"inLanguage":"ro-RO","potentialAction":[{"@type":"ReadAction","target":["https:\/\/xenobg.com\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/"]}]},{"@type":"ImageObject","inLanguage":"ro-RO","@id":"https:\/\/xenobg.com\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/#primaryimage","url":"https:\/\/xenobg.com\/wp-content\/uploads\/2025\/03\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg","contentUrl":"https:\/\/xenobg.com\/wp-content\/uploads\/2025\/03\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg","width":1080,"height":1080,"caption":"Pyruaceto \u043e\u0442 LSLabs \u043c\u0438\u043a\u0441 \u043e\u0442 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442"},{"@type":"BreadcrumbList","@id":"https:\/\/xenobg.com\/produkt\/pyruaceto-pyrucet-liquid-ethyl-pyruvatea-ceatoacetate-mix-alternative-idealabs-lslabs\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u041d\u0430\u0447\u0430\u043b\u043e","item":"https:\/\/xenobg.com\/"},{"@type":"ListItem","position":2,"name":"\u041c\u0430\u0433\u0430\u0437\u0438\u043d","item":"https:\/\/xenobg.com\/magazin\/"},{"@type":"ListItem","position":3,"name":"Pyruaceto -\u0442\u0435\u0447\u0435\u043d \u043f\u0438\u0440\u0443\u0432\u0430\u0442\/\u0430\u0446\u0435\u0430\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442 \u043c\u0438\u043a\u0441"}]},{"@type":"WebSite","@id":"https:\/\/xenobg.com\/#website","url":"https:\/\/xenobg.com\/","name":"Sim\u021bi\u021bi, g\u00e2ndi\u021bi, ac\u021biona\u021bi","description":"Simte, g\u00e2nde\u0219te, ac\u021bioneaz\u0103 cu Veselin \u0219i IdeaLabs \u0219i LSlabs","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/xenobg.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ro-RO"}]}},"jetpack_publicize_connections":[],"featured_img":"https:\/\/xenobg.com\/wp-content\/uploads\/2025\/03\/Pyruaceto-lslabs-liquid-supplements-laboratories-idealabs-alternative-europe-ethyl-acetoacetate-pyruvate-30ml.jpg","coauthors":[],"author_meta":{"author_link":"https:\/\/xenobg.com\/ro\/author\/xenobg\/","display_name":"\u0425\u0430\u0439\u0434\u0443\u0442\u0438\u043d"},"relative_dates":{"created":"Posted 1 an ago","modified":"Updated 4 luni ago"},"absolute_dates":{"created":"Posted on 08.11.2024","modified":"Updated on 05.01.2026"},"absolute_dates_time":{"created":"Posted on 08.11.2024 12:51 am","modified":"Updated on 05.01.2026 11:31 pm"},"featured_img_caption":"Pyruaceto \u043e\u0442 LSLabs \n\u043c\u0438\u043a\u0441 \u043e\u0442 \u0435\u0442\u0438\u043b \u043f\u0438\u0440\u0443\u0432\u0430\u0442 \u0438 \u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442","tax_additional":{"product_brand":{"linked":[],"unlinked":[],"slug":"product_brand","name":"Branduri"},"product_type":{"linked":["<a href=\"https:\/\/xenobg.com\/ro\/?taxonomy=product_type&#038;term=simple\" class=\"advgb-post-tax-term\">simple<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">simple<\/span>"],"slug":"product_type","name":"Tip de produs"},"product_visibility":{"linked":[],"unlinked":[],"slug":"product_visibility","name":"Vizibilitate produs"},"product_cat":{"linked":["<a href=\"https:\/\/xenobg.com\/ro\/produktova-kategoria\/haidut\/\" class=\"advgb-post-tax-term\">haidut<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktova-kategoria\/lslabs\/\" class=\"advgb-post-tax-term\">LSLabs-liquid supplements labs<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktova-kategoria\/%d1%80%d0%b5%d0%b9-%d0%bf%d0%b8%d0%b9%d1%82-%d0%b4%d0%be%d0%b1%d0%b0%d0%b2%d0%ba%d0%b8\/\" class=\"advgb-post-tax-term\">\u0440\u0435\u0439 \u043f\u0438\u0439\u0442 \u0434\u043e\u0431\u0430\u0432\u043a\u0438<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">haidut<\/span>","<span class=\"advgb-post-tax-term\">LSLabs-liquid supplements labs<\/span>","<span class=\"advgb-post-tax-term\">\u0440\u0435\u0439 \u043f\u0438\u0439\u0442 \u0434\u043e\u0431\u0430\u0432\u043a\u0438<\/span>"],"slug":"product_cat","name":"Categorii de produse"},"product_tag":{"linked":["<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%b0%d0%bd%d1%82%d0%b8%d0%be%d0%ba%d1%81%d0%b8%d0%b4%d0%b0%d0%bd%d1%82\/\" class=\"advgb-post-tax-term\">\u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%b3%d0%bb%d1%8e%d0%ba%d0%be%d0%b7%d0%bd%d0%be-%d0%be%d0%ba%d0%b8%d1%81%d0%bb%d0%b5%d0%bd%d0%b8%d0%b5\/\" class=\"advgb-post-tax-term\">\u0433\u043b\u044e\u043a\u043e\u0437\u043d\u043e \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%b5%d0%bd%d0%b5%d1%80%d0%b3%d0%b8%d0%b5%d0%bd-%d0%bc%d0%b5%d1%82%d0%b0%d0%b1%d0%be%d0%bb%d0%b8%d0%b7%d1%8a%d0%bc\/\" class=\"advgb-post-tax-term\">\u0435\u043d\u0435\u0440\u0433\u0438\u0435\u043d \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%b5%d1%82%d0%b8%d0%bb-%d0%b0%d1%86%d0%b5%d1%82%d0%be%d0%b0%d1%86%d0%b5%d1%82%d0%b0%d1%82\/\" class=\"advgb-post-tax-term\">\u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%b5%d1%82%d0%b8%d0%bb-%d0%bf%d0%b8%d1%80%d1%83%d0%b2%d0%b0%d1%82\/\" class=\"advgb-post-tax-term\">\u0435\u0442\u0438\u043b-\u043f\u0438\u0440\u0443\u0432\u0430\u0442<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%ba%d0%be%d0%b3%d0%bd%d0%b8%d1%82%d0%b8%d0%b2%d0%bd%d0%b0-%d1%8f%d1%81%d0%bd%d0%be%d1%82%d0%b0\/\" class=\"advgb-post-tax-term\">\u043a\u043e\u0433\u043d\u0438\u0442\u0438\u0432\u043d\u0430 \u044f\u0441\u043d\u043e\u0442\u0430<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%ba%d1%80%d1%8a%d0%b2%d0%bd%d0%b0-%d0%b7%d0%b0%d1%85%d0%b0%d1%80\/\" class=\"advgb-post-tax-term\">\u043a\u0440\u044a\u0432\u043d\u0430 \u0437\u0430\u0445\u0430\u0440<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%bb%d0%be%d0%ba%d0%b0%d0%bb%d0%bd%d0%b0-%d0%b4%d0%be%d0%b1%d0%b0%d0%b2%d0%ba%d0%b0\/\" class=\"advgb-post-tax-term\">\u043b\u043e\u043a\u0430\u043b\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%bc%d0%b5%d1%82%d0%b0%d0%b1%d0%be%d0%bb%d0%b8%d1%82%d0%bd%d0%b0-%d0%be%d0%bf%d1%82%d0%b8%d0%bc%d0%b8%d0%b7%d0%b0%d1%86%d0%b8%d1%8f\/\" class=\"advgb-post-tax-term\">\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0430 \u043e\u043f\u0442\u0438\u043c\u0438\u0437\u0430\u0446\u0438\u044f<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%bc%d0%b5%d1%82%d0%b0%d0%b1%d0%be%d0%bb%d0%b8%d1%82%d0%bd%d0%be-%d0%b7%d0%b4%d1%80%d0%b0%d0%b2%d0%b5\/\" class=\"advgb-post-tax-term\">\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%bf%d0%b5%d1%80%d0%be%d1%80%d0%b0%d0%bb%d0%bd%d0%b0-%d0%b4%d0%be%d0%b1%d0%b0%d0%b2%d0%ba%d0%b0\/\" class=\"advgb-post-tax-term\">\u043f\u0435\u0440\u043e\u0440\u0430\u043b\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d0%bf%d1%80%d0%be%d1%82%d0%b8%d0%b2%d0%be%d0%b2%d1%8a%d0%b7%d0%bf%d0%b0%d0%bb%d0%b8%d1%82%d0%b5%d0%bb%d0%bd%d0%be\/\" class=\"advgb-post-tax-term\">\u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u043e<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d1%80%d0%b5%d0%b9-%d0%bf%d0%b8%d0%b9%d1%82\/\" class=\"advgb-post-tax-term\">\u0420\u0435\u0439 \u041f\u0438\u0439\u0442<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d1%81%d0%bf%d0%be%d1%80%d1%82%d0%bd%d0%b0-%d0%b8%d0%b7%d0%b4%d1%80%d1%8a%d0%b6%d0%bb%d0%b8%d0%b2%d0%be%d1%81%d1%82\/\" class=\"advgb-post-tax-term\">\u0441\u043f\u043e\u0440\u0442\u043d\u0430 \u0438\u0437\u0434\u0440\u044a\u0436\u043b\u0438\u0432\u043e\u0441\u0442<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d1%85%d0%b0%d0%b9%d0%b4%d1%83%d1%82\/\" class=\"advgb-post-tax-term\">\u0445\u0430\u0439\u0434\u0443\u0442<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d1%85%d0%be%d0%bb%d0%b8%d1%81%d1%82%d0%b8%d1%87%d0%bd%d0%be-%d0%b7%d0%b4%d1%80%d0%b0%d0%b2%d0%b5\/\" class=\"advgb-post-tax-term\">\u0445\u043e\u043b\u0438\u0441\u0442\u0438\u0447\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435<\/a>","<a href=\"https:\/\/xenobg.com\/ro\/produktov-etiket\/%d1%85%d1%80%d0%be%d0%bd%d0%b8%d1%87%d0%bd%d0%b0-%d1%83%d0%bc%d0%be%d1%80%d0%b0\/\" class=\"advgb-post-tax-term\">\u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0430 \u0443\u043c\u043e\u0440\u0430<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">\u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442<\/span>","<span class=\"advgb-post-tax-term\">\u0433\u043b\u044e\u043a\u043e\u0437\u043d\u043e \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435<\/span>","<span class=\"advgb-post-tax-term\">\u0435\u043d\u0435\u0440\u0433\u0438\u0435\u043d \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0437\u044a\u043c<\/span>","<span class=\"advgb-post-tax-term\">\u0435\u0442\u0438\u043b \u0430\u0446\u0435\u0442\u043e\u0430\u0446\u0435\u0442\u0430\u0442<\/span>","<span class=\"advgb-post-tax-term\">\u0435\u0442\u0438\u043b-\u043f\u0438\u0440\u0443\u0432\u0430\u0442<\/span>","<span class=\"advgb-post-tax-term\">\u043a\u043e\u0433\u043d\u0438\u0442\u0438\u0432\u043d\u0430 \u044f\u0441\u043d\u043e\u0442\u0430<\/span>","<span class=\"advgb-post-tax-term\">\u043a\u0440\u044a\u0432\u043d\u0430 \u0437\u0430\u0445\u0430\u0440<\/span>","<span class=\"advgb-post-tax-term\">\u043b\u043e\u043a\u0430\u043b\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430<\/span>","<span class=\"advgb-post-tax-term\">\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u0430 \u043e\u043f\u0442\u0438\u043c\u0438\u0437\u0430\u0446\u0438\u044f<\/span>","<span class=\"advgb-post-tax-term\">\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0442\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435<\/span>","<span class=\"advgb-post-tax-term\">\u043f\u0435\u0440\u043e\u0440\u0430\u043b\u043d\u0430 \u0434\u043e\u0431\u0430\u0432\u043a\u0430<\/span>","<span class=\"advgb-post-tax-term\">\u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u043e<\/span>","<span class=\"advgb-post-tax-term\">\u0420\u0435\u0439 \u041f\u0438\u0439\u0442<\/span>","<span class=\"advgb-post-tax-term\">\u0441\u043f\u043e\u0440\u0442\u043d\u0430 \u0438\u0437\u0434\u0440\u044a\u0436\u043b\u0438\u0432\u043e\u0441\u0442<\/span>","<span class=\"advgb-post-tax-term\">\u0445\u0430\u0439\u0434\u0443\u0442<\/span>","<span class=\"advgb-post-tax-term\">\u0445\u043e\u043b\u0438\u0441\u0442\u0438\u0447\u043d\u043e \u0437\u0434\u0440\u0430\u0432\u0435<\/span>","<span class=\"advgb-post-tax-term\">\u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0430 \u0443\u043c\u043e\u0440\u0430<\/span>"],"slug":"product_tag","name":"Etichete produs"},"product_shipping_class":{"linked":[],"unlinked":[],"slug":"product_shipping_class","name":"Clase de livrare produse"},"pos_product_visibility":{"linked":[],"unlinked":[],"slug":"pos_product_visibility","name":"Vizibilitate produse \u00een POS"},"pa_color":{"linked":[],"unlinked":[],"slug":"pa_color","name":"color produs"},"pa_size":{"linked":[],"unlinked":[],"slug":"pa_size","name":"size produs"},"woo-feed-brand":{"linked":[],"unlinked":[],"slug":"woo-feed-brand","name":"Brand by CTX Feed"}},"series_order":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/product\/23962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/comments?post=23962"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/media\/24560"}],"wp:attachment":[{"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/media?parent=23962"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/product_brand?post=23962"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/product_cat?post=23962"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/product_tag?post=23962"},{"taxonomy":"woo-feed-brand","embeddable":true,"href":"https:\/\/xenobg.com\/ro\/wp-json\/wp\/v2\/woo-feed-brand?post=23962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}