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Още едно изследване за ендотоксинът. Този път темата е връзката на високата чувствителност към ендотоксин с по-малките шансове за излекуване на хора с лимфома. Докато изследването по-долу наблюдава единствено пациенти с лимфома, съществуват много други проучвания, откриващи подобна връзка с други видове рак. Ендотоксинът и ракът вървят ръка за ръка.

https://www.dovepress.com/tlr4-expression-correlated-with-pd-l1-expression-indicates-a-poor-prog-peer-reviewed-article-CMAR

“…Background: Toll-like receptor 4 (TLR4), a member of the pattern recognition receptors, has been reported to be involved in carcinogenesis. However, the clinical impact of TLR4 in peripheral T-cell lymphomas (PTCL) remains unclear. Methods: The current study, using immunohistochemical staining, first examined TLR4 and programmed cell death-ligand 1 (PD-L1) expression in patients with PTCL, to correlate TLR4 and PD-L1 expression with clinicopathological parameters. Results: It was found that the rates of high expression of TLR4 and PD-L1 were 41.7% and 45.8%, respectively. TLR4 expression was closely associated with PD-L1 expression. The expression of TLR4 was closely related to primary extranodal site involvement, increased Ann Arbor stage, and low hemoglobin expression, while the expression of PD-L1 was closely related to a low platelet count and multiple extranodal organ involvements (>1). High expression of either TLR4 or PD-L1 indicated a poor survival rate for patients with PTCL. Multivariate analyses further confirmed that increased expression levels of TLR4 and PD-L1 are unfavorable prognostic factors for PTCL.”

Източник:

http://haidut.me/?p=148

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