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Документи за Аципамокс

https://en.wikipedia.org/wiki/Acipimox

https://www.ncbi.nlm.nih.gov/pubmed/8306591

“…After 3 days of acipimox treatment, fasting and 24-h plasma glucose and serum triglyceride concentrations were significantly reduced (p < 0.05), but no longer after 4 weeks of treatment. Despite the rebound rise in NEFA, acute administration of acipimox still inhibited both oxidative and non-oxidative NEFA metabolism in the basal state (p < 0.01-0.001) and during insulin infusion (p < 0.05-0.001). Inhibition of NEFA metabolism was associated with increased insulin-stimulated glucose uptake (from 3.56 +/- 0.28 to 5.14 +/- 0.67 mumol kg-1 min-1, p < 0.05), mainly due to stimulation of non-oxidative glucose disposal (from 1.74 +/- 0.23 to 3.03 +/- 0.53 mumol kg-1 min-1, p < 0.05). In conclusion, acipimox administered acutely inhibits NEFA appearance (lipolysis), which is associated with improved glucose uptake.”

https://dm5migu4zj3pb.cloudfront.net/manuscripts/115000/115432/cache/115432.1-20150302164831-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf

“…Acipimox increased glucose oxidation in the basal state (76 +/- 4 vs. 50 +/- 4 mg/m2

per min, P less than 0.01). During insulin infusion Acipimox increased both glucose

oxidation (121 +/- 7 vs. 95 +/- 4 mg/m2 per min, P less than 0.01) and nonoxidative glucose

disposal (248 […]”

https://link.springer.com/article/10.1007/BF00580753

“…Acipimox decreased basal NEFA concentrations (P<0.01) and reduced lipid oxidation during low-dose insulin infusion (P<0.05). Glucose uptake, predominantly glycogen formation, was stimulated by acipimox (P<0.05). In conclusion, the insulin resistance of glucose metabolism associated with hypertriglyceridaemia is largely due to a defect in non-oxidative glucose metabolism. Acipimox improves glucose metabolism both by affecting glucose oxidation (low-dose insulin) and non-oxidative glucose metabolism (high-dose insulin).”

Randle Cycle който показва, че може или само мазнина или захар да се метаболизира от клетката в даден момент.

https://en.wikipedia.org/wiki/Randle_cycle

алкохолния коктейл “Контесата” или “Дюкесата” за руските олимпийци:

https://www.businessinsider.com/russia-drugs-sochi-athletes-performance-2016-5

“…Rodchenkov said his formula was exact: For very milliliter of alcohol, he used one milligram of the steroid blend. Rather than just downing the mixture, which would delay the absorption of the drugs until they could crossed the barrier of the stomach, the athletes “were instructed to swish the liquid around in their mouths, under the tongue,” The Times reported.”

Виж последното изречение на цитата. Там пише че се държи под езика, както и наще продукти.

Ето и резултата:

“…Russian athletes took home 33 medals at the Sochi games, including 13 golds. One-third of them were awarded to athletes who are now being accused of receiving Rodchenkov’s cocktail. According to The Times, the names of these athletes are included on a spreadsheet outlining the doping plan that Rodchenkov said was given to him by the Russian government sports ministry.”

За липолиз и диабета:

https://link.springer.com/article/10.1007/BF01213565

“…High plasma levels of free fatty acids decrease glucose utilization of muscle and the effects of insulin thereon. Therefore, pharmacologic inhibition of lipolysis has been investigated in order to find new and better ways to adjust the metabolic situation in diabetes mellitus. We have used 5-methylpyrazole-3-carboxylic acid as a model antilipolytic compound. This drug, nicotinic acid and prostaglandin E1 not only inhibit lipolysis, but they also markedly enhance glucose uptake of adipose tissuein vivo. 5-methylpyrazole-3-carboxylic acid prevents the rise of the free fatty acids and of blood glucose acutely after the administration of anti-insulin serum. “

Аспирин за Диабет

https://diabetes.diabetesjournals.org/content/27/7/750

https://academic.oup.com/jcem/article/93/7/2523/2598525

https://journals.sagepub.com/doi/10.1345/aph.1M483

Никотинамид за Диабет(инсулинозависим)

http://journal.diabetes.org/diabetescare/FullText/Supplements/DiabetesCare/Supplement299/B16.asp

https://diabetes.diabetesjournals.org/content/31/9/749

https://lpi.oregonstate.edu/book/export/html/80#type-1-diabetes-prevention

никотинамидза диабет тип 2

https://www.ncbi.nlm.nih.gov/pubmed/24314867

https://www.ncbi.nlm.nih.gov/pubmed/24314867

ето а статията от 1858 година, която показва че със захар може да се лекува диабет.

https://www.jstor.org/stable/25192136?seq=1#metadata_info_tab_contents

почват от втората страница и се казва  “Sugar and Diabetes”.

и ето 3 статии, които показват че мазнините в кръвта имат токсичен ефект върху панкреаса.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063119/

https://diabetes.diabetesjournals.org/content/51/suppl_1/S134

https://diabetes.diabetesjournals.org/content/51/5/1437

и последно и може би най-важно е че лекарства които намаляват кръвната захар увеличават рисковете за умиране от всякакви причини.

https://www.pharmaceutical-journal.com/news-and-analysis/study-claims-low-hba1c-increases-mortality-risk/10994510.article?firstPass=false

3 линка за beta-hydroxybutyrate i acetoacetate.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058661/

https://www.ncbi.nlm.nih.gov/pubmed/18184896

https://diabetes.diabetesjournals.org/content/20/7/485

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